HIV-1 neuropathogenesis: Glial mechanisms revealed through substance abuse

Journal of Neurochemistry

Volumn 100, Issue 3, 2007, Pages 567-586

  Hauser, Kurt F ^a   El Hage, Nazira ^a   Stiene Martin, Anne ^a   Maragos, William F ^a   Nath, Avindra ^b   Persidsky, Yuri ^c   Volsky, David J ^d   Knapp, Pamela E ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^d College of Physicians and Surgeons ^*  (United States)

Author keywords

AIDS; Alcohol; Cocaine; HIV encephalopathy; Methamphetamine; Neuroimmunology; Opiates

Indexed keywords

ANTIRETROVIRUS AGENT; BUPRENORPHINE; CHEMOKINE; COCAINE; CYTOKINE; DIDANOSINE; LEVACETYLMETHADOL; METHADONE; METHAMPHETAMINE; METHANOL; OPIATE; PROTEINASE INHIBITOR; PSYCHOSTIMULANT AGENT; STAVUDINE; ZIDOVUDINE;

ALCOHOL ABUSE; CELL INTERACTION; CENTRAL NERVOUS SYSTEM; COGNITION; CYTOKINE PRODUCTION; DISEASE EXACERBATION; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MACROGLIA; MICROGLIA; NERVE CELL; NERVE CELL LESION; NERVE DEGENERATION; NEUROPATHOLOGY; NEUROTOXICITY; OPIATE ADDICTION; PRIORITY JOURNAL; REVIEW; STEM CELL; SUBSTANCE ABUSE; VIRUS EXPRESSION; VIRUS REPLICATION;

AIDS DEMENTIA COMPLEX; ANIMALS; BRAIN; CAUSALITY; CELL COMMUNICATION; HIV-1; HUMANS; NERVE DEGENERATION; NEUROGLIA; PSYCHOTROPIC DRUGS; SUBSTANCE-RELATED DISORDERS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 33846245892     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2006.04227.x     Document Type: Review

References (280)

1. Abraham S., Sawaya B. E., Safak M., Batuman O., Khalili K. and Amini S. (2003) Regulation of MCP-1 gene transcription by Smads and HIV-1 Tat in human glial cells. Virology 309, 196-202.
2. Abraham S., Sweet T., Sawaya B. E., Rappaport J., Khalili K. and Amini S. (2005) Cooperative interaction of C/EBP beta and Tat modulates MCP-1 gene transcription in astrocytes. J. Neuroimmunol. 160, 219-227.
3. Abrous D. N., Koehl M. and Le M. M. (2005) Adult neurogenesis: from precursors to network and physiology. Physiol. Rev. 85, 523-569.
4. Adamson D. C., Kopnisky K. L., Dawson T. M. and Dawson V. L. (1999) Mechanisms and structural determinants of HIV-1 coat protein, gp41- induced neurotoxicity. J. Neurosci. 19, 64-71.
5. Adler M. W., Geller E. B., Rogers T. J., Henderson E. E. and Eisenstein T. K. (1993) Opioids, receptors, and immunity. Adv. Exp. Med. Biol. 335, 13-20.
6. Aksenov M. Y., Aksenova M. V., Nath A., Ray P. D., Mactutus C. F. and Booze R. M. (2006) Cocaine-mediated enhancement of Tat toxicity in rat hippocampal cell cultures: the role of oxidative stress and D1 dopamine receptor. Neurotoxicology 27, 217-228.
7. Ansari A. A. (2004) Drugs of abuse and HIV - a perspective. J. Neuroimmunol. 147, 9-12.
8. Anthony I. C., Ramage S. N., Carnie F. W., Simmonds P. and Bell J. E. (2005) Does drug abuse alter microglial phenotype and cell turnover in the context of advancing HIV infection? Neuropathol. Appl. Neurobiol. 31, 325-338.
9. Arango J. C., Simmonds P., Brettle R. P. and Bell J. E. (2004) Does drug abuse influence the microglial response in AIDS and HIV encephalitis? AIDS 18, S69-S74.
10. Archibald S. L., Masliah E., Fennema-Notestine C., Marcotte T. D., Ellis R. J., McCutchan J. A., Heaton R. K., Grant I., Mallory M., Miller A. and Jernigan T. L. (2004) Correlation of in vivo neuroimaging abnormalities with postmortem human immunodeficiency virus encephalitis and dendritic loss. Arch. Neurol. 61, 369-376.
11. Avison M., Berger J. R., McArthur J. C. and Nath A. (2003) HIV meningitis and dementia, in Clinical Neurovirology (Nath, A. and Berger, J. R., eds), pp. 251-276. Marcel Dekker, Inc., New York.
12. Avison M. J., Nath A., Greene-Avison R., Schmitt F. A., Bales R. A., Ethisham A., Greenberg R. N. and Berger J. R. (2004) Inflammatory changes and breakdown of microvascular integrity in early human immunodeficiency virus dementia. J. Neurovirol. 10, 223-232.
13. Bagby G. J., Stoltz D. A., Zhang P., Kolls J. K., Brown J., Bohm R. P. Jr, Rockar R., Purcell J., Murphey-Corb M. and Nelson S. (2003) The effect of chronic binge ethanol consumption on the primary stage of SIV infection in rhesus macaques. Alcohol Clin. Exp. Res. 27, 495-502.
14. Baldwin G. C., Roth M. D. and Tashkin D. P. (1998) Acute and chronic effects of cocaine on the immune system and the possible link to AIDS. J. Neuroimmunol. 83, 133-138.
15. Bautista A. P. (2001) Free radicals, chemokines, and cell injury in HIV-1 and SIV infections and alcoholic hepatitis. Free Radic. Biol. Med. 31, 1527-1532.
16. Bautista A. P. and Wang E. (2001) Chronic ethanol intoxication enhances the production of cytokine-induced neutrophil chemoattractant and macrophage inflammatory protein-2 by hepatocytes after human immunodeficiency virus-1 glycoprotein 120 vaccination. Alcohol 24, 35-44.
17. Bautista A. P. and Wang E. (2002) Acute ethanol administration downregulates human immunodeficiency virus-1 glycoprotein 120-induced KC and RANTES production by murine Kupffer cells and splenocytes. Life Sci. 71, 371-382.
18. Becker J. T., Lopez O. L., Dew M. A. and Aizenstein H. J. (2004) Prevalence of cognitive disorders differs as a function of age in HIV virus infection. AIDS 18, S11-S18.
19. Belcheva M. M., Clark A. L., Haas P. D., Serna J. S., Hahn J. W., Kiss A. and Coscia C. J. (2005) Mu and kappa opioid receptors activate ERK/MAPK via different protein kinase C isoforms and secondary messengers in astrocytes. J. Biol. Chem. 280, 27 662-27 669.
20. Bell J. E., Brettle R. P., Chiswick A. and Simmonds P. (1998) HIV encephalitis, proviral load and dementia in drug users and homosexuals with AIDS. Effect of neocortical involvement. Brain 121, 2043-2052.
21. Bellizzi M. J., Lu S.-M. and Gelbard H. A. (2006) Protecting the synapse: evidence for a rational strategy to treat HIV-1 associated neurologic disease. Neuroimmune Pharmacol. 1, 20-31.
22. Ben-Ari Y., Khazipov R., Leinekugel X., Caillard O. and Gaiarsa J. L. (1997) GABAA, NMDA and AMPA receptors: a developmentally regulated 'menage a trois'. Trends. Neurosci. 20, 523-529.
23. Benos D. J., Hahn B. H., Bubien J. K., Ghosh S. K., Mashburn N. A., Chaikin M. A., Shaw G. M. and Benveniste E. N. (1994a) Envelope glycoprotein gp120 of human immunodeficiency virus type 1 alters ion transport in astrocytes: implications for AIDS dementia complex. Proc. Natl Acad. Sci. U S A 91, 494-498.
24. Benos D. J., McPherson S., Hahn B. H., Chaikin M. A. and Benveniste E. N. (1994b) Cytokines and HIV envelope glycoprotein gp120 stimulate Na+/H+ exchange in astrocytes. J. Biol. Chem. 269, 13 811-13 816.
25. Blalock J. E. (2005) The immune system as the sixth sense. J. Intern. Med. 257, 126-138.
26. Blalock J. E. and Smith E. M. (1981) Human leukocyte interferon (HuIFN-alpha): potent endorphin-like opioid activity. Biochem. Biophys. Res. Commun. 101, 472-478.
27. Blanco A. M., Valles S. L., Pascual M. and Guerri C. (2005) Involvement of TLR4/type I IL-1 receptor signaling in the induction of inflammatory mediators and cell death induced by ethanol in cultured astrocytes. J. Immunol. 175, 6893-6899.
