Up-regulation of urokinase-type plasminogen activator and its receptor correlates with enhanced invasion activity of human glioma cells mediated by transforming growth factor-α or basic fibroblast growth factor

Journal of Neuro-Oncology

Volumn 46, Issue 2, 2000, Pages 115-123

  Mori, Teruaki ^a   Abe, Tatsuya ^a   Wakabayashi, Yukihiro ^a   Hikawa, Takamitsu ^a   Matsuo, Ken Ichi ^b   Yamada, Yuji ^b   Kuwano, Michihiko ^c   Hori, Shigeaki ^a  

^a OITA UNIVERSITY   (Japan)

^b TAIHO PHARMACEUTICAL CO LTD   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

Author keywords

Glioma; Invasion; Irsogladine; Plasminogen activator; uPA receptor

Indexed keywords

FIBROBLAST GROWTH FACTOR; IRSOGLADINE MALEATE; MESSENGER RNA; TRANSFORMING GROWTH FACTOR ALPHA; UROKINASE; UROKINASE RECEPTOR;

ARTICLE; CANCER INVASION; CELL LINE; DRUG INHIBITION; GLIOMA CELL; HUMAN; IN VITRO STUDY; PROTEIN EXPRESSION;

FIBROBLAST GROWTH FACTOR 2; GLIOMA; HUMANS; NEOPLASM INVASIVENESS; RECEPTORS, CELL SURFACE; RNA, MESSENGER; TISSUE PLASMINOGEN ACTIVATOR; TRANSFORMING GROWTH FACTOR ALPHA; TRIAZINES; TUMOR CELLS, CULTURED; UP-REGULATION; URINARY PLASMINOGEN ACTIVATOR;

EID: 0034037266     PISSN: 0167594X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1006339717748     Document Type: Article

References (41)

