Mimicking phosphorylation of αB-crystallin on serine-59 is necessary and sufficient to provide maximal protection of cardiac myocytes from apoptosis

Circulation Research

Volumn 92, Issue 2, 2003, Pages 203-211

  Morrison, Lisa E ^a   Hoover, Holly E ^a   Thuerauf, Donna J ^a   Glembotski, Christopher C ^a  

^a SAN DIEGO STATE UNIVERSITY   (United States)

Author keywords

B crystallin; Apoptosis; Cardiac myocytes; Phosphorylation

Indexed keywords

ALPHA CRYSTALLIN; BETA CRYSTALLIN; CASPASE 3; ENZYME PRECURSOR; SERINE; CASP3 PROTEIN, RAT; CASPASE; SORBITOL;

AMINO ACID SUBSTITUTION; APOPTOSIS; ARTICLE; ENZYME INHIBITION; HEART MUSCLE CELL; HEART PROTECTION; HYPOXIA; OSMOTIC STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; ANIMAL; BIOSYNTHESIS; CELL CULTURE; CELL HYPOXIA; CELL SURVIVAL; CYTOLOGY; DRUG EFFECT; GENETIC TRANSFECTION; GENETICS; METABOLISM; MOLECULAR GENETICS; MOLECULAR MIMICRY; NICK END LABELING; NUCLEOTIDE SEQUENCE; OSMOLARITY; PHOSPHORYLATION; PHYSIOLOGY; RAT; SITE DIRECTED MUTAGENESIS; SPRAGUE DAWLEY RAT; STRUCTURE ACTIVITY RELATION;

ALPHA-CRYSTALLIN B CHAIN; AMINO ACID SUBSTITUTION; ANIMALS; APOPTOSIS; BASE SEQUENCE; CASPASE 3; CASPASES; CELL HYPOXIA; CELL SURVIVAL; CELLS, CULTURED; IN SITU NICK-END LABELING; MOLECULAR MIMICRY; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MYOCYTES, CARDIAC; OSMOLAR CONCENTRATION; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; SORBITOL; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

EID: 0037422859     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000052989.83995.A5     Document Type: Article

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