28. Bohn L. M., Belcheva M. M. and Coscia C. J. (2000) Mu-opioid agonist inhibition of kappa-opioid receptor-stimulated extracellular signal-regulated kinase phosphorylation is dynamin-dependent in C6 glioma cells. J. Neurochem. 74, 574-581.
29. Brack-Werner R. (1999) Astrocytes: HIV cellular reservoirs and important participants in neuropathogenesis. AIDS 13, 1-22.
30. Brunswick D. J., Benmansour S., Tejani-Butt S. M. and Hauptmann M. (1992) Effects of high-dose methamphetamine on monoamine uptake sites in rat brain measured by quantitative autoradiography. Synapse 11, 287-293.
31. Burdo T. H., Katner S. N., Taffe M. A. and Fox H. S. (2006) Neuroimmunity, drugs of abuse, and neuroAIDS. Neuroimmune Pharmacol. 1, 41-49.
32. Cabral G. A. and Dove Pettit D. A. (1998) Drugs and immunity: cannabinoids and their role in decreased resistance to infectious disease. J. Neuroimmunol. 83, 116-123.
33. Cabral G. A. and Marciano-Cabral F. (2005) Cannabinoid receptors in microglia of the central nervous system: immune functional relevance. J. Leukoc. Biol. 78, 1192-1197.
34. Cabral G. A. and Staab A. (2005) Effects on the immune system. Handb. Exp. Pharmacol. 168, 385-423.
35. Cass W. A. (1997) Decreases in evoked overflow of dopamine in rat striatum after neurotoxic doses of methamphetamine. J. Pharmacol. Exp. Ther. 280, 105-113.
36. Cass W. A., Harned M. E., Peters L. E., Nath A. and Maragos W. F. (2003) HIV-1 protein Tat potentiation of methamphetamine-induced decreases in evoked overflow of dopamine in the striatum of the rat. Brain Res. 984, 133-142.
37. Chang L., Ernst T., Speck O. and Grob C. S. (2005) Additive effects of HIV and chronic methamphetamine use on brain metabolite abnormalities. Am. J. Psychiatry 162, 361-369.
38. Chang L., Ernst T., H. C. and Conant K. (2004) Antiretroviral treatment alters relationship between MCP-1 and neurometabolites in HIV patients. Antivir. Ther. 9, 431-440.
39. Chao C. C., Hu S., Shark K. B., Sheng W. S., Gekker G. and Peterson P. K. (1997) Activation of mu opioid receptors inhibits microglial cell chemotaxis. J. Pharmacol. Exp. Ther. 281, 998-1004.
40. Chao C. C., Gekker G., Sheng W. S., Hu S. and Peterson P. K. (2001) U50488 inhibits HIV-1 expression in acutely infected monocyte-derived macrophages. Drug Alcohol Depend. 62, 149-154.
41. Chen P., Hubner W., Riviere K., Liu Y. X. and Chen B. K. (2006) Chimeric HIV-1 containing SIV matrix exhibit enhanced assembly in murine cells and replicate in a cell-type-dependent manner in human T cells. Virology: 349, 1-12.
42. Chuang R. Y., Suzuki S., Chuang T. K., Miyagi T., Chuang L. F. and Doi R. H. (2005) Opioids and the progression of simian AIDS. Front. Biosci. 10, 1666-1677.
43. Conant K., Garzino-Demo A., Nath A., McArthur J. C., Halliday W., Power C., Gallo R. C. and Major E. O. (1998) Induction of monocyte chemoattractant protein-1 in HIV-1 Tat-stimulated astrocytes and elevation in AIDS dementia. Proc. Natl Acad. Sci. U S A 95, 3117-3121.
44. Conant K., St Hillaire C., Anderson C., Galey D., Wang J. and Nath A. (2004) Human immunodeficiency virus type 1 Tat and methamphetamine affect the release and activation of matrix-degrading proteinases. J. Neurovirol. 10, 21-28.
45. Concha M., Graham N. M., Munoz A., Vlahov D., Royal W. III, Updike M., Nance-Sproson T., Selnes O. A. and McArthur J. C. (1992) Effect of chronic substance abuse on the neuropsychological performance of intravenous drug users with a high prevalence of HIV-1 seropositivity. Am. J. Epidemiol. 136, 1338-1348.
46. Crews F. T. and Nixon K. (2003) Alcohol, neural stem cells, and adult neurogenesis. Alcohol Res. Health 27, 197-204.
47. Croxford J. L. (2003) Therapeutic potential of cannabinoids in CNS disease. CNS Drugs 17, 179-202.
48. Czub S., Koutsilieri E., Sopper S. et al. (2001) Enhancement of central nervous system pathology in early simian immunodeficiency virus infection by dopaminergic drugs. Acta Neuropathol. 101, 85-91.
49. Czub S., Czub M., Koutsilieri E., Sopper S., Villinger F., Muller J. G., Stahl-Hennig C., ter Riederer P. M., V. and Gosztonyi G. (2004) Modulation of simian immunodeficiency virus neuropathology by dopaminergic drugs. Acta Neuropathol. 107, 216-226.
50. D'Ascenzo M., Piacentini R., Casalbore P., Budoni M., Pallini R., Azzena G. B. and Grassi C. (2006) Role of L-type Ca2+ channels in neural stem/progenitor cell differentiation. Eur. J. Neurosci. 23, 935-944.
51. Davis R. L. and Syapin P. J. (2004) Chronic ethanol inhibits CXC chemokine ligand 10 production in human A172 astroglia and astroglial-mediated leukocyte chemotaxis. Neurosci. Lett. 362, 220-225.
52. Des Jarlais D. C. and Friedman S. R. (1987) HIV infection among intravenous drug users: epidemiology and risk reduction. AIDS 1, 67-76.
53. Des Jarlais D. C., Friedman S. R., Choopanya K., Vanichseni S. and Ward T. P. (1992) International epidemiology of HIV and AIDS among injecting drug users. AIDS 6, 1053-1068.
54. Deshpande M., Zheng J., Borgmann K., Persidsky R., Wu L., Schellpeper C. and Ghorpade A. (2005) Role of activated astrocytes in neuronal damage: potential links to HIV-1-associated dementia. Neurotox. Res. 7, 183-192.
55. Donahoe R. M. (2004) Multiple ways that drug abuse might influence AIDS progression: clues from a monkey model. J. Neuroimmunol. 147, 28-32.
56. Donahoe R. M., Byrd L. D., McClure H. M., Fultz P., Brantley M., Marsteller F., Ansari A. A., Wenzel D. and Aceto M. (1993) Consequences of opiate-dependency in a monkey model of AIDS. Adv. Exp. Med. Biol. 335, 21-28.
57. Dong Y. and Benveniste E. N. (2001) Immune function of astrocytes. Glia 36, 180-190.
58. Dreyer E. B., Kaiser P. K., Offermann J. T. and Lipton S. A. (1990) HIV-1 coat protein neurotoxicity prevented by calcium channel antagonists. Science 248, 364-367.
59. Duman R. S., Malberg J. and Nakagawa S. (2001) Regulation of adult neurogenesis by psychotropic drugs and stress. J. Pharmacol. Exp. Ther. 299, 401-407.
60. Durvasula R. S., Myers H. F., Mason K. and Hinkin C. (2006) Relationship between alcohol use/abuse, HIV infection and neuropsychological performance in African American men. J. Clin. Exp. Neuropsychol. 28, 383-404.
61. Eisch A. J., Barrot M., Schad C. A., Self D. W. and Nestler E. J. (2000) Opiates inhibit neurogenesis in the adult rat hippocampus. Proc. Natl Acad. Sci. U S A 97, 7579-7584.
62. 2+, and the release of MCP-1, RANTES, and IL-6 by astrocytes treated with opiates and HIV-1 Tat. Glia 50, 91-106.
63. El-Hage N., Wu G., Ambati J., Bruce-Keller A. J., Knapp P. E. and Hauser K. F. (2006a) CCR2 mediates increases in glial activation caused by exposure to HIV-1 Tat and opiates. J. Neuroimmunol. 178, 9-16.
64. 1-72 and opiate-induced changes in astrocytes promote chemotaxis of microglia through the expression of MCP-1 and alternative chemokines. Glia 53, 132-146.
65. Ellis R. J., Childers M. E., Cherner M., Lazzaretto D., Letendre S. and Grant I. (2003) Increased human immunodeficiency virus loads in active methamphetamine users are explained by reduced effectiveness of antiretroviral therapy. J. Infect. Dis. 188, 1820-1826.
66. Emdad L., Sarkar D., Su Z. Z., Randolph A., Boukerche H., Valerie K. and Fisher P. B. (2006) Activation of the nuclear factor kappaB pathway by astrocyte elevated gene-1: implications for tumor progression and metastasis. Cancer Res. 66, 1509-1516.
