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Volumn 17, Issue 3, 2005, Pages 316-325

Nonsense-mediated mRNA decay: Molecular insights and mechanistic variations across species

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; PROTEIN; PROTEIN SKI; PROTEIN UPF 1; PROTEIN UPF 2; PROTEIN UPF 3; PROTEIN XRN 1; UNCLASSIFIED DRUG;

EID: 19344374029     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ceb.2005.04.005     Document Type: Review
Times cited : (373)

References (60)
  • 1
    • 2342456308 scopus 로고    scopus 로고
    • Nonsense-mediated mRNA decay: Terminating erroneous gene expression
    • K.E. Baker, and R. Parker Nonsense-mediated mRNA decay: terminating erroneous gene expression Curr Opin Cell Biol 16 2004 293 299
    • (2004) Curr Opin Cell Biol , vol.16 , pp. 293-299
    • Baker, K.E.1    Parker, R.2
  • 2
    • 1842689543 scopus 로고    scopus 로고
    • Nonsense-Mediated mRNA Decay: A comparative analysis of different species
    • L.E. Maquat Nonsense-Mediated mRNA Decay: A comparative analysis of different species Curr Genomics 5 2004 175 190
    • (2004) Curr Genomics , vol.5 , pp. 175-190
    • Maquat, L.E.1
  • 4
    • 6944256813 scopus 로고    scopus 로고
    • Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise
    • J.T. Mendell, N.A. Sharifi, J.L. Meyers, F. Martinez-Murillo, and H.C. Dietz Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise Nat Genet 36 2004 1073 1078 In this paper, the authors analyze gene expression profiles in human cells depleted of UPF1. They show that ∼5% of detectable transcripts are up-regulated in these cells. The up-regulated transcripts are involved in a broad range of cellular processes.
    • (2004) Nat Genet , vol.36 , pp. 1073-1078
    • Mendell, J.T.1    Sharifi, N.A.2    Meyers, J.L.3    Martinez-Murillo, F.4    Dietz, H.C.5
  • 5
    • 0347416978 scopus 로고    scopus 로고
    • Genome-wide analysis of mRNAs regulated by the nonsense-mediated and 5′-to-3′ mRNA decay pathways in yeast
    • F. He, X. Li, P. Spatrick, R. Casillo, S. Dong, and A. Jacobson Genome-wide analysis of mRNAs regulated by the nonsense-mediated and 5′-to-3′ mRNA decay pathways in yeast Mol Cell 12 2003 1439 1452 In this study it is shown that NMD regulates the expression of ∼10% of the yeast transcriptome. This study identifies several structural classes of NMD targets, which are involved in various cellular processes.
    • (2003) Mol Cell , vol.12 , pp. 1439-1452
    • He, F.1    Li, X.2    Spatrick, P.3    Casillo, R.4    Dong, S.5    Jacobson, A.6
  • 6
    • 0032825494 scopus 로고    scopus 로고
    • Yeast Upf proteins required for RNA surveillance affect global expression of the yeast transcriptome
    • M.J. Lelivelt, and M.R. Culbertson Yeast Upf proteins required for RNA surveillance affect global expression of the yeast transcriptome Mol Cell Biol 19 1999 6710 6719
    • (1999) Mol Cell Biol , vol.19 , pp. 6710-6719
    • Lelivelt, M.J.1    Culbertson, M.R.2
  • 7
    • 0024444026 scopus 로고
    • A new kind of informational suppression in the nematode Caenorhabditis elegans
    • J. Hodgkin, A. Papp, R. Pulak, V. Ambros, and P. Anderson A new kind of informational suppression in the nematode Caenorhabditis elegans Genetics 123 1989 301 313
    • (1989) Genetics , vol.123 , pp. 301-313
    • Hodgkin, J.1    Papp, A.2    Pulak, R.3    Ambros, V.4    Anderson, P.5
  • 8
    • 0025786141 scopus 로고
    • The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon
    • P. Leeds, S.W. Peltz, A. Jacobson, and M.R. Culbertson The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon Genes Dev 5 1991 2303 2314
    • (1991) Genes Dev , vol.5 , pp. 2303-2314
    • Leeds, P.1    Peltz, S.W.2    Jacobson, A.3    Culbertson, M.R.4
  • 9
    • 0028934876 scopus 로고
