Anthocyanidins inhibit migration of glioblastoma cells: Structure-activity relationship and involvement of the plasminolytic system

Journal of Cellular Biochemistry

Volumn 100, Issue 1, 2007, Pages 100-111

  Lamy, Sylvie ^a   Lafleur, René ^a   Bédard, Valérie ^a   Moghrabi, Albert ^b   Barrette, Stéphane ^b   Gingras, Denis ^a   Béliveau, Richard ^a,b  

^a UNIVERSITÉ DU QUÉBEC À MONTRÉAL   (Canada)

^b UNIVERSITY OF MONTREAL   (Canada)

Author keywords

Anthocyanidins; Cell invasion; Cell migration; Glioblastoma; Plasminogen activator

Indexed keywords

ANTHOCYANIN; CYANIDIN; DELPHINIDIN; HYDROXYL GROUP; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; PETUNIDIN CHLORIDE; PLASMINOGEN; PLASMINOGEN ACTIVATOR INHIBITOR 1; UROKINASE;

ARTICLE; BERRY; CANCER INVASION; CANCER PREVENTION; CANCER RISK; CANCER THERAPY; CELL MIGRATION; CONTROLLED STUDY; FRUIT; GENETIC TRANSCRIPTION; GLIOBLASTOMA; HUMAN; HUMAN CELL; PLASMINOGEN ACTIVATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION;

ANTHOCYANINS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL MOVEMENT; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOBLASTOMA; HUMANS; LDL-RECEPTOR RELATED PROTEIN 1; NEOPLASM INVASIVENESS; PLASMIN; PLASMINOGEN; PLASMINOGEN ACTIVATOR INHIBITOR 1; RECEPTORS, CELL SURFACE; STRUCTURE-ACTIVITY RELATIONSHIP; URINARY PLASMINOGEN ACTIVATOR;

EID: 33845635095     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.21023     Document Type: Article

References (56)

