HIV-1 Tat molecular diversity and induction of TNF-α: Implications for HIV-induced neurological disease

NeuroImmunoModulation

Volumn 5, Issue 3-4, 1998, Pages 184-192

  Mayne, Michael ^d   Bratanich, Ana Christina ^a   Chen, Peiqin ^a   Rana, Farazana ^b   Nath, Avindra ^c   Power, Christopher ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

^b UNIVERSITY OF NAIROBI   (Kenya)

^c UNIVERSITY OF KENTUCKY   (United States)

^d NONE

Author keywords

Astrocytes; Brain; HIV 1; Macrophages; Molecular diversity; NF B; Tat; TNF

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; PHOSPHOLIPASE C; PROTEIN TYROSINE KINASE; TRANSACTIVATOR PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BIODIVERSITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVITY; GLIA CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INTRACELLULAR TRANSPORT; MACROPHAGE; NEUROLOGIC DISEASE; NEUROPATHOLOGY; PRIORITY JOURNAL; PROTEIN INDUCTION; VIRUS GENOME; VIRUS REPLICATION;

AIDS DEMENTIA COMPLEX; ASTROCYTOMA; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; GENE EXPRESSION REGULATION, VIRAL; GENE PRODUCTS, TAT; HIV-1; HUMANS; JURKAT CELLS; MOLECULAR SEQUENCE DATA; NF-KAPPA B; RNA, MESSENGER; SEQUENCE HOMOLOGY, AMINO ACID; TUMOR NECROSIS FACTOR-ALPHA; U937 CELLS; VARIATION (GENETICS); VIRAL PROTEINS;

EID: 0031697077     PISSN: 10217401     EISSN: None     Source Type: Journal    
DOI: 10.1159/000026336     Document Type: Article

References (67)