67. Everall I. P., Heaton R. K., Marcotte T. D., Ellis R. J., McCutchan J. A., Atkinson J. H., Grant I., Mallory M. and Masliah E. (1999) Cortical synaptic density is reduced in mild to moderate human immunodeficiency virus neurocognitive disorder. HNRC Group. HIV Neurobehavioral Research Center. Brain Pathol. 9, 209-217.
68. Everall I. P., Bell C., Mallory M., Langford D., Adame A., Rockestein E. and Masliah E. (2002) Lithium ameliorates HIV-gp120-mediated neurotoxicity. Mol. Cell Neurosci. 21, 493-501.
69. Everall I. P., Hansen L. A. and Masliah E. (2005a) The shifting patterns of HIV encephalitis neuropathology. Neurotox. Res. 8, 51-62.
70. Everall I., Salaria S., Roberts E., Corbeil J., Sasik R., Fox H., Grant I. and Masliah E. (2005b) Methamphetamine stimulates interferon inducible genes in HIV infected brain. J. Neuroimmunol. 170, 158-171.
71. Fang J., Acheampong E., Dave R., Wang F., Mukhtar M. and Pomerantz R. J. (2005) The RNA helicase DDX1 is involved in restricted HIV-1 Rev. function in human astrocytes. Virology 336, 299-307.
72. Farber K., Pannasch U. and Kettenmann H. (2005) Dopamine and noradrenaline control distinct functions in rodent microglial cells. Mol. Cell Neurosci. 29, 128-138.
73. Fattore L., Puddu M. C., Picciau S., Cappai A., Fratta W., Serra G. P. and Spiga S. (2002) Astroglial in vivo response to cocaine in mouse dentate gyrus: a quantitative and qualitative analysis by confocal microscopy. Neuroscience 110, 1-6.
74. Fiala M., Gan X. H., Zhang L., House S. D., Newton T., Graves M. C., Shapshak P., Stins M., Kim K. S., Witte M. and Chang S. L. (1998) Cocaine enhances monocyte migration across the blood-brain barrier. Cocaine's connection to AIDS dementia and vasculitis? Adv. Exp. Med. Biol. 437, 199-205.
75. Fiala M., Eshleman A. J., Cashman J. et al. (2005) Cocaine increases human immunodeficiency virus type 1 neuroinvasion through remodeling brain microvascular endothelial cells. J. Neurovirol. 11, 281-291.
76. Fields R. D. and Stevens-Graham B. (2002) New insights into neuronglia communication. Science 298, 556-562.
77. Fittipaldi A. and Giacca M. (2005) Transcellular protein transduction using the Tat protein of HIV-1. Adv. Drug Deliv. Rev. 57, 597-608.
78. Flora G., Lee Y. W., Nath A., Maragos W., Hennig B. and Toborek M. (2002) Methamphetamine-induced TNF-alpha gene expression and activation of AP-1 in discrete regions of mouse brain: potential role of reactive oxygen intermediates and lipid peroxidation. Neuromol. Med. 2, 71-85.
79. Flora G., Lee Y. W., Nath A., Hennig B., Maragos W. and Toborek M. (2003) Methamphetamine potentiates HIV-1 Tat protein-mediated activation of redox-sensitive pathways in discrete regions of the brain. Exp. Neurol. 179, 60-70.
80. Flora G., Pu H., Lee Y. W., Ravikumar R., Nath A., Hennig B. and Toborek M. (2005) Proinflammatory synergism of ethanol and HIV-1 Tat protein in brain tissue. Exp. Neurol. 191, 2-12.
81. Gan X., Zhang L., Berger O. et al. (1999) Cocaine enhances brain endothelial adhesion molecules and leukocyte migration. Clin. Immunol. 91, 68-76.
82. Garden G. A. (2002) Microglia in human immunodeficiency virus-associated neurodegeneration. Glia 40, 240-251.
83. Garden G. A., Budd S. L., Tsai E., Hanson L., Kaul M., D'Emilia D. M., Friedlander R. M., Yuan J., Masliah E. and Lipton S. A. (2002) Caspase cascades in human immunodeficiency virus-associated neurodegeneration. J. Neurosci. 22, 4015-4024.
84. Gardner B., Zhu L. X., Roth M. D., Tashkin D. P., Dubinett S. M. and Sharma S. (2004) Cocaine modulates cytokine and enhances tumor growth through sigma receptors. J. Neuroimmunol. 147, 95-98.
85. Gavrilin M. A., Mathes L. E. and Podell M. (2002) Methamphetamine enhances cell-associated feline immunodeficiency virus replication in astrocytes. J. Neurovirol. 8, 240-249.
86. Gekker G., Hu S., Wentland M. P., Bidlack J. M., Lokensgard J. R. and Peterson P. K. (2004) Kappa-opioid receptor ligands inhibit cocaine-induced HIV-1 expression in microglial cells. J. Pharmacol. Exp. Ther. 309, 600-606.
87. Gendelman H. E., Persidsky Y., Ghorpade A., Limoges J., Stins M., Fiala M. and Morrisett R. (1997) The neuropathogenesis of the AIDS dementia complex. AIDS 11, 35-45.
88. Gendelman H., Zheng J., Coulter C. et al. (1998) The HIV-associated dementia complex: a metabolic encephalopathy reversed by highly active antiretroviral therapy. J. Infect. Dis 178, 1000-1007.
89. Glass J. D., Fedor H., Wesselingh S. L. and McArthur J. C. (1995) Immunocytochemical quantitation of human immunodeficiency virus in the brain: correlations with dementia. Ann. Neurol. 38, 755-762.
90. Goodkin K., Shapshak P., Metsch L. R. et al. (1998) Cocaine abuse and HIV-1 infection: epidemiology and neuropathogenesis. J. Neuroimmunol. 83, 88-101.
91. Gorry P. R., Ong C., Thorpe J., Bannwarth S., Thompson K. A., Gatignol A., Vesselingh S. L. and Purcell D. F. (2003) Astrocyte infection by HIV-1: mechanisms of restricted virus replication, and role in the pathogenesis of HIV-1-associated dementia. Curr. HIV Res. 1, 463-473.
92. Grattendick K., Jansen D. B., Lefkowitz D. L. and Lefkowitz S. S. (2000) Cocaine causes increased type I interferon secretion by both L929 cells and murine macrophages. Clin. Diagn. Lab. Immunol. 7, 245-250.
93. Gray F., Haug H., Chimelli L., Geny C., Gaston A., Scaravilli F. and Budka H. (1991) Prominent cortical atrophy with neuronal loss as correlate of human immunodeficiency virus encephalopathy. Acta Neuropathol. 82, 229-233.
94. Gray F., Adle-Biassette H., Chretien F., Lorin de la Grandmaison G., Force G. and Keohane C. (2001) Neuropathology and neurodegeneration in human immunodeficiency virus infection. Pathogenesis of HIV-induced lesions of the brain, correlations with HIV-associated disorders and modifications according to treatments. Clin. Neuropathol. 20, 146-155.
95. Gray F., Bazille C., dle-Biassette H., Mikol J., Moulignier A. and Scaravilli F. (2005) Central nervous system immune reconstitution disease in acquired immunodeficiency syndrome patients receiving highly active antiretroviral treatment. J. Neurovirol. 11, 16-22.
96. Grimm M. C., Ben-Baruch A., Taub D. D., Howard O. M., Resau J. H., Wang J. M., Ali H., Richardson R., Snyderman R. and Oppenheim J. J. (1998) Opiates transdeactivate chemokine receptors: delta and mu opiate receptor-mediated heterologous desensitization. J. Exp. Med. 20, 317-325.
97. Guillemin G., Croitoru J., Le Grand R. L., Franck-Duchenne M., Dormont D. and Boussin F. D. (2000) Simian immunodeficiency virus mac251 infection of astrocytes. J. Neurovirol. 6, 173-186.
98. Gurwell J. A., Nath A., Sun Q., Zhang J., Martin K. M., Chen Y. and Hauser K. F. (2001) Synergistic neurotoxicity of opioids and human immunodeficiency virus-1 Tat protein in striatal neurons in vitro. Neuroscience 102, 555-563.
99. Hagino Y., Kariura Y., Manago Y., Amano T., Wang B., Sekiguchi M., Nishikawa K., Aoki S., Wada K. and Noda M. (2004) Heterogeneity and potentiation of AMPA type of glutamate receptors in rat cultured microglia. Glia. 47, 68-77.
100. Hanson G. R., Rau K. S. and Fleckenstein A. E. (2004a) The methamphetamine experience: a NIDA partnership. Neuropharmacology. 47, 92-100.