    • Identification and characterization of genes that are required for the accelerated degradation of mRNAs containing a premature translational termination codon
    • Y. Cui, K.W. Hagan, S. Zhang, and S.W. Peltz Identification and characterization of genes that are required for the accelerated degradation of mRNAs containing a premature translational termination codon Genes Dev 9 1995 423 436.5
    • (1995) Genes Dev , vol.9 , pp. 423-4365
    • Cui, Y.1    Hagan, K.W.2    Zhang, S.3    Peltz, S.W.4
  • 10
    • 0031025296 scopus 로고    scopus 로고
    • Upf1p, Nmd2p, and Upf3p are interacting components of the yeast nonsense-mediated mRNA decay pathway
    • F. He, A.H. Brown, and A. Jacobson Upf1p, Nmd2p, and Upf3p are interacting components of the yeast nonsense-mediated mRNA decay pathway Mol Cell Biol 17 1997 1580 1594
    • (1997) Mol Cell Biol , vol.17 , pp. 1580-1594
    • He, F.1    Brown, A.H.2    Jacobson, A.3
  • 11
    • 0032771414 scopus 로고    scopus 로고
    • SMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeast
    • M.F. Page, B. Carr, K.R. Anders, A. Grimson, and P. Anderson SMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeast Mol Cell Biol 19 1999 5943 5951
    • (1999) Mol Cell Biol , vol.19 , pp. 5943-5951
    • Page, M.F.1    Carr, B.2    Anders, K.R.3    Grimson, A.4    Anderson, P.5
  • 12
    • 0034751160 scopus 로고    scopus 로고
    • Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4)
    • G. Serin, A. Gersappe, J.D. Black, R. Aronoff, and L.E. Maquat Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4) Mol Cell Biol 21 2001 209 223
    • (2001) Mol Cell Biol , vol.21 , pp. 209-223
    • Serin, G.1    Gersappe, A.2    Black, J.D.3    Aronoff, R.4    Maquat, L.E.5
  • 13
    • 0042025014 scopus 로고    scopus 로고
    • Nonsense-mediated mRNA decay in Drosophila: At the intersection of the yeast and mammalian pathways
    • D. Gatfield, L. Unterholzner, F.D. Ciccarelli, P. Bork, and E. Izaurralde Nonsense-mediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathways EMBO J 22 2003 3960 3970
    • (2003) EMBO J , vol.22 , pp. 3960-3970
    • Gatfield, D.1    Unterholzner, L.2    Ciccarelli, F.D.3    Bork, P.4    Izaurralde, E.5
  • 14
    • 0034704201 scopus 로고    scopus 로고
    • Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon
    • J. Lykke-Andersen, M.D. Shu, and J.A. Steitz Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon Cell 103 2000 1121 1131
    • (2000) Cell , vol.103 , pp. 1121-1131
    • Lykke-Andersen, J.1    Shu, M.D.2    Steitz, J.A.3
  • 15
    • 0037064145 scopus 로고    scopus 로고
    • Separable roles for rent1/hUpf1 in altered splicing and decay of nonsense transcripts
    • C.M. Mendell JT: ap Rhys, and H.C. Dietz Separable roles for rent1/hUpf1 in altered splicing and decay of nonsense transcripts Science 298 2002 419 422
    • (2002) Science , vol.298 , pp. 419-422
    • Mendell, J.T.1    Ap Rhys, C.M.2    Dietz, H.C.3
  • 16
    • 0034672093 scopus 로고    scopus 로고
    • The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions
    • H. Le Hir, E. Izaurralde, L.E. Maquat, and M.J. Moore The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions EMBO J 19 2000 6860 6869
    • (2000) EMBO J , vol.19 , pp. 6860-6869
    • Le Hir, H.1    Izaurralde, E.2    Maquat, L.E.3    Moore, M.J.4
  • 17
    • 0035823150 scopus 로고    scopus 로고
    • Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex
    • V.N. Kim, N. Kataoka, and G. Dreyfuss Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex Science 293 2001 1832 1836
    • (2001) Science , vol.293 , pp. 1832-1836
    • Kim, V.N.1    Kataoka, N.2    Dreyfuss, G.3
  • 19
    • 1842473091 scopus 로고    scopus 로고
    • The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3
    • •], this represents the second example in NMD of a canonical RBD that lacks RNA binding activity and is instead involved in protein-protein interactions.
