Alcohol abuse enhances neuroinflammation and impairs immune responses in an animal model of human immunodeficiency virus-1 encephalitis

American Journal of Pathology

Volumn 168, Issue 4, 2006, Pages 1335-1344

  Potula, Raghava ^a   Haorah, James ^a   Knipe, Bryan ^a   Leibhart, Jessica ^a   Chrastil, Jesse ^a   Heilman, David ^a   Dou, Huanyu ^a   Reddy, Rindha ^a   Ghorpade, Anuja ^a   Persidsky, Yuri ^a,b  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; CD8 ANTIGEN; GAMMA INTERFERON;

ALCOHOL ABUSE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; DISEASE EXACERBATION; DISEASE MODEL; ENCEPHALITIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOPATHOLOGY; LYMPHOCYTE; LYMPHOCYTIC INFILTRATION; MACROPHAGE; MALE; MICROGLIA; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RISK FACTOR; SCID MOUSE; SPLEEN; VIREMIA;

EID: 33645453995     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.2353/ajpath.2006.051181     Document Type: Article

References (63)

1. Rosenbloom MJ, O'Reilly A, Sassoon SA, Sullivan EV, Pfefferbaum A: Persistent cognitive deficits in community-treated alcoholic men and women volunteering for research: limited contribution from psychiatric comorbidity. J Stud Alcohol 2005, 66:254-265
2. McArthur JC, Brew BJ, Nath A: Neurological complications of HIV infection. Lancet Neurol 2005, 4:543-555
3. Adamson P, Etienne S, Couraud P, Calder V, Greenwood J: Lymphocyte migration through brain endothelial cell monolayers involves signaling through endothelial ICAM-1 via a rho-dependent pathway. Immunology 1999, 162:2964-2973
4. Persidsky Y, Gendelman HE: Mononuclear phagocyte immunity and the neuropathogenesis of HIV-1 infection. J Leukoc Biol 2003, 74:691-701
5. Harper C: The neuropathology of alcohol-specific brain damage, or does alcohol damage the brain? J Neuropathol Exp Neurol 1998, 57:101-110
6. Sullivan EV, Pfefferbaum A: Neurocircuitry in alcoholism: a substrate of disruption and repair. Psychopharmacology (Berl) 2005, 180:583-594
7. Ashida N, Arai H, Yamasaki M, Kita T: Distinct signaling pathways for MCP-1-dependent integrin activation and chemotaxis. J Biol Chem 2001, 276:16555-16560
8. Meyerhoff D, Bloomer C, Cardenas V, Norman D, Weiner M, Fein G: Elevated subcortical choline metabolites in cognitively and clinically symptomatic HIV+ patients. Neurology 1999, 52:995-1003
9. Riikonen J, Jaatinen P, Rintala J, Porsti I, Karjala K, Hervonen A: Intermittent ethanol exposure increases the number of cerebellar microglia. Alcohol Alcohol 2002, 37:421-426
10. Wang X, Douglas SD, Metzger DS, Guo CJ, Li Y, O'Brien CP, Song L, Davis-Vogal A, Ho WZ: Alcohol potentiates HIV-1 infection of human blood mononuclear phagocytes. Alcohol Clin Exp Res 2002, 26:1880-1886
11. Bagby GJ, Stoltz DA, Zhang P, Kolls JK, Brown J, Bohm Jr RP, Rockar R, Purcell J, Murphey-Corb M, Nelson S: The effect of chronic binge ethanol consumption on the primary stage of SIV infection in rhesus macaques. Alcohol Clin Exp Res 2003, 27:495-502
12. Kumar R, Perez-Casanova AE, Tirado G, Noel RJ, Torres C, Rodriguez I, Martinez M, Staprans S, Kraiselburd E, Yamamura Y, Higley JD, Kumar A: Increased viral replication in simian immunodeficiency virus/simian-HIV-infected macaques with self-administering model of chronic alcohol consumption. J Acquir Immune Defic Syndr 2005, 39:386-390