101. Hanson G. R., Sandoval V., Riddle E. and Fleckenstein A. E. (2004b) Psychostimulants and vesicle trafficking: a novel mechanism and therapeutic implications. Ann. N. Y. Acad. Sci. 1025, 146-150.
102. Haorah J., Heilman D., Diekmann C., Osna N., Donohue T. M. Jr, Ghorpade A. and Persidsky Y. (2004) Alcohol and HIV decrease proteasome and immunoproteasome function in macrophages: implications for impaired immune function during disease. Cell Immunol. 229, 139-148.
103. Haorah J., Knipe B., Leibhart J., Ghorpade A. and Persidsky Y. (2005) Alcohol-induced oxidative stress in brain endothelial cells causes blood-brain barrier dysfunction. J. Leukoc. Biol. 78, 1223-1232.
104. Harper C. (1998) The neuropathology of alcohol-specific brain damage, or does alcohol damage the brain? J. Neuropathol. Exp. Neurol. 57, 101-110.
105. Harvey J. A. (2004) Cocaine effects on the developing brain: current status. Neurosci. Biobehav. Rev. 27, 751-764.
106. Haughey N. J., Holden C. P., Nath A. and Geiger J. D. (1999) Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 Protein Tat. J. Neurochem. 73, 1363-1374.
107. Haughey N. J., Nath A., Mattson M. P., Slevin J. T. and Geiger J. D. (2001) HIV-1 Tat through phosphorylation of NMDA receptors potentiates glutamate excitotoxicity. J. Neurochem. 78, 457-467.
108. Hauser K. F. and Mangoura D. (1998) Diversity of the endogenous opioid system in development: novel signal transduction translates multiple extracellular signals into neural cell growth and differentiation. Perspect. Dev. Neurobiol. 5, 437-449.
109. Hauser K. F., McLaughlin P. J. and Zagon I. S. (1989) Endogenous opioid systems and the regulation of dendritic growth and spine formation. J. Comp. Neurol. 281, 13-22.
110. 2+-dependent mechanism. Brain Res. 720, 191-203.
111. Hauser K. F., Khurdayan V. K., Goody R. J., Nath A., Pauly J. R. and Saria A. (2003) Selective vulnerability of cerebellar granule neuroblasts and their progeny to drugs with abuse liability. Cerebellum 2, 184-195.
112. Hauser K. F., El-Hage N., Buch S., Berger J. R., Tyor W. R., Nath A., Bruce-Keller A. J. and Knapp P. E. (2005) Molecular targets of opiate drug abuse in neuroAIDS. Neurotox. Res. 8, 63-80.
113. Hauser K. F., El-Hage N., Buch S., Barnes G. N., Bada H. S. and Pauly J. R. (2006a) Neural Precursors as Preferential Targets for Drug Abuse - Long Term Consequences and Latent Susceptibility to CNS Disorders (Miller, M. W., eds), Wiley, New York.
114. Hauser K. F., El-Hage N., Buch S., Tyor W. R., Nath A., Bruce-Keller A. J. and Knapp P. E. (2006b) Impact of opiate-HIV)1 interactions on neurotoxic signaling. J. Neuroimmune Pharmacol. 1, 98-105.
115. Hickey W. F. and Kimura H. (1988) Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo. Science 239, 290-292.
116. Hoglinger G. U., Rizk P., Muriel M. P., Duyckaerts C., Oertel W. H., Caille I. and Hirsch E. C. (2004) Dopamine depletion impairs precursor cell proliferation in Parkinson disease. Nat. Neurosci. 7, 726-735.
117. Holden C. P., Nath A., Haughey N. J. and Geiger J. D. (1999) Involvement of Na+/H+ exchangers, Ca2+ channels, and excitatory amino acid receptors in intracellular Ca2+ responses to HIV-1 gp120 in cultured human fetal brain cells. Neuroscience 91, 1369-1378.
118. House R. V., Thomas P. T. and Bhargava H. N. (1995) Selective modulation of immune function resulting from in vitro exposure to methylenedioxymethamphetamine (Ecstasy). Toxicology 96, 59-69.
119. Hu S., Peterson P. K. and Chao C. C. (1998) Kappa-opioid modulation of human microglial cell superoxide anion generation. Biochem. Pharmacol. 56, 285-288.
120. Hu S., Sheng W. S., Lokensgard J. R. and Peterson P. K. (2005) Morphine potentiates HIV-1 gp120-induced neuronal apoptosis. J. Infect. Dis. 191, 886-889.
121. In S. W., Son E. W., Rhee D. K. and Pyo S. (2004) Modulation of murine macrophage function by methamphetamine. J. Toxicol. Environ. Health A 67, 1923-1937.
122. In S. W., Son E. W., Rhee D. K. and Pyo S. (2005) Methamphetamine administration produces immunomodulation in mice. J. Toxicol. Environ. Health A 68, 2133-2145.
123. Inazu M., Takeda H. and Matsumiya T. (2003) Functional expression of the norepinephrine transporter in cultured rat astrocytes. J. Neurochem. 84, 136-144.
124. Jones G. and Power C. (2006) Regulation of neural cell survival by HIV-1 infection. Neurobiol. Dis. 21, 1-17.
125. Kadiu I., Glanzer J. G., Kipnis J., Gendelman H. E. and Thomas M. P. (2005) Mononuclear phagocytes in the pathogenesis of neurodegenerative diseases. Neurotox. Res. 8, 25-50.
126. Kang D. C., Su Z. Z., Sarkar D., Emdad L., Volsky D. J. and Fisher P. B. (2005) Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1. Gene 20, 8-15.
127. Kao A. W. and Price R. W. (2004) Chemokine receptors, neural progenitor cells, and the AIDS dementia complex. J. Infect. Dis. 190, 211-215.
128. Kaul M. and Lipton S. A. (1999) Chemokines and activated macrophages in HIV gp120-induced neuronal apoptosis. Proc. Natl Acad. Sci. U S A 96, 8212-8216.
129. Kaul M. and Lipton S. A. (2004) Signaling pathways to neuronal damage and apoptosis in human immunodeficiency virus type 1-associated dementia: Chemokine receptors, excitotoxicity, and beyond. J. Neurovirol. 10, 97-101.
130. Kaul M. and Lipton S. A. (2005) Experimental and potential future therapeutic approaches for HIV-1 associated dementia targeting receptors for chemokines, glutamate and erythropoietin. Neurotox. Res. 8, 167-186.
131. Kaul M., Garden G. A. and Lipton S. A. (2001) Pathways to neuronal injury and apoptosis in HIV-associated dementia. Nature 410, 988-994.
132. Kendall S. L., Anderson C. F., Nath A., Turchan-Cholewo J., Land C. L., Mactutus C. F. and Booze R. M. (2005) Gonadal steroids differentially modulate neurotoxicity of HIV and cocaine: testosterone and ICI 182,780 sensitive mechanism. BMC Neurosci. 6, 40.
133. Khan M. Z., Brandimarti R., Patel J. P., Huynh N., Wang J., Huang Z., Fatatis A. and Meucci O. (2004) Apoptotic and antiapoptotic effects of CXCR4: is it a matter of intrinsic efficacy? Implications for HIV neuropathogenesis. AIDS Res. Hum. Retroviruses 20, 1063-1071.
134. Khurdayan V. K., Buch S., El-Hage N., Lutz S. E., Goebel S. M., Singh I. N., Knapp P. E., Turchan-Cholewo J., Nath A. and Hauser K. F. (2004) Preferential vulnerability of astroglia and glial precursors to combined opioid and HIV-1 Tat exposure in vitro. Eur. J. Neurosci. 19, 3171-3182.
135. Kim W. K., Avarez X. and Williams K. (2005) The role of monocytes and perivascular macrophages in HIV and SIV neuropathogenesis: information from non-human primate models. Neurotox. Res. 8, 107-116.
136. King J. E., Eugenin E. A., Buckner C. M. and Berman J. W. (2006) HIV tat and neurotoxicity. Microbes Infect. 8, 1347-1357.
137. Kippin T. E., Kapur S. and van der Kooy D. (2005) Dopamine specifically inhibits forebrain neural stem cell proliferation, suggesting a novel effect of antipsychotic drugs. J. Neurosci. 25, 5815-5823.
138. Kita T., Philbert M. A., Wagner G. C., Huang J. and Lowndes H. E. (1998) Methamphetamine-induced modification of dopamine metabolism in cultured striatal astrocytes. Pharmacol. Toxicol. 83, 36-39.
139. Kogan F. J., Nichols W. K. and Gibb J. W. (1976) Influence of methamphetamine on nigral and striatal tyrosine hydroxylase activity and on striatal dopamine levels. Eur. J. Pharmacol. 36, 363-371.