1. Abou-Agag LH, Aikens ML, Tabengwa EM, Benza RL, Shows SR, Grenett HE, Booyse FM. 2001. Polyphyenolics increase t-PA and u-PA gene transcription in cultured human endothelial cells. Alcohol Clin Exp Res 25:155-162.
2. Andreasen PA, Kjoller L, Christensen L, Duffy MJ. 1997. The urokinase-type plasminogen activator system in cancer metastasis: A review. Int J Cancer 72:1-22.
3. Andreasen PA, Egelund R, Petersen HH. 2000. The plasminogen activation system in tumor growth, invasion, and metastasis. Cell Mol Life Sci 57:25-40.
4. Andres-Lacueva C, Shukitt-Hale B, Galli RL, Jauregui O, Lamuela-Raventos RM, Joseph JA. 2005. Anthocyanins in aged blueberry-fed rats are found centrally and may enhance memory. Nutr Neurosci 8:111-120.
5. Atalay M, Gordillo G, Roy S, Rovin B, Bagchi D, Bagchi M, Sen CK. 2003. Anti-angiogenic property of edible berry in a model of hemangioma. FEBS Lett 544:252-257.
6. Block G, Patterson B, Subar A. 1992. Fruit, vegetables, and cancer prevention: A review of the epidemiological evidence. Nutr Cancer 18:1-29.
7. Chazaud B, Bonavaud S, Plonquet A, Pouchelet M, Gherardi RK, Barlovatz-Meimon G. 2000. Involvement of the [uPAR:uPA:PAI-1:LRP] complex in human myogenic cell motility. Exp Cell Res 258:237-244.
8. Chen PN, Chu SC, Chiou HL, Kuo WH, Chiang CL, Hsieh YS. 2006. Mulberry anthocyanins, cyanidin 3-rutinoside and cyanidin 3-glucoside, exhibited an inhibitory effect on the migration and invasion of a human lung cancer cell line. Cancer Lett 235:248-259.
9. Cho SY, Klemke RL. 2000. Extracellular-regulated kinase activation and CAS/Crk coupling regulate cell migration and suppress apoptosis during invasion of the extracellular matrix. J Cell Biol 149:223-236.
10. Choong PF, Nadesapillai AP. 2003. Urokinase plasminogen activator system: A multifunctional role in tumor progression and metastasis. Clin Orthop Relat Res XX: S46-S58.
11. Conese M, Nykjaer A, Petersen CM, Cremona O, Pardi R, Andreasen PA, Gliemann J, Christensen EI, Blasi F. 1995. alpha-2 Macroglobulin receptor/Ldl receptor-related protein(Lrp)-dependent internalization of the urokinase receptor. J Cell Biol 131:1609-1622.
12. Czekay RP, Kuemmel TA, Orlando RA, Farquhar MG. 2001. Direct binding of occupied urokinase receptor (uPAR) to LDL receptor-related protein is required for endocytosis of uPAR and regulation of cell surface urokinase activity. Mol Biol Cell 12:1467-1479.
13. Dell'Agli M, Busciala A, Bosisio E. 2004. Vascular effects of wine polyphenols. Cardiovasc Res 63:593-602.
14. Demuth T, Berens ME. 2004. Molecular mechanisms of glioma cell migration and invasion. J Neurooncol 70: 217-228.
15. Greenwald P, Clifford CK, Milner JA. 2001. Diet and cancer prevention. Eur J Cancer 37:948-965.
16. Hamel W, Westphal M. 2000. Growth factors in gliomas revisited. Acta Neurochir (Wien) 142:113-137 (discussion 137-138).
17. Harborne JB. 1988. The flavonoids: Advances in research since 1980. London; New York: Chapman and Hall. p 621.
18. Hauck CR, Hsia DA, Schlaepfer DD. 2000. Focal adhesion kinase facilitates platelet-derived growth factor-BB-stimulated ERK2 activation required for chemotaxis migration of vascular smooth muscle cells. J Biol Chem 275:41092-41099.
19. Hollman PC, Katan MB. 1999. Dietary flavonoids: Intake, health effects and bioavailability. Food Chem Toxicol 37:937-942.
20. Hong WK, Sporn MB. 1997. Recent advances in chemoprevention of cancer. Science 278:1073-1077.
21. Hou DX. 2003. Potential mechanisms of cancer chemoprevention by anthocyanins. Curr Mol Med 3:149-159.
22. Howe AK, Aplin AE, Juliano RL. 2002. Anchorage-dependent ERK signaling-Mechanisms and consequences. Curr Opin Genet Dev 12:30-35.
23. Huang H, Colella S, Kurrer M, Yonekawa Y, Kleihues P, Ohgaki H. 2000. Gene expression profiling of low-grade diffuse astrocytomas by cDNA arrays. Cancer Res 60: 6868-6874.
24. Irigoyen JP, Munoz-Canoves P, Montero L, Koziczak M, Nagamine Y. 1999. The plasminogen activator system: Biology and regulation. Cell Mol Life Sci 56:104-132.
25. Joshi SS, Kuszynski CA, Bagchi D. 2001. The cellular and molecular basis of health benefits of grape seed proanthocyanidin extract. Curr Pharm Biotechnol 2:187-200.
26. Kang SY, Seeram NP, Nair MG, Bourquin LD. 2003. Tart cherry anthocyanins inhibit tumor development in Apc(Min) mice and reduce proliferation of human colon cancer cells. Cancer Lett 194:13-19.
27. Kresty LA, Morse MA, Morgan C, Carlton PS, Lu J, Gupta A, Blackwood M, Stoner GD. 2001. Chemoprevention of esophageal tumorigenesis by dietary administration of lyophilized black raspberries. Cancer Res 61:6112-6119.
28. Labrecque L, Lamy S, Chapus A, Mihoubi S, Durocher Y, Cass B, Bojanowski MW, Gingras D, Beliveau R. 2005. Combined inhibition of PDGF and VEGF receptors by ellagic acid, a dietary-derived phenolic compound. Carcinogenesis 26:821-826.
29. Lemke DM. 2004. Epidemiology, diagnosis, and treatment of patients with metastatic cancer and high-grade gliomas of the central nervous system. J Infus Nurs 27: 263-269.