13. Kim WK, Corey S, Chesney G, Knight H, Klumpp S, Wuthrich C, Letvin N, Koralnik I, Lackner A, Veasey R, Williams K: Identification of T lymphocytes in simian immunodeficiency virus encephalitis: distribution of CD8+ T cells in association with central nervous system vessels and virus. J Neurovirol 2004, 10:315-325
14. Potula R, Poluektova L, Knipe B, Chrastil J, Heilman D, Dou H, Takikawa O, Munn DH, Gendelman HE, Persidsky Y: Inhibition of indoleamine 2,3-dioxygenase (IDO) enhances elimination of virus-infected macrophages in an animal model of HIV-1 encephalitis. Blood 2005, 106:2382-2390
15. Poluektova LY, Munn DH, Persidsky Y, Gendelman HE: Generation of cytotoxic T cells against virus-infected human brain macrophages in a murine model of HIV-1 encephalitis. J Immunol 2002, 168:3941-3949
16. Gendelman HE, Orenstein JM, Martin MA, Ferrua C, Mitra R, Phipps T, Wahl LA, Lane HC, Fauci AS, Burke DS, Meltzer MS: Efficient isolation and propagation of human immunodeficiency virus on recombinant colony-stimulating factor 1-treated monocytes. J Exp Med 1988, 167:1428-1441
17. Jerrells TR, Smith W, Eckardt MJ: Murine model of ethanol-induced immunosuppression. Alcohol Clin Exp Res 1990, 14:546-550
18. Persidsky Y, Limoges J, McComb R, Bock P, Baldwin T, Tyor W, Patil A, Nottet HS, Epstein L, Gelbard H, Flanagan E, Reinhard J, Pirruccello SJ, Gendelman HE: Human immunodeficiency virus encephalitis in SCID mice. Am J Pathol 1996, 149:1027-1053
19. Piccinini M, Tazartes O, Mostert M, Musso A, DeMarchi M, Rinaudo MT: Structural and functional characterization of 20S and 26S proteasomes from bovine brain. Brain Res Mol Brain Res 2000, 76:103-114
20. Fruh K, Gruhler A, Krishna RM, Schoenhals GJ: A comparison of viral immune escape strategies targeting the MHC class I assembly pathway. Immunol Rev 1999, 168:157-166
21. Khan S, van den Broek M, Schwarz K, de Giuli R, Diener PA, Groettrup M: Immunoproteasomes largely replace constitutive proteasomes during an antiviral and antibacterial immune response in the liver. J Immunol 2001, 167:6859-6868
22. Haorah J, Heilman D, Diekmann C, Osna N, Donohue Jr TM, Ghorpade A, Persidsky Y: Alcohol and HIV decrease proteasome and immunoproteasome function in macrophages: implications for impaired immune function during disease. Cell Immunol 2004, 229:139-148
23. Flora G, Pu H, Lee YW, Ravikumar R, Nath A, Hennig B, Toborek M: Proinflammatory synergism of ethanol and HIV-1 Tat protein in brain tissue. Exp Neurol 2005, 191:2-12
24. Goodwin GM, Pretsell DO, Chiswick A, Egan V, Brettle RP: The Edinburgh cohort of HIV-positive injecting drug users at 10 years after infection: a case-control study of the evolution of dementia. AIDS 1996, 10:431-440
25. Meyerhoff DJ: Effects of alcohol and HIV infection on the central nervous system. Alcohol Res Health 2001, 25:288-298
26. Rothlind JC, Greenfield TM, Bruce AV, Meyerhoff DJ, Flenniken DL, Lindgren JA, Weiner MW: Heavy alcohol consumption in individuals with HIV infection: effects on neuropsychological performance. J lnt Neuropsychol Soc 2005, 11:70-83
27. Boven LA, Gomes L, Hery C, Gray F, Verhoef J, Portegies P, Tardieu M, Mottet HS: Increased peroxynitrite activity in AIDS dementia complex: implications for the neuropathogenesis of HIV-1 infection. J Immunol 1999, 162:4319-4327
