Signaling pathways regulating protein synthesis during ageing

Experimental Gerontology

Volumn 41, Issue 10, 2006, Pages 1020-1025

  Syntichaki, Popi ^a   Tavernarakis, Nektarios ^a  

^a INSTITUTE OF MOLECULAR BIOLOGY AND BIOTECHNOLOGY   (Greece)

Author keywords

Caenorhabditis elegans; Drosophila melanogaster; IGF 1; Insulin; mRNA; P bodies; TOR kinase; Translation factor; Yeast

Indexed keywords

INSULIN; MESSENGER RNA; PROTEIN; SOMATOMEDIN C; TARGET OF RAPAMYCIN KINASE;

AGING; ARTICLE; AUTOPHAGY; CAENORHABDITIS ELEGANS; CALORIC RESTRICTION; CELL GROWTH; CELL PROLIFERATION; CULTURE MEDIUM; DROSOPHILA; DROSOPHILA MELANOGASTER; HYPOXIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RIBOSOME; RNA TRANSLATION; SACCHAROMYCES CEREVISIAE; SENESCENCE; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AGING; ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CYTOPLASM; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; HUMANS; INSULIN; INSULIN-LIKE GROWTH FACTOR I; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN BIOSYNTHESIS; PROTEIN KINASES; RNA, MESSENGER; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION;

CAENORHABDITIS ELEGANS; DROSOPHILA MELANOGASTER;

EID: 33751430965     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exger.2006.05.014     Document Type: Article

References (59)

