Negative regulation of phagocytosis in macrophages by the CD47-SHPS-1 system

Journal of Immunology

Volumn 174, Issue 4, 2005, Pages 2004-2011

  Okazawa, Hideki ^a   Motegi, Sei Ichiro ^a,b   Ohyama, Naoko ^a,b   Ohnishi, Hiroshi ^a   Tomizawa, Takeshi ^b   Kaneko, Yoriaki ^b   Oldenborg, Per Arne ^c   Ishikawa, Osamu ^b   Matozaki, Takashi ^a  

^a GUNMA UNIVERSITY   (Japan)

^b GUNMA UNIVERSITY   (Japan)

^c UMEÅ UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CD47 ANTIGEN; IMMUNOGLOBULIN G; LIGAND; MEMBRANE PROTEIN; PHOSPHOTRANSFERASE; PROTEIN TYROSINE PHOSPHATASE SUBTRATE 1; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; B LYMPHOCYTE; CALCIUM MOBILIZATION; CELL STIMULATION; CROSS LINKING; DEPHOSPHORYLATION; FLOW CYTOMETRY; GENE CONVERSION; GENE TRANSFER; IMMUNOBLOTTING; IMMUNOPRECIPITATION; LIGATION; MACROPHAGE; MOUSE; MUTAGENESIS; MUTANT; MUTATION; NONHUMAN; OPSONIZATION; PHAGOCYTOSIS; PHOSPHORYLATION; PRIORITY JOURNAL; REGULATORY MECHANISM; RNA INTERFERENCE; STATISTICAL ANALYSIS; WESTERN BLOTTING; WILD TYPE;

EID: 13544266570     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.174.4.2004     Document Type: Article

References (55)