    • (2004) Nat Struct Mol Biol , vol.11 , pp. 330-337
    • Kadlec, J.1    Izaurralde, E.2    Cusack, S.3
  • 20
    • 0029842901 scopus 로고    scopus 로고
    • Interaction between Nmd2p and Upf1p is required for activity but not for dominant-negative inhibition of the nonsense-mediated mRNA decay pathway in yeast
    • F. He, A.H. Brown, and A. Jacobson Interaction between Nmd2p and Upf1p is required for activity but not for dominant-negative inhibition of the nonsense-mediated mRNA decay pathway in yeast RNA 2 1996 153 170
    • (1996) RNA , vol.2 , pp. 153-170
    • He, F.1    Brown, A.H.2    Jacobson, A.3
  • 21
    • 0035038083 scopus 로고    scopus 로고
    • Evidence that phosphorylation of human Upf1 protein varies with intracellular location and is mediated by a wortmannin-sensitive and rapamycin-sensitive PI 3-kinase-related kinase signaling pathway
    • M. Pal, Y. Ishigaki, E. Nagy, and L.E. Maquat Evidence that phosphorylation of human Upf1 protein varies with intracellular location and is mediated by a wortmannin-sensitive and rapamycin-sensitive PI 3-kinase-related kinase signaling pathway RNA 7 2001 5 15
    • (2001) RNA , vol.7 , pp. 5-15
    • Pal, M.1    Ishigaki, Y.2    Nagy, E.3    Maquat, L.E.4
  • 22
    • 0027382460 scopus 로고
    • MRNA surveillance by the Caenorhabditis elegans smg genes
    • R. Pulak, and P. Anderson mRNA surveillance by the Caenorhabditis elegans smg genes Genes Dev 7 1993 1885 1897
    • (1993) Genes Dev , vol.7 , pp. 1885-1897
    • Pulak, R.1    Anderson, P.2
  • 23
    • 0032940802 scopus 로고    scopus 로고
    • Smg-7 is required for mRNA surveillance in Caenorhabditis elegans
    • S.L. Cali BM: Kuchma, J. Latham, and P. Anderson smg-7 is required for mRNA surveillance in Caenorhabditis elegans Genetics 151 1999 605 616
    • (1999) Genetics , vol.151 , pp. 605-616
    • Cali, B.M.1    Kuchma, S.L.2    Latham, J.3    Anderson, P.4
  • 24
    • 0035933889 scopus 로고    scopus 로고
    • Cloning of a novel phosphatidylinositol kinase-related kinase: Characterization of the human SMG-1 RNA surveillance protein
    • G. Denning, L. Jamieson, L.E. Maquat, E.A. Thompson, and A.P. Fields Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein J Biol Chem 276 2001 22709 22714
    • (2001) J Biol Chem , vol.276 , pp. 22709-22714
    • Denning, G.1    Jamieson, L.2    Maquat, L.E.3    Thompson, E.A.4    Fields, A.P.5
  • 25
    • 0035449691 scopus 로고    scopus 로고
    • Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay
    • A. Yamashita, T. Ohnishi, I. Kashima, Y. Taya, and S. Ohno Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay Genes Dev 15 2001 2215 2228
    • (2001) Genes Dev , vol.15 , pp. 2215-2228
    • Yamashita, A.1    Ohnishi, T.2    Kashima, I.3    Taya, Y.4    Ohno, S.5
  • 26
    • 4344570947 scopus 로고    scopus 로고
