Stress-induced corneal epithelial apoptosis mediated by K+ channel activation

Progress in Retinal and Eye Research

Volumn 25, Issue 6, 2006, Pages 515-538

  Lu, Luo ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; CYTOSKELETON PROTEIN; EPIDERMAL GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE P38; POTASSIUM CHANNEL; POTASSIUM CHANNEL KV3.4; POTASSIUM ION; PROTEIN P53; SCAFFOLD PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

APOPTOSIS; CELL CYCLE ARREST; CELL DAMAGE; CELL DIFFERENTIATION; CELL MEMBRANE; CELL PROLIFERATION; CELL SIZE; CELL VIABILITY; CORNEA EPITHELIUM; CYTOSKELETON; DNA DAMAGE; ENZYME ACTIVATION; EPITHELIUM CELL; HUMAN; NONHUMAN; POTASSIUM CELL LEVEL; POTASSIUM TRANSPORT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION; THEORETICAL MODEL; ULTRAVIOLET IRRADIATION;

ANIMALS; APOPTOSIS; EPITHELIUM, CORNEAL; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; POTASSIUM CHANNELS; TUMOR NECROSIS FACTOR-ALPHA; TUMOR SUPPRESSOR PROTEIN P53; ULTRAVIOLET RAYS;

EID: 33751065125     PISSN: 13509462     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.preteyeres.2006.07.004     Document Type: Review

References (214)

1. Abbott G.W., Butler M.H., Bendahhou S., Dalakas M.C., Ptacek L.J., and Goldstein S.A. MiRP2 forms potassium channels in skeletal muscle with Kv3.4 and is associated with periodic paralysis. Cell 104 (2001) 217-231
2. Abrahams P.J., Schouten R., van Laar T., Houweling A., Terleth C., and van der Eb A.J. Different regulation of p53 stability in UV-irradiated normal and DNA repair deficient human cells. Mutat. Res. 336 (1995) 169-180
3. Adler V., Schaffer A., Kim J., Dolan L., and Ronai Z. UV irradiation and heat shock mediate JNK activation via alternate pathways. J. Biol. Chem. 270 (1995) 26071-26077
4. Adler V., Polotskaya A., Kim J., Dolan L., Davis R., Pincus M., and Ronai Z. Dose rate and mode of exposure are key factors in JNK activation by UV irradiation. Carcinogenesis 17 (1996) 2073-2076
5. Almeida E.A., Ilic D., Han Q., Hauck C.R., Jin F., Kawakatsu H., Schlaepfer D.D., and Damsky C.H. Matrix survival signaling: from fibronectin via focal adhesion kinase to c-Jun NH(2)-terminal kinase. J. Cell Biol. 149 (2000) 741-754
6. + channels. J. Immunol. 144 (1990) 2038-2045
7. Amigorena S., Choquet D., Teillaud J.L., Korn H., and Fridman W.H. Ion channels and B cell mitogenesis. Molec. Immunol. 27 (1990) 1259-1268
8. Ashcroft M., and Vousden K.H. Regulation of p53 stability. Oncogene 18 (1999) 7637-7643
9. Asher G., Lotem J., Cohen B., Sachs L., and Shaul Y. Regulation of p53 stability and p53-dependent apoptosis by NADH quinone oxidoreductase 1. Proc. Natl. Acad. Sci. USA 98 (2001) 1188-1193
10. Ashkenazi A., and Dixit V.M. Death receptors: signaling and modulation. Science 281 (1998) 1305-1308
11. Auer K.L., Contessa J., Brenz-Verca S., Pirola L., Rusconi S., Cooper G., Abo A., Wymann M.P., Davis R.J., Birrer M., and Dent P. The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytes. Mol. Biol. Cell 9 (1998) 561-573
12. Barbiero G., Duranti F., Bonelli G., Amenta J.S., and Baccino F.M. Intracellular ionic variations in the apoptotic death of L cells by inhibitors of cell cycle progression. Exp. Cell Res. 217 (1995) 410-418
13. Beauvais F., Burtin C., and Benveniste J. Voltage-dependent ion channels on human basophils: do they exist?. Immunol. Lett. 46 (1995) 81-83
14. + channels. J. Leukoc. Biol. 57 (1995) 851-855
15. Bender K., Blattner C., Knebel A., Iordanov M., Herrlich P., and Rahmsdorf H.J. UV-induced signal transduction. [Review] [187 refs]. J. Photochem. Photobiol. B Biol. 37 (1997) 1-17
16. + in HeLa cells. FEBS Lett. 424 (1998) 221-224
17. Bitko V., Garmon N.E., Cao T., Estrada B., Oakes J.E., Lausch R.N., and Barik S. Activation of cytokines and NF-kappa B in corneal epithelial cells infected by respiratory syncytial virus: potential relevance in ocular inflammation and respiratory infection. BMC Microbiol. 4 (2004) 28
18. Blaise R., Masdehors P., Lauge A., Stoppa-Lyonnet D., Alapetite C., Merle-Beral H., Binet J.L., Omura S., Magdelenat H., Sabatier L., and Delic J. Chromosomal DNA and p53 stability, ubiquitin system and apoptosis in B-CLL lymphocytes. Leuk. Lymphoma 42 (2001) 1173-1180
19. Bockman C., Griffith M., and Watsky M. Properties of whole-cell ionic currents in cultured human corneal epithelial cells. Invest. Ophthalmol. Vis. Sci. 39 (1998) 1143-1151
20. Bodero A.J., Ye R., and Lees-Miller S.P. UV-light induces p38 MAPK-dependent phosphorylation of Bcl10. Biochem. Biophys. Res. Commun. 301 (2003) 923-926
21. + efflux in the activation of apoptosis. J. Biol. Chem. 272 (1997) 32436-32442
22. Bright J., Khar J., and Khar A. Apoptosis: programmed cell death in health and disease. [Review] [104 Refs]. Biosci. Rep. 14 (1994) 67-81