140. Koka P., He K., Zack J. A., Kitchen S., Peacock W., Fried I., Tran T., Yashar S. S. and Merrill J. E. (1995) Human immunodeficiency virus 1 envelope proteins induce interleukin 1, tumor necrosis factor alpha, and nitric oxide in glial cultures derived from fetal, neonatal, and adult human brain. J. Exp. Med. 182, 941-951.
141. Kolson D. L. (2002) Neuropathogenesis of central nervous system HIV-1 infection. Clin. Lab. Med. 22, 703-717.
142. Kramer-Hammerle S., Rothenaigner I., Wolff H., Bell J. E. and Brack-Werner R. (2005) Cells of the central nervous system as targets and reservoirs of the human immunodeficiency virus. Virus Res. 111, 194-213.
143. Krathwohl M. D. and Kaiser J. L. (2004) HIV-1 promotes quiescence in human neural progenitor cells. J. Infect. Dis. 190, 216-226.
144. Kreek M. J. (1987) Tolerance and dependence: implications for the pharmacological treatment of addiction. NIDA Res. Monogr. 76, 53-62.
145. Kreek M. J. (2001) Drug addictions. Molecular and cellular endpoints. Ann. N. Y. Acad. Sci. 937, 27-49.
146. Kruman I. I., Nath A. and Mattson M. P. (1998) HIV-1 protein Tat induces apoptosis of hippocampal neurons by a mechanism involving caspase activation, calcium overload, and oxidative stress. Exp. Neurol. 154, 276-288.
147. Kubota N., Kiuchi Y., Nemoto M., Oyamada H., Ohno M., Funahashi H., Shioda S. and Oguchi K. (2001) Regulation of serotonin transporter gene expression in human glial cells by growth factors. Eur. J. Pharmacol. 417, 69-76.
148. Kumar R., Torres C., Yamamura Y., Rodriguez I., Martinez M., Staprans S., Donahoe R. M., Kraiselburd E., Stephens E. B. and Kumar A. (2004) Modulation by morphine of viral set point in rhesus macaques infected with simian immunodeficiency virus and simian-human immunodeficiency virus. J. Virol. 78, 11 425-11 428.
149. Kumar R., Perez-Casanova A. E., Tirado G. et al. (2005) Increased viral replication in simian immunodeficiency virus/simian-HIV-infected macaques with self-administering model of chronic alcohol consumption. J. Acquir. Immune Defic. Syndr. 39, 386-390.
150. Lambotte O., Deiva K. and Tardieu M. (2003) HIV-1 persistence, viral reservoir, and the central nervous system in the HAART era. Brain Pathol. 13, 95-103.
151. Langford D., Adame A., Grigorian A., Grant I., McCutchan J. A., Ellis R. J., Marcotte T. D. and Masliah E. (2003) Patterns of selective neuronal damage in methamphetamine-user AIDS patients. J. Acquir. Immune Defic. Syndr. 34, 467-474.
152. Langford D., Grigorian A., Hurford R., Adame A., Crews L. and Masliah E. (2004) The role of mitochondrial alterations in the combined toxic effects of human immunodeficiency virus Tat protein and methamphetamine on calbindin positive-neurons. J. Neurovirol. 10, 327-337.
153. Lawrence D. M., Durham L. C., Schwartz L., Seth P., Maric D. and Major E. O. (2004) Human immunodeficiency virus type 1 infection of human brain-derived progenitor cells. J. Virol. 78, 7319-7328.
154. Lawrence D. M., Seth P., Durham L., Diaz F., Boursiquot R., Ransohoff R. M. and Major E. O. (2006) Astrocyte differentiation selectively upregulates CCL2/monocyte chemoattractant protein-1 in cultured human brain-derived progenitor cells. Glia 53, 81-91.
155. Lee S. C., Dickson D. W., Liu W. and Brosnan C. F. (1993) Induction of nitric oxide synthase activity in human astrocytes by interleukin-1 beta and interferon-gamma. J. Neuroimmunol. 46, 19-24.
156. Lee M. Y., Heo J. S. and Han H. J. (2006) Dopamine regulates cell cycle regulatory proteins via cAMP, Ca (2+)/PKC, MAPKs, and NF-kappaB in mouse embryonic stem cells. J. Cell Physiol. 208, 399-406.
157. Leshner A. I. (1997) Addiction is a brain disease, and it matters. Science 278, 45-47.
158. Leshner A. I. and Koob G. F. (1999) Drugs of abuse and the brain. Proc. Assoc. Am. Physicians 111, 99-108.
159. Y., Merrill J. D., Mooney K., Song L., Wang X., Guo C. J., Savani R. C., Metzger D. S., Douglas S. D. and Ho W. Z. (2003) Morphine enhances HIV infection of neonatal macrophages. Pediatr. Res. 54, 282-288.
160. Lidow M. S. and Song Z. M. (2001) Primates exposed to cocaine in utero display reduced density and number of cerebral cortical neurons. J. Comp. Neurol. 435, 263-275.
161. Liu Y., Qin L., Wilson B. C., An L., Hong J. S. and Liu B. (2002) Inhibition by naloxone stereoisomers of beta-amyloid peptide (1-42)-induced superoxide production in microglia and degeneration of cortical and mesencephalic neurons. J. Pharmacol. Exp. Ther. 302, 1212-1219.
162. Luo Y., Berman M. A., Abromson-Leeman S. R. and Dorf M. E. (2003) Tumor necrosis factor is required for RANTES-induced astrocyte monocyte chemoattractant protein-1 production. Glia 43, 119-127.
163. Ma W., Pancrazio J. J., Andreadis J. D., Shaffer K. M., Stenger D. A., Li B. S., Zhang L., Barker J. L. and Maric D. (2001) Ethanol blocks cytosolic Ca2+ responses triggered by activation of GABA (A) receptor/Cl- channels in cultured proliferating rat neuroepithelial cells. Neuroscience 104, 913-922.
164. Mackie K. (2006) Cannabinoid receptors as therapeutic targets. Annu. Rev. Pharmacol. Toxicol. 46, 101-122.
165. Maggirwar S. B., Tong N., Ramirez S., Gelbard H. A. and Dewhurst S. (1999) HIV-1 Tat-mediated activation of glycogen synthase kinase-3beta contributes to Tat-mediated neurotoxicity [In Process Citation]. J. Neurochem. 73, 578-586.
166. Mahajan S. D., Aalinkeel R., Reynolds J. L., Nair B. B., Fernandez S. F., Schwartz S. A. and Nair M. P. (2005) Morphine exacerbates HIV-1 viral protein gp120 induced modulation of chemokine gene expression in U373 astrocytoma cells. Curr. HIV Res. 3, 277-288.
167. Mahe C., Loetscher E., Dev K. K., Bobirnac I., Otten U. and Schoeffter P. (2005) Serotonin 5-HT7 receptors coupled to induction of interleukin-6 in human microglial MC-3 cells. Neuropharmacology 49, 40-47.
168. Managlia E. Z., Carroll D., Zloza A. and Al-Harthi L. (2004) Immune modulation of HIV replication: relevance to HIV immuno- and neuro-pathogenesis. Curr. HIV Res. 2, 395-401.
169. Maragos W. F., Young K. L., Turchan J. T., Guseva M., Pauly J. R., Nath A. and Cass W. A. (2002) Human immunodeficiency virus-1 Tat protein and methamphetamine interact synergistically to impair striatal dopaminergic function. J. Neurochem. 83, 955-963.
170. van Marle G., Antony J. M., Silva C., Sullivan A. and Power C. (2005) Aberrant cortical neurogenesis in a pediatric neuroAIDS model: neurotrophic effects of growth hormone. AIDS 19, 1781-1791.
171. Mattana J., Gibbons N. and Singhal P. C. (1994) Cocaine interacts with macrophages to modulate mesangial cell proliferation. J. Pharmacol. Exp. Ther. 271, 311-318.
172. Mattson M. P., Haughey N. J. and Nath A. (2005) Cell death in HIV dementia. Cell Death Differ. 12, 893-904.
173. Mayne M., Bratanich A. C., Chen P., Rana F., Nath A. and Power C. (1998) HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease. Neuroimmunomodulation 5, 184-192.
174. McArthur J. C., Brew B. J. and Nath A. (2005) Neurological complications of HIV infection. Lancet Neurol. 4, 543-555.
175. McCance-Katz E. F. (2005) Treatment of opioid dependence and coinfection with HIV and hepatitis C virus in opioid-dependent patients: the importance of drug interactions between opioids and antiretroviral agents. Clin. Infect. Dis. 41, S89-S95.
176. McCance-Katz E. F., Rainey P. M., Friedland G., Kosten T. R. and Jatlow P. (2001) Effect of opioid dependence pharmacotherapies on zidovudine disposition. Am. J. Addict. 10, 296-307.
