메뉴 건너뛰기




Volumn 3, Issue 4, 2006, Pages 577-583

Anti-obesity pharmacotherapy: Future perspectives utilising 5-HT2C receptor agonists

Author keywords

[No Author keywords available]

Indexed keywords

1 [1 PYRROLO(ISO)QUINOLINYL] 2 PROPYLAMINE; 1,4 DIHYDROINDENO[1,2 B]PYRROLE DERIVATIVE; 2 (6 CHLORO 5 FLUORO 1 INDOLYL) 1 METHYLETHYLAMINE; 5384; 6 CHLORO 5 METHYL 1 [[2 [(2 METHYL 3 PYRIDYL)OXY] 5 PYRIDYL]CARBAMOYL]INDOLINE; ANTIOBESITY AGENT; APD 356; ATHX 105; ATHX 88651; BVT 933; FENFLURAMINE; IL 639; INDOLE DERIVATIVE; LORCASERIN; LY 448100; PIPERAZINE DERIVATIVE; PLACEBO; PYRAZINE DERIVATIVE; RO 600032; SEROTONIN 2A RECEPTOR; SEROTONIN 2B RECEPTOR; SEROTONIN 2C AGONIST; SEROTONIN 2C RECEPTOR; SIBUTRAMINE; TETRAHYDROLIPSTATIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VER 2692; VER 3323; VER 5384; VER 5593; WAY 161503; WAY 163909; WAY 629; YM 348;

EID: 33846262179     PISSN: 17406773     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ddstr.2006.11.005     Document Type: Review
Times cited : (18)

References (51)
  • 1
    • 33645782262 scopus 로고    scopus 로고
    • Obesity drugs in clinical development
    • Halford J.C. Obesity drugs in clinical development. Curr. Opin. Invest. Drugs 7 (2006) 312-318
    • (2006) Curr. Opin. Invest. Drugs , vol.7 , pp. 312-318
    • Halford, J.C.1
  • 2
    • 0022457673 scopus 로고
    • Serotonin manipulations and the structure of feeding behaviour
    • Blundell J.E. Serotonin manipulations and the structure of feeding behaviour. Appetite 7 (1988) 39-56
    • (1988) Appetite , vol.7 , pp. 39-56
    • Blundell, J.E.1
  • 3
    • 0023815043 scopus 로고
    • The interaction of metergoline, a 5-HT receptor blocker, and dexfenfluramine in human feeding
    • Goodall E., and Silverstone T. The interaction of metergoline, a 5-HT receptor blocker, and dexfenfluramine in human feeding. Clin. Neuropharmacol. 11 (1988) S135-S138
    • (1988) Clin. Neuropharmacol. , vol.11
    • Goodall, E.1    Silverstone, T.2
  • 4
    • 0022540417 scopus 로고
    • Neurobiology of an anorectic drug: fenfluramine
    • Rowland N.E., and Carlton J. Neurobiology of an anorectic drug: fenfluramine. Progr. Neurobiol. 27 (1986) 13-62
    • (1986) Progr. Neurobiol. , vol.27 , pp. 13-62
    • Rowland, N.E.1    Carlton, J.2
  • 5
    • 0024572781 scopus 로고
    • A behavioural profile of fluoxetine-induced anorexia
    • Clifton P.G., et al. A behavioural profile of fluoxetine-induced anorexia. Psychopharmacology 97 (1989) 89-95
    • (1989) Psychopharmacology , vol.97 , pp. 89-95
    • Clifton, P.G.1
  • 6
    • 0025329192 scopus 로고
    • The effect of the 5-HT reuptake inhibitor fluoxetine on food intake and body weight in healthy male subjects
    • McGuirk J., and Silverstone T. The effect of the 5-HT reuptake inhibitor fluoxetine on food intake and body weight in healthy male subjects. Int. J. Obesity 14 (1990) 361-372
    • (1990) Int. J. Obesity , vol.14 , pp. 361-372
    • McGuirk, J.1    Silverstone, T.2
  • 7
    • 0017260199 scopus 로고
