Enzyme induction in cryopreserved human hepatocyte cultures

Toxicology

Volumn 220, Issue 2-3, 2006, Pages 117-125

  Kafert Kasting, Sabine ^a   Alexandrova, Krassimira ^a   Barthold, Marc ^a   Laube, Britta ^a   Friedrich, Gerhard ^b   Arseniev, Lubomir ^a,c   Hengstler, Jan G ^d  

^a Cytonet Hannover GmbH   (Germany)

^b Institute of Contract Research   (Germany)

^c HANNOVER MEDICAL SCHOOL   (Germany)

^d Rudolf Boehm Institute of Pharmacology and Toxicology   (Germany)

Author keywords

Cryopreservation; Enzyme indication; Hepatocytes; Rifampicin

Indexed keywords

COLLAGEN GEL; CYTOCHROME P450; CYTOCHROME P450 3A4; RIFAMPICIN; TESTOSTERONE;

ADULT; AGED; ARTICLE; CELL ADHESION; CONTROLLED STUDY; CRYOPRESERVATION; CULTURE TECHNIQUE; ENZYME INDUCTION; FEMALE; HUMAN; HUMAN CELL; HYDROXYLATION; LIVER CELL CULTURE; MALE; PRESERVATION; PRIORITY JOURNAL;

AGED; CELL CULTURE TECHNIQUES; CELL SURVIVAL; CELLS, CULTURED; COLLAGEN; CRYOPRESERVATION; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INDUCTION; FEMALE; HEPATOCYTES; HUMANS; HYDROXYLATION; MALE; MIDDLE AGED; RIFAMPIN; TESTOSTERONE;

EID: 33244486573     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2005.12.013     Document Type: Article

References (28)

