Oxo-piperazine derivatives of N-arylpiperazinones as inhibitors of farnesyltransferase

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 4, 2001, Pages 537-540

  Dinsmore, Christopher J ^a   Bergman, Jeffrey M ^a   Wei, Donna D ^a   Zartman, C Blair ^a   Davide, Joseph P ^a   Greenberg, Ian B ^a   Liu, Dongming ^a   O'Neill, Timothy J ^a   Gibbs, Jackson B ^a   Koblan, Kenneth S ^a   Kohl, Nancy E ^a   Lobell, Robert B ^a   Chen, I Wu ^a   McLoughlin, Debra A ^a   Olah, Timothy V ^a   Graham, Samuel L ^a   Hartman, George D ^a   Williams, Theresa M ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 DIKETOPIPERAZINE DERIVATIVE; ANTINEOPLASTIC AGENT; PIPERAZINE DERIVATIVE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION;

ALKYL AND ARYL TRANSFERASES; ANIMALS; DOGS; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; PIPERAZINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035952277     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00710-1     Document Type: Article

References (26)