    • SMG-1 is a phosphatidylinositol kinase-related protein kinase required for nonsense-mediated mRNA decay in Caenorhabditis elegans
    • A. Grimson, S. O'Connor, C.L. Newman, and P. Anderson SMG-1 is a phosphatidylinositol kinase-related protein kinase required for nonsense-mediated mRNA decay in Caenorhabditis elegans Mol Cell Biol 24 2004 7483 7490
    • (2004) Mol Cell Biol , vol.24 , pp. 7483-7490
    • Grimson, A.1    O'Connor, S.2    Newman, C.L.3    Anderson, P.4
  • 29
    • 0037279012 scopus 로고    scopus 로고
    • Characterization of human Smg5/7a: A protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1
    • S.Y. Chiu, G. Serin, O. Ohara, and L.E. Maquat Characterization of human Smg5/7a: A protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1 RNA 9 2003 77 87
    • (2003) RNA , vol.9 , pp. 77-87
    • Chiu, S.Y.1    Serin, G.2    Ohara, O.3    Maquat, L.E.4
  • 30
    • 13944259434 scopus 로고    scopus 로고
    • SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway
    • in press.
    • Fukuhara N, Ebert J, Unterholzner L, Lindner D, Izaurralde E, Conti E: SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway. Mol Cell 2005, in press. The crystal structure of the N-terminal domain of SMG7 reveals that this protein contains a 14-3-3-like phosphoserine-binding domain. Mutations at the 14-3-3-like binding site in SMG7 impair UPF1 binding in vitro. These residues are conserved among SMG7, SMG5 and SMG6, suggesting that these proteins act as 14-3-3-like adaptors in NMD.
    • (2005) Mol Cell
    • Fukuhara, N.1    Ebert, J.2    Unterholzner, L.3    Lindner, D.4    Izaurralde, E.5    Conti, E.6
  • 31
    • 0034649546 scopus 로고    scopus 로고
    • PIN domains in nonsense-mediated mRNA decay and RNAi
    • P.M. Clissold, and C.P. Ponting PIN domains in nonsense-mediated mRNA decay and RNAi Curr Biol 10 2000 R888 R890
    • (2000) Curr Biol , vol.10
    • Clissold, P.M.1    Ponting, C.P.2
  • 32
    • 0035823247 scopus 로고    scopus 로고
    • Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1
    • J. Lykke-Andersen, M.D. Shu, and J.A. Steitz Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1 Science 293 2001 1836 1839
    • (2001) Science , vol.293 , pp. 1836-1839
    • Lykke-Andersen, J.1    Shu, M.D.2    Steitz, J.A.3
  • 34
    • 0038814325 scopus 로고    scopus 로고
    • Y14 and hUpf3b form an NMD-activating complex
    • N.H. Gehring, G. Neu-Yilik, T. Schell, M.W. Hentze, and A.E. Kulozik Y14 and hUpf3b form an NMD-activating complex Mol Cell 11 2003 939 949 This study provides the first evidence for a role of Y14 in NMD in human cells. The authors show that UPF3b/Y14 interaction is required for NMD, whereas the UPF3-UPF2 interaction is dispensable when UPF3b is artificially tethered to a reporter transcript.