177. McCann U. D., Wong D. F., Yokoi F., Villemagne V., Dannals R. F. and Ricaurte G. A. (1998) Reduced striatal dopamine transporter density in abstinent methamphetamine and methcathinone users: evidence from positron emission tomography studies with [11C]WIN-35,428. J. Neurosci. 18, 8417-8422.
178. McCrossan M., Marsden M., Carnie F. W., Minnis S., Hansoti B., Anthony I. C., Brettle R. P., Bell J. E. and Simmonds P. (2006) An immune control model for viral replication in the CNS during presymptomatic HIV infection. Brain 129, 503-516.
179. Meyerhoff D. J., Bloomer C., Cardenas V., Norman D., Weiner M. W. and Fein G. (1999) Elevated subcortical choline metabolites in cognitively and clinically asymptomatic HIV+ patients. Neurology 52, 995-1003.
180. Miller R. J. and Meucci O. (1999) AIDS and the brain: is there a chemokine connection? Trends Neurosci. 22, 471-479.
181. Misse D., Gajardo J., Oblet C., Religa A., Riquet N., Mathieu D., Yssel H. and Veas F. (2005) Soluble HIV-1 gp120 enhances HIV-1 replication in non-dividing CD4+ T cells, mediated via cell signaling and Tat cofactor overexpression. AIDS 19, 897-905.
182. Miyatake M., Narita M., Shibasaki M., Nakamura A. and Suzuki T. (2005) Glutamatergic neurotransmission and protein kinase C play a role in neuron-glia communication during the development of methamphetamine-induced psychological dependence. Eur. J. Neurosci. 22, 1476-1488.
183. Moore J. P. (1997) Coreceptors: implications for HIV pathogenesis and therapy. Science 276, 51-52.
184. Nair M. P., Chadha K. C., Hewitt R. G., Mahajan S., Sweet A. and Schwartz S. A. (2000) Cocaine differentially modulates chemokine production by mononuclear cells from normal donors and human immunodeficiency virus type 1-infected patients. Clin. Diagn. Lab. Immunol. 7, 96-100.
185. Nair M. P., Mahajan S. D., Schwartz S. A., Reynolds J., Whitney R., Bernstein Z., Chawda R. P., Sykes D., Hewitt R. and Hsiao C. B. (2005) Cocaine modulates dendritic cell-specific C type intercellular adhesion molecule-3-grabbing nonintegrin expression by dendritic cells in HIV-1 patients. J. Immunol. 174, 6617-6626.
186. Nakayama M., Koyama T. and Yamashita I. (1993) Long-lasting decrease in dopamine uptake sites following repeated administration of methamphetamine in the rat striatum. Brain Res. 601, 209-212.
187. Narita M., Miyatake M., Narita M., Shibasaki M., Shindo K., Nakamura A., Kuzumaki N., Nagumo Y. and Suzuki T. (2006) Direct evidence of astrocytic modulation in the development of rewarding effects induced by drugs of abuse. Neuropsychopharmacology 31, 2476-2488.
188. Nath A. (1999) Pathobiology of human immunodeficiency virus dementia. Semin. Neurol. 19, 113-127.
189. Nath A. (2002) Human immunodeficiency virus (HIV) proteins in neuropathogenesis of HIV dementia. J. Infect. Dis. 186, S193-S198.
190. Nath A., Conant K., Chen P., Scott C. and Major E. O. (1999) Transient exposure to HIV-1 Tat protein results in cytokine production in macrophages and astrocytes: a hit and run phenomenon. J. Biol. Chem. 274, 17 098-17 102.
191. Nath A., Jones M., Maragos W., Booze R., Mactutus C., Bell J., Hauser K. F. and Mattson M. (2000) Neurotoxicity and dysfunction of dopamine systems associated with AIDS dementia. Psychopharmacology 14, 222-227.
192. Nath A., Maragos W. F., Avison M. J., Schmitt F. A. and Berger J. R. (2001) Acceleration of HIV dementia with methamphetamine and cocaine. J. Neurovirol. 7, 66-71.
193. Nath A., Hauser K. F., Wojna V., Booze R. M., Maragos W., Prendergast M., Cass W. and Turchan J. T. (2002) Molecular basis for interactions of HIV and drugs of abuse. J. Acquir. Immune Defic. Syndr. 31, S62-S69.
194. Navia B. A., Cho E. S., Petito C. K. and Price R. W. (1986) The AIDS dementia complex. II. Neuropathology. Ann. Neurol. 19, 525-535.
195. Ni H. T., Hu S., Sheng W. S., Olson J. M., Cheeran M. C., Chan A. S., Lokensgard J. R. and Peterson P. K. (2004) High-level expression of functional chemokine receptor CXCR4 on human neural precursor cells. Brain Res. Dev. Brain Res. 152, 159-169.
196. Nitkiewicz J., Chao W., Bentsman G., Li J., Kim S. Y., Choi S. Y., Grunig G., Gelbard H., Potash M. J. and Volsky D. J. (2004) Productive infection of primary murine astrocytes, lymphocytes, and macrophages by human immunodeficiency virus type 1 in culture. J. Neurovirol. 10, 400-408.
197. Nixon K. and Crews F. T. (2002) Binge ethanol exposure decreases neurogenesis in adult rat hippocampus. J. Neurochem. 83, 1087-1093.
198. Nixon K. and Crews F. T. (2004) Temporally specific burst in cell proliferation increases hippocampal neurogenesis in protracted abstinence from alcohol. J. Neurosci. 24, 9714-9722.
199. Peng X., Mosser D. M., Adler M. W., Rogers T. J., Meissler J. J. and Eisenstein T. K. (2000) Morphine enhances interleukin-12 and the production of other pro-inflammatory cytokines in mouse peritoneal macrophages. J. Leukoc. Biol. 68, 723-728.
200. Persidsky Y. and Gendelman H. E. (2003) Mononuclear phagocyte immunity and the neuropathogenesis of HIV-1 infection. J. Leukoc. Biol. 74, 691-701.
201. Persidsky Y., Heilman D., Haorah J., Zelivyanskaya M., Persidsky R., Weber G. A., Shimokawa H., Kaibuchi K. and Ikezu T. (2006) Rho-mediated regulation of tight junctions during monocyte migration across blood-brain barrier in HIV-1 encephalitis (HIVE). Blood 107, 4770-4780.
202. Persson A. I., Thorlin T., Bull. C. and Eriksson P. S. (2003a) Opioid-induced proliferation through the MAPK pathway in cultures of adult hippocampal progenitors. Mol. Cell Neurosci. 23, 360-372.
203. Persson A. I., Thorlin T., Bull. C., Zarnegar P., Ekman R., Terenius L. and Eriksson P. S. (2003b) Mu- and delta-opioid receptor antagonists decrease proliferation and increase neurogenesis in cultures of rat adult hippocampal progenitors. Eur. J. Neurosci. 17, 1159-1172.
204. Peterson P. K., Gekker G., Schut R., Hu S., Balfour H. H., Jr. and Chao C. C. (1993) Enhancement of HIV-1 replication by opiates and cocaine: The cytokine connection. Adv. Exp. Med. Biol. 335, 181-188.
205. Peterson P. K., Hu S., Anderson W. R. and Chao C. C. (1994) Nitric oxide production and neurotoxicity mediated by activated microglia from human versus mouse brain. J. Infect. Dis. 170, 457-460.
206. Peterson P. K., Gekker G., Hu S., Sheng W. S., Molitor T. W. and Chao C. C. (1995) Morphine stimulates phagocytosis of Mycobacterium tuberculosis by human microglial cells: involvement of a G protein-coupled opiate receptor. Adv. Neuroimmunol. 5, 299-309.
207. Peterson P. K., Molitor T. W. and Chao C. C. (1998) The opioid-cytokine connection. J. Neuroimmunol. 83, 63-69.
208. Peterson P. K., Gekker G., Lokensgard J. R., Bidlack J. M., Chang A., Fang X. and Portoghese P. S. (2001) kappa-Opioid receptor agonist suppression of HIV-1 expression in CD4(+) lymphocytes. Biochem. Pharmacol. 61, 1145-1151.
209. Piller S. C., Jans P., Gage P. W. and Jans D. A. (1998) Extracellular HIV-1 virus protein R. causes a large inward current and cell death in cultured hippocampal neurons: implications for AIDS pathology. Proc. Natl Acad. Sci. U S A 95, 4595-4600.
210. Potula R., Haorah J., Knipe B., Leibhart J., Chrastil J., Heilman D., Dou H., Reddy R., Ghorpade A. and Persidsky Y. (2006) Alcohol abuse enhances neuroinflammation and impairs immune responses in an animal model of human immunodeficiency virus-1 encephalitis. Am. J. Pathol 168, 1335-1344.