1. Woolley, DE: Collagenolytic mechanisms in tumor cell invasion. Cancer Metast Rev 3: 361-372, 1984
2. Reich R, Thompson EW, Iwamoto YY, Martin GR, Deason JR, Fuller GC and Miskin R: Effects of inhibitors of plasminogen activator, serine proteinases, and collagenase IV on the invasion of basement membranes by metastatic cells. Cancer Res 48: 3307-3312, 1988
3. Ossowski L, Clunie G, Masucci MT and Blasi F: In vivo paracrine interaction between urokinase and its receptor: effect on tumor cell invasion. J Cell Bio 115: 1107-1112, 1991
4. Abe T, Mori T, Kohno K, Seiki M, Hayakawa T, Welgus HG, Hori S and Kuwano M: Expression of 72 Dka type IV collagenase and invasion activity of human glioma cells. Clin Exp Metast 12: 296-304, 1994
5. Declerck YA, Perez N, Shimada HH, Boone TC, Langley KE and Taylor SM: Inhibition of invasion and metastasis in cells transfected with an inhibitor of metalloproteinases. Cancer Res 52: 701-708, 1992
6. Lyons RM, Gentry LE, Purchio AF and Moses HL: Mechanism of activation of latent recombination transforming growth factor beta-1 by plasmin. J Cell Bio 110: 1361-1367, 1990
7. Giese A and Westphal M: Glioma invasion in the central nervous system. Neurosurgery 39: 235-252, 1990
8. Lund JM, Engebraaten O, Bjerkvig R and Laerum OD: Invasive glioma cells in tissue culture. Anticancer Res 10: 1135-1151, 1991
9. DE Ridder L, Laerum OD, Mork SJ and Bigner DD: Invasiveness of human glioma cell lines in vitro: relation to tumorigenicity in athymic mice. Acta Neuropathol 72: 207-213, 1987
10. Sitrin RG, Gyetko MR, Kole KL, McKeever P and Varani J: Expression of heterogeneous profiles of plasminogen activators and plasminogen activator inhibitors by human glioma lines. Cancer Res 50: 4957-4961, 1990
11. Murphy P and Hart DA: Modulation of plasminogen activator and plasminogen activator inhibitor expression in the human U373 glioblastoma/astrocytoma cell line by inflammatory mediators, Exp Cell Res 198: 93-100, 1992
12. Mohanam S, Sawaya R, McCutcheon I, Ali-Osman F, Boyd D and Rao JS: Modulation of in vitro invasion of human glioblastoma cells by urokinase plasminogen activator receptor antibody. Cancer Res 53: 4143-4147, 1993
13. Blasi F: Urokinase and urokinase receptor: a paracrine/autocrine system regulating cell migration and invasiveness. BioEssay 15: 105-111, 1993
14. Yamamoto M, Sawaya R, Mohanam S, Rao VH, Bruner JM, Nicolson GL and Rao JS: Expression and localization of urokinase-type plasminogen activator receptor in human gliomas. Cancer Res 54: 5016-5020, 1994
15. Abe T, Okamura K, Ono M, Kohno K, Mori T, Hori S and Kuwano M: Induction of vascular endothelial tubular morphogenesis by human glioma cells: a model system for tumor angiogenesis. J Clin Invest 92: 54-61, 1993
16. Takahashi JA, Fukumoto M, Kozai Y, Ito N, Oda Y, Kikuchi H, Hatanaka MA: Inhibition of cell growth and tumorgenesis of human glioblastoma cells by a neutralizing antibody against human basic fibroblast growth factor. FEBS Lett 288, 65-71, 1991
17. Wong AJ, Bigner SH, Bigner DD, Kinzler KW, Hamilton SR, Vogelstein B : Increased expression of the EGF receptor gene in malignant gliomas is invariably associated with gene amplification. Proc Natl Acad Sci USA 84: 6899-6903, 1987
18. Mizoguchi H, Komiyama S, Matsui K, Hamanaka R, Ono M, Kiue A, Kobayashi M, Shimizu N, Welgus HG and Kuwano M: The response to epidermal growth factor of human maxillary tumor cells in terms of tumor growth, invasion and expression of proteinase inhibitors. Int J Cancer 49: 738-743, 1991
19. Nakayama Y, Kohno K, Nomura Y, Naito S, Ono M, Shimizu K, Osato K and Kuwano M: Enhanced invasive activity and decreased expression of tissue inhibitors of metalloproteinases by hepatocyte growth factor in human renal cancer cells. The Cancer J 6: 213-219, 1993
20. Hollas W, Blasi F and Boyd D: Role of the urokinase receptor in facilitating extracellular matrix invasion by cultured colon cancer. Cancer Res 57: 3690-3695, 1991
21. Abe T, Mori T, Wakabayashi Y, Nakagawa M, Cole SPC, Koike K, Kuwano M and Hori S: Expression of multidrug resistance gene in patients with glioma after chemotherapy. J Neuroonc 40: 11-18, 1998
