-
1
-
-
33645782262
-
Obesity drugs in clinical development
-
Halford J.C. Obesity drugs in clinical development. Curr. Opin. Invest. Drugs 7 (2006) 312-318
-
(2006)
Curr. Opin. Invest. Drugs
, vol.7
, pp. 312-318
-
-
Halford, J.C.1
-
2
-
-
0022457673
-
Serotonin manipulations and the structure of feeding behaviour
-
Blundell J.E. Serotonin manipulations and the structure of feeding behaviour. Appetite 7 (1988) 39-56
-
(1988)
Appetite
, vol.7
, pp. 39-56
-
-
Blundell, J.E.1
-
3
-
-
0023815043
-
The interaction of metergoline, a 5-HT receptor blocker, and dexfenfluramine in human feeding
-
Goodall E., and Silverstone T. The interaction of metergoline, a 5-HT receptor blocker, and dexfenfluramine in human feeding. Clin. Neuropharmacol. 11 (1988) S135-S138
-
(1988)
Clin. Neuropharmacol.
, vol.11
-
-
Goodall, E.1
Silverstone, T.2
-
4
-
-
0022540417
-
Neurobiology of an anorectic drug: fenfluramine
-
Rowland N.E., and Carlton J. Neurobiology of an anorectic drug: fenfluramine. Progr. Neurobiol. 27 (1986) 13-62
-
(1986)
Progr. Neurobiol.
, vol.27
, pp. 13-62
-
-
Rowland, N.E.1
Carlton, J.2
-
5
-
-
0024572781
-
A behavioural profile of fluoxetine-induced anorexia
-
Clifton P.G., et al. A behavioural profile of fluoxetine-induced anorexia. Psychopharmacology 97 (1989) 89-95
-
(1989)
Psychopharmacology
, vol.97
, pp. 89-95
-
-
Clifton, P.G.1
-
6
-
-
0025329192
-
The effect of the 5-HT reuptake inhibitor fluoxetine on food intake and body weight in healthy male subjects
-
McGuirk J., and Silverstone T. The effect of the 5-HT reuptake inhibitor fluoxetine on food intake and body weight in healthy male subjects. Int. J. Obesity 14 (1990) 361-372
-
(1990)
Int. J. Obesity
, vol.14
, pp. 361-372
-
-
McGuirk, J.1
Silverstone, T.2
-
7
-
-
0017260199
-
Hyperphagia and increased growth in rats after intraventricular injection of 5,7-dihydroxytryptamine
-
Saller C.F., and Stricker E.M. Hyperphagia and increased growth in rats after intraventricular injection of 5,7-dihydroxytryptamine. Science 192 (1976) 385-387
-
(1976)
Science
, vol.192
, pp. 385-387
-
-
Saller, C.F.1
Stricker, E.M.2
-
8
-
-
3042567101
-
Tonic regulation of satiety by 5-HT1B receptors in the mouse: converging evidence from behavioural and c-fos immunoreactivity studies
-
Lee M.D., et al. Tonic regulation of satiety by 5-HT1B receptors in the mouse: converging evidence from behavioural and c-fos immunoreactivity studies. Eur. J. Neurosci. 19 (2004) 3017-3025
-
(2004)
Eur. J. Neurosci.
, vol.19
, pp. 3017-3025
-
-
Lee, M.D.1
-
9
-
-
0032527896
-
Absence of fenfluramine-induced anorexia and reduced c-Fos induction in the hypothalamus and central amygdaloid complex of serotonin 1B receptor knock-out mice
-
Lucas J.J., et al. Absence of fenfluramine-induced anorexia and reduced c-Fos induction in the hypothalamus and central amygdaloid complex of serotonin 1B receptor knock-out mice. J. Neurosci. 18 (1998) 5537-5544
-
(1998)
J. Neurosci.
, vol.18
, pp. 5537-5544
-
-
Lucas, J.J.1
-
10
-
-
0035851864
-
Male and female 5-HT(1B) receptor knockout mice have higher body weights than wildtypes
-
Bouwknecht J.A., et al. Male and female 5-HT(1B) receptor knockout mice have higher body weights than wildtypes. Physiol. Behav. 74 (2001) 507-516
-
(2001)
Physiol. Behav.