1. Bluher M., Kahn B.B., and Kahn C.R. Extended longevity in mice lacking the insulin receptor in adipose tissue. Science 299 (2003) 572-574
2. Boehm M., and Slack F. A developmental timing microRNA and its target regulate life span in C. elegans. Science 310 (2005) 1954-1957
3. Brengues M., Teixeira D., and Parker R. Movement of eukaryotic mRNAs between polysomes and cytoplasmic processing bodies. Science 310 (2005) 486-489
4. Clancy D.J., Gems D., Harshman L.G., Oldham S., Stocker H., Hafen E., Leevers S.J., and Partridge L. Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science 292 (2001) 104-106
5. Coller J., and Parker R. General translational repression by activators of mRNA decapping. Cell 122 (2005) 875-886
6. Cypser J.R., and Johnson T.E. Multiple stressors in Caenorhabditis elegans induce stress hormesis and extended longevity. J. Gerontol. A Biol. Sci. Med. Sci. 57 (2002) B109-B114
7. Ding L., Spencer A., Morita K., and Han M. The developmental timing regulator AIN-1 interacts with miRISCs and may target the argonaute protein ALG-1 to cytoplasmic P bodies in C. elegans. Mol. Cell 19 (2005) 437-447
8. Fabian T.J., and Johnson T.E. Total RNA, rRNA and poly(A)+RNA abundances during aging in Caenorhabditis elegans. Mech. Ageing Dev. 83 (1995) 155-170
9. Fabrizio P., Pozza F., Pletcher S.D., Gendron C.M., and Longo V.D. Regulation of longevity and stress resistance by Sch9 in yeast. Science 292 (2001) 288-290
10. Ferraiuolo M.A., Basak S., Dostie J., Murray E.L., Schoenberg D.R., and Sonenberg N. A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay. J. Cell Biol. 170 (2005) 913-924
11. Flurkey K., Papaconstantinou J., Miller R.A., and Harrison D.E. Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production. Proc. Natl. Acad. Sci. USA 98 (2001) 6736-6741
12. Friedman D.B., and Johnson T.E. A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility. Genetics 118 (1988) 75-86
13. Gebauer F., and Hentze M.W. Molecular mechanisms of translational control. Nat. Rev. Mol. Cell Biol. 5 (2004) 827-835
14. Gems D., and Partridge L. Insulin/IGF signalling and ageing: seeing the bigger picture. Curr. Opin. Genet. Dev. 11 (2001) 287-292
15. Giannakou M.E., Goss M., Junger M.A., Hafen E., Leevers S.J., and Partridge L. Long-lived Drosophila with overexpressed dFOXO in adult fat body. Science 305 (2004) 361
16. Gingras A.C., Raught B., and Sonenberg N. eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Annu. Rev. Biochem. 68 (1999) 913-963
17. Gingras A.C., Raught B., and Sonenberg N. mTOR signaling to translation. Curr. Top. Microbiol. Immunol. 279 (2004) 169-197
18. Hamilton B., Dong Y., Shindo M., Liu W., Odell I., Ruvkun G., and Lee S.S. A systematic RNAi screen for longevity genes in C. elegans. Genes Dev. 19 (2005) 1544-1555
19. Hay N., and Sonenberg N. Upstream and downstream of mTOR. Genes Dev. 18 (2004) 1926-1945
20. Holcik M., and Sonenberg N. Translational control in stress and apoptosis. Nat. Rev. Mol. Cell Biol. 6 (2005) 318-327
21. Holzenberger M., Dupont J., Ducos B., Leneuve P., Geloen A., Even P.C., Cervera P., and Le Bouc Y. IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature 421 (2003) 182-187
22. Holz M.K., Ballif B.A., Gygi S.P., and Blenis J. mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. Cell 123 (2005) 569-580
23. Hsieh C.C., and Papaconstantinou J. Akt/PKB and p38 MAPK signaling, translational initiation and longevity in Snell dwarf mouse livers. Mech. Ageing Dev. 125 (2004) 785-798
24. Hwangbo D.S., Gershman B., Tu M.P., Palmer M., and Tatar M. Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. Nature 429 (2004) 562-566
25. Jia K., Chen D., and Riddle D.L. The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span. Development 131 (2004) 3897-3906
26. Johnson T.E., and McCaffrey G. Programmed aging or error catastrophe? An examination by two-dimensional polyacrylamide gel electrophoresis. Mech. Ageing Dev. 30 (1985) 285-297
27. Kaeberlein M., Powers III R.W., Steffen K.K., Westman E.A., Hu D., Dang N., Kerr E.O., Kirkland K.T., Fields S., and Kennedy B.K. Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science 310 (2005) 1193-1196
28. Kapahi P., Zid B.M., Harper T., Koslover D., Sapin V., and Benzer S. Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr. Biol. 14 (2004) 885-890
29. Kenyon C., Chang J., Gensch E., Rudner A., and Tabtiang R. A C. elegans mutant that lives twice as long as wild type. Nature 366 (1993) 461-464
30. Kimura K.D., Tissenbaum H.A., Liu Y., and Ruvkun G. daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 277 (1997) 942-946