23. Cejkova J., and Lojda Z. The damaging effect of UV rays (with the wavelength shorter than 320 nm) on the rabbit anterior eye segment. I. Early changes and their prevention by catalase-aprotinin application. Acta Histochem. 96 (1994) 281-286
24. Cejkova J., Stipek S., Crkovska J., Ardan T., Platenik J., Cejka C., and Midelfart A. UV Rays, the prooxidant/antioxidant imbalance in the cornea and oxidative eye damage. Physiol. Res. 53 (2004) 1-10
25. Chernova O.B., Chernov M.V., Agarwal M.L., Taylor W.R., and Stark G.R. The role of p53 in regulating genomic stability when DNA and RNA synthesis are inhibited. Tr. Biochem. Sci. 20 (1995) 431-434
26. Colman M.S., Afshari C.A., and Barrett J.C. Regulation of p53 stability and activity in response to genotoxic stress. Mutat. Res. 462 (2000) 179-188
27. Cook E.B., Stahl J.L., Lowe L., Chen R., Morgan E., Wilson J., Varro R., Chan A., Graziano F.M., and Barney N.P. Simultaneous measurement of six cytokines in a single sample of human tears using microparticle-based flow cytometry: allergics vs. non-allergics. J. Immunol. Methods 254 (2001) 109-118
28. Costanzo V., Shechter D., Lupardus P.J., Cimprich K.A., Gottesman M., and Gautier J. An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication. Mol. Cell 11 (2003) 203-213
29. Cross J.V., and Templeton D.J. Oxidative stress inhibits MEKK1 by site-specific glutathionylation in the ATP-binding domain. Biochem. J. 381 (2004) 675-683
30. Dallaporta B., Hirsch T., Susin S.A., Zamzami N., Larochette N., Brenner C., Marzo I., and Kroemer G. Potassium leakage during the apoptotic degradation phase. J. Immunol. 160 (1998) 5605-5615
31. + channel in mouse early embryos. Nature 365 (1993) 560-562
32. + channels in human T lymphocytes: a role in mitogenesis?. Nature 307 (1984) 465-468
33. Decoursey T.E., Chandy K.G., Gupta S., and Cahalan M.D. Mitogen induction of ion channels in murine T lymphocytes. J. Gen. Physiol. 89 (1987) 405-420
34. Derijard B., Hibi M., Wu I.H., Barrett T., Su B., Deng T., Karin M., and Davis R.J. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76 (1994) 1025-1037
35. Deterre P., Paupardin-Tritsch D., Bockaert J., and Gerschenfeld H.M. Role of cyclic AMP in a serotonin-evoked slow inward current in snail neurones. Nature 290 (1981) 783-785
36. + channels and mitogenesis. Prog. Clin. Biol. Res. 334 (1990) 251-271
37. + channels in T lymphocytes: functional consequences for volume regulation. Proc. Natl. Acad. Sci. USA 90 (1993) 10036-10040
38. Deutsch C., Slater L., and Goldstein P. Volume regulation of human peripheral blood lymphocytes and stimulated proliferation of volume-adapted cells. Biochim. Biophys. Acta 721 (1982) 262-267
39. Devary Y., Gottlieb R.A., Lau L.F., and Karin M. Rapid and preferential activation of the c-jun gene during the mammalian UV response. Molec. Cell. Biol. 11 (1991) 2804-2811
40. Dikstein S., and Maurice D.M. The metabolic basis to the fluid pump in the cornea. J. Physiol. (Lond.) 221 (1972) 29-41
41. Diochot S., Schweitz H., Beress L., and Lazdunski M. Sea anemone peptides with a specific blocking activity against the fast inactivating potassium channel Kv3.4. J. Biol. Chem. 273 (1998) 6744-6749
42. Dodson G.E., Shi Y., and Tibbetts R.S. DNA replication defects, spontaneous DNA damage, and ATM-dependent checkpoint activation in replication protein A-deficient cells. J. Biol. Chem. 279 (2004) 34010-34014
43. Dolfi F., Garcia-Guzman M., Ojaniemi M., Nakamura H., Matsuda M., and Vuori K. The adaptor protein Crk connects multiple cellular stimuli to the JNK signaling pathway. Proc. Natl. Acad. Sci. USA 95 (1998) 15394-15399
44. Dubois J.M., and Rouzaire-Dubois B. Role of potassium channels in mitogenesis. [Review] [149 Refs]. Prog. Biophys. Molec. Biol. 59 (1993) 1-21
45. + channels: generating excitement in pancreatic beta-cells. [Review]. Diabetes 45 (1996) 845-853
46. + channels to reactive oxygen species. Proc. Natl. Acad. Sci. USA 92 (1995) 11796-11800
47. Eldadah B.A., Yakovlev A.G., and Faden A.I. The role of CED-3-related cysteine proteases in apoptosis of cerebellar granule cells. J. Neurosci. 17 (1997) 6105-6113
48. Farrugia G., and Rae J. Regulation of a potassium-selective current in rabbit corneal epithelium by cyclic GMP, carbachol and diltiazem. J. Membr. Biol. 129 (1992) 99-107
49. Farrugia G., and Rae J. Effect of volume changes on a potassium current in rabbit corneal epithelial cells. Am. J. Physiol. 264 (1993) C1238-C1245
50. + channel profile of microglia at immunologically defined functional states. Neuroscience 64 (1995) 183-191
51. Freedman B.D., Price M.A., and Deutsch C.J. Evidence for voltage modulation of IL-2 production in mitogen-stimulated human peripheral blood lymphocytes. J. Immunol. 149 (1992) 3784-3794