    • Hyperphagia and increased growth in rats after intraventricular injection of 5,7-dihydroxytryptamine
    • Saller C.F., and Stricker E.M. Hyperphagia and increased growth in rats after intraventricular injection of 5,7-dihydroxytryptamine. Science 192 (1976) 385-387
    • (1976) Science , vol.192 , pp. 385-387
    • Saller, C.F.1    Stricker, E.M.2
  • 8
    • 3042567101 scopus 로고    scopus 로고
    • Tonic regulation of satiety by 5-HT1B receptors in the mouse: converging evidence from behavioural and c-fos immunoreactivity studies
    • Lee M.D., et al. Tonic regulation of satiety by 5-HT1B receptors in the mouse: converging evidence from behavioural and c-fos immunoreactivity studies. Eur. J. Neurosci. 19 (2004) 3017-3025
    • (2004) Eur. J. Neurosci. , vol.19 , pp. 3017-3025
    • Lee, M.D.1
  • 9
    • 0032527896 scopus 로고    scopus 로고
    • Absence of fenfluramine-induced anorexia and reduced c-Fos induction in the hypothalamus and central amygdaloid complex of serotonin 1B receptor knock-out mice
    • Lucas J.J., et al. Absence of fenfluramine-induced anorexia and reduced c-Fos induction in the hypothalamus and central amygdaloid complex of serotonin 1B receptor knock-out mice. J. Neurosci. 18 (1998) 5537-5544
    • (1998) J. Neurosci. , vol.18 , pp. 5537-5544
    • Lucas, J.J.1
  • 10
    • 0035851864 scopus 로고    scopus 로고
    • Male and female 5-HT(1B) receptor knockout mice have higher body weights than wildtypes
    • Bouwknecht J.A., et al. Male and female 5-HT(1B) receptor knockout mice have higher body weights than wildtypes. Physiol. Behav. 74 (2001) 507-516
    • (2001) Physiol. Behav. , vol.74 , pp. 507-516
    • Bouwknecht, J.A.1
  • 11
    • 0030610867 scopus 로고    scopus 로고
    • SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist
    • Kennett G.A., et al. SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist. Neuropharmacology 36 (1997) 609-620
    • (1997) Neuropharmacology , vol.36 , pp. 609-620
    • Kennett, G.A.1
  • 12
    • 0036009197 scopus 로고    scopus 로고
    • Role of 5-HT2C receptors in the hypophagic effect of m-CPP, ORG 37684 and CP-94,253 in the rat
    • Schreiber R., and De Vry J. Role of 5-HT2C receptors in the hypophagic effect of m-CPP, ORG 37684 and CP-94,253 in the rat. Progr. Neuro-Psychopharmacol. Biol. Psychiatry 26 (2002) 441-449
    • (2002) Progr. Neuro-Psychopharmacol. Biol. Psychiatry , vol.26 , pp. 441-449
    • Schreiber, R.1    De Vry, J.2
  • 13
    • 0033778106 scopus 로고    scopus 로고
    • Similarities in the action of Ro 60-0175, a 5-HT2C receptor agonist, and d-fenfluramine on feeding patterns in the rat
    • Clifton P.G., et al. Similarities in the action of Ro 60-0175, a 5-HT2C receptor agonist, and d-fenfluramine on feeding patterns in the rat. Psychopharmacology 152 (2000) 256-267
    • (2000) Psychopharmacology , vol.152 , pp. 256-267
    • Clifton, P.G.1
  • 14
    • 0031015701 scopus 로고    scopus 로고
    • Appetite suppression by commonly used drugs depends on 5-HT receptors but not on 5-HT availability