, vol.74
, pp. 507-516
-
-
Bouwknecht, J.A.1
-
11
-
-
0030610867
-
SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist
-
Kennett G.A., et al. SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist. Neuropharmacology 36 (1997) 609-620
-
(1997)
Neuropharmacology
, vol.36
, pp. 609-620
-
-
Kennett, G.A.1
-
12
-
-
0036009197
-
Role of 5-HT2C receptors in the hypophagic effect of m-CPP, ORG 37684 and CP-94,253 in the rat
-
Schreiber R., and De Vry J. Role of 5-HT2C receptors in the hypophagic effect of m-CPP, ORG 37684 and CP-94,253 in the rat. Progr. Neuro-Psychopharmacol. Biol. Psychiatry 26 (2002) 441-449
-
(2002)
Progr. Neuro-Psychopharmacol. Biol. Psychiatry
, vol.26
, pp. 441-449
-
-
Schreiber, R.1
De Vry, J.2
-
13
-
-
0033778106
-
Similarities in the action of Ro 60-0175, a 5-HT2C receptor agonist, and d-fenfluramine on feeding patterns in the rat
-
Clifton P.G., et al. Similarities in the action of Ro 60-0175, a 5-HT2C receptor agonist, and d-fenfluramine on feeding patterns in the rat. Psychopharmacology 152 (2000) 256-267
-
(2000)
Psychopharmacology
, vol.152
, pp. 256-267
-
-
Clifton, P.G.1
-
14
-
-
0031015701
-
Appetite suppression by commonly used drugs depends on 5-HT receptors but not on 5-HT availability
-
Curzon G., et al. Appetite suppression by commonly used drugs depends on 5-HT receptors but not on 5-HT availability. Trends Pharmacol. Sci. 18 (1997) 21-25
-
(1997)
Trends Pharmacol. Sci.
, vol.18
, pp. 21-25
-
-
Curzon, G.1
-
15
-
-
4544261771
-
Pharmacological characterisation of the agonist radioligand binding site of 5-HT2A, 5-HT2B and 5-HT2C receptors
-
Knight A.R., et al. Pharmacological characterisation of the agonist radioligand binding site of 5-HT2A, 5-HT2B and 5-HT2C receptors. Naunyn-Schmiedeberg's Arch. Pharmacol. 370 (2004) 114-123
-
(2004)
Naunyn-Schmiedeberg's Arch. Pharmacol.
, vol.370
, pp. 114-123
-
-
Knight, A.R.1
-
16
-
-
0034899208
-
Evidence that hypophagia indiced by d-fenfluramine and d-norfenfluramine in the rat is mediated by 5-HT2C receptors
-
Vickers S.P., et al. Evidence that hypophagia indiced by d-fenfluramine and d-norfenfluramine in the rat is mediated by 5-HT2C receptors. Neuropharmacology 41 (2001) 200-209
-
(2001)
Neuropharmacology
, vol.41
, pp. 200-209
-
-
Vickers, S.P.1
-
17
-
-
0026567695
-
Role of serotonin receptors in the effect of d-fenfluramine on feeding patterns in the rat
-
Grignaschi G., and Samanin R. Role of serotonin receptors in the effect of d-fenfluramine on feeding patterns in the rat. Eur. J. Pharmacol. 212 (1992) 287-289
-
(1992)
Eur. J. Pharmacol.
, vol.212
, pp. 287-289
-
-
Grignaschi, G.1
Samanin, R.2
-
18
-
-
33344469812
-
Serotonin 1B and 2C receptor interactions in the modulation of feeding behaviour in the mouse
-
Dalton G.L., et al. Serotonin 1B and 2C receptor interactions in the modulation of feeding behaviour in the mouse. Psychopharmacology 185 (2006) 45-57
-
(2006)
Psychopharmacology
, vol.185
, pp. 45-57
-
-
Dalton, G.L.1
-
19
-
-
0642274899
-
Mouse genetic approaches to feeding regulation: serotonin 5-HT2C receptor mutant mice
-
Tecott L.H., and Abdallah L. Mouse genetic approaches to feeding regulation: serotonin 5-HT2C receptor mutant mice. CNS Spectrums 8 (2003) 584-588
-
(2003)
CNS Spectrums
, vol.8
, pp. 584-588
-
-
Tecott, L.H.1
Abdallah, L.2
-
20
-
-
0028909857
-
Eating disorder and epilepsy in mice lacking 5HT2C serotonin receptors
-
Tecott L.H., et al. Eating disorder and epilepsy in mice lacking 5HT2C serotonin receptors. Nature 374 (1995) 542-546
-
(1995)
Nature
, vol.374
, pp. 542-546
-
-
Tecott, L.H.1
-
21
-
-
0031721271
-
Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene
-
Nonogaki K., et al. Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene. Nat. Med. 4 (1998) 1152-1156
-
(1998)
Nat. Med.
