Discovery and SAR of new benzazepines as potent and selective 5-HT 2C receptor agonists for the treatment of obesity

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 5, 2005, Pages 1467-1470

  Smith, Brian M ^a   Smith, Jeffrey M ^a   Tsai, James H ^a   Schultz, Jeffrey A ^a   Gilson, Charles A ^a   Estrada, Scott A ^a   Chen, Rita R ^a   Park, Douglas M ^a   Prieto, Emily B ^a   Gallardo, Charlemagne S ^a   Sengupta, Dipanjan ^a   Thomsen, William J ^a   Saldana, Hazel R ^a   Whelan, Kevin T ^a   Menzaghi, Frederique ^a   Webb, Robert R ^a   Beeley, Nigel R A ^a  

^a ARENA PHARMACEUTICALS   (United States)

Author keywords

5 HT2C; Benzazepine; Obesity; Serotonin

Indexed keywords

BENZAZEPINE DERIVATIVE; INOSITOL PHOSPHATE; SEROTONIN 2A RECEPTOR; SEROTONIN 2B RECEPTOR; SEROTONIN 2C AGONIST; SEROTONIN 2C RECEPTOR; THYMIDINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; EXPERIMENTAL MODEL; FEEDING; FOOD INTAKE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MALE; NONHUMAN; OBESITY; RAT; STRUCTURE ACTIVITY RELATION;

EID: 13944263169     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.12.080     Document Type: Article

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