28. Monahan CM, Padgett EL, Biber KL, Moscatello KM, Johnston FL, Wolcott RM: Dose response to ethanol-containing liquid diets for use in a murine model for studies of biological effects due to ethanol consumption. Alcohol Clin Exp Res 1997, 21:1092-1099
29. Deutch SR, Christian C, Hoyer S, Christensen EF, Dragsholt C, Hansen AC, Kristensen IB, Hougaard K: Drug and alcohol use among patients admitted to a Danish trauma centre: a prospective study from a regional trauma centre in Scandinavia. Eur J Emerg Med 2004, 11:318-322
30. Cherpitel CJ, Ye Y, Bond J: Attributable risk of injury associated with alcohol use: cross-national data from the emergency room collaborative alcohol analysis project. Am J Public Health 2005, 95:266-272
31. Mason CM, Dobard E, Zhang P, Nelson S: Alcohol exacerbates murine pulmonary tuberculosis. Infect Immun 2004, 72:2556-2563
32. Bagasra O, Bachman SE, Jew L, Tawadros R, Cater J, Boden G, Ryan I, Pomerantz RJ: Increased human immunodeficiency virus type 1 replication in human peripheral blood mononuclear cells induced by ethanol: potential immunopathogenic mechanisms. J Infect Dis 1996, 173:550-558
33. Bagasra O, Kajdacsy-Balla A, Lischner HW, Pomerantz RJ: Alcohol intake increases human immunodeficiency virus type 1 replication in human peripheral blood mononuclear cells. J Infect Dis 1993, 167:789-797
34. Liu X, Zha J, Nishitani J, Chen H, Zack JA: HIV-1 infection in peripheral blood lymphocytes (PBLs) exposed to alcohol. Virology 2003, 307:37-44
35. Pruett SB, Han YC, Wu WJ: A brief review of immunomodulation caused by acute administration of ethanol: involvement of neuroendocrine pathways. Alcohol Alcohol Suppl 1994, 2:431-437
36. Fong IW, Read S, Wainberg MA, Chia WK, Major C: Alcoholism and rapid progression to AIDS after seroconversion. Clin Infect Dis 1994, 19:337-338
37. Watson RR, Prabhala RH, Abril E, Smith TL: Changes in lymphocyte subsets and macrophage functions from high, short-term dietary ethanol in C57/BL6 mice. Life Sci 1988, 43:865-870
38. Kaplan DR: A novel mechanism of immunosuppression mediated by ethanol. Cell Immunol 1986, 102:1-9
39. Chang MP, Norman DC, Makinodan T: Immunotoxicity of alcohol in young and old mice. I. In vitro suppressive effects of ethanol on the activities of T and B immune cells of aging mice. Alcohol Clin Exp Res 1990, 14:210-215
40. Greenberg SS, Ouyang J, Zhao X, Parrish C, Nelson S, Giles TD: Effects of ethanol on neutrophil recruitment and lung host defense in nitric oxide synthase I and nitric oxide synthase II knockout mice. Alcohol Clin Exp Res 1999, 23:1435-1445
41. Tamura DY, Moore EE, Partrick DA, Johnson JL, Offner PJ, Harbeck RJ, Silliman CC: Clinically relevant concentrations of ethanol attenuate primed neutrophil bactericidal activity. J Trauma 1998, 44:320-324
42. Chen GJ, Huang DS, Watzl B, Watson RR: Ethanol modulation of tumor necrosis factor and gamma interferon production by murine splenocytes and macrophages. Life Sci 1993, 52:1319-1326
43. Arbabi S, Garcia I, Bauer GJ, Maier RV: Alcohol (ethanol) inhibits IL-8 and TNF: role of the p38 pathway. J Immunol 1999, 162:7441-7445
44. Szabo G, Catalano D, White B, Mandrekar P: Acute alcohol consumption inhibits accessory cell function of monocytes and dendritic cells. Alcohol Clin Exp Res 2004, 28:824-828
45. Bagasra O, Howeedy A, Dorio R, Kajdacsy-Balla A: Functional analysis of T-cell subsets in chronic experimental alcoholism. Immunology 1987, 61:63-69