, vol.4
, pp. 1152-1156
-
-
Nonogaki, K.1
-
22
-
-
0037315191
-
Hyperactivity and reduced energy cost of physical activity in serotonin 5-HT2C receptor mutant mice
-
Nonogaki K., et al. Hyperactivity and reduced energy cost of physical activity in serotonin 5-HT2C receptor mutant mice. Diabetes 52 (2003) 315-320
-
(2003)
Diabetes
, vol.52
, pp. 315-320
-
-
Nonogaki, K.1
-
23
-
-
15744364142
-
Weight gain associated with the -759 C/T polymorphism of the 5HT2C receptor and olanzapine
-
Ellingrod V.L., et al. Weight gain associated with the -759 C/T polymorphism of the 5HT2C receptor and olanzapine. Am. J. Med. Genet. Part B 134B (2005) 76-78
-
(2005)
Am. J. Med. Genet. Part B
, vol.134 B
, pp. 76-78
-
-
Ellingrod, V.L.1
-
24
-
-
12944265464
-
Cllozapine-induced weight gain associated with the 5HT2C receptor -759C/T polymorphism
-
Miller D.D., et al. Cllozapine-induced weight gain associated with the 5HT2C receptor -759C/T polymorphism. Am. J. Med. Genet. Part B 133B (2005) 97-100
-
(2005)
Am. J. Med. Genet. Part B
, vol.133 B
, pp. 97-100
-
-
Miller, D.D.1
-
25
-
-
14844322355
-
Low gene expression conferred by association of an allele of the 5-HT2C receptor gene with antipsychotic-induced weight gain
-
Buckland P.R., et al. Low gene expression conferred by association of an allele of the 5-HT2C receptor gene with antipsychotic-induced weight gain. Am. J. Psychiatry 162 (2005) 613-615
-
(2005)
Am. J. Psychiatry
, vol.162
, pp. 613-615
-
-
Buckland, P.R.1
-
26
-
-
17644365724
-
2C receptor (HTR2C) and other genes
-
2C receptor (HTR2C) and other genes. Pharmacogenet. Genomics 15 (2005) 193-194
-
(2005)
Pharmacogenet. Genomics
, vol.15
, pp. 193-194
-
-
Harrison, P.J.1
-
27
-
-
33644772628
-
The potential use of selective 5-HT2C agonists in treating obesity
-
Smith B.M., et al. The potential use of selective 5-HT2C agonists in treating obesity. Expert Opin. Invest. Drugs 14 (2006) 257-266
-
(2006)
Expert Opin. Invest. Drugs
, vol.14
, pp. 257-266
-
-
Smith, B.M.1
-
28
-
-
0034610435
-
Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications
-
Rothman R.B., et al. Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications. Circulation 102 (2000) 2836-2841
-
(2000)
Circulation
, vol.102
, pp. 2836-2841
-
-
Rothman, R.B.1
-
29
-
-
13944263169
-
Discovery and SAR of new benzazepines as potent and selective 5-HT2C receptor agonists for the treatment of obesity
-
Smith B.M., et al. Discovery and SAR of new benzazepines as potent and selective 5-HT2C receptor agonists for the treatment of obesity. Bioorg. Med. Chem. Lett. 15 (2005) 1467-1470
-
(2005)
Bioorg. Med. Chem. Lett.
, vol.15
, pp. 1467-1470
-
-
Smith, B.M.1
-
30
-
-
33745843852
-
Preclinical in vivo pharmacology of BVT.933, a selective 5-HT2C receptor agonist
-
(Abstracts 29, 509.9)
-
Svartengren J., et al. Preclinical in vivo pharmacology of BVT.933, a selective 5-HT2C receptor agonist. Soc. Neurosci. (2003) (Abstracts 29, 509.9)
-
(2003)
Soc. Neurosci.