    • (2003) Mol Cell , vol.11 , pp. 939-949
    • Gehring, N.H.1    Neu-Yilik, G.2    Schell, T.3    Hentze, M.W.4    Kulozik, A.E.5
  • 35
    • 3543032700 scopus 로고    scopus 로고
    • Molecular insights into the interaction of PYM with the Mago-Y14 core of the exon junction complex
    • F. Bono, J. Ebert, L. Unterholzner, T. Guttler, E. Izaurralde, and E. Conti Molecular insights into the interaction of PYM with the Mago-Y14 core of the exon junction complex EMBO Rep 5 2004 304 310
    • (2004) EMBO Rep , vol.5 , pp. 304-310
    • Bono, F.1    Ebert, J.2    Unterholzner, L.3    Guttler, T.4    Izaurralde, E.5    Conti, E.6
  • 38
    • 1842577707 scopus 로고    scopus 로고
    • EIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsense-mediated decay
    • T. Shibuya, T.O. Tange, N. Sonenberg, and M.J. Moore eIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsense-mediated decay Nat Struct Mol Biol 11 2004 346 351
    • (2004) Nat Struct Mol Biol , vol.11 , pp. 346-351
    • Shibuya, T.1    Tange, T.O.2    Sonenberg, N.3    Moore, M.J.4
  • 39
    • 1442354190 scopus 로고    scopus 로고
    • An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay
    • I.M. Palacios, D. Gatfield, D. St Johnston, and E. Izaurralde An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay Nature 427 2004 753 757
    • (2004) Nature , vol.427 , pp. 753-757
    • Palacios, I.M.1    Gatfield, D.2    St Johnston, D.3    Izaurralde, E.4
  • 40
    • 4043118349 scopus 로고    scopus 로고
    • Association of the breast cancer protein MLN51 with the exon junction complex via its speckle localizer and RNA binding module
    • S. Degot, H. Le Hir, F. Alpy, V. Kedinger, I. Stoll, C. Wendling, B. Seraphin, M.C. Rio, and C. Tomasetto Association of the breast cancer protein MLN51 with the exon junction complex via its speckle localizer and RNA binding module J Biol Chem 279 2004 33702 33715
    • (2004) J Biol Chem , vol.279 , pp. 33702-33715
    • Degot, S.1    Le Hir, H.2    Alpy, F.3    Kedinger, V.4    Stoll, I.5    Wendling, C.6    Seraphin, B.7    Rio, M.C.8    Tomasetto, C.9
  • 41
    • 0035687504 scopus 로고    scopus 로고
    • The protein Mago provides a link between splicing and mRNA localization
    • H. Le Hir, D. Gatfield, I.C. Braun, D. Forler, and E. Izaurralde The protein Mago provides a link between splicing and mRNA localization EMBO Rep 2 2001 1119 1124
    • (2001) EMBO Rep , vol.2 , pp. 1119-1124
    • Le Hir, H.1    Gatfield, D.2    Braun, I.C.3    Forler, D.4    Izaurralde, E.5
  • 42
    • 0035975970 scopus 로고    scopus 로고
    • Drosophila Y14 shuttles to the posterior of the oocyte and is required for oskar mRNA transport
    • O. Hachet, and A. Ephrussi Drosophila Y14 shuttles to the posterior of the oocyte and is required for oskar mRNA transport Curr Biol 11 2001 1666 1674
    • (2001) Curr Biol , vol.11 , pp. 1666-1674
    • Hachet, O.1    Ephrussi, A.2
  • 43
    • 0035498967 scopus 로고    scopus 로고
    • The RNA-binding protein Tsunagi interacts with Mago Nashi to establish polarity and localize oskar mRNA during Drosophila oogenesis
    • S.E. Mohr, S.T. Dillon, and R.E. Boswell The RNA-binding protein Tsunagi interacts with Mago Nashi to establish polarity and localize oskar mRNA during Drosophila oogenesis Genes Dev 15 2001 2886 2899
    • (2001) Genes Dev , vol.15 , pp. 2886-2899
