Cycloalkyl[b][1,4]benzodiazepinoindoles are agonists at the human 5-HT 2C receptor

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 10, 2004, Pages 2603-2607

  Sabb, Annmarie L ^a   Vogel, Robert L ^a   Welmaker, Gregory S ^a   Sabalski, Joan E ^a   Coupet, Joseph ^a   Dunlop, John ^a   Rosenzweig Lipson, Sharon ^a   Harrison, Boyd ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENERGIC RECEPTOR; DOPAMINE RECEPTOR; HISTAMINE RECEPTOR; INDOLE DERIVATIVE; MUSCARINIC RECEPTOR; RECEPTOR SUBTYPE; SEROTONIN 2C AGONIST; SEROTONIN RECEPTOR; UNCLASSIFIED DRUG; WAY 629;

ARTICLE; DRUG POTENCY; DRUG SCREENING; FEEDING BEHAVIOR; STRUCTURE ACTIVITY RELATION;

ANIMALS; BENZODIAZEPINES; FEEDING BEHAVIOR; HUMANS; INDOLES; RATS; RECEPTOR, SEROTONIN, 5-HT2C; SEROTONIN AGONISTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 1942438459     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.02.100     Document Type: Article

References (11)

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10. Certain intermediates cyclized without the necessity of further heating in acid during the test period.
11. 1H NMR spectra, mass spectral data and combustion analysis. For experimental procedures, see: Sabb, A. L.; Vogel, R. L.; Welmaker, G. S.; Sabalski, J. E. WO 02/36596 A2, 2002; CAN 136:355252.