1. Savill, J., and V. Fadok. 2000, Corpse clearance defines the meaning of cell death. Nature 407:784.
2. Greenberg, S., and S. Grinstein. 2002. Phagocytosis and innate immunity. Curr. Opin. Immunol. 14:136.
3. Medzhitov, R., and C. A. Janeway, Jr. 2002. Decoding the patterns of self and nonself by the innate immune system. Science 296:298.
4. Platt, N., R. P. da Silva, and S. Gordon. 1998. Recognizing death: the phagocytosis of apoptotic cells. Trends Cell Biol. 8:365.
5. Aderem, A., and D. M. Underhill. 1999. Mechanisms of phagocytosis in macrophages. Annu. Rev. Immunol. 17:593.
6. Ravetch, J. V., and S. Bolland. 2001. IgG Fc receptors. Annu. Rev. Immunol. 19:275.
7. Fujioka, Y., T. Matozaki, T. Noguchi, A. Iwamatsu, T. Yamao, N. Takahashi, M. Tsuda, T. Takada, and M. Kasuga. 1996. A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion. Mol. Cell. Biol. 16:6887.
8. Yamao, T., T. Matozaki, K. Amano, Y. Matsuda, N. Takahashi, F. Ochi, Y. Fujioka, and M. Kasuga. 1997. Mouse and human SHPS-1: molecular cloning of cDNAs and chromosomal localization of genes. Biochem. Biophys. Res. Commun. 231:61.
9. Kharitonenkov, A., Z. Chen, I. Sures, H. Wang, J. Schilling, and A. Ullrich. 1997. A family of proteins that inhibit signalling through tyrosine kinase receptors. Nature 386:181.
10. Ohnishi, H., M. Kubota, A. Ohtake, K. Sato, and S. Sano. 1996. Activation of protein-tyrosine phosphatase SH-PTP2 by a tyrosine-based activation motif of a novel brain molecule. J. Biol. Chem. 271:25569.
11. Saginario, C., H. Sterling, C. Beckers, R. Kobayashi, M. Solimena, E. Ullu, and A. Vignery. 1998. MFR, a putative receptor mediating the fusion of macrophages. Mol. Cell. Biol. 18:6213.
12. Comu, S., W. Weng, S. Olinsky, P. Ishwad, Z. Mi, J. Hempel, S. Watkins, C. F. Lagenaur, and V. Narayanan. 1997. The murine P84 neural adhesion molecule is SHPS-1, a member of the phosphatase-binding protein family. J. Neurosci. 17:8702.
13. Noguchi, T., T. Matozaki, Y. Fujioka, T. Yamao, M. Tsuda, T. Takada, and M. Kasuga. 1996. Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation. J. Biol. Chem. 271:27652.
14. Cant, C. A., and A. Ullrich. 2001. Signal regulation by family conspiracy. Cell Mol. Life Sci. 58:117.
15. Veillette, A., E. Thibaudeau, and S. Latour. 1998. High expression of inhibitory receptor SHPS-I and its association with protein-tyrosine phosphatase SHP-1 in macrophages. J. Biol. Chem. 273:22719.
16. Seiffert, M., P. Brossart, C. Cant, M. Cella, M. Colonna, W. Brugger, L. Kanz, A. Ullrich, and H. J. Bühring. 2001. Human signal-regulatory protein is expressed on normal, but not on subsets of leukemic myeloid cells and mediates cellular adhesion involving its counterreceptor CD47. Blood 97:2741.
17. Chuang, W., and C. F. Lagenaur. 1990. Central nervous system antigen P84 can serve as a substrate for neurite outgrowth. Dev. Biol. 137:219.
18. Jiang, P., C. F. Lagenaur, and V. Narayanan. 1999. Integrin-associated protein is a ligand for the P84 neural adhesion molecule. J. Biol. Chem. 274:559.
19. Brown, E., L. Hooper, T. Ho, and H. Gresham. 1990. Integrin-associated protein: a 50-kD plasma membrane antigen physically and functionally associated with integrins. J. Cell Biol. 111:2785.
20. Brown, E. J., and W. A. Frazier. 2001. Integrin-associated protein (CD47) and its ligands. Trends Cell Biol. 11:130.
21. Oldenborg, P. A., A. Zheleznyak, Y. F. Fang, C. F. Lagenaur, H. D. Gresham, and F. P. Lindberg. 2000. Role of CD47 as a marker of self on RBCs. Science 288:2051.
22. Oldenborg, P. A., H. D. Gresham, and F. P. Lindberg. 2001. CD47-signal regulatory protein α (SIRPα) regulates Fc-γ and complement receptor-mediated phagocytosis. J. Exp. Med. 193:855.
23. Inagaki, K., T. Yamao, T. Noguchi, T. Matozaki, K. Fukunaga, T. Takada, T. Hosooka, S. Akira, and M. Kasuga. 2000. SHPS-1 regulates integrin-mediated cytoskeletal reorganization and cell motility. EMBO J. 19:6721.
24. Yamao, T., T. Noguchi, O. Takeuchi, U. Nishiyama, H. Morita, T. Hagiwara, H. Akahori, T. Kato, K. Inagaki, H. Okazawa, et al. 2002. Negative reguration of platelet clearance and of the macrophage phagocytic response by the transmembrane glycoprotein SHPS-1. J. Biol. Chem. 277:39833.
25. Miyashita, M., H. Ohnishi, H. Okazawa, H. Tomonaga, A. Hayashi, T. T. Fujimoto, N. Furuya, and T. Matozaki. 2004. Promotion of neurite and filopodium formation by CD47: roles of integrins, Rac, and Cdc42. Mol. Biol. Cell 15:3950.
26. Hayashi, A., H. Ohnishi, H. Okazawa, S. Nakazawa, H. Ikeda, S. Motegi, N. Aoki, S. Kimura, M. Mikuni, and T. Matozaki. 2004. Positive regulation of phagocytosis by SIRPβ and its signaling mechanism in macrophages. J. Biol. Chem. 279:29450.
27. Motegi, S., H. Okazawa, H. Ohnishi, R. Sato, Y. Kaneko, H. Kobayashi, K. Tomizawa, T. Ito, N. Honma, H. J. Bühring, et al. 2003. Role of the CD47-SHPS-1 system in regulation of cell migration. EMBO J. 22:2634.
28. Elbashir, S. M., J. Harborth, W. Lendeckel, A. Yalcin, K. Weber, and T. Tuschl. 2001. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411:494.
29. Lindberg, F. P., D. M. Lublin, M. J. Telen, R. A. Veile, Y. E. Miller, H. Donis-Keller, and E. J. Brown. 1994. Rh-related antigen CD47 is the signal-transducer integrin-associated protein. J. Biol. Chem. 269:1567.
30. Lindberg, F. P., D. C. Bullard, T. E. Caver, H. D. Gresham, A. L. Beaudet, and E. J. Brown. 1996. Decreased resistance to bacterial infection and granulocyte defects in IAP-deficient mice. Science 274:795.