211. Prochiantz A. and Joliot A. (2003) Can transcription factors function as cell-cell signalling molecules? Nat. Rev. Mol. Cell Biol. 4, 814-819.
212. Pu C. and Vorhees C. V. (1993) Developmental dissociation of methamphetamine-induced depletion of dopaminergic terminals and astrocyte reaction in rat striatum. Brain Res. Dev. Brain Res. 72, 325-328.
213. Pu C., Broening H. W. and Vorhees C. V. (1996) Effect of methamphetamine on glutamate-positive neurons in the adult and developing rat somatosensory cortex. Synapse 23, 328-334.
214. Pulliam L., West D., Haigwood N. and Swanson R. A. (1993) HIV-1 envelope gp120 alters astrocytes in human brain cultures. AIDS Res. Hum. Retroviruses 9, 439-444.
215. Reyes M. G., Faraldi F., Senseng C. S., Flowers C. and Fariello R. (1991) Nigral degeneration in acquired immune deficiency syndrome (AIDS). Acta Neuropathol. 82, 39-44.
216. Reznikov K., Hauser K. F., Nazarevskaja G., Trunova Y., Derjabin V. and Bakalkin G. (1999) Opioids modulate cell division in the germinal zone of the late embryonic neocortex. Eur. J. Neurosci. 11, 2711-2719.
217. Riddle E. L., Topham M. K., Haycock J. W., Hanson G. R. and Fleckenstein A. E. (2002) Differential trafficking of the vesicular monoamine transporter-2 by methamphetamine and cocaine. Eur. J. Pharmacol. 449, 71-74.
218. Riikonen J., Jaatinen P., Rintala J., Porsti I., Karjala K. and Hervonen A. (2002) Intermittent ethanol exposure increases the number of cerebellar microglia. Alcohol Alcohol. 37, 421-426.
219. Rogers T. J., Steele A. D., Howard O. M. and Oppenheim J. J. (2000) Bidirectional heterologous desensitization of opioid and chemokine receptors. Ann. N. Y. Acad. Sci. 917, 19-28.
220. Rogers T. J. and Peterson P. K. (2003) Opioid G protein-coupled receptors: signals at the crossroads of inflammation. Trends Immunol. 24, 116-121.
221. Roth M. D., Whittaker K. M., Choi R., Tashkin D. P. and Baldwin G. C. (2005) Cocaine and sigma-1 receptors modulate HIV infection, chemokine receptors, and the HPA axis in the huPBL-SCID model. J. Leukoc. Biol. 78, 1198-1203.
222. Roy S., Wang J., Gupta S., Charboneau R., Loh H. H. and Barke R. A. (2004) Chronic morphine treatment differentiates T helper cells to Th2 effector cells by modulating transcription factors GATA 3 and T-bet. J. Neuroimmunol. 147, 78-81.
223. Roy S., Wang J., Kelschenbach J., Koodie L. and Martin J. (2006) Modulation of immune function by morphine: implications for the susceptibility to infection. J. Neuroimmune Pharmacol. 1, 77-89.
224. Sa M. J., Madeira M. D., Ruela C., Volk B., Mota-Miranda A. and Paula-Barbosa M. M. (2004) Dendritic changes in the hippocampal formation of AIDS patients: a quantitative Golgi study. Acta Neuropathol. 107, 97-110.
225. Sabatier J. M., Vives E., Marbrouk K., Benjouad A., Rochat H., Duval A., Hue B. and Bahraoui E. (1991) Evidence for neurotoxic activity of tat from human immunodeficiency virus type 1. J. Virol. 65, 961-967.
226. Scheller C., Sopper S., Jenuwein M., Neuen-Jacob E., Tatschner T., ter Grunblatt E. M. V., Riederer P. and Koutsilieri E. (2005) Early impairment in dopaminergic neurotransmission in brains of SIV-infected rhesus monkeys due to microglia activation. J. Neurochem. 95, 377-387.
227. Schulte T., Mueller-Oehring E. M., Rosenbloom M. J., Pfefferbaum A. and Sullivan E. V. (2005) Differential effect of HIV infection and alcoholism on conflict processing, attentional allocation, and perceptual load: evidence from a Stroop Match-to-Sample task. Biol. Psychiatry 57, 67-75.
228. Seiden L. S. and Ricaurte G. A. (1987) Neurotoxicity of methamphetamine and related drugs,. in Psychopharmacology: a Third Generation of Progress (Meltzer H., ed.), pp. 359-366. Raven, New York.
229. Selnes O. A., Galai N., McArthur J. C., Cohn S., Royal W. III, Esposito D. and Vlahov D. (1997) HIV infection and cognition in intravenous drug users: long-term follow-up. Neurology 48, 223-230.
230. Sharp B. M., Roy S. and Bidlack J. M. (1998) Evidence for opioid receptors on cells involved in host defense and the immune system. J. Neuroimmunol. 83, 45-56.
231. Shapshak P., Crandall K. A., Xin K. Q. et al. (1996) HIV-1 neuropathogenesis and abused drugs: current reviews, problems, and solutions. Adv. Exp. Med. Biol. 402, 171-186.
232. Sheng W. S., Hu S., Lokensgard J. R. and Peterson P. K. (2003) U50,488 inhibits HIV-1 Tat-induced monocyte chemoattractant protein-1 (CCL2) production by human astrocytes. Biochem. Pharmacol. 65, 9-14.
233. Singh I. N., El-Hage N., Campbell M. E., Lutz S. E., Knapp P. E., Nath A. and Hauser K. F. (2005) Differential involvement of p38 and JNK MAP kinases in HIV-1 Tat and gp120-induced apoptosis and neurite degeneration in striatal neurons. Neuroscience 135, 781-790.
234. Singh I. N., Goody R. J., Dean C., Ahmad N. M., Lutz S. E., Knapp P. E., Nath A. and Hauser K. F. (2004) Apoptotic death of striatal neurons induced by HIV-1 Tat and gp120: differential involvement of caspase-3 and endonuclease G. J. Neurovirol. 10, 141-151.
235. Singhal P. C., Sharma P., Kapasi A. A., Reddy K., Franki N. and Gibbons N. (1998) Morphine enhances macrophage apoptosis. J. Immunol. 160, 1886-1893.
236. Singhal P. C., Bhaskaran M., Patel J., Patel K., Kasinath B. S., Duraisamy S., Franki N., Reddy K. and Kapasi A. A. (2002) Role of p38 mitogen-activated protein kinase phosphorylation and Fas-Fas ligand interaction in morphine-induced macrophage apoptosis. J. Immunol. 168, 4025-4033.
237. Sriram K., Miller D. B. and O'Callaghan J. P. (2006) Minocycline attenuates microglial activation but fails to mitigate striatal dopaminergic neurotoxicity: role of tumor necrosis factor-alpha. J. Neurochem. 96, 706-718.
238. Stadlin A., Lau J. W. and Szeto Y. K. (1998) A selective regional response of cultured astrocytes to methamphetamine. Ann. N. Y. Acad. Sci. 844, 108-121.
239. Stiene-Martin A., Knapp P. E., Martin K. M., Gurwell J. A., Ryan S., Thornton S. R., Smith F. L. and Hauser K. F. (2001) Opioid system diversity in developing neurons, astroglia, and oligodendroglia in the subventricular zone and striatum: impact on gliogenesis in vivo. Glia 36, 78-88.
240. Streit W. J., Davis C. N. and Harrison J. K. (2005) Role of fractalkine (CX3CL1) in regulating neuron-microglia interactions: development of viral-based CX3CR1 antagonists. Curr. Alzheimer Res. 2, 187-189.
241. Sui Y., Potula R., Dhillon N. et al. (2004) Neuronal apoptosis is mediated by CXCL10 overexpression in simian human immunodeficiency virus encephalitis. Am. J. Pathol. 164, 1557-1566.
242. Sui Y., Stehno-Bittel L., Li S., Loganathan R., Dhillon N. K., Pinson D., Nath A., Kolson D., Narayan O. and Buch S. (2006) CXCL10-induced cell death in neurons: role of calcium dysregulation. Eur. J. Neurosci. 23, 957-964.
243. Sullivan E. V. and Pfefferbaum A. (2005) Neurocircuitry in alcoholism: a substrate of disruption and repair. Psychopharmacology (Berl.) 180, 583-594.
244. Suzuki S., Chuang A. J., Chuang L. F., Doi R. H. and Chuang R. Y. (2002) Morphine promotes simian acquired immunodeficiency syndrome virus replication in monkey peripheral mononuclear cells: induction of CC chemokine receptor 5 expression for virus entry. J. Infect. Dis. 185, 1826-1829.
