Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents

Journal of Medicinal Chemistry

Volumn 46, Issue 14, 2003, Pages 2973-2984

  DeSolms, S Jane ^a   Ciccarone, Terrence M ^a   MacTough, Suzanne C ^a   Shaw, Anthony W ^a   Buser, Carolyn A ^a   Ellis Hutchings, Michelle ^a   Fernandes, Christine ^a   Hamilton, Kelly A ^a   Huber, Hans E ^a   Kohl, Nancy E ^a   Lobell, Robert B ^a   Robinson, Ronald G ^a   Tsou, Nancy N ^a   Walsh, Eileen S ^a   Graham, Samuel L ^a   Beese, Lorena S ^b   Taylor, Jeffrey S ^b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANISOLE; GENE PRODUCT; GERANYLGERANYLTRANSFERASE 1 INHIBITOR; GERANYLTRANSFERASE; LACTAM; MEPTAZINOL; PROTEIN FARNESYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CANCER CHEMOTHERAPY; CELL PROLIFERATION; COMPLEX FORMATION; ENZYME INHIBITION; MOUSE; NONHUMAN; ONCOGENE K RAS; PRENYLATION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

ALKYL AND ARYL TRANSFERASES; ANIMALS; ANTINEOPLASTIC AGENTS; CARRIER PROTEINS; CRYSTALLOGRAPHY, X-RAY; DRUG SCREENING ASSAYS, ANTITUMOR; HEAT-SHOCK PROTEINS; HSP40 HEAT-SHOCK PROTEINS; HUMANS; MICE; MICE, NUDE; MODELS, MOLECULAR; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; PROTEIN ISOPRENYLATION; RAP1 GTP-BINDING PROTEINS; RAS PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 0038121716     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020587n     Document Type: Article

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