-
-
Svartengren, J.1
-
31
-
-
33745838246
-
5-Hydroxytryptamine2C (5-HT2C) receptor agonists as potential antiobesity agents
-
Nilsson B.M. 5-Hydroxytryptamine2C (5-HT2C) receptor agonists as potential antiobesity agents. J. Med. Chem. 49 (2006) 4023-4034
-
(2006)
J. Med. Chem.
, vol.49
, pp. 4023-4034
-
-
Nilsson, B.M.1
-
32
-
-
11144357722
-
Indoline derivatives as 5-HT2C receptor agonists
-
Bentley J.M., et al. Indoline derivatives as 5-HT2C receptor agonists. Bioorg. Med. Chem. Lett. 14 (2004) 2367-2370
-
(2004)
Bioorg. Med. Chem. Lett.
, vol.14
, pp. 2367-2370
-
-
Bentley, J.M.1
-
33
-
-
29544434335
-
Pyrrolo(iso)quinoline derivatives as 5-HT2C receptor agonists
-
Adams D.R., et al. Pyrrolo(iso)quinoline derivatives as 5-HT2C receptor agonists. Bioorg. Med. Chem. Lett. 16 (2006) 677-680
-
(2006)
Bioorg. Med. Chem. Lett.
, vol.16
, pp. 677-680
-
-
Adams, D.R.1
-
34
-
-
31344459084
-
Synthesis and biological evaluation of novel hexahydro-pyrido[3′,2′:4,5]pyrrolo[1,2-a]pyrazines as potent and selective 5-HT2C receptor agonists
-
Richter H.G.F., et al. Synthesis and biological evaluation of novel hexahydro-pyrido[3′,2′:4,5]pyrrolo[1,2-a]pyrazines as potent and selective 5-HT2C receptor agonists. Bioorg. Med. Chem. Lett. 16 (2006) 1207-1211
-
(2006)
Bioorg. Med. Chem. Lett.
, vol.16
, pp. 1207-1211
-
-
Richter, H.G.F.1
-
35
-
-
0034605255
-
Synthesis and 5-hydroxytryptamine (5-HT) activity of 2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5-(6H)ones and 2,3,4,4a,5,6-Hexahydro-1H-pyrazino[1,2-a]quinoxalines
-
Welmaker G.S., et al. Synthesis and 5-hydroxytryptamine (5-HT) activity of 2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5-(6H)ones and 2,3,4,4a,5,6-Hexahydro-1H-pyrazino[1,2-a]quinoxalines. Bioorg. Med. Chem. Lett. 10 (2000) 1991-1994
-
(2000)
Bioorg. Med. Chem. Lett.
, vol.10
, pp. 1991-1994
-
-
Welmaker, G.S.1
-
36
-
-
1942438459
-
Cycloalkyl[b][1,4]benzodiazepinoindoles are agonists at the human 5-HT2C receptor
-
Sabb A.L., et al. Cycloalkyl[b][1,4]benzodiazepinoindoles are agonists at the human 5-HT2C receptor. Bioorg. Med. Chem. Lett. 14 (2004) 2603-2607
-
(2004)
Bioorg. Med. Chem. Lett.
, vol.14
, pp. 2603-2607
-
-
Sabb, A.L.1
-
37
-
-
20944441963
-
WAY-163909 [(7bR,10aR)-1,2,3,4,8,9,10,10a-octahydro-7bhcyclopenta-[b][1,4]diazepino [6,7,1hi]indole], a novel 5-hydroxytryptamine 2C receptor selective agonist with anorectic activity
-
Dunlop J., et al. WAY-163909 [(7bR,10aR)-1,2,3,4,8,9,10,10a-octahydro-7bhcyclopenta-[b][1,4]diazepino [6,7,1hi]indole], a novel 5-hydroxytryptamine 2C receptor selective agonist with anorectic activity. J. Pharmacol. Exp. Ther. 313 (2005) 862-869
-
(2005)
J. Pharmacol. Exp. Ther.
, vol.313
, pp. 862-869
-
-
Dunlop, J.1
-
38
-
-
33644936933
-
Antiobesity-like effects of the 5-HT2C receptor agonist WAY-161503
-
Rosenzweig-Lipson S., et al. Antiobesity-like effects of the 5-HT2C receptor agonist WAY-161503. Brain Res. 1073-1074 (2006) 240-251
-
(2006)
Brain Res.