    • Curzon G., et al. Appetite suppression by commonly used drugs depends on 5-HT receptors but not on 5-HT availability. Trends Pharmacol. Sci. 18 (1997) 21-25
    • (1997) Trends Pharmacol. Sci. , vol.18 , pp. 21-25
    • Curzon, G.1
  • 15
    • 4544261771 scopus 로고    scopus 로고
    • Pharmacological characterisation of the agonist radioligand binding site of 5-HT2A, 5-HT2B and 5-HT2C receptors
    • Knight A.R., et al. Pharmacological characterisation of the agonist radioligand binding site of 5-HT2A, 5-HT2B and 5-HT2C receptors. Naunyn-Schmiedeberg's Arch. Pharmacol. 370 (2004) 114-123
    • (2004) Naunyn-Schmiedeberg's Arch. Pharmacol. , vol.370 , pp. 114-123
    • Knight, A.R.1
  • 16
    • 0034899208 scopus 로고    scopus 로고
    • Evidence that hypophagia indiced by d-fenfluramine and d-norfenfluramine in the rat is mediated by 5-HT2C receptors
    • Vickers S.P., et al. Evidence that hypophagia indiced by d-fenfluramine and d-norfenfluramine in the rat is mediated by 5-HT2C receptors. Neuropharmacology 41 (2001) 200-209
    • (2001) Neuropharmacology , vol.41 , pp. 200-209
    • Vickers, S.P.1
  • 17
    • 0026567695 scopus 로고
    • Role of serotonin receptors in the effect of d-fenfluramine on feeding patterns in the rat
    • Grignaschi G., and Samanin R. Role of serotonin receptors in the effect of d-fenfluramine on feeding patterns in the rat. Eur. J. Pharmacol. 212 (1992) 287-289
    • (1992) Eur. J. Pharmacol. , vol.212 , pp. 287-289
    • Grignaschi, G.1    Samanin, R.2
  • 18
    • 33344469812 scopus 로고    scopus 로고
    • Serotonin 1B and 2C receptor interactions in the modulation of feeding behaviour in the mouse
    • Dalton G.L., et al. Serotonin 1B and 2C receptor interactions in the modulation of feeding behaviour in the mouse. Psychopharmacology 185 (2006) 45-57
    • (2006) Psychopharmacology , vol.185 , pp. 45-57
    • Dalton, G.L.1
  • 19
    • 0642274899 scopus 로고    scopus 로고
    • Mouse genetic approaches to feeding regulation: serotonin 5-HT2C receptor mutant mice
    • Tecott L.H., and Abdallah L. Mouse genetic approaches to feeding regulation: serotonin 5-HT2C receptor mutant mice. CNS Spectrums 8 (2003) 584-588
    • (2003) CNS Spectrums , vol.8 , pp. 584-588
    • Tecott, L.H.1    Abdallah, L.2
  • 20
    • 0028909857 scopus 로고
    • Eating disorder and epilepsy in mice lacking 5HT2C serotonin receptors
    • Tecott L.H., et al. Eating disorder and epilepsy in mice lacking 5HT2C serotonin receptors. Nature 374 (1995) 542-546
    • (1995) Nature , vol.374 , pp. 542-546
    • Tecott, L.H.1
  • 21
    • 0031721271 scopus 로고    scopus 로고
    • Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene
    • Nonogaki K., et al. Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene. Nat. Med. 4 (1998) 1152-1156
    • (1998) Nat. Med. , vol.4 , pp. 1152-1156
    • Nonogaki, K.1
  • 22
    • 0037315191 scopus 로고    scopus 로고
    • Hyperactivity and reduced energy cost of physical activity in serotonin 5-HT2C receptor mutant mice
    • Nonogaki K., et al. Hyperactivity and reduced energy cost of physical activity in serotonin 5-HT2C receptor mutant mice. Diabetes 52 (2003) 315-320