52. Frisch S.M., Vuori K., Kelaita D., and Sicks S. A role for Jun-N-terminal kinase in anoikis; suppression by bcl-2 and crmA. J. Cell Biol. 135 (1996) 1377-1382
53. Fuchs S.Y., Adler V., Buschmann T., Yin Z., Wu X., Jones S.N., and Ronai Z. JNK targets p53 ubiquitination and degradation in nonstressed cells. Genes Dev. 12 (1998) 2658-2663
54. Fuchs S.Y., Adler V., Pincus M.R., and Ronai Z. MEKK1/JNK signaling stabilizes and activates p53. Proc. Natl. Acad. Sci. USA 95 (1998) 10541-10546
55. Gao J., Wu D., Guo T.B., Ruan Q., Li T., Lu Z., Xu M., Dai W., and Lu L. K(+) channel activity and redox status are differentially required for JNK activation by UV and reactive oxygen species. Exp. Cell Res. 297 (2004) 461-471
56. + channels. J. Biol. Chem. 261 (1986) 11520-11523
57. Gentiletti F., Mancini F., D'Angelo M., Sacchi A., Pontecorvi A., Jochemsen A.G., and Moretti F. MDMX stability is regulated by p53-induced caspase cleavage in NIH3T3 mouse fibroblasts. Oncogene 21 (2002) 867-877
58. Ginsberg D., Michael-Michalovitz D., and Oren M. Induction of growth arrest by a temperature-sensitive p53 mutant is correlated with increased nuclear localization and decreased stability of the protein. Mol. Cell Biol. 11 (1991) 582-585
59. Goodarzi A.A., Block W.D., and Lees-Miller S.P. The role of ATM and ATR in DNA damage-induced cell cycle control. Prog. Cell Cycle Res. 5 (2003) 393-411
60. Gopel S.O., Kanno T., Barg S., and Rorsman P. Patch-clamp characterisation of somatostatin-secreting-cells in intact mouse pancreatic islets. J. Physiol. 528 (2000) 497-507
61. Grinstein S., and Foskett J.K. Ionic mechanisms of cell volume regulation in leukocytes. Annu. Rev. Physiol. 52 (1990) 399-414
62. Guo J., Thinakaran G., Guo Y., Sisodia S.S., and Yu F.X. A role for amyloid precursor-like protein 2 in corneal epithelial wound healing. Invest. Ophthalmol. Vis. Sci. 39 (1998) 292-300
63. +-channel-sensitive Akt pathway is primary mediator of ML-1 cell proliferation. Am. J. Physiol. Cell Physiol. 289 (2005) C257-C263
64. Guymer R.H., and Mandel T.E. UV-B irradiation of donor skin and cornea prior to allotransplantation in mice. Transpl. Proc. 21 (1989) 3771-3772
65. Han W., Bao W., Wang Z., and Nattel S. Comparison of ion-channel subunit expression in canine cardiac Purkinje fibers and ventricular muscle. Circ. Res. 91 (2002) 790-797
66. Haupt S., Berger M., Goldberg Z., and Haupt Y. Apoptosis-the p53 network. J. Cell Sci. 116 (2003) 4077-4085
67. Hofseth L.J., Robles A.I., Yang Q., Wang X.W., Hussain S.P., and Harris C. p53: at the crossroads of molecular carcinogenesis and molecular epidemiology. Chest 125 (2004) 83S-85S
68. Holmes T.C., Fadool D.A., Ren R., and Levitan I.B. Association of Src tyrosine kinase with a human potassium channel mediated by SH3 domain. Science 274 (1996) 2089-2091
69. Hoover H.E., Thuerauf D.J., Martindale J.J., and Glembotski C.C. alpha B-crystallin gene induction and phosphorylation by MKK6-activated p38. A potential role for alpha B-crystallin as a target of the p38 branch of the cardiac stress response. J. Biol. Chem. 275 (2000) 23825-23833
70. Houzen H., Kikuchi S., Kanno M., Shinpo K., and Tashiro K. Tumor necrosis factor enhancement of transient outward potassium currents in cultured rat cortical neurons. J. Neurosci. Res. 50 (1997) 990-999
71. + suppresses the activation of apoptosis in lymphocytes. J. Biol. Chem. 272 (1997) 30567-30576
72. Hussain S.P., and Harris C.C. Molecular epidemiology of human cancer: contribution of mutation spectra studies of tumor suppressor genes. Cancer Res. 58 (1998) 4023-4037
73. Hussain S.P., Raja K., Amstad P.A., Sawyer M., Trudel L.J., Wogan G.N., Hofseth L.J., Shields P.G., Billiar T.R., Trautwein C., Hohler T., Galle P.R., Phillips D.H., Markin R., Marrogi A.J., and Harris C.C. Increased p53 mutation load in nontumorous human liver of Wilson disease and hemochromatosis: oxyradical overload diseases. Proc. Natl. Acad. Sci. USA 97 (2000) 12770-12775
74. Irarrazabal C.E., Liu J.C., Burg M.B., and Ferraris J.D. ATM, a DNA damage-inducible kinase, contributes to activation by high NaCl of the transcription factor TonEBP/OREBP. Proc. Natl. Acad. Sci. USA 101 (2004) 8809-8814
75. Ito K., Nakazato T., Miyakawa Y., Yamato K., Ikeda Y., and Kizaki M. Caffeine induces G2/M arrest and apoptosis via a novel p53-dependent pathway in NB4 promyelocytic leukemia cells. J. Cell Physiol. 196 (2003) 276-283
76. Jan L.Y., and Jan Y.N. Voltage-sensitive ion channels. [Review] [149 Refs]. Cell 56 (1989) 13-25
77. Johnson D.G., Kezirian G.M., George S.P., Casebeer J.C., and Ashton J. Removal of corneal epithelium with phototherapeutic technique during multizone, multipass photorefractive keratectomy. J. Refract. Surg. 14 (1998) 38-48