, vol.1073-1074
, pp. 240-251
-
-
Rosenzweig-Lipson, S.1
-
39
-
-
2442421711
-
Antiobesity effect of YM348, a novel 5-HT2C receptor agonist in Zucker rats
-
Hayashi A., et al. Antiobesity effect of YM348, a novel 5-HT2C receptor agonist in Zucker rats. Brain Res. 1011 (2004) 221-227
-
(2004)
Brain Res.
, vol.1011
, pp. 221-227
-
-
Hayashi, A.1
-
40
-
-
0347987923
-
Pharmacological profile of YM348, a novel, potent and orally active 5-HT2C receptor agonist
-
Kimura Y., et al. Pharmacological profile of YM348, a novel, potent and orally active 5-HT2C receptor agonist. Eur. J. Pharmacol. 483 (2004) 37-43
-
(2004)
Eur. J. Pharmacol.
, vol.483
, pp. 37-43
-
-
Kimura, Y.1
-
41
-
-
17144438260
-
Pyrrolo[3,2,1-ij]quinoline derivatives, a 5-HT2c receptor agonist with selectivity over the 5-HT2a receptor: potential therapeutic applications for epilepsy and obesity
-
Isaac M., et al. Pyrrolo[3,2,1-ij]quinoline derivatives, a 5-HT2c receptor agonist with selectivity over the 5-HT2a receptor: potential therapeutic applications for epilepsy and obesity. Bioorg. Med. Chem. Lett. 10 (2000) 919-921
-
(2000)
Bioorg. Med. Chem. Lett.
, vol.10
, pp. 919-921
-
-
Isaac, M.1
-
42
-
-
33846200751
-
-
Briner, K. et al. (2001) Novel benzothiophenes and their use as 5-HT2C receptor agonists. WO-00109126
-
-
-
-
43
-
-
33846228784
-
-
Robichaud, A.J. et al. (2002) Substituted pyridoindoles as serotonin agonists and antagonists. WO-02059129
-
-
-
-
44
-
-
0032219620
-
5-HT2C receptor agonists: pharmacological characteristics and therapeutic potential
-
Martin J.R., et al. 5-HT2C receptor agonists: pharmacological characteristics and therapeutic potential. J. Pharmacol. Exp. Ther. 286 (1998) 913-924
-
(1998)
J. Pharmacol. Exp. Ther.
, vol.286
, pp. 913-924
-
-
Martin, J.R.1
-
45
-
-
33846228375
-
-
Ladoucer, G.H. et al. (2003) Novel 1-(2-aminoalkyl)-1H-pyrazole derivatives useful as 5-HT2C ligands for the treatment of obesity and eating disorders. WO-03057674
-
-
-
-
46
-
-
33846202508
-
-
Chian, P.Y.C. et al. (2003) Piperazine derivative 5-HT receptor ligands. WO-03000663
-
-
-
-
48
-
-
33645230435
-
2C receptors as a target for the treatment of depressive and anxious states: focus on novel therapeutic strategies
-
2C receptors as a target for the treatment of depressive and anxious states: focus on novel therapeutic strategies. Therapie 60 (2005) 441-460
-
(2005)
Therapie
, vol.60
, pp. 441-460
-
-
Millan, M.J.1
-
49
-
-
15044340115
-
2C receptor-mediated weight control in rats
-
2C receptor-mediated weight control in rats. Psychpharmacology 178 (2005) 241-249
-
(2005)
Psychpharmacology
, vol.178
, pp. 241-249
-
-
Hayashi, A.1
-
50
-
-
0034781254
-
2C receptor alters agonist-receptor-effector coupling specificity
-
2C receptor alters agonist-receptor-effector coupling specificity. Br. J. Pharmacol. 134 (2001) 386-392
-
(2001)
Br. J. Pharmacol.
, vol.134
, pp. 386-392
-
-
Berg, K.A.1
-
51
-
-
0033861845
-
The multiplicity of serotonin receptors: uselessly diverse molecules or an embarrassment of riches?
-
Roth B.L., et al. The multiplicity of serotonin receptors: uselessly diverse molecules or an embarrassment of riches?. Neuroscientist 6 (2000) 252-262
-
(2000)
Neuroscientist
, vol.6
, pp. 252-262
-
-
Roth, B.L.1
|