1. Bell JE, Busuttil A, Ironside JW, Rebus S, Donaldson YK, Simmonds P, Peutherer JF: Human immunodeficiency virus and the brain: Investigations of virus load and neuropathologic changes in pre-AIDS subjects. J Infect Dis 1993;168:818-824.
2. Lipton SD, Gendelman HE: Dementia associated with the acquired immunodeficiency syndrome. N Engl J Med 1995;332:934-940.
3. Stoler MH, Eskin TA, Benn S, Angerer RC, Angerer LM: Human T-cell lymphotropic virus type III infection of the central nervous system. A preliminary in situ analysis. JAMA 1986; 256:2360-2364.
4. Koenig S, Gendelman HE, Orenstein JM, Dal Canto MC, Pezeshpour GH, Yungbluth M, Janotta F, Akasimit A, Martin MA, Fauci AS: Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy. Science 1986;233:1089-1093.
5. Glass JD, Fedor H, Wesselingh SL, McArthur JC: Immunocytochemical quantitation of human immunodeficiency virus in the brain: Correlations with dementia. Ann Neurol 1995;38: 755-762.
6. Wiley CA, Schrier RD, Nelson JA, Lampert PW, Oldstone MB: Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients. Proc Natl Acad Sci USA 1986; 83:7089-7093.
7. Takahashi K, Wesselingh SL, Griffin DE, McArthur JC, Johnson RT, Glass JD: Localization of HIV-1 in human brain using polymerase chain reaction/in situ hybridization and immunocytochemistry. Ann Neurol 1996; 39:705-711.
8. Reddy RT, Achim CL, Sirko DA, Tehranchi S, Kraus FG, Wong Staal F, Wiley CA: Sequence analysis of the V3 loop in brain and spleen of patients with HIV encephalitis. AIDS Res Hum Retroviruses 1996;12:477-482.
9. Jordan CA, Watkins BA, Kufta C, Dubois-Dalcq M: Infection of brain microglial cells by human immunodeficiency virus type 1 is CD4 dependent. J Virol 1991;65:736-742.
10. Power C, McArthur JC, Johnson RT, Griffin DE, Glass JD, Dewey R, Chesebro B: Distinct HIV-1 env sequences are associated with neurotropism and neurovirulence. Curr Top Microbiol Immunol 1995;202:89-104.
11. Gartner S, McDonald R, Hunter E, Bouwman F, Liu Y, Popovic M: Gp120 sequence variation in brain and in T-lymphocyte human immunodeficiency virus type 1 primary isolates. J Hum Virol 1997;1:3-18.
12. Wong JK, Ignacio CC, Torriani F, Havlir D, Fitch NJS, Richman DD: In vivo compartmentalization of human immunodeficiency virus: Evidence from the examination of pol sequences from autopsy tissues. J Virol 1997;71: 2059-2071.
13. Hughes ES, Bell JE, Simmonds P: Investigation of the dynamics of the spread of human immunodeficiency virus to brain and other tissues by evolutionary analysis of sequences from the p17gag and env genes. J Virol 1997;71:1272-1280.
14. Ward AC: Neurovirulence of influenza A virus. J Neurovirol 1996;2:139-151.
15. Mankowski JL, Flahery MT, Spelamn JP, Hauer DA, Didier PJ, Amedee AM, Murphey-Corb M, Kirstein LM, Munoz A, Clements JE, Zink MC: Pathogenesis of simian immunodeficiency virus encephalitis: Viral determinants of neurovirulence. J Virol 1997;71:6055-6060.
16. Hasenkrug KJ, Robertson SJ, Porti J, McAtee F, Nishio J, Chesebro B: Two separate envelope regions influence induction of brain disease by a polytropic murine retrovirus (FMCF98). J Virol 1996;70:4825-4828.
17. Corboy JR, Buzy JM, Zink MC, Clements JE: Expression directed from HIV long terminal repeats in the central nervous system of transgenic mice. Science 1992;258:1804-1808.
18. Magnuson DSK, Knudsen BE, Geiger JD, Brownstone RM, Nath A: Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity. Ann Neurol 1995;37: 373-380.
19. Dreyer EB, Kaiser PK, Offermann JT, Lipton SA: HIV-1 coat protein neurotoxicity prevented by calcium channel antagonists. Science 1990;248:364-367.
20. Adamson DC, Dawson TM, Zink MC, Clements JE, Dawson VL: Neurovirulent simian immunodeficiency virus infection induces neuronal, endothelial, and glial apoptosis. Mol Med 1996;2:417-428.
21. Gaynor RB: Regulation of HIV-1 gene expression by the transactivator protein Tat. Curr Top Microbiol Immunol 1995;193:51-77.
22. Ensoli B, Buonaguro L, Barillari G, Fiorelli V, Gendelman R, Morgan RA, Wingfield P, Gallo RC: Release, uptake, and effects of extracellular human immunodeficiency virus type 1 Tat protein on cell growth and viral transactivation. J Virol 1993;67:277-287.
23. Tardieu M, Hery C, Peudenier S, Boespflug O, Montagnier L: Human immunodeficiency virus type 1-infected monocytic cells can destroy human neural cells after cell-to-cell adhesion. Ann Neurol 1992;32:11-17.
24. Conant K, Ma M, Nath A, Major EO: Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytes. J Virol 1996;70:1384-1389.
25. Ma M, Nath A: Molecular determinants for cellular uptake of Tat protein of human immunodeficiency virus type 1 in brain cells. J Virol 1997;71:2495-2499.