    • (2003) Diabetes , vol.52 , pp. 315-320
    • Nonogaki, K.1
  • 23
    • 15744364142 scopus 로고    scopus 로고
    • Weight gain associated with the -759 C/T polymorphism of the 5HT2C receptor and olanzapine
    • Ellingrod V.L., et al. Weight gain associated with the -759 C/T polymorphism of the 5HT2C receptor and olanzapine. Am. J. Med. Genet. Part B 134B (2005) 76-78
    • (2005) Am. J. Med. Genet. Part B , vol.134 B , pp. 76-78
    • Ellingrod, V.L.1
  • 24
    • 12944265464 scopus 로고    scopus 로고
    • Cllozapine-induced weight gain associated with the 5HT2C receptor -759C/T polymorphism
    • Miller D.D., et al. Cllozapine-induced weight gain associated with the 5HT2C receptor -759C/T polymorphism. Am. J. Med. Genet. Part B 133B (2005) 97-100
    • (2005) Am. J. Med. Genet. Part B , vol.133 B , pp. 97-100
    • Miller, D.D.1
  • 25
    • 14844322355 scopus 로고    scopus 로고
    • Low gene expression conferred by association of an allele of the 5-HT2C receptor gene with antipsychotic-induced weight gain
    • Buckland P.R., et al. Low gene expression conferred by association of an allele of the 5-HT2C receptor gene with antipsychotic-induced weight gain. Am. J. Psychiatry 162 (2005) 613-615
    • (2005) Am. J. Psychiatry , vol.162 , pp. 613-615
    • Buckland, P.R.1
  • 26
    • 17644365724 scopus 로고    scopus 로고
    • 2C receptor (HTR2C) and other genes
    • 2C receptor (HTR2C) and other genes. Pharmacogenet. Genomics 15 (2005) 193-194
    • (2005) Pharmacogenet. Genomics , vol.15 , pp. 193-194
    • Harrison, P.J.1
  • 27
    • 33644772628 scopus 로고    scopus 로고
    • The potential use of selective 5-HT2C agonists in treating obesity
    • Smith B.M., et al. The potential use of selective 5-HT2C agonists in treating obesity. Expert Opin. Invest. Drugs 14 (2006) 257-266
    • (2006) Expert Opin. Invest. Drugs , vol.14 , pp. 257-266
    • Smith, B.M.1
  • 28
    • 0034610435 scopus 로고    scopus 로고
    • Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications
    • Rothman R.B., et al. Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications. Circulation 102 (2000) 2836-2841
    • (2000) Circulation , vol.102 , pp. 2836-2841
    • Rothman, R.B.1
  • 29
    • 13944263169 scopus 로고    scopus 로고
    • Discovery and SAR of new benzazepines as potent and selective 5-HT2C receptor agonists for the treatment of obesity
    • Smith B.M., et al. Discovery and SAR of new benzazepines as potent and selective 5-HT2C receptor agonists for the treatment of obesity. Bioorg. Med. Chem. Lett. 15 (2005) 1467-1470
    • (2005) Bioorg. Med. Chem. Lett. , vol.15 , pp. 1467-1470
    • Smith, B.M.1
  • 30
    • 33745843852 scopus 로고    scopus 로고
    • Preclinical in vivo pharmacology of BVT.933, a selective 5-HT2C receptor agonist
    • (Abstracts 29, 509.9)
    • Svartengren J., et al. Preclinical in vivo pharmacology of BVT.933, a selective 5-HT2C receptor agonist. Soc. Neurosci. (2003) (Abstracts 29, 509.9)
    • (2003) Soc. Neurosci.