245. Takeda H., Inazu M. and Matsumiya T. (2002) Astroglial dopamine transport is mediated by norepinephrine transporter. Naunyn Schmiedebergs Arch. Pharmacol. 366, 620-623.
246. Theodore S., Cass W. A. and Maragos W. F. (2006a) Involvement of cytokines in human immunodeficiency virus-1 protein Tat and methamphetamine interactions in the striatum. Exp. Neurol. 199, 490-498.
247. Theodore S., Cass W. A., Nath A., Steiner J., Young K. L. and Maragos W. F. (2006b) Inhibition of tumor necrosis factor-α signaling prevents human immunodeficiency virus-1 protein Tat and methamphetamine interaction. Neurobiol. Dis. 23, 663-668.
248. Theodore S., Stolberg S., Cass W. A. and Maragos W. F. (2006c) Human immunodeficiency virus-1 protein Tat and methamphetamine interactions. Ann. N. Y. Acad. Sci. 1074, 178-190.
249. Thomas D. M. and Kuhn D. M. (2005) MK-801 and dextromethorphan block microglial activation and protect against methamphetamine-induced neurotoxicity. Brain Res. 1050, 190-198.
250. Thomas D. M., Francescutti-Verbeem D. M., Liu X. and Kuhn D. M. (2004a) Identification of differentially regulated transcripts in mouse striatum following methamphetamine treatment - an oligonucleotide microarray approach. J. Neurochem. 88, 380-393.
251. Thomas D. M., Walker P. D., Benjamins J. A., Geddes T. J. and Kuhn D. M. (2004b) Methamphetamine neurotoxicity in dopamine nerve endings of the striatum is associated with microglial activation. J. Pharmacol. Exp. Ther. 311, 1-7.
252. Toborek M., Lee Y. W., Pu H., Malecki A., Flora G., Garrido R., Hennig B., Bauer H. C. and Nath A. (2003) HIV-Tat protein induces oxidative and inflammatory pathways in brain endothelium. J. Neurochem. 84, 169-179.
253. Tomassini N., Renaud F., Roy S. and Loh H. H. (2004) Morphine inhibits Fc-mediated phagocytosis through mu and delta opioid receptors. J. Neuroimmunol. 147, 131-133.
254. Tomlinson G. S., Simmonds P., Busuttil A., Chiswick A. and Bell J. E. (1999) Upregulation of microglia in drug users with and without pre-symptomatic HIV infection. Neuropathol. Appl. Neurobiol. 25,369-379.
255. Tong N., Sanchez J. F., Maggirwar S. B., Ramirez S. H., Guo H., Dewhurst S. and Gelbard H. A. (2001) Activation of glycogen synthase kinase 3 beta (GSK-3beta) by platelet activating factor mediates migration and cell death in cerebellar granule neurons. Eur. J. Neurosci. 13, 1913-1922.
256. Tornatore C., Meyers K., Atwood W., Conant K. and Major E. (1994) Temporal patterns of human immunodeficiency virus type 1 transcripts in human fetal astrocytes. J. Virol. 68, 93-102.
257. Tran P. B. and Miller R. J. (2005) HIV-1, chemokines and neurogenesis. Neurotox. Res. 8, 149-158.
258. Tran P. B., Ren D., Veldhouse T. J. and Miller R. J. (2004) Chemokine receptors are expressed widely by embryonic and adult neural progenitor cells. J. Neurosci. Res. 76, 20-34.
259. Turchan-Cholewo J., Liu Y., Gartner S. et al. (2006) Increased vulnerability of ApoE4 neurons to HIV proteins and opiates: protection by diosgenin and 1-deprenyl. Neurobiol. Dis. 23, 109-119.
260. Tyor W. R. and Middaugh L. D. (1999) Do alcohol and cocaine abuse alter the course of HIV-associated dementia complex? J. Leukoc. Biol. 65, 475-481.
261. Tyor W. R., Wesselingh S. L., Griffin J. W., McArthur J. C. and Griffin D. E. (1995) Unifying hypothesis for the pathogenesis of HIV-associated dementia complex, vacuolar myelopathy, and sensory neuropathy. J. AIDS Human Retroviruses 9, 379-388.
262. UNAIDS (2006) Estimating the status of the AIDS epidemic in countries. UNAIDS, the Joint United Nations Programme on HIV/AIDS [WWW document]. http://data.unaids.org/pub/PressStatement/2006/20060410_PS_EPI_Estimates_en.pdf.
263. Valles S. L., Blanco A. M., Pascual M. and Guerri C. (2004) Chronic ethanol treatment enhances inflammatory mediators and cell death in the brain and in astrocytes. Brain Pathol. 14, 365-371.
264. Vivien D. and Ali C. (2006) Transforming growth factor-beta signalling in brain disorders. Cytokine Growth Factor Rev. 17, 121-128.
265. Wagner G. C., Ricaurte G. A., Seiden L. S., Schuster C. R., Miller R. J. and Westley J. (1980) Long-lasting depletions of striatal dopamine and loss of dopamine uptake sites following repeated administration of methamphetamine. Brain Res. 181, 151-160.
266. Wang J. Y., Liang B. and Watson R. R. (1997) Alcohol consumption alters cytokine release during murine AIDS. Alcohol 14, 155-159.
267. Wang X., Douglas S. D., Metzger D. S., Guo C. J., Li Y., O'Brien C. P., Song L., vis-Vogal A. and Ho W. Z. (2002) Alcohol potentiates HIV-1 infection of human blood mononuclear phagocytes. Alcohol Clin. Exp. Res. 26, 1880-1886.
268. Wang Z., Pekarskaya O., Bencheikh M., Chao W., Gelbard H. A., Ghorpade A., Rothstein J. D. and Volsky D. J. (2003) Reduced expression of glutamate transporter EAAT2 and impaired glutamate transport in human primary astrocytes exposed to HIV-1 or gp120. Virology 312, 60-73.
269. Wang G. J., Chang L., Volkow N. D., Telang F., Logan J., Ernst T. and Fowler J. S. (2004a) Decreased brain dopaminergic transporters in HIV-associated dementia patients. Brain 127, 2452-2458.
270. Wang Z., Trillo-Pazos G., Kim S. Y. et al. (2004b) Effects of human immunodeficiency virus type 1 on astrocyte gene expression and function: potential role in neuropathogenesis. J. Neurovirol. 10, 25-32.
271. Watson K. and Edwards R. J. (1999) HIV-1-trans-activating (Tat) protein: both a target and a tool in therapeutic approaches. Biochem. Pharmacol. 58, 1521-1528.
272. Wetzel M. A., Steele A. D., Eisenstein T. K., Adler M. W., Henderson E. E. and Rogers T. J. (2000) Mu-opioid induction of monocyte chemoattractant protein-1, RANTES, and IFN-gamma-inducible protein-10 expression in human peripheral blood mononuclear cells. J. Immunol. 165, 6519-6524.
273. Wilson J. M., Levey A. I., Bergeron C. et al. (1996) Striatal dopamine, dopamine transporter, and vesicular monoamine transporter in chronic cocaine users. Ann. Neurol. 40, 428-439.
274. Xiong H., Zeng Y. C., Lewis T., Zheng J., Persidsky Y. and Gendelman H. E. (2000) HIV-1 infected mononuclear phagocyte secretory products affect neuronal physiology leading to cellular demise: relevance for HIV-1-associated dementia. J. Neurovirol. 6, S14-S23.
275. Xu W., Bai F., Tummalapalli C. M., Miller D. D., Middaugh L. and Boggan W. O. (1997) The interactive effects of cocaine/gender on immune function in mice. An observation of in vivo acute cocaine exposure. Int. J. Immunopharmacol. 19, 333-340.
276. Yamaguchi M., Suzuki T., Seki T., Namba T., Juan R., Arai H., Hori T. and Asada T. (2004) Repetitive cocaine administration decreases neurogenesis in adult rat hippocampus. Ann. N. Y. Acad. Sci. 1025, 351-362.
277. Zagon I. S. and McLaughlin P. J. (1983) Increased brain size and cellular content in infant rats treated with an opioid antagonist. Science 221, 1179-1180.
278. Zhang L., Looney D., Taub D., Chang S. L., Way D., Witte M. H., Graves M. C. and Fiala M. (1998) Cocaine opens the blood-brain barrier to HIV-1 invasion. J. Neurovirol. 4, 619-626.
279. Zhu Y., Hsu M. S. and Pintar J. E. (1998) Developmental expression of the mu, kappa, and delta opioid receptor mRNAs in mouse. J. Neurosci. 18, 2538-2549.
280. Zocchi M. R., Rubartelli A., Morgavi P. and Poggi A. (1998) HIV-1 Tat inhibits human natural killer cell function by blocking 1-type calcium channels. J. Immunol. 161, 2938-2943.