26. Sabatier JM, Vives E, Mabrouk K, Benjouad A, Rochat H, Duval A, Hue B, Bahraoui E: Evidence for neurotoxic activity of tat from human immunodeficiency virus type 1. J Virol 1991;65:961-967.
27. Weeks BS, Lieberman DM, Johnson B, Roque E, Green M, Loewenstein P, Oldfield EH, Kleinman HK: Neurotoxicity of the human immunodeficiency virus type 1 tat transactivator to PC12 cells requires the Tat amino acid 49-58 basic domain. J Neurosci Res 1995;42:34-40.
28. Nath A, Psooy K, Martin C, Knudsen B, Magnuson DS, Haughey N, Geiger JD: Identification of a human immunodeficiency virus type 1 Tat epitope that is neuroexcitatory and neurotoxic. J Virol 1996;70:1475-1480.
29. New DR, Ma M, Epstein LG, Nath A, Gelbard HA: Human immunodeficiency virus type 1 Tat protein induces death by apoptosis in primary human neuron cultures. J Neurovirol 1997;3:168-173.
30. Kolson DL, Pomerantz RJ: AIDS dementia and HIV-1-induced neurotoxicity: Possible pathogenic associations and mechanisms. J Biomed Sci 1996;3:389-414.
31. Genis P, Jett M, Bernton EW, Boyle T, Gelbard HA, Dzenko K, Keane RW, Resnick L, Mizrachi Y, Volsky DJ: Cytokines and arachidonic metabolites produced during human immunodeficiency virus (HIV)-infected macrophage-astroglia interactions: Implications for the neuropathogenesis of HIV disease. J Exp Med 1992;176:1703-1718.
32. Gelbard HA, Dzenko KA, DiLoreto D, del Cerro C, del Cerro M, Epstein LG: Neurotoxic effects of tumor necrosis factor alpha in primary human neuronal cultures are mediated by activation of the glutamate AMPA receptor subtype: Implications for AIDS neuropathogenesis. Dev Neurosci 1993;15:417-422.
33. Merrill JE, Koyanagi Y, Zack J, Thomas L, Martin F, Chen IS: Induction of interleukin-1 and tumor necrosis factor alpha in brain cultures by human immunodeficiency virus type 1. J Virol 1992;66:2217-2225.
34. Wilt SG, Mihvard E, Zhou JM, Nagasato K, Patton H, Rusten R, Griffin DE, M OC, Dubois-Dalcq M: In vitro evidence for a dual role of tumor necrosis factor-alpha in human immunodeficiency virus type 1 encephalopathy. Ann Neurol 1995;37:381-394.
35. Westmoreland SV, Kolson D, Gonzalez Scarano F: Toxicity of TNF alpha and platelet activating factor for human NT2N neurons: A tissue culture model for human immunodeficiency virus dementia. J Neurovirol 1996;2:118-126.
36. Selmaj KW, Raine CS: Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro. Ann Neurol 1988;23:339-346.
37. Le Naour R, Clayette P, Henin Y, Mabondzo A, Raoul H, Bousseau A, Dormont D: Infection of human macrophages with an endogenous tumour necrosis factor-alpha (TNF-alpha)-independent human immunodeficiency virus type 1 isolate is unresponsive to the TNF-alpha synthesis inhibitor RP 55778. J Gen Virol 1994;75:1379-1388.
38. Fauci AS: Host factors and the pathogenesis of HIV-induced disease. Nature 1996;384:529-534.
39. Chen P, Mayne M, Power C, Nath A: The Tat protein of HIV-1 induces tumor necrosis factor-a production: Implications for HIV-1 associated neurological diseases. J Biol Chem 1997; 272:22385-22388.
40. Rana F, Hawken MP, Meme HK, Chakaya JM, Githui WA, Odhiambo JA, Porter JD, McAdam KP, Lucas SJ: Autopsy findings in HIV-1-infected adults in Kenya (letter). J Acquir Immune Defic Syndr Hum Retrovirol 1997;14: 83-85.
41. Power C, McArthur JC, Johnson RT, Griffin DE, Glass JD, Penyman S, Chesebro B: Demented and nondemented patients with AIDS differ in brain-derived human immunodeficiency virus type 1 envelope sequences. J Virol 1994;68:4643-4649.
42. Furer M, Hartloper V, Wilkins J, Nath A: Lymphocyte emperipolesis in human glial cells. Cell Adhes Commun 1993;1:223-237.
43. Wesselingh SL, Power C, Glass JD, Tyor WR, McArthur JC, Farber JM, Griffin JW, Griffin DE: Intracerebral cytokine messenger RNA expression in acquired immunodeficiency syndrome dementia. Ann Neurol 1993;33:576-582.
44. Lorenzo E, Herrera RJ, Shenghan L, Fischl MA, Hills MD: The tat and C2-V3 envelope genes in the molecular epidemiology of human immunodeficiency virus-1. Virology 1996; 221:310-317.
45. Neuveut C, Jeang KT: Recombinant human immunodeficiency virus type 1 genomes with tat unconstrained by overlapping reading frames reveal residues in Tat important for replication in tissue culture. J Virol 1996;70: 5572-5581.
46. Myers G: Human retroviruses and AIDS: A compilation and analysis of nucleic acid and amino acid sequences. Theoretical biology and biophysics group T-10, Los Alamos, 1995.
47. Locardi C, Petrini C, Boccoli G, Testa U, Dieffenbach C, Butto S, Belardelli F: Increased human immunodeficiency virus (HIV) expression in chronically infected U937 cells upon in vitro differentiation by hydroxyvitamin D3: Roles of interferon and tumor necrosis factor in regulation of HIV production. J Virol 1990;64: 5874-5882.