30. Li Y, Wood N, Grimsley P, Yellowlees D, Donnelly PK. 1998. In vitro invasiveness of human breast cancer cells is promoted by low density lipoprotein receptor-related protein. Invasion Metastasis 18:240-251.
31. Marko D, Puppel N, Tjaden Z, Jakobs S, Pahlke G. 2004. The substitution pattern of anthocyanidins affects different cellular signaling cascades regulating cell proliferation. Mol Nutr Food Res 48:318-325.
32. Matsuzawa K, Fukuyama K, Hubbard SL, Dirks PB, Rutka JT. 1996. Transfection of an invasive human astrocytoma cell line with a TIMP-1 cDNA: Modulation of astrocytoma invasive potential. J Neuropathol Exp Neurol 55:88-96.
33. Mazza G, Kay CD, Cottrell T, Holub BJ. 2002. Absorption of anthocyanins from blueberries and serum antioxidant status in human subjects. J Agric Food Chem 50:7731-7737.
34. Meiers S, Kemeny M, Weyand U, Gastpar R, von Angerer E, Marko D. 2001. The anthocyanidins cyanidin and delphinidin are potent inhibitors of the epidermal growth-factor receptor. J Agric Food Chem 49:958-962.
35. Mori T, Abe T, Wakabayashi Y, Hikawa T, Matsuo K, Yamada Y, Kuwano M, Hori S. 2000. Up-regulation of urokinase-type plasminogen activator and its receptor correlates with enhanced invasion activity of human glioma cells mediated by transforming growth factor-alpha or basic fibroblast growth factor. J Neurooncol 46: 115-123.
36. Murphy GM, Jr., Lee YL, Jia XC, Yu AC, Majewska A, Song Y, Schmidt K, Eng LF. 1995. Tumor necrosis factor-alpha and basic fibroblast growth factor decrease glial fibrillary acidic protein and its encoding mRNA in astrocyte cultures and glioblastoma cells. J Neurochem 65:2716-2724.
37. Nagase H, Sasaki K, Kito H, Haga A, Sato T. 1998. Inhibitory effect of delphinidin from Solanum melongena on human fibrosarcoma HT-1080 invasiveness in vitro. Planta Med 64:216-219.
38. Nykjaer A, Conese M, Christensen EI, Olson D, Cremona O, Gliemann J, Blasi F. 1997. Recycling of the urokinase receptor upon internalization of the uPA:serpin complexes. EMBO J 16:2610-2620.
39. Ohgaki H, Kleihues P. 2005. Epidemiology and etiology of gliomas. Acta Neuropathol (Berl) 109:93-108.
40. Orth K, Willnow T, Herz J, Gething MJ, Sambrook J. 1994. Low density lipoprotein receptor-related protein is necessary for the internalization of both tissue-type plasminogen activator-inhibitor complexes and free tissue-type plasminogen activator. J Biol Chem 269: 21117-21122.
41. Passamonti S, Vrhovsek U, Vanzo A, Mattivi F. 2003. The stomach as a site for anthocyanins absorption from food. FEBS Lett 544:210-213.
42. Passamonti S, Vrhovsek U, Vanzo A, Mattivi F. 2005. Fast access of some grape pigments to the brain. J Agric Food Chem 53:7029-7034.
43. Pepper MS, Sappino AP, Stocklin R, Montesano R, Orci L, Vassalli JD. 1993. Upregulation of urokinase receptor expression on migrating endothelial cells. J Cell Biol 122: 673-684.
44. Reuning U, Sperl S, Kopitz C, Kessler H, Kruger A, Schmitt M, Magdolen V. 2003. Urokinase-type plasminogen activator (uPA) and its receptor (uPAR): Development of antagonists of uPA/uPAR interaction and their effects in vitro and in vivo. Curr Pharm Des 9:1529-1543.
45. Rooprai HK, Christidou M, Pilkington GJ. 2003. The potential for strategies using micronutrients and heterocyclic drugs to treat invasive gliomas. Acta Neurochir (Wien) 145:683-690.
46. Seeram NP, Zhang Y, Nair MG. 2003. Inhibition of proliferation of human cancer cells and cyclooxygenase enzymes by anthocyanidins and catechins. Nutr Cancer 46:101-106.
47. Shapiro WR. 1999. Current therapy for brain tumors: Back to the future. Arch Neurol 56:429-432.
48. Steinmetz KA, Potter JD. 1996. Vegetables, fruit, and cancer prevention: A review. J Am Diet Assoc 96:1027-1039.
49. Surh YJ. 2003. Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer 3:768-780.
50. Talavera S, Felgines C, Texier O, Besson C, Manach C, Lamaison JL, Remesy C. 2004. Anthocyanins are efficiently absorbed from the small intestine in rats. J Nutr 134:2275-2279.
51. Van Brooklyn JR, Young N, Roof R. 2003. Sphingosine-1-phosphate stimulates motility and invasiveness of human glioblastoma multiforme cells. Cancer Lett 199: 53-60.
52. VandenBerg SR. 1992. Current diagnostic concepts of astrocytic tumors. J Neuropathol Exp Neurol 51: 644-657.
53. Xue H, Aziz RM, Sun N, Cassady JM, Kamendulis LM, Xu Y, Stoner GD, Klaunig JE. 2001. Inhibition of cellular transformation by berry extracts. Carcinogenesis 22: 351-356.
54. Zhang X, Fei Z, Bu X, Zhen H, Zhang Z, Gu J, Chen Y. 2000. Expression and significance of urokinase type plasminogen activator gene in human brain gliomas. J Surg Oncol 74:90-94.
55. Zhang Y, Vareed SK, Nair MG. 2005. Human tumor cell growth inhibition by nontoxic anthocyanidins, the pigments in fruits and vegetables. Life Sci 76:1465-1472.
56. Zheng W, Wang SY. 2003. Oxygen radical absorbing capacity of phenolics in blueberries, cranberries, chokeberries, and lingonberries. J Agric Food Chem 51:502-509.