78. Jumblatt M.M. PGE2 synthesis and response pathways in cultured corneal endothelial cells: the effects of in vitro aging. Curr. Eye Res. 16 (1997) 428-435
79. Kaneko Y., Matsumoto G., and Hanyu Y. Pax-6 expression during retinal regeneration in the adult newt. Dev. Growth Differ 41 (1999) 723-729
80. Kanemasa T., Gan L., Perney T.M., Wang L.Y., and Kaczmarek L.K. Electrophysiological and pharmacological characterization of a mammalian Shaw channel expressed in NIH 3T3 fibroblasts. J. Neurophysiol. 74 (1995) 207-217
81. Kang S.S., Li T., Xu D., Reinach P.S., and Lu L. Inhibitory effect of PGE2 on EGF-induced MAP kinase activity and rabbit corneal epithelial proliferation. Invest. Ophthalmol. Vis. Sci. 41 (2000) 2164-2169
82. Kang S.S., Wang L., Kao W.W., Reinach P.S., and Lu L. Control of SV-40 transformed RCE cell proliferation by growth-factor-induced cell cycle progression. Curr. Eye Res. 23 (2001) 397-405
83. Karin M., Liu Z., and Zandi E. AP-1 function and regulation. Curr. Opin. Cell Biol. 9 (1997) 240-246
84. Kastan M.B. ATM-the first step in helping cells deal with DNA damage. Biomed. Pharmacother. 58 (2004) 72-73
85. King G.G., Moore B.J., Seow C.Y., and Pare P.D. Time course of increased airway narrowing caused by inhibition of deep inspiration during methacholine challenge. Am. J. Respir. Crit. Care Med. 160 (1999) 454-457
86. Kinzler K.W., and Vogelstein B. Cancer-susceptibility genes. Gatekeepers and caretakers. Nature 386 (1997) 761-763
87. Kitagawa D., Tanemura S., Ohata S., Shimizu N., Seo J., Nishitai G., Watanabe T., Nakagawa K., Kishimoto H., Wada T., Tezuka T., Yamamoto T., Nishina H., and Katada T. Activation of extracellular signal-regulated kinase by ultraviolet is mediated through Src-dependent epidermal growth factor receptor phosphorylation. Its implication in an anti-apoptotic function. J. Biol. Chem. 277 (2002) 366-371
88. Klyce S. Electrical profiles in the corneal epithelium. J. Phys. 226 (1972) 407-429
89. Klyce S.D. Enhancing fluid secretion by the corneal epithelium. Invest. Ophthalmol. Vis. Sci. 16 (1977) 968-973
90. Klyce S.D., and Wong R.K.S. Site and mode of adrenaline action on chloride transport across the rabbit corneal epithelium. J. Physiol. (Lond.) 266 (1977) 777-799
91. Kolozsvari L., Nogradi A., Hopp B., and Bor Z. UV absorbance of the human cornea in the 240- to 400-nm range. Invest. Ophthalmol. Vis. Sci. 43 (2002) 2165-2168
92. Kong A.N., Yu R., Lei W., Mandlekar S., Tan T.H., and Ucker D.S. Differential activation of MAPK and ICE/Ced-3 protease in chemical-induced apoptosis. The role of oxidative stress in the regulation of mitogen-activated protein kinases (MAPKs) leading to gene expression and survival or activation of caspases leading to apoptosis. Restor. Neurol. Neurosci. 12 (1998) 63-70
93. + conductance of human T cells. Pflugers Arch. 412 (1988) 133-140
94. Kumar A., Zhang J., and Yu F.S. Innate immune response of corneal epithelial cells to Staphylococcus aureus infection: role of peptidoglycan in stimulating proinflammatory cytokine secretion. Invest. Ophthalmol. Vis. Sci. 45 (2004) 3513-3522
95. Kurpakus-Wheater M., Sexton R., McDermott M.L., Mrock L.K., and Sosne G. Caspase-9 activation in hypoxic human corneal epithelial cells. Apoptosis 8 (2003) 681-688
96. Kwan R., Burnside J., Kurosaki T., and Cheng G. MEKK1 is essential for DT40 cell apoptosis in response to microtubule disruption. Mol. Cell Biol. 21 (2001) 7183-7190
97. Lang F., Friedrich F., Paulmichl M., Schobersberger W., Jungwirth A., Ritter M., Steidl M., Weiss H., Woll E., Tschernko E., et al. Ion channels in Madin-Darby canine kidney cells. Ren. Physiol. Biochem. 13 (1990) 82-93
98. Lei W., Yu R., Mandlekar S., and Kong A.N. Induction of apoptosis and activation of interleukin 1beta-converting enzyme/Ced-3 protease (caspase-3) and c-Jun NH2-terminal kinase 1 by benzo(a)pyrene. Cancer Res. 58 (1998) 2102-2106
99. Levine A.J. p53, the cellular gatekeeper for growth and division. Cell 88 (1997) 323-331
100. Lewis R.S., and Cahalan M.D. Ion channels and signal transduction in lymphocytes. Annu. Rev. Physiol. 52 (1990) 415-430
101. Li T., and Lu L. EGF-induced proliferation requires down-regulation of Pax6 in corneal epithelial cells. J. Biol. Chem. (2005)
102. Li T., Dai W., and Lu L. Ultraviolet-induced junD activation and apoptosis in myeloblastic leukemia ML-1 cells. J. Biol. Chem. 277 (2002) 32668-32676
103. Lieber J.G., Webb S., Suratt B.T., Young S.K., Johnson G.L., Keller G.M., and Worthen G.S. The in vitro production and characterization of neutrophils from embryonic stem cells. Blood 103 (2004) 852-859
104. Lin C.S., Boltz R.C., Blake J.T., Nguyen M., Talento A., Fischer P.A., Springer M.S., Sigal N.H., Slaughter R.S., Garcia M.L., et al. Voltage-gated potassium channels regulate calcium-dependent pathways involved in human T lymphocyte activation. J. Exp. Med. 177 (1993) 637-645
