Farnesyltransferase pharmacophore model derived from diverse classes of inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 1, 2007, Pages 243-249

  Lu, Aijun ^a,b   Zhang, Jian ^b   Yin, Xiaojin ^a   Luo, Xiaomin ^b   Jiang, Hualiang ^b,c  

^a Jiangsu Simcere Pharmaceutical R and D Co Ltd   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^c EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Anticancer; Farnesyltransferase; Inhibitor; Pharmacophore model; QSAR

Indexed keywords

PROTEIN FARNESYLTRANSFERASE INHIBITOR;

ARTICLE; DRUG POTENCY; HYDROGEN BOND; HYDROPHOBICITY; IC 50; PHARMACOPHORE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RELIABILITY; VALIDATION PROCESS;

ANTINEOPLASTIC AGENTS; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; MODELS, CHEMICAL; MOLECULAR STRUCTURE; SOFTWARE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33845800256     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.09.055     Document Type: Article

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