    • Mohr, S.E.1    Dillon, S.T.2    Boswell, R.E.3
  • 44
    • 0035817634 scopus 로고    scopus 로고
    • Barentsz is essential for the posterior localization of oskar mRNA and colocalizes with it to the posterior pole
    • F.J.M. van Eeden, I.M. Palacios, M. Petronczki, M.J.D. Weston, and D. St Johnston Barentsz is essential for the posterior localization of oskar mRNA and colocalizes with it to the posterior pole J Cell Biol 154 2001 511 523
    • (2001) J Cell Biol , vol.154 , pp. 511-523
    • Van Eeden, F.J.M.1    Palacios, I.M.2    Petronczki, M.3    Weston, M.J.D.4    St Johnston, D.5
  • 46
    • 0030886559 scopus 로고    scopus 로고
    • Mago nashi mediates the posterior follicle cell-to-oocyte signal to organize axis formation in Drosophila
    • P.A. Newmark, S.E. Mohr, L. Gong, and R.E. Boswell mago nashi mediates the posterior follicle cell-to-oocyte signal to organize axis formation in Drosophila Development 124 1997 3197 3207
    • (1997) Development , vol.124 , pp. 3197-3207
    • Newmark, P.A.1    Mohr, S.E.2    Gong, L.3    Boswell, R.E.4
  • 47
    • 18844463753 scopus 로고    scopus 로고
    • Identifying the right stop: Determining how the surveillance complex recognizes and degrades an aberrant mRNA
    • M.J. Ruiz-Echevarria, C.I. Gonzalez, and S.W. Peltz Identifying the right stop: determining how the surveillance complex recognizes and degrades an aberrant mRNA EMBO J 17 1998 575 589
    • (1998) EMBO J , vol.17 , pp. 575-589
    • Ruiz-Echevarria, M.J.1    Gonzalez, C.I.2    Peltz, S.W.3
  • 48
    • 0033679905 scopus 로고    scopus 로고
    • The yeast hnRNP-like protein Hrp1/Nab4 marks a transcript for nonsense-mediated mRNA decay
    • C.I. Gonzalez, M.J. Ruiz-Echevarria, S. Vasudevan, M.F. Henry, and S.W. Peltz The yeast hnRNP-like protein Hrp1/Nab4 marks a transcript for nonsense-mediated mRNA decay Mol Cell 5 2000 489 499
    • (2000) Mol Cell , vol.5 , pp. 489-499
    • Gonzalez, C.I.1    Ruiz-Echevarria, M.J.2    Vasudevan, S.3    Henry, M.F.4    Peltz, S.W.5
  • 49
    • 0033016753 scopus 로고    scopus 로고
    • MRNA surveillance in eukaryotes: Kinetic proofreading of proper translation termination as assessed by mRNP domain organization?
    • P. Hilleren, and R. Parker mRNA surveillance in eukaryotes: kinetic proofreading of proper translation termination as assessed by mRNP domain organization? RNA 5 1999 711 719
    • (1999) RNA , vol.5 , pp. 711-719
    • Hilleren, P.1    Parker, R.2
  • 50
    • 8544253956 scopus 로고    scopus 로고
    • A faux 3′-UTR promotes aberrant termination and triggers nonsense-mediated mRNA decay
    • N. Amrani, R. Ganesan, S. Kervestin, D.A. Mangus, S. Ghosh, and A. Jacobson A faux 3′-UTR promotes aberrant termination and triggers nonsense-mediated mRNA decay Nature 432 2004 112 118 This paper demonstrates that translation termination at a premature stop codon is intrinsically aberrant, and that the premature terminating ribosome is not efficiently released. Interestingly, the authors show that tethering of Pab1p in the proximity of a PTC abrogates aberrant translation termination. This study provides strong support to the hypothesis that NMD is activated as a consequence of an aberrant translation termination event that occurs because the stop codon is not in the appropriate context (i.e. it is not upstream of a proper 3′ UTR).