105. Lu J., Park J.H., Liu A.Y., and Chen K.Y. Activation of heat shock factor 1 by hyperosmotic or hypo-osmotic stress is drastically attenuated in normal human fibroblasts during senescence. J. Cell Physiol. 184 (2000) 183-190
106. + current during the differentiation of ML-1 human myeloblastic leukemia cells. J. Membr. Biol. 132 (1993) 267-274
107. Lu L., Reinach P., and Kao W. Corneal epithelial wound healing. Exp. Biol. Med. (Maywood) 226 (2001) 653-664
108. Lu L., Reinach P.S., and Kao W.W. Corneal epithelial wound healing. Exp. Biol. Med. (Maywood) 226 (2001) 653-664
109. Lu L., Wang L., and Shell B. UV-induced signaling pathways associated with corneal epithelial cell apoptosis. Invest. Ophthalmol. Vis. Sci. 44 (2003) 5102-5109
110. Lu M.L., Sato M., Cao B., and Richie J.P. UV irradiation-induced apoptosis leads to activation of a 36-kDa myelin basic protein kinase in HL-60 cells. Proc. Natl. Acad. Sci. USA 93 (1996) 8977-8982
111. Ma W.Y., Huang C., and Dong Z. Inhibition of ultraviolet C irradiation-induced AP-1 activity by aspirin is through inhibition of JNKs but not erks or P38 MAP kinase. Int. J. Oncol. 12 (1998) 565-568
112. Malek A.M., Goss G.G., Jiang L., Izumo S., and Alper S.L. Mannitol at clinical concentrations activates multiple signaling pathways and induces apoptosis in endothelial cells. Stroke 29 (1998) 2631-2640
113. Martina M., Yao G.L., and Bean B.P. Properties and functional role of voltage-dependent potassium channels in dendrites of rat cerebellar Purkinje neurons. J. Neurosci. 23 (2003) 5698-5707
114. Matsuoka S., Huang M., and Elledge S.J. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science 282 (1998) 1893-1897
115. Maurice D.M. The location of the fluid pump in the cornea. J. Physiol. (Lond.) 221 (1972) 43-54
116. Mauro T.M., Isseroff R.R., Lasarow R., and Pappone P.A. Ion channels are linked to differentiation in keratinocytes. J. Membr. Biol. 132 (1993) 201-209
117. McCarthy J.V., Fernandes R.S., and Gotter T.G. Increased resistance to apoptosis associated with HL-60 myeloid differentiation status. Anticancer Res. 14 (1994) 2063-2072
118. McLarnon J.G., Michikawa M., and Kim S.U. Effects of tumor necrosis factor on inward potassium current and cell morphology in cultured human oligodendrocytes. Glia 9 (1993) 120-126
119. Medina D., Ullrich R., Meyn R., Wiseman R., and Donehower L. Environmental carcinogens and p53 tumor-suppressor gene interactions in a transgenic mouse model for mammary carcinogenesis. Environ. Mol. Mutagen 39 (2002) 178-183
120. Merienne K., Jacquot S., Zeniou M., Pannetier S., Sassone-Corsi P., and Hanauer A. Activation of RSK by UV-light: phosphorylation dynamics and involvement of the MAPK pathway. Oncogene 19 (2000) 4221-4229
121. Minami M., Kita M., Yan X.Q., Yamamoto T., Iida T., Sekikawa K., Iwakura Y., and Imanishi J. Role of IFN-gamma and tumor necrosis factor-alpha in herpes simplex virus type 1 infection. J. Interferon. Cytokine Res. 22 (2002) 671-676
122. Mohan R.R., Liang Q., Kim W.J., Helena M.C., Baerveldt F., and Wilson S.E. Apoptosis in the cornea: further characterization of Fas/Fas ligand system. Exp. Eye Res. 65 (1997) 575-589
123. Morrison L.E., Hoover H.E., Thuerauf D.J., and Glembotski C.C. Mimicking phosphorylation of alpha B-crystallin on serine-59 is necessary and sufficient to provide maximal protection of cardiac myocytes from apoptosis. Circ. Res. 92 (2003) 203-211
124. Nagy Z.Z., Seitz B., Maldonado M.J., and Simon M. Changes of the corneal endothelium after ultraviolet-B exposure in previously photokeratectomized eyes. Acta Chir. Hung. 35 (1995) 325-332
125. Nagy Z.Z., Hiscott P., Seitz B., Schlotzer-Schrehardt U., Suveges I., and Naumann G.O. Clinical and morphological response to UV-B irradiation after excimer laser photorefractive keratectomy. Surv. Ophthalmol. 42 Suppl 1 (1997) S64-S76
126. Nietsch H.H., Roe M.W., Fiekers J.F., Moore A.L., and Lidofsky S.D. Activation of potassium and chloride channels by tumor necrosis factor alpha. Role in liver cell death. J. Biol. Chem. 275 (2000) 20556-20561
127. Nishikawa T., Salim E.I., Morimura K., Kaneko M., Ogawa M., Kinoshita A., Osugi H., Kinoshita H., and Fukushima S. High susceptibility of p53 knockout mice to esophageal and urinary bladder carcinogenesis induced by N, N-dibutylnitrosamine. Cancer Lett. 194 (2003) 45-54
128. Nitabach M.N., Llamas D.A., Araneda R.C., Intile J.L., Thompson I.J., Zhou Y.I., and Holmes T.C. A mechanism for combinatorial regulation of electrical activity: Potassium channel subunits capable of functioning as Src homology 3-dependent adaptors. Proc. Natl. Acad. Sci. USA 98 (2001) 705-710