    • Svartengren, J.1
  • 31
    • 33745838246 scopus 로고    scopus 로고
    • 5-Hydroxytryptamine2C (5-HT2C) receptor agonists as potential antiobesity agents
    • Nilsson B.M. 5-Hydroxytryptamine2C (5-HT2C) receptor agonists as potential antiobesity agents. J. Med. Chem. 49 (2006) 4023-4034
    • (2006) J. Med. Chem. , vol.49 , pp. 4023-4034
    • Nilsson, B.M.1
  • 32
    • 11144357722 scopus 로고    scopus 로고
    • Indoline derivatives as 5-HT2C receptor agonists
    • Bentley J.M., et al. Indoline derivatives as 5-HT2C receptor agonists. Bioorg. Med. Chem. Lett. 14 (2004) 2367-2370
    • (2004) Bioorg. Med. Chem. Lett. , vol.14 , pp. 2367-2370
    • Bentley, J.M.1
  • 33
    • 29544434335 scopus 로고    scopus 로고
    • Pyrrolo(iso)quinoline derivatives as 5-HT2C receptor agonists
    • Adams D.R., et al. Pyrrolo(iso)quinoline derivatives as 5-HT2C receptor agonists. Bioorg. Med. Chem. Lett. 16 (2006) 677-680
    • (2006) Bioorg. Med. Chem. Lett. , vol.16 , pp. 677-680
    • Adams, D.R.1
  • 34
    • 31344459084 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of novel hexahydro-pyrido[3′,2′:4,5]pyrrolo[1,2-a]pyrazines as potent and selective 5-HT2C receptor agonists
    • Richter H.G.F., et al. Synthesis and biological evaluation of novel hexahydro-pyrido[3′,2′:4,5]pyrrolo[1,2-a]pyrazines as potent and selective 5-HT2C receptor agonists. Bioorg. Med. Chem. Lett. 16 (2006) 1207-1211
    • (2006) Bioorg. Med. Chem. Lett. , vol.16 , pp. 1207-1211
    • Richter, H.G.F.1
  • 35
    • 0034605255 scopus 로고    scopus 로고
    • Synthesis and 5-hydroxytryptamine (5-HT) activity of 2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5-(6H)ones and 2,3,4,4a,5,6-Hexahydro-1H-pyrazino[1,2-a]quinoxalines
    • Welmaker G.S., et al. Synthesis and 5-hydroxytryptamine (5-HT) activity of 2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5-(6H)ones and 2,3,4,4a,5,6-Hexahydro-1H-pyrazino[1,2-a]quinoxalines. Bioorg. Med. Chem. Lett. 10 (2000) 1991-1994
    • (2000) Bioorg. Med. Chem. Lett. , vol.10 , pp. 1991-1994
    • Welmaker, G.S.1
  • 36
    • 1942438459 scopus 로고    scopus 로고
    • Cycloalkyl[b][1,4]benzodiazepinoindoles are agonists at the human 5-HT2C receptor
    • Sabb A.L., et al. Cycloalkyl[b][1,4]benzodiazepinoindoles are agonists at the human 5-HT2C receptor. Bioorg. Med. Chem. Lett. 14 (2004) 2603-2607
    • (2004) Bioorg. Med. Chem. Lett. , vol.14 , pp. 2603-2607
    • Sabb, A.L.1
  • 37
    • 20944441963 scopus 로고    scopus 로고
    • WAY-163909 [(7bR,10aR)-1,2,3,4,8,9,10,10a-octahydro-7bhcyclopenta-[b][1,4]diazepino [6,7,1hi]indole], a novel 5-hydroxytryptamine 2C receptor selective agonist with anorectic activity
    • Dunlop J., et al. WAY-163909 [(7bR,10aR)-1,2,3,4,8,9,10,10a-octahydro-7bhcyclopenta-[b][1,4]diazepino [6,7,1hi]indole], a novel 5-hydroxytryptamine 2C receptor selective agonist with anorectic activity. J. Pharmacol. Exp. Ther. 313 (2005) 862-869
    • (2005) J. Pharmacol. Exp. Ther. , vol.313 , pp. 862-869
    • Dunlop, J.1
  • 38
    • 33644936933 scopus 로고    scopus 로고
    • Antiobesity-like effects of the 5-HT2C receptor agonist WAY-161503
    • Rosenzweig-Lipson S., et al. Antiobesity-like effects of the 5-HT2C receptor agonist WAY-161503. Brain Res. 1073-1074 (2006) 240-251
    • (2006) Brain Res. , vol.1073-1074 , pp. 240-251
    • Rosenzweig-Lipson, S.1
  • 39
    • 2442421711 scopus 로고    scopus 로고
    • Antiobesity effect of YM348, a novel 5-HT2C receptor agonist in Zucker rats