46. Mili F, Flanders WD, Boring JR, Annest JL, DeStefano F: The associations of alcohol drinking and drinking cessation to measures of the immune system in middle-aged men. Alcohol Clin Exp Res 1992, 16:688-694
47. Jerrells TR, Marietta CA, Bone G, Weight FF, Eckardt MJ: Ethanol-associated immunosuppression. Adv Biochem Psychopharmacol 1988, 44:173-185
48. Kaelin RM, Semerjian A, Center DM, Bernardo J: Influence of ethanol on human T-lymphocyte migration. J Lab Clin Med 1984, 104:752-760
49. Nelson S, Bagby GJ, Bainton BG, Summer WR: The effects of acute and chronic alcoholism on tumor necrosis factor and the inflammatory response. J Infect Dis 1989, 160:422-429
50. Kawakami M, Switzer BR, Herzog SR, Meyer AA: Immune suppression after acute ethanol ingestion and thermal injury. J Surg Res 1991, 51:210-215
51. Gentilello LM, Cobean RA, Walker AP, Moore EE, Wertz MJ, Dellinger EP: Acute ethanol intoxication increases the risk of infection following penetrating abdominal trauma. J Trauma 1993, 34:665-674
52. Friedman H: Alcohol effects on cytokine responses by immunocytes. Alcohol Clin Exp Res 1998, 22:1843-1873
53. Szabo G, Verma B, Catalano D: Selective inhibition of antigen-specific T lymphocyte proliferation by acute ethanol exposure: the role of impaired monocyte antigen presentation capacity and mediator production. J Leukoc Biol 1993, 54:534-544
54. Groettrup M, Soza A, Kuckelkorn U, Kloetzel PM: Peptide antigen production by the proteasome: complexity provides efficiency. Immunol Today 1996, 17:429-435
55. Bardag-Gorce F, Yuan QX, Li J, French BA, Fang C, Ingelman-Sundberg M, French SW: The effect of ethanol-induced cytochrome p4502E1 on the inhibition of proteasome activity by alcohol. Biochem Biophys Res Commun 2000, 279:23-29
56. Fehling HJ, Swat W, Laplace C, Kuhn R, Rajewsky K, Muller U, von Boehmer H: MHC class I expression in mice lacking the proteasome subunit LMP-7. Science 1994, 265:1234-1237
57. Van Kaer L, Ashton-Rickardt PG, Eichelberger M, Gaczynska M, Nagashima K, Rock KL, Goldberg AL, Doherty PC, Tonegawa S: Altered peptidase and viral-specific T cell response in LMP2 mutant mice. Immunity 1994, 1:533-541
58. Herrera DG, Yague AG, Johnsen-Soriano S, Bosch-Morell F, Collado-Morente L, Muriach M, Romero FJ, Garcia-Verdugo JM: Selective impairment of hippocampal neurogenesis by chronic alcoholism: protective effects of an antioxidant. Proc Natl Acad Sci USA 2003, 100:7919-7924
59. Sun AY, Sun GY: Ethanol and oxidative mechanisms in the brain. J Biomed Sci 2001, 8:37-43
60. Amici M, Lupidi G, Angeletti M, Fioretti E, Eleuteri AM: Peroxynitrite-induced oxidation and its effects on isolated proteasomal systems. Free Radic Biol Med 2003, 34:987-996
61. Hansson T, Tindberg N, Ingelman-Sundberg M, Kohler C: Regional distribution of ethanol-inducible cytochrome P450 IIE1 in the rat central nervous system. Neuroscience 1990, 34:451-463
62. Carson MJ, Thrash JC, Lo D: Analysis of microglial gene expression: identifying targets for CNS neurodegenerative and autoimmune disease. Am J Pharmacogenomics 2004, 4:321-330
63. Belmadani A, Neafsey EJ, Collins MA: Human immunodeficiency virus type 1 gp120 and ethanol coexposure in rat organotypic brain slice cultures: curtailment of gp120-induced neurotoxicity and neurotoxic mediators by moderate but not high ethanol concentrations. J Neurovirol 2003, 9:45-54