129. O'Neill L.A. Interleukin-1 signal transduction. Int. J. Clin. Lab. Res. 25 (1995) 169-177
130. Pappone P.A., and Ortiz-Miranda S.I. Blockers of voltage-gated K channels inhibit proliferation of cultured brown fat cells. Am. J. Physiol. 264 (1993)
131. Pepose J.S., and Ubels J.L. The Cornea. In: Hart W.M. (Ed). Adler's Physiology of the Eye (1992), Mosby Year Book, St. Louis
132. Pluquet O., North S., Bhoumik A., Dimas K., Ronai Z., and Hainaut P. The cytoprotective aminothiol WR1065 activates p53 through a non-genotoxic signaling pathway involving c-Jun N-terminal kinase. J. Biol. Chem. 278 (2003) 11879-11887
133. Podskochy A., Gan L., and Fagerholm P. Apoptosis in UV-exposed rabbit corneas. Cornea 19 (2000) 99-103
134. Price M., Lee S.C., and Deutsch C. Charybdotoxin inhibits proliferation and interleukin 2 production in human peripheral blood lymphocytes. Proc. Natl. Acad. Sci. USA 86 (1989) 10171-10175
135. Price M.A., Cruzalegui F.H., and Treisman R. The p38 and ERK MAP kinase pathways cooperate to activate Ternary Complex Factors and c-fos transcription in response to UV light. Embo J. 15 (1996) 6552-6563
136. Qin S., Minami Y., Kurosaki T., and Yamamura H. Distinctive functions of Syk and Lyn in mediating osmotic stress- and ultraviolet C irradiation-induced apoptosis in chicken B cells. J. Biol. Chem. 272 (1997) 17994-17999
137. Radler-Pohl A., Sachsenmaier C., Gebel S., Auer H.P., Bruder J.T., Rapp U., Angel P., Rahmsdorf H.J., and Herrlich P. UV-induced activation of AP-1 involves obligatory extranuclear steps including Raf-1 kinase. Embo J. 12 (1993) 1005-1012
138. Rae J. The application of patch clamp methods to ocular epithelia. Curr. Eye Res. 4 (1985) 409-420
139. Rae J., and Farrugia G. Whole-cell potassium current in rabbit corneal epithelium activated by fenamates. J. Membr. Biol. 129 (1992) 81-97
140. Rae J., and Shepard A. Kir2.1 potassium channels and corneal epithelia. Curr. Eye Res. 20 (2000) 144-152
141. Rae J., Dewey J., Rae J., Nesler M., and Cooper K. Single potassium channels in corneal epithelium. Invest. Ophthalmol. Vis. Sci. 31 (1990) 1799-1809
142. Rae J., Dewey J., and Rae J. The large-conductance potassium ion channel of rabbit corneal epithelium is blocked by quinidine. Invest. Ophthalmol. Vis. Sci. 33 (1992) 286-290
143. Rae J., Rich A., Zamudio A., and Candia O. Effect of Prozac on whole cell ionic currents in lens and corneal epithelia. Am. J. Physiol. 269 (1995) C250-C256
144. Reinehr R., Schliess F., and Haussinger D. Hyperosmolarity and CD95L trigger CD95/EGF receptor association and tyrosine phosphorylation of CD95 as prerequisites for CD95 membrane trafficking and DISC formation. Faseb J. 17 (2003) 731-733
145. + channels: an essential pathway in programmed cell death. Am. J. Physiol. Lung Cell Mol. Physiol. 286 (2004) L49-L67
146. Rich A., Farrugia G., and Rae J. Carbon monoxide stimulates a potassium-selective current in rabbit corneal epithelial cells. Am. J. Physiol. 267 (1994) C435-C442
147. Rich A., Bartling C., Farrugia G., and Rae J. Effects of pH on the potassium current in rabbit corneal epithelial cells. Am. J. Physiol. 272 (1997) C744-C753
148. Ringvold A. In vitro evidence for UV-protection of the eye by the corneal epithelium mediated by the cytoplasmic protein, RNA, and ascorbate. Acta Ophthalmol. Scand. 75 (1997) 496-498
149. Ringvold A. Corneal epithelium and UV-protection of the eye. Acta Ophthalmol. Scand. 76 (1998) 149-153
150. Ringvold A., and Davanger M. Changes in the rabbit corneal stroma caused by UV-radiation. Acta Ophthalmol. (Copenh.) 63 (1985) 601-606
151. Roderick C., Reinach P.S., Wang L., and Lu L. Modulation of rabbit corneal epithelial cell proliferation by growth factor-regulated K(+) channel activity. J. Membr. Biol. 196 (2003) 41-50
152. Rosette C., and Karin M. Ultraviolet light and osmotic stress: activation of the JNK cascade through multiple growth factor and cytokine receptors. Science 274 (1996) 1194-1197
153. + channel block-induced mammalian neuroblastoma cell swelling: a possible mechanism to influence proliferation. J. Physiol. 510 Pt 1 (1998) 93-102
154. Rudy B., Chow A., Lau D., Amarillo Y., Ozaita A., Saganich M., Moreno H., Nadal M.S., Hernandez-Pineda R., Hernandez-Cruz A., Erisir A., Leonard C., and Vega-Saenz de Miera E. Contributions of Kv3 channels to neuronal excitability. Ann. NY Acad. Sci. 868 (1999) 304-343
155. Sanchez I., Hughes R.T., Mayer B.J., Yee K., Woodgett J.R., Avruch J., Kyriakis J.M., and Zon L.I. Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun. Nature 372 (1994) 794-798
156. Sanchez Y., Bachant J., Wang H., Hu F., Liu D., Tetzlaff M., and Elledge S.J. Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms. Science 286 (1999) 1166-1171