    • Hayashi A., et al. Antiobesity effect of YM348, a novel 5-HT2C receptor agonist in Zucker rats. Brain Res. 1011 (2004) 221-227
    • (2004) Brain Res. , vol.1011 , pp. 221-227
    • Hayashi, A.1
  • 40
    • 0347987923 scopus 로고    scopus 로고
    • Pharmacological profile of YM348, a novel, potent and orally active 5-HT2C receptor agonist
    • Kimura Y., et al. Pharmacological profile of YM348, a novel, potent and orally active 5-HT2C receptor agonist. Eur. J. Pharmacol. 483 (2004) 37-43
    • (2004) Eur. J. Pharmacol. , vol.483 , pp. 37-43
    • Kimura, Y.1
  • 41
    • 17144438260 scopus 로고    scopus 로고
    • Pyrrolo[3,2,1-ij]quinoline derivatives, a 5-HT2c receptor agonist with selectivity over the 5-HT2a receptor: potential therapeutic applications for epilepsy and obesity
    • Isaac M., et al. Pyrrolo[3,2,1-ij]quinoline derivatives, a 5-HT2c receptor agonist with selectivity over the 5-HT2a receptor: potential therapeutic applications for epilepsy and obesity. Bioorg. Med. Chem. Lett. 10 (2000) 919-921
    • (2000) Bioorg. Med. Chem. Lett. , vol.10 , pp. 919-921
    • Isaac, M.1
  • 42
    • 33846200751 scopus 로고    scopus 로고
    • Briner, K. et al. (2001) Novel benzothiophenes and their use as 5-HT2C receptor agonists. WO-00109126
  • 43
    • 33846228784 scopus 로고    scopus 로고
    • Robichaud, A.J. et al. (2002) Substituted pyridoindoles as serotonin agonists and antagonists. WO-02059129
  • 44
    • 0032219620 scopus 로고    scopus 로고
    • 5-HT2C receptor agonists: pharmacological characteristics and therapeutic potential
    • Martin J.R., et al. 5-HT2C receptor agonists: pharmacological characteristics and therapeutic potential. J. Pharmacol. Exp. Ther. 286 (1998) 913-924
    • (1998) J. Pharmacol. Exp. Ther. , vol.286 , pp. 913-924
    • Martin, J.R.1
  • 45
    • 33846228375 scopus 로고    scopus 로고
    • Ladoucer, G.H. et al. (2003) Novel 1-(2-aminoalkyl)-1H-pyrazole derivatives useful as 5-HT2C ligands for the treatment of obesity and eating disorders. WO-03057674
  • 46
    • 33846202508 scopus 로고    scopus 로고
    • Chian, P.Y.C. et al. (2003) Piperazine derivative 5-HT receptor ligands. WO-03000663
  • 48
    • 33645230435 scopus 로고    scopus 로고
    • 2C receptors as a target for the treatment of depressive and anxious states: focus on novel therapeutic strategies
    • 2C receptors as a target for the treatment of depressive and anxious states: focus on novel therapeutic strategies. Therapie 60 (2005) 441-460
    • (2005) Therapie , vol.60 , pp. 441-460
    • Millan, M.J.1
  • 49
    • 15044340115 scopus 로고    scopus 로고
    • 2C receptor-mediated weight control in rats
    • 2C receptor-mediated weight control in rats. Psychpharmacology 178 (2005) 241-249
    • (2005) Psychpharmacology , vol.178 , pp. 241-249
    • Hayashi, A.1
  • 50
    • 0034781254 scopus 로고    scopus 로고
    • 2C receptor alters agonist-receptor-effector coupling specificity
    • 2C receptor alters agonist-receptor-effector coupling specificity. Br. J. Pharmacol. 134 (2001) 386-392
    • (2001) Br. J. Pharmacol. , vol.134 , pp. 386-392
    • Berg, K.A.1
  • 51
    • 0033861845 scopus 로고    scopus 로고
    • The multiplicity of serotonin receptors: uselessly diverse molecules or an embarrassment of riches?
    • Roth B.L., et al. The multiplicity of serotonin receptors: uselessly diverse molecules or an embarrassment of riches?. Neuroscientist 6 (2000) 252-262
    • (2000) Neuroscientist , vol.6 , pp. 252-262
    • Roth, B.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.