    • (2004) Nature , vol.432 , pp. 112-118
    • Amrani, N.1    Ganesan, R.2    Kervestin, S.3    Mangus, D.A.4    Ghosh, S.5    Jacobson, A.6
  • 51
    • 0742288008 scopus 로고    scopus 로고
    • The enzymes and control of eukaryotic mRNA turnover
    • R. Parker, and H. Song The enzymes and control of eukaryotic mRNA turnover Nat Struct Mol Biol 11 2004 121 127
    • (2004) Nat Struct Mol Biol , vol.11 , pp. 121-127
    • Parker, R.1    Song, H.2
  • 52
    • 0027932513 scopus 로고
    • Premature translational termination triggers mRNA decapping
    • D. Muhlrad, and R. Parker Premature translational termination triggers mRNA decapping Nature 370 1994 578 581
    • (1994) Nature , vol.370 , pp. 578-581
    • Muhlrad, D.1    Parker, R.2
  • 53
    • 0038402506 scopus 로고    scopus 로고
    • Computational modeling and experimental analysis of nonsense-mediated decay in yeast
    • •].
    • (2003) Cell , vol.113 , pp. 533-545
    • Cao, D.1    Parker, R.2
  • 54
    • 0037762554 scopus 로고    scopus 로고
    • An NMD pathway in yeast involving accelerated deadenylation and exosome-mediated 3′→5′ degradation
    • •] show that decay of NMD targets in yeast occurs by exonucleolytic digestion from the two ends of the transcript. Although it was already well established that NMD triggers deadenylation-independent decapping and 5′-to-3′ decay, these papers show for the first time that exosome-mediated 3′-to-5′ decay also contributes to the degradation of nonsense transcripts.
    • (2003) Mol Cell , vol.11 , pp. 1405-1413
    • Mitchell, P.1    Tollervey, D.2
  • 55
    • 0038112021 scopus 로고    scopus 로고
    • Rapid deadenylation triggered by a nonsense codon precedes decay of the RNA body in a mammalian cytoplasmic nonsense-mediated decay pathway
    • C.Y. Chen, and A.B. Shyu Rapid deadenylation triggered by a nonsense codon precedes decay of the RNA body in a mammalian cytoplasmic nonsense-mediated decay pathway Mol Cell Biol 23 2003 4805 4813
    • (2003) Mol Cell Biol , vol.23 , pp. 4805-4813
    • Chen, C.Y.1    Shyu, A.B.2
  • 56
    • 1342307287 scopus 로고    scopus 로고
    • Premature termination codons enhance mRNA decapping in human cells
    • P. Couttet, and T. Grange Premature termination codons enhance mRNA decapping in human cells Nucleic Acids Res 32 2004 488 494
    • (2004) Nucleic Acids Res , vol.32 , pp. 488-494
    • Couttet, P.1    Grange, T.2
  • 57
    • 0141819096 scopus 로고    scopus 로고
    • Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities
    • F. Lejeune, X. Li, and L.E. Maquat Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities Mol Cell 12 2003 675 687
    • (2003) Mol Cell , vol.12 , pp. 675-687
    • Lejeune, F.1    Li, X.2    Maquat, L.E.3
  • 58
    • 2942595765 scopus 로고    scopus 로고
    • Nonsense-mediated mRNA decay is initiated by endonucleolytic cleavage in Drosophila
    • D. Gatfield, and E. Izaurralde Nonsense-mediated mRNA decay is initiated by endonucleolytic cleavage in Drosophila Nature 429 2004 575 578 This study shows that decay of NMD substrates in Drosophila is initiated by endonucleolytic cleavage in the vicinity of the premature stop codon.
    • (2004) Nature , vol.429 , pp. 575-578
    • Gatfield, D.1    Izaurralde, E.2
  • 59
    • 8844245615 scopus 로고    scopus 로고
    • SMG7 acts as a molecular link between mRNA surveillance and mRNA decay
    • L. Unterholzner, and E. Izaurralde SMG7 acts as a molecular link between mRNA surveillance and mRNA decay Mol Cell 16 2004 587 596
    • (2004) Mol Cell , vol.16 , pp. 587-596
    • Unterholzner, L.1    Izaurralde, E.2
  • 60


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.