157. Schlaepfer D.D., and Hunter T. Integrin signalling and tyrosine phosphorylation: just the FAKs?. Trends Cell Biol. 8 (1998) 151-157
158. + uptake. [Review]. Annu. Rev. Biophys. Biomolec. Struct. 23 (1994) 441-471
159. Schulz J.B., Weller M., and Klockgether T. Potassium deprivation-induced apoptosis of cerebellar granule neurons: a sequential requirement for new mRNA and protein synthesis, ICE-like protease activity, and reactive oxygen species. J. Neurosci. 16 (1996) 4696-4706
160. Schwarz T. UV light affects cell membrane and cytoplasmic targets. J. Photochem. Photobiol. B 44 (1998) 91-96
161. Sharma E., and Lombroso P.J. A neuronal protein tyrosine phosphatase induced by nerve growth factor. J. Biol. Chem. 270 (1995) 49-53
162. Shirai N., Tsukamoto T., Yamamoto M., Iidaka T., Sakai H., Yanai T., Masegi T., Donehower L.A., and Tatematsu M. Elevated susceptibility of the p53 knockout mouse esophagus to methyl-N-amylnitrosamine carcinogenesis. Carcinogenesis 23 (2002) 1541-1547
163. Smirnova I.S., Yakovleva T.K., Rosanov Y.M., Aksenov N.D., and Pospelova T.V. Analysis of p53-dependent mechanisms in the maintenance of genetic stability in diploid tumourigenic line SK-UT-1B of human uterine leiomyosarcoma. Cell Biol. Int. 25 (2001) 1101-1115
164. Smith P.G., Garcia R., and Kogerman L. Strain reorganizes focal adhesions and cytoskeleton in cultured airway smooth muscle cells. Exp. Cell Res. 232 (1997) 127-136
165. Smith P.G., Garcia R., and Kogerman L. Mechanical strain increases protein tyrosine phosphorylation in airway smooth muscle cells. Exp. Cell Res. 239 (1998) 353-360
166. Sogame N., Kim M., and Abrams J.M. Drosophila p53 preserves genomic stability by regulating cell death. Proc. Natl. Acad. Sci. USA 100 (2003) 4696-4701
167. + current expression in cultured oligodendrocytes. J. Membr. Biol. 124 (1991) 127-137
168. + channel in T lymphocytes upon Fas stimulation. J. Biol. Chem. 271 (1996) 20465-20469
169. + currents modulated by arachidonic acid in bovine corneal epithelial cells. Invest. Ophthalmol. Vis. Sci. 42 (2001) 1847-1854
170. Tang Z.H., Cai Q.F., and Ye X.A. Expression of bcl-2, c-erbB2, and p53 protein in cervical epithelial carcinogenesis. Ai Zheng 22 (2003) 1057-1061
171. Taylor J.M., Hildebrand J.D., Mack C.P., Cox M.E., and Parsons J.T. Characterization of graf, the GTPase-activating protein for rho associated with focal adhesion kinase. Phosphorylation and possible regulation by mitogen-activated protein kinase. J Biol Chem. 273 (1998) 8063-8070
172. Tominaga K., Morisaki H., Kaneko Y., Fujimoto A., Tanaka T., Ohtsubo M.,
173. Trimarchi J.R., Liu L., Smith P.J., and Keefe D.L. Apoptosis recruits two-pore domain potassium channels used for homeostatic volume regulation. Am. J. Physiol. Cell Physiol. 282 (2002) C588-C594
174. Tronnier H. Hazards due to UV-light. Strahlenschutz Forsch Prax 20 (1980) 36-49
175. + channel responses during proliferation and activation in macrophages. J. Biol. Chem. 278 (2003) 46307-46320
176. Vicente R., Coma M., Busquets S., Moore-Carrasco R., Lopez-Soriano F.J., Argiles J.M., and Felipe A. The systemic inflammatory response is involved in the regulation of K(+) channel expression in brain via TNF-alpha-dependent and -independent pathways. FEBS Lett. 572 (2004) 189-194
177. Vullhorst D., Klocke R., Bartsch J.W., and Jockusch H. Expression of the potassium channel KV3.4 in mouse skeletal muscle parallels fiber type maturation and depends on excitation pattern. FEBS Lett. 421 (1998) 259-262
178. Walev I., Reske K., Palmer M., Valeva A., and Bhakdi S. Potassium-inhibited processing of IL-1 beta in human monocytes. Embo J. 14 (1995) 1607-1614
179. + channel, a regulator of tumor cell apoptosis and proliferation. Cancer Res. 62 (2002) 4843-4848
180. Wang J., Wang H., Zhang Y., Gao H., Nattel S., and Wang Z. Impairment of HERG K(+) channel function by tumor necrosis factor-alpha: role of reactive oxygen species as a mediator. J. Biol. Chem. 279 (2004) 13289-13292
181. + channel activity associated with human myeloblastic ML-1 cell proliferation. Am. J. Physiol. 273 (1997) C1657-C1665
182. + channel mediates apoptosis of myeloblastic leukemia cells. J. Biol. Chem. 274 (1999) 3678-3685
183. Wang L., Zhou P., Craig R.W., and Lu L. Protection from cell death by mcl-1 is mediated by membrane hyperpolarization induced by K(+) channel activation. J. Membr. Biol. 172 (1999) 113-120
184. Wang L., Li T., and Lu L. UV-induced corneal epithelial cell death by activation of potassium channels. Invest. Ophthalmol. Vis. Sci. 44 (2003) 5095-5101
185. Wang L., Fyffe R.E., and Lu L. Identification of a Kv3.4 channel in corneal epithelial cells. Invest. Ophthalmol. Vis. Sci. 45 (2004) 1796-1803
186. Wang L., Dai W., and Lu L. Ultraviolet irradiation-induced K(+) channel activity involving p53 activation in corneal epithelial cells. Oncogene 24 (2005) 3020-3027