31. Tada, K., M. Tanaka, R. Hanayama, K. Miwa, A. Shinohara, A. Iwamatsu, and S. Nagata. 2003. Tethering of apoptotic cells to phagocytes through binding of CD47 to Src homology 2 domain-bearing protein tyrosine phosphatase substrate-1. J. Immunol. 171:5718.
32. Strzelecka, A., K. Kwiatkowska, and A. Sobota. 1997. Tyrosine phosphorylation and Fcγ receptor-mediated phagocytosis. FEBS Lett. 400:11.
33. Ninomiya, N., K. Hazeki, Y. Fukui, T. Seya, T. Okada, O. Hazeki, and M. Ui. 1994. Involvement of phosphatidylinositol 3-kinase in Fcγ receptor signaling. J. Biol. Chem. 269:22732.
34. Araki, N., M. T. Johnson, and J. A. Swanson. 1996. A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophages. J. Cell Biol. 135:1249.
35. Karimi, K., and M. R. Lennartz. 1998. Mitogen-activated protein kinase is activated during IgG-mediated phagocytosis, but is not required for target ingestion. Inflammation 22:67.
36. Mansfield, P. J., J. A. Shayman, and L. A. Boxer. 2000. Regulation of polymorphonuclear leukocyte phagocytosis by myosin light chain kinase after activation of mitogen-activated protein kinase. Blood 95:2407.
37. Hanke, J. H., J. P. Gardner, R. L. Dow, P. S. Changelian, W. H. Brissette, E. J. Weringer, B. A. Pollok, and P. A. Connelly. 1996. Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor: study of Lck- and FynT-dependent T cell activation. J. Biol. Chem. 271:695.
38. Oliver, J. M., D. L. Burg, B. S. Wilson, J. L. McLaughlin, and R. L. McLaughlin. 1994. Inhibition of mast cell FcεRI-mediated signaling and effector function by the Syk-selective inhibitor, piceatannol. J. Biol. Chem. 269:29697.
39. Yano, H., S. Nakanishi, K. Kimura, N. Hanai, Y. Saitoh, Y. Fukui, Y. Nonomura, and Y. Matsuda. 1993. Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells. J. Biol. Chem. 268:25846.
40. Vlahos, C. J., W. F. Matter, K. Y. Hui, and R. F. Brown. 1994. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1- benzopyran-4-one (LY294002). J. Biol. Chem. 269:5241.
41. Dudley, D. T., L. Pang, S. J. Decker, A. J. Bridges, and A. R. Saltiel. 1995. A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc. Natl. Acad. Sci. USA 92:7686.
42. Favata, M. F., K. Y. Horiuchi, E. J. Manos, A. J. Daulerio, D. A. Stradley, W. S. Feeser, D. E. Van Dyk, W. J. Pitts, R. A. Earl, F. Hobbs, et al. 1998. Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J. Biol. Chem. 273:18623.
43. Sato, N., M. K. Kim, and A. D. Schreiber. 1999. Enhancement of Fcγ receptor-mediated phagocytosis by transforming mutants of Cbl. J. Immunol. 163:6123.
44. Shultz, L., D., P. A. Schweitzer, T. V. Rajan, T. Yi, J. N. Ihle, R. J. Matthews, M. L. Thomas, and D. R. Beier. 1993. Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene. Cell 73:1445.
45. Zhang, J., A. K. Somani, and K. A. Siminovitch. 2000. Roles of the SHP-1 tyrosine phosphatase in the negative regulation of cell signalling. Semin. Immunol. 12:361.
46. Timms, J. F., K. Carlberg, H. Gu, H. Chen, S. Kamatkar, M. J. Nadler, L. R. Rohrschneider, and B. G. Neel. 1998. Identification of major binding proteins and substrates for the SH2-containing protein tyrosine phosphatase SHP-1 in macrophages. Mol. Cell. Biol. 18:3838.
47. Timms, J. F., K. D. Swanson, A. Marie-Cardine, M. Raab, C. E. Rudd, B. Schraven, and B. G. Neel. 1999. SHPS-1 is a scaffold for assembling distinct adhesion-regulated multi-protein complexes in macrophages. Curr. Biol. 9:927.
48. Oshima, K., A. R. Ruhul Amin, A. Suzuki, M. Hamaguchi, and S. Matsuda. 2002. SHPS-1, a multifunctional transmembrane glycoprotein. FEBS Lett. 519:1.
49. Tsuda, M., T. Matozaki, K. Fukunaga, Y. Fujioka, A. Imamoto, T. Noguchi, T. Takada, T. Yamao, H. Takeda, F. Ochi, et al. 1998. Integrin-mediated tyrosine phosphorylation of SHPS-1 and its association with SHP-2: roles of Fak and Src family kinases. J. Biol. Chem. 273:13223.
50. Gresham, H. D., B. M. Dale, J. W. Potter, P. W. Chang, C. M. Vines, C. A. Lowell, C. F. Lagenaur, and C. L. Willman. 2000. Negative regulation of phagocytosis in murine macrophages by the Src kinase family member, Fgr. J. Exp. Med. 192:515.
51. Cox, D., P. Chang, Q. Zhang, P. G. Reddy, G. M. Bokoch, and S. Greenberg. 1997. Requirements for both Rac1 and Cdc42 in membrane ruffling and phagocytosis in leukocytes. J. Exp. Med. 186:1487.
52. Suzuki, T., H. Kono, N. Hirose, M. Okada, T. Yamamoto, K. Yamamoto, and Z. Honda. 2000. Differential involvement of Src family kinases in Fcγ receptor-mediated phagocytosis. J. Immunol. 165:473.
53. Bonilla, F. A., R. M. Fujita, V. I. Pivniouk, A. C. Chan, and R. S. Geha. 2000. Adapter proteins SLP-76 and BLNK both are expressed by murine macrophages and are linked to signaling via Fcγ receptors I and II/III. Proc. Natl. Acad. Sci. USA 97:1725.
54. Gu, H., R. J. Botelho, M. Yu, S. Grinstein, and B. G. Neel. 2003. Critical role for scaffolding adapter Gab2 in FcγR-mediated phagocytosis. J. Cell Biol. 161:1151.
55. Momose, H., H. Kurosu, N. Tsujimoto, K. Kontani, K. Tsujita, H. Nishina, and T. Katada. 2003. Dual phosphorylation of phosphoinositide 3-kinase adaptor Grb2-associated binder 2 is responsible for superoxide formation synergistically stimulated by Fcγ and formyl-methionyl-leucyl-phenylalanine receptors in differentiated THP-1 cells. J. Immunol. 171:4227.