1. M. Arand, M.E. Herrero Plana, J.G. Hengstler, M. Lohmann, A. Cronin, and F. Oesch Detoxification strategy of epoxide hydrolase the basis for a threshold in chemical carcinogenesis EXCLI J. 22 2003 22 30
2. W. Beerheide, M.A. von Mach, M. Ringel, C. Fleckenstein, S. Schumann, N. Renzing, A. Hildebrandt, W. Brenner, O. Jensen, S. Gebhard, K. Reifenberg, J. Bender, F. Oesch, and J.G. Hengstler Downregulation of beta2-microglobulin in human cord blood somatic stem cells after transplantation into livers of SCID-mice: an escape mechanism of stem cells? Biochem. Biophys. Res. Commun. 294 2002 1052 1063
3. G.D. Block, J. Locker, W.C. Bowen, B.E. Petersen, S. Katyal, S.C. Strom, T. Riley, T.A. Howard, and G.K. Michalopoulos Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF, EGF and TGF alpha in a chemically defined (HGM) medium J. Cell Biol. 132 6 1996 1133 1149
4. H. Carmo, J.G. Hengstler, D. Boer, M. Ringel, F. Remiao, F. Carvalho, E. Fernandes, L.A. Reys, F. Oesch, and L. Bastos Mde Metabolic pathways of 4-bromo-2,5-dimethoxyphenethylamine (2C-B): analysis of phase I metabolism with hepatocytes of six species including human Toxicology 206 2005 75 89
5. H. Carmo, J.G. Hengstler, D. de Boer, M. Ringel, F. Carvalho, E. Fernandes, F. Remiao, L.A. dos Reys, F. Oesch, and M. de Lourdes Bastos Comparative metabolism of the designer drug 4-methylthioamphetamine by hepatocytes from man, monkey, dog, rabbit, rat and mouse Naunyn. Schmiedebergs. Arch. Pharmacol. 369 2004 198 205
6. J.C.Y. Dunn, M.L. Yarmush, H.G. Koebe, and R.G. Tompkins Hepatocyte function and extracellular matrix geometry: long-term culture in a sandwich configuration FASEB J. 3 1989 174 177
7. G. Friedrich, T. Rose, and K. Rissler Determination of testosterone metabolites in human hepatocytes I. Development of an on-line sample preparation liquid chromatography technique and mass spectroscopic detection of 6beta-hydroxysterone J. Chromotogr. B 784 2002 49 61
8. M. Garcia, J. Rager, Q. Wang, R. Strab, I.J. Hidalgo, A. Owen, and J. Li Cryopreserved human hepatocytes as alternative in vitro model for cytochrome p450 induction studies In Vitro Cell Dev. Biol. Anim. 39 7 2003 283 287
9. R. Gebhardt, J.G. Hengstler, D. Müller, R. Glöckner, P. Buenning, B. Laube, E. Schmelzer, Martina Ullrich, D. Utesch, N. Hewitt, M. Ringel, B. Reder Hilz, A. Bader, A. Langsch, T. Koose, H.J. Burger, J. Maas, and F. Oesch New hepatocyte in vitro systems for drug metabolism: metabolic capacity and recommendations for application in basic research and drug development, standard operation procedures Drug Metab. Rev. 35 2003 145 213
10. J.G. Hengstler, M. Brulport, W. Schormann, A. Bauer, M. Hermes, A.K. Nussler, F. Fandrich, M. Ruhnke, H. Ungefroren, L. Griffin, E. Bockamp, F. Oesch, and M.-A. von Mach Generation of human hepatocytes by stem cell technology: definition of the hepatocyte Expert Opin. Drug Metab. Toxicol. 1 2005 61 74
11. J.G. Hengstler, D. Utesch, P. Steinberg, M. Ringel, N. Swales, K. Biefang, K.L. Platt, B. Diener, T. Böttger, T. Fischer, and F. Oesch Cryopreserved primary hepatocytes as an in vitro model for the evaluation of drug metabolism and enzyme induction Drug Metab. Rev. 32 2000 81 118
12. J.G. Hengstler, U. Bolm-Audorff, A. Faldum, K. Janssen, M. Reifenrath, W. Gotte, D. Jung, O. Mayer-Popken, J. Fuchs, S. Gebhard, H.G. Bienfait, K. Schlink, C. Dietrich, D. Faust, B. Epe, and F. Oesch Occupational exposure to heavy metals: DNA damage induction and DNA repair inhibition prove co-exposures to cadmium, cobalt and lead as more dangerous than hitherto expected Carcinogenesis 24 2003 63 73
13. N.J. Hewitt, K.U. Buhring, J. Dasenbrock, J. Haunschild, B. Ladstetter, and D. Utesch Studies comparing in vivo:in vitro metabolism of three pharmaceutical compounds in rat, dog, monkey, and human using cryopreserved hepatocytes, microsomes, and collagen gel immobilized hepatocyte cultures Drug Metab. Dispos. 29 7 2001 1042 1050
14. N.J. Hewitt, S. Lloyd, M. Hayden, R. Butler, Y. Sakai, R. Springer, A. Fackett, and A.P. Li Correlation between troglitazone cytotoxicity and drug metabolic enzyme activities in cryopreserved human hepatocytes Chem. Biol. Interact 142 1/2 2002 73 82
15. H.G. Koebe, C. Dahnhardt, J. Muller-Hocker, H. Wagner, and F.W. Schildberg Cryopreservation of porcine hepatocyte cultures Cryobiology 33 1 1996 127 141
16. H.G. Koebe, B. Muhling, C.J. Deglmann, and F.W. Schildberg Cryopreserved porcine hepatocyte cultures Chem. Biol. Interact 121 1 1999 99 115
17. M. Osterod, S. Hollenbach, J.G. Hengstler, D.E. Barnes, T. Lindahl, and B. Epe Age-related and tissue-specific accumulation of oxidative DNA base damage in 7,8-dihydro-8-oxoguanine-DNA glycosylase (ogg1) deficient mice Carcinogenesis 22 2001 1459 1463
18. M. Osterod, E. Larsen, F. Le Page, J.G. Hengstler, G.T. Van Der Horst, S. Boiteux, A. Klungland, and B. Epe A global DNA repair mechanism involving the Cockayne syndrome B (CSB) gene product can prevent the in vivo accumulation of endogenous oxidative DNA base damage Oncogene 28 2002 8232 8239
19. B. Reder-Hilz, M. Ullrich, M. Ringel, N. Hewitt, D. Utesch, F. Oesch, and J.G. Hengstler Metabolism of propafenone and verapamil by cryopreserved human, rat mouse and dog hepatocytes: comparison with metabolism in vivo Naunyn Schmiedebergs Arch. Pharmacol. 369 2004 408 417
20. M. Ringel, F. Oesch, A. Bader, M. Gerl, M. Klebach, M. Quint, B. Tanner, W. Dillenburg, T. Böttger, and J.G. Hengstler Permissive and suppressive effects of dexamethasone on enzyme induction in hepatocyte cultures Xenobiotica 32 2002 653 666
21. D. Roymans, P. Annaert, J. Van Houdt, A. Weygers, J. Noukens, C. Sensenhauser, J. Silva, C. Van Looveren, J. Hendrickx, G. Mannens, and W. Meuldermans Expression and induction potential of cytochromes P450 in human cryopreserved hepatocytes Drug Metab. Dispos. 33 7 2005 1004 1016 (Epub 2005 Mar 31)
22. D. Roymans, C. Van Looveren, A. Leone, J.B. Parker, M. McMillian, M.D. Johnson, A. Koganti, R. Gilissen, P. Silber, G. Mannens, and W. Meuldermans Determination of cytochrome P450 1A2 and cytochrome P450 3A4 induction in cryopreserved human hepatocytes Biochem. Pharmacol. 67 3 2004 427 437
23. M. Ruhnke, A.K. Nussler, H. Ungefroren, J.G. Hengstler, B. Kremer, W. Hoeckh, T. Gottwald, P. Heeckt, and F. Fandrich Human monocyte-derived neohepatocytes: a promising alternative to primary human hepatocytes for autologous cell therapy Transplantation 79 2005 1097 1103
24. M. Ruhnke, H. Ungefroren, A. Nussler, F. Martin, M. Brulport, W. Schormann, J.G. Hengstler, W. Klapper, K. Ulrichs, J.A. Hutchinson, B. Soria, R.M. Parwaresch, P. Heeckt, B. Kremer, and F. Fändrich Reprogramming of human peripheral blood monocytes into functional hepatocyte and pancreatic islet-like cells Gastroenterology 128 2005 1774 1786
25. P.O. Seglen Isolation of hepatocytes by collagenase perfusion Meth. Tox. 1A 1993 231 243
26. J.M. Silva, S.H. Day, and D.A. Nicoll-Griffith Induction of cytochrome-P450 in cryopreserved rat and human hepatocytes Chem. Biol. Interact 121 1 1999 49 63
27. M.A. von Mach, J.G. Hengstler, M. Brulport, M. Eberhardt, W. Schormann, M. Hermes, D. Prawitt, B. Zabel, J. Grosche, A. Reichenbach, B. Muller, L.S. Weilemann, and H. Zulewski In vitro cultured islet-derived progenitor cells of human origin express human albumin in severe combined immunodeficiency mouse liver in vivo Stem Cells 22 2004 1134 1141
28. P. Zhao, K.L. Kunze, and C.A. Lee Evaluation of time-dependent inactivation of CYP3A in cryopreserved human hepatocytes Drug Metab. Dispos. 33 6 2005 853 861 (Epub 2005 Mar 2)