48. Han X, Becker K, Degen HJ, Jablonowski H, Strohmeyer G: Synergistic stimulatory effects of tumour necrosis factor alpha and interferon gamma on replication of human immunodeficiency virus type 1 and on apoptosis of HIV-1-infected host cells. Eur J Clin Invest 1996;26: 286-292.
49. Tornatore C, Nath A, Amemiya K, Major EO: Persistent human immunodeficiency virus type 1 infection in human fetal glial cells reactivated by T-cell factor(s) or by the cytokines tumor necrosis factor alpha and interleukin-1 beta. J Virol 1991;65:6094-6100.
50. Nuovo GJ, Gallery F, MacConnell P, Braun A: In situ detection of polymerase chain reaction-amplified HIV-1 nucleic acids and tumor necrosis factor-alpha RNA in the central nervous system. Am J Pathol 1994;144:659-666.
51. Wiley CA, Baldwin M, Achim CL: Expression of HIV regulatory and structural mRNA in the central nervous system. AIDS 1996;10:843-847.
52. Benveniste EN, Benos DJ: TNF-alpha- and IFN-gamma-mediated signal transduction pathways: Effects on glial cell gene expression and function. FASEB J 1995;9:1577-1584.
53. Lafortune L, Nalbantoglu J, Antel JP: Expression of tumor necrosis factor alpha (TNF alpha) and interleukin 6 (IL-6) mRNA in adult human astrocytes: Comparison with adult microglia and fetal astrocytes. J Neuropathol Exp Neurol 1996;55:515-521.
54. Westendorp MO, Shatrov VA, Schulze Osthoff K, Frank R, Kraft M, Los M, Krammer PH, Droge W, Lehmann V: HIV-1 Tat potentiates TNF-induced NF-kappa B activation and cytotoxicity by altering the cellular redox state. EMBO J 1995;14:546-554.
55. Demarchi F, d'Adda di Fagagna F, Falaschi A, Giacca M: Activation of transcription factor NF-kappa B by the Tat protein of human immunodeficiency virus type 1. J Virol 1996; 70:4427-4437.
56. Renier G, Skamene E, DeSanctis JB, Radzioch D: Induction of tumor necrosis factor alpha gene expression by lipoprotein lipase. J Lipid Res 1994;35:271-278.
57. Black RA, Rauch CT, Kozlosky CJ, Peschon JJ, Slack JL, Wolfson MF, Castner BJ, Stocking KL, Reddy P, Srinivasan S, Nelson N, Boiani N, Schooley KA, Gerhart M, Davis R, Fitzner JN, Johnson RS, Paxton RJ, March CJ, Cerretti DP: A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells. Nature 1997;385:729-733.
58. Moss ML, Jin SL, Milla ME, Burkhart W, Carter HL, Chen WJ, Clay WC, Didsbury JR, Hassler D, Hoffman CR, Kost TA, Lambert MH, Leesnitzer MA, McCauley P, McGeehan G, Mitchell J, Moyer M, Pahel G, Rocque W, Overton LK, Schoenen F, Seaton T, Su JL, Warner J, Becherer JD: Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha. Nature 1997;385: 733-736.
59. Zheng ZM, Specter S: Dynamic production of tumour necrosis factor-alpha (TNF-alpha) messenger RNA, intracellular and extracellular TNF-alpha by murine macrophages and possible association with protein tyrosine phosphorylation of STAT1 alpha and ERK2 as an early signal. Immunology 1996;87:544-550.
60. Glass JD, Wesselingh SL, Seines OA, McArthur JC: Clinical-neuropathologic correlation in HIV-associated dementia. Neurology 1993; 43:2230-2237.
61. Wesselingh S, Takahashi K, Glass JD, McArthur JR, Griffin JW, Griffin DE: Cellular localization of tumour necrosis factor mRNA in neurological tissue from HIV-infected patients by combined reverse transcriptase/polymerase chain reaction in situ hybridization and immunocytochemistry. J Neuroimmunol 1997;74: 1-8.
62. Renjifo B, Borrero I, Essex M: Tax mutation associated with tropical spastic paraparesis/ human T-cell leukemia virus type I-associated myelopathy. J Virol 1995;69:2611-2616.
63. 1. J Virol 1997;71:6982-6989.
64. Gibellini D, Zauli G, Re MC, Milani D, Furlini G, Caramelli E, Capitani S, La Placa M: Recombinant human immunodeficiency virus type-1 (HIV-1) Tat protein sequentially upregulates IL-6 and TGF-beta 1 mRNA expression and protein synthesis in peripheral blood monocytes. Br J Haematol 1994;88:261-267.
65. Rautonen J, Rautonen N, Martin NL, Wara DW: HIV type 1 Tat protein induces immunoglobulin and interleukin 6 synthesis by uninfected peripheral blood mononuclear cells. AIDS Res Hum Retroviruses 1994;10:781-785.
66. Lafrenie RM, Wahl LM, Epstein JS, Hewlett IK, Yamada KM, Dhawan S: HIV-1-Tat protein promotes chemotaxis and invasive behavior by monocytes. J Immunol 1996;157:974-977.
67. Schmidtmayerova H, Nottet HS, Nuovo G, Raabe T, Flanagan CR, Dubrovsky L, Gendelman HE, Cerami A, Bukrinsky M, Sherry B: Human immunodeficiency virus type 1 infection alters chemokine beta peptide expression in human monocytes: Implications for recruitment of leukocytes into brain and lymph nodes. Proc Natl Acad Sci USA 1996;93:700-704.