6-(4-Chlorophenyl)-3-substituted-thieno[3,2-d]pyrimidin-4(3H)-one-based melanin-concentrating hormone receptor 1 antagonist

Journal of Medicinal Chemistry

Volumn 49, Issue 24, 2006, Pages 7108-7118

  Tavares, Francis X ^a   Al Barazanji, Kamal A ^a   Bishop, Michael J ^a   Britt, Christy S ^a   Carlton, David L ^a   Cooper, Joel P ^a   Feldman, Paul L ^a   Garrido, Dulce M ^a   Goetz, Aaron S ^a   Grizzle, Mary K ^a   Hertzog, Donald L ^a   Ignar, Diane M ^a   Lang, Daniel G ^a   McIntyre, Maggie S ^a   Ott, Ronda J ^a   Peat, Andrew J ^a   Zhou, Hui Qiang ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 (4 CHLOROPHENYL) 3 [2 [(4 METHYLPIPERAZIN 1 YL)METHYL] 1 BENZOTHIEN 5 YL]THIENO[3,2 D]PYRIMIDIN 4(3H) ONE; BENZENE DERIVATIVE; CHLORINE DERIVATIVE; HORMONE RECEPTOR; HORMONE RECEPTOR BLOCKING AGENT; MELANIN CONCENTRATING HORMONE; MELANIN CONCENTRATING HORMONE RECEPTOR 1 ANTAGONIST; PYRIMIDINE DERIVATIVE; RIMONABANT;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DOSE INCREASE; DRUG HALF LIFE; DRUG METABOLISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; ENERGY BALANCE; GENETIC MANIPULATION; HYDROGEN BOND; IC 50; LIPID DIET; METABOLIC RATE; MOUSE; NONHUMAN; OBESITY; PHENOTYPE; SINGLE DRUG DOSE; STRUCTURE ACTIVITY RELATION; WEIGHT REDUCTION;

ANIMALS; ANTI-OBESITY AGENTS; BINDING SITES; CHO CELLS; CRICETINAE; CRICETULUS; MICE; PYRIMIDINES; RATS; RECEPTORS, SOMATOSTATIN; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 33845452394     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm060814b     Document Type: Article

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