187. Wang L.D., Zhou Q., Wei J.P., Yang W.C., Zhao X., Wang L.X., Zou J.X., Gao S.S., Li Y.X., and Yang C. Apoptosis and its relationship with cell proliferation, p53, Waf1p21, bcl-2 and c-myc in esophageal carcinogenesis studied with a high-risk population in northern China. World J. Gastroenterol. 4 (1998) 287-293
188. Wang W., Sackin H., and Giebisch G. Renal potassium channels and their regulation. Annu. Rev. Physiol. 54 (1992) 81-96
189. Watanabe S., Tanizaki M., and Kaneko A. Two types of stretch-activated channels coexist in the rabbit corneal epithelial cell. Exp. Eye Res. 64 (1997) 1027-1035
190. + channels in the thick ascending limb of rat kidney. Am. J. Physiol. Renal Physiol. 285 (2003) F491-F497
191. + channels in the rat central nervous system. J. Neurosci. 14 (1994) 949-972
192. Wickert H., Zaar K., Grauer A., John M., Zimmermann M., and Gillardon F. Differential induction of proto-oncogene expression and cell death in ocular tissues following ultraviolet irradiation of the rat eye. Br. J. Ophthalmol. 83 (1999) 225-230
193. Wilson S.E. Molecular cell biology for the refractive corneal surgeon: programmed cell death and wound healing. J. Refract. Surg. 13 (1997) 171-175
194. Wilson S.E., He Y.G., and Lloyd S.A. EGF, EGF receptor, basic FGF, TGF beta-1, and IL-1 alpha mRNA in human corneal epithelial cells and stromal fibroblasts. Invest. Ophthalmol. Vis. Sci. 33 (1992) 1756-1765
195. Wilson S.E., Lloyd S.A., and He Y.G. EGF, basic FGF, and TGF beta-1 messenger RNA production in rabbit corneal epithelial cells. Invest. Ophthalmol. Vis. Sci. 33 (1992) 1987-1995
196. Wilson S.E., Walker J.W., Chwang E.L., and He Y.G. Hepatocyte growth factor, keratinocyte growth factor, their receptors, fibroblast growth factor receptor-2, and the cells of the cornea. Invest. Ophthalmol. Vis. Sci. 34 (1993) 2544-2561
197. Wilson S.E., Li Q., Weng J., Barry-Lane P.A., Jester J.V., Liang Q., and Wordinger R.J. The Fas-Fas ligand system and other modulators of apoptosis in the cornea. Invest. Ophthalmol. Vis. Sci. 37 (1996) 1582-1592
198. + conductance of frog corneal epithelium. Am. J. Physiol. 253 (1987) C555-C560
199. Wonderlin W.F., and Strobl J.S. Potassium channels, proliferation and G1 progression. J. Membr. Biol. 154 (1996) 91-107
200. Xie S., Wang Q., Wu H., Cogswell J., Lu L., Jhanwar-Uniyal M., and Dai W. Reactive oxygen species-induced phosphorylation of p53 on serine 20 is mediated in part by polo-like kinase-3. J. Biol. Chem. 276 (2001) 36194-36199
201. + channel activity. Am. J. Physiol. 271 (1996) C2037-C2044
202. +-channel activity in growth factor-mediated extracellular signal-regulated kinase activation in human myeloblastic leukemia ML-1 cells. Blood 94 (1999) 139-145
203. Yang H., Sun X., Wang Z., Ning G., Zhang F., Kong J., Lu L., and Reinach P.S. EGF stimulates growth by enhancing capcitative calcium entry in rabbit corneal epithelial cells. J. Membr. Biol. 193 (2003)
204. Yang J., Xu Z.P., Huang Y., Hamrick H.E., Duerksen-Hughes P.J., and Yu Y.N. ATM and ATR: sensing DNA damage. World J. Gastroenterol. 10 (2004) 155-160
205. Yano Y., Geibel J., and Sumpio B.E. Tyrosine phosphorylation of pp125FAK and paxillin in aortic endothelial cells induced by mechanical strain. Am. J. Physiol. 271 (1996) C635-C649
206. Ye R., Bodero A., Zhou B.B., Khanna K.K., Lavin M.F., and Lees-Miller S.P. The plant isoflavenoid genistein activates p53 and Chk2 in an ATM-dependent manner. J. Biol. Chem. 276 (2001) 4828-4833
207. Yu S.P., and Choi D.W. Ions, cell volume, and apoptosis. Proc. Natl. Acad. Sci. USA 97 (2000) 9360-9362
208. Yu S.P., Yeh C.H., Sensi S.L., Gwag B.J., Canzoniero L.M., Farhangrazi Z.S., Ying H.S., Tian M., Dugan L.L., and Choi D.W. Mediation of neuronal apoptosis by enhancement of outward potassium current. Science 278 (1997) 114-117
209. Yu S.P., Farhangrazi Z.S., Ying H.S., Yeh C.H., and Choi D.W. Enhancement of outward potassium current may participate in beta-amyloid peptide-induced cortical neuronal death. Neurobiol. Dis. 5 (1998) 81-88
210. + efflux and neuronal apoptosis. Science 284 (1999) 336-339
211. + current in ceramide-induced caspase activation and apoptosis in cultured cortical neurons. J. Neurochem. 73 (1999) 933-941
212. Yujiri T., Nawata R., Takahashi T., Sato Y., Tanizawa Y., Kitamura T., and Oka Y. MEK kinase 1 interacts with focal adhesion kinase and regulates insulin receptor substrate-1 expression. J. Biol. Chem. 278 (2003) 3846-3851
213. Zhao J.H., Reiske H., and Guan J.L. Regulation of the cell cycle by focal adhesion kinase. J. Cell Biol. 143 (1998) 1997-2008
214. Zhou B.B., and Elledge S.J. The DNA damage response: putting checkpoints in perspective. Nature 408 (2000) 433-439