31. Long X., Spycher C., Han Z.S., Rose A.M., Muller F., and Avruch J. TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation. Curr. Biol. 12 (2002) 1448-1461
32. Lum J.J., DeBerardinis R.J., and Thompson C.B. Autophagy in metazoans: cell survival in the land of plenty. Nat. Rev. Mol. Cell Biol. 6 (2005) 439-448
33. Lund J., Tedesco P., Duke K., Wang J., Kim S.K., and Johnson T.E. Transcriptional profile of aging in C. elegans. Curr. Biol. 12 (2002) 1566-1573
34. Makrides S.C., and Goldthwaite J. The content and size distribution of membrane-bound and free polyribosomes in mouse liver during aging. Mech. Ageing Dev. 27 (1984) 111-134
35. Martin D.E., and Hall M.N. The expanding TOR signaling network. Curr. Opin. Cell Biol. 17 (2005) 158-166
36. Meissner B., Boll M., Daniel H., and Baumeister R. Deletion of the intestinal peptide transporter affects insulin and TOR signaling in Caenorhabditis elegans. J. Biol. Chem. 279 (2004) 36739-36745
37. Melendez A., Talloczy Z., Seaman M., Eskelinen E.L., Hall D.H., and Levine B. Autophagy genes are essential for dauer development and life-span extension in C. elegans. Science 301 (2003) 1387-1391
38. Miron M., Lasko P., and Sonenberg N. Signaling from Akt to FRAP/TOR targets both 4E-BP and S6K in Drosophila melanogaster. Mol. Cell. Biol. 23 (2003) 9117-9126
39. Orgel L.E. Ageing of clones of mammalian cells. Nature 243 (1973) 441-445
40. Park S.K., and Prolla T.A. Lessons learned from gene expression profile studies of aging and caloric restriction. Ageing Res. Rev. 4 (2005) 55-65
41. Powers III R.W., Kaeberlein M., Caldwell S.D., Kennedy B.K., and Fields S. Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes Dev. 20 (2006) 174-184
42. Proud C.G. mTOR-mediated regulation of translation factors by amino acids. Biochem. Biophys. Res. Commun. 313 (2004) 429-436
43. Rattan S.I. Synthesis, modifications, and turnover of proteins during aging. Exp. Gerontol. 31 (1996) 33-47
44. Rattan S.I. Aging, anti-aging, and hormesis. Mech. Ageing Dev. 125 (2004) 285-289
45. Reiling J.H., Doepfner K.T., Hafen E., and Stocker H. Diet-dependent effects of the Drosophila Mnk1/Mnk2 homolog Lk6 on growth via eIF4E. Curr. Biol. 15 (2005) 24-30
46. Richter J.D., and Sonenberg N. Regulation of cap-dependent translation by eIF4E inhibitory proteins. Nature 433 (2005) 477-480
47. Scott R.C., Schuldiner O., and Neufeld T.P. Role and regulation of starvation-induced autophagy in the Drosophila fat body. Dev. Cell 7 (2004) 167-178
48. Sharp Z.D., and Bartke A. Evidence for down-regulation of phosphoinositide 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR)-dependent translation regulatory signaling pathways in Ames dwarf mice. J. Gerontol. A Biol. Sci. Med. Sci. 60 (2005) 293-300
49. Sheth U., and Parker R. Decapping and decay of messenger RNA occur in cytoplasmic processing bodies. Science 300 (2003) 805-808
50. Tatar M., Kopelman A., Epstein D., Tu M.P., Yin C.M., and Garofalo R.S. A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. Science 292 (2001) 107-110
51. Tatar M., Bartke A., and Antebi A. The endocrine regulation of aging by insulin-like signals. Science 299 (2003) 1346-1351
52. Tavernarakis N., and Driscoll M. Caloric restriction and lifespan: a role for protein turnover?. Mech. Ageing Dev. 123 (2002) 215-229
53. Teleman A.A., Chen Y.W., and Cohen S.M. 4E-BP functions as a metabolic brake used under stress conditions but not during normal growth. Genes Dev. 19 (2005) 1844-1848
54. Tettweiler G., Miron M., Jenkins M., Sonenberg N., and Lasko P.F. Starvation and oxidative stress resistance in Drosophila are mediated through the eIF4E-binding protein, d4E-BP. Genes Dev. 19 (2005) 1840-1843
55. Vellai T., Takacs-Vellai K., Zhang Y., Kovacs A.L., Orosz L., and Muller F. Genetics: influence of TOR kinase on lifespan in C. elegans. Nature 426 (2003) 620
56. Wang X., Flynn A., Waskiewicz A.J., Webb B.L., Vries R.G., Baines I.A., Cooper J.A., and Proud C.G. The phosphorylation of eukaryotic initiation factor eIF4E in response to phorbol esters, cell stresses, and cytokines is mediated by distinct MAP kinase pathways. J. Biol. Chem. 273 (1998) 9373-9377
57. Webster G.C., and Webster S.L. Decline in synthesis of elongation factor one (EF-1) precedes the decreased synthesis of total protein in aging Drosophila melanogaster. Mech. Ageing Dev. 22 (1983) 121-128
58. Wullschleger S., Loewith R., and Hall M.N. TOR signaling in growth and metabolism. Cell 124 (2006) 471-484
59. Yang J., Anzo M., and Cohen P. Control of aging and longevity by IGF-I signaling. Exp. Gerontol. 40 (2005) 867-872