22. Vecchio SD, Stoppelli MP, Carriero MV, Fonti R, Massa O, Li PY, Botti G, Cerra M, D'Aiuto G, Esposito G and Salvatore M: Human urokinase receptor concentration in malignant and benign breast tumors by in vitro quantitative autoradiograpy: comparison with urokinase levels. Cancer Res 53: 3198-3206, 1993
23. Soto Y, Morimoto A, Kiue A, Okamura K, Hamanaka R, Kohno K, Kuwano M and Sakata T: Irsogladine is a potent inhibitor of angiogenesis. FEBS Lett 322: 155-158, 1993
24. Ono M, Kawahara N, Goto D, Wakabayashi Y, Ushiro S, Yamada S, Izumi H, Kuwano M and Sato Y: Inhibition of tumor growth and neovascularization by an anti-gastric ulcer agent, Irsogladine. Cancer Res 56: 1512-1516, 1996
25. Laiho M and Keski OLJ: Growth factors in the regulation of pericellular proteolysis: a review. Cancer Res 49: 2533-2553, 1990
26. Haward EW, Bullen EC and Banda MJ: Preferential inhibition of 72- and 92-kDa gelatinases by tissue inhibitor of metalloproteinases-2. J Biol Chem 266: 13070-13075, 1991
27. Mignatti P and Rifkin DB: Biology and biochemistry of proteinases in tumor invasion. Physiol Rev 73: 161-195, 1993
28. Bindal AK, Hammound M, Shi WM, Wu SZ, Sawaya R and Rao JS: Prognostic significance of proteolytic enzymes in human brain tumors. J Neuroonc 22: 101-110, 1994
29. Nakata S, Ito K, Fujimoto K, Kajiwara S, Adachi W, Matsuyama I, Tsuchiya S, Kuwano M and Amano J: Involvement of vascular endothelial growth factor and urokinase-type plasminogen activator receptor in microvessel invasion in human colorectol cancers. Int J Cancer 79: 179-186, 1998
30. Danø K, Andreasen PA, Grondahl-Hansen J, Kristensen P, Nielsen LS and Skriver L: Plasminogen activators, tissue degradation, and cancer. Adv Cancer Res 44: 139-266, 1985
31. Rømer J, Bugge TH, Pyke C, Lund LR, Flick MJ, Degen JL and Danø K: Impaired wound healing in mice with a disrupted plasminogen gene. Nat Med 2: 287-292, 1996
32. Ploug M, Rønne E, Behrendet N, Jensen AL, Blasi F and Danø K: Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol. J Biol Chem 266: 1926-1933, 1991
33. Stephens RW, Pollanen J, Tapiovaara H, Leung K-C, Sim P-S, Salonen E-M, Rønne E and Danø K: Activation of pro-urokinase and plasminogen on human sarcoma cells: a proteolytic system with surface-bound reactants. J Cell Biol 108: 1987-1995, 1989
34. Ellis V, Wun Y-C, Behrendt N, Rønne E and Danø K: Inhibition of receptor-bound urokinase by plasminogen-activator inhibitors. J Biol Chem 265: 9904-9908, 1990
35. Manchanda N and Schwartz BS: Augmentation of enzymatic activity upon binding to monocytes. J Biol Chem 266: 14580-14584, 1990
36. Vassalli J-D, Baccino D and Belin D: A cellular binding site for the Mr 55,000 form of the human plasminogen activator, urokinase. J Cell Biol 100: 86-92, 1985
37. Fazioli F and Blasu F: Urokinase-type plasminogen activator and its receptor: new targets for anti-metastatic theraphy? Trends Pharmacol Sci 15: 25-29, 1994
38. Nayakama Y, Okazaki K, Shibao T, Hirata K, Nagata N, Kuwano M and Itoh K: Alternative expression of the collagenase and adhesion molecules in the highly metastatic clones of human colonie cancer cell lines. Clin Exp Metast 16: 461-469, 1998
39. Pepper MS, Vassalli J-D, Montesano R and Orct L: Urokinase-type plasminogen activator is induced in migrating capillary endothelial cells. J Cell Biol 105: 2535-2541, 1987
40. Sato Y, Okamura K, Morimoto A, Hamanaka R, Hamaguchi K, Shimada T, Ono M, Kohno K, Sakata T and Kuwano M: Indispensable role of tissue-type plasminogen activator in the growth factor-dependent tube formation of human microvascular endothelial cells in vitro. Expt Cell Res. 204: 223-229, 1993
41. Ushiro S, Mizoguchi K, Yoshida S, Jimi S, Fujiwara T, Yoshida M, Wei ET, Kitabgi P, Amagaya S, Ono M and Kuwano M: Stimulation of cell-surface urokinase-type plasminogen activator activity and cell migration in vascular endothelial cells by a novel hexapeptide analogue of neurotensin. FEBS Lett 418: 341-345, 1997