Synthesis and 5-hydroxytryptamine (5-HT) activity of 2,3,4,4a-Tetrahydro-1H-pyrazino[1,2-a]quinozalin-5-(6H)ones and 2,3,4,4a,5,6-hexahydro-1H-pyrazino [1,2-,a] quinoxalines

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 17, 2000, Pages 1991-1994

  Welmaker, Gregory S ^a   Nelson, James A ^a   Sabalski, Joan E ^a   Sabb, Annmarie L ^a   Potoski, John R ^a   Graziano, Denise ^a   Kagan, Michael ^a   Coupet, Joseph ^a   Dunlop, John ^a   Mazandarani, Hossein ^a   Rosenzweig Lipson, Sharon ^a   Sukoff, Stacey ^a   Zhang, Yingxin ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,4,4A TETRAHYDRO 1H PYRAZINO[1,2 A]QUINOXALIN 5 (6H)ONE DERIVATIVE; 2,3,4,4A,5,6 HEXAHYDRO 1H PYRAZINO[1,2 A]QUINOXALINE DERIVATIVE; QUINOXALINE DERIVATIVE; SEROTONIN 2C AGONIST; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG BINDING; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; FOOD INTAKE; ISOMER; MALE; NONHUMAN; OBESITY; RAT; REACTION ANALYSIS;

ANIMALS; APPETITE DEPRESSANTS; EATING; MALE; PYRAZINES; QUINOXALINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT2C; RECEPTORS, SEROTONIN; SEROTONIN AGONISTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034605255     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00400-5     Document Type: Article

References (25)