HOX decoy peptide enhances the ex vivo expansion of human umbilical cord blood CD34+ hematopoietic stem cells/hematopoietic progenitor cells

Stem Cells

Volumn 24, Issue 11, 2006, Pages 2592-2602

  Tanaka, Hirokazu ^a,b,d   Matsumura, Itaru ^b   Itoh, Kiminari ^a   Hatsuyama, Asako ^a   Shikamura, Masayuki ^a   Satoh, Yusuke ^b   Heike, Toshio ^c   Nakahata, Tatsutoshi ^c   Kanakura, Yuzuru ^b  

^a INSTITUTE OF BIOMEDICAL RESEARCH AND INNOVATION   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Ex vivo expansion; Hematopoietic stem progenitor cells; HOX; Peptide mimetics

Indexed keywords

HOMEODOMAIN PROTEIN; HOX PROTEIN; MYC PROTEIN; PROTEIN P21;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CD34 SELECTION; CELL COUNT; CELL POPULATION; CONTROLLED STUDY; EX VIVO STUDY; GENE EXPRESSION; GENE TARGETING; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; MOUSE; NONHUMAN; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN SYNTHESIS; STEM CELL TRANSPLANTATION; UMBILICAL CORD BLOOD;

ANIMALS; ANTIGENS, CD34; BONE MARROW; CELL PROLIFERATION; CELLS, CULTURED; CHROMATIN IMMUNOPRECIPITATION; CORD BLOOD STEM CELL TRANSPLANTATION; CYTOKINES; DNA-BINDING PROTEINS; FETAL BLOOD; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOPHENOTYPING; MICE; MICE, INBRED NOD; MICE, SCID; MOLECULAR MIMICRY; PEPTIDES; PROTO-ONCOGENE PROTEINS; RECOMBINANT FUSION PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION, GENETIC; WHOLE-BODY IRRADIATION;

EID: 33750570211     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.2005-0434     Document Type: Article

References (66)

1. Benito AI, Diaz MA, Gonzalez-Vicent M et al. Hematopoietic stem cell transplantation using umbilical cord blood progenitors: Review of current clinical results. Bone Marrow Transplant 2004;33:675-690.
2. Devine SM, Lazarus HM, Emerson SG. Clinical application of hematopoietic progenitor cell expansion: Current status and future prospects. Bone Marrow Transplant 2003;31:241-252.
3. Heike T, Nakahata T. Ex vivo expansion of hematopoietic stem cells by cytokines. Biochim Biophys Acta 2002;1592:313-321.
4. Ueda T, Tsuji K, Yoshino H et al. Expansion of human NOD/SCID- repopulating cells by stem cell factor, Flk2/Flt3 ligand, thrombopoietin, IL-6, and soluble IL-6 receptor. J Clin Invest 2000;105:1013-1021.
5. Shpall EJ, Quinones R, Giller R et al. Transplantation of ex vivo expanded cord blood. Biol Blood Marrow Transplant 2002;8:368-376.
6. Jaroscak J, Goltry K, Smith A et al. Augmentation of umbilical cord blood (UCB) transplantation with ex vivo-expanded UCB cells: Results of a phase 1 trial using the AastromReplicell System. Blood 2003;101:5061-5067.
7. Brandon C, Eisenberg LM, Eisenberg CA. WNT signaling modulates the diversification of hematopoietic cells. Blood 2000;96:4132-4141.
8. Murdoch B, Chadwick K, Martin M et al. Wnt-5A augments repopulating capacity and primitive hematopoietic development of human blood stem cells in vivo. Proc Natl Acad Sci U S A 2003;100:3422-3427.
9. Reya T, Duncan AW, Ailles L et al. A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature 2003;423:409-414.
10. Willert K, Brown JD, Danenberg E et al. Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature 2003;423:448-452.
11. Bhatia M, Bonnet D, Wu D et al. Bone morphogenetic proteins regulate the developmental program of human hematopoietic stem cells. J Exp Med 1999;189:1139-1148.
12. Bhardwaj G, Murdoch B, Wu D. Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation. Nat Immunol 2001;2:178-180.
13. Varnum-Finney B, Xu L, Brashem-Stein C et al. Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling. Nat Med 2000;6:1278-1281.
14. Karanu FN, Murdoch B, Gallacher L et al. The notch ligand jagged-1 represents a novel growth factor of human hematopoietic stem cells. J Exp Med 2000;192:1365-1372.
15. Ohishi K, Varnum-Finney B, Bernstein ID. Delta-1 enhances marrow and thymus repopulating ability of human CD34(+)CD38(-) cord blood cells. J Clin Invest 2002;110:1165-1174.
16. Antonchuk J, Sauvageau G, Humphries RK. HOXB4-induced expansion of adult hematopoietic stem cells ex vivo. Cell 2002;109:39-45.
17. Lessard J, Sauvageau G. Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature 2003;423:255-260.
18. Park IK, Qian D, Kiel M et al. Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature 2003;423:302-305.
19. Amsellem S, Pflumio F, Bardinet D et al. Ex vivo expansion of human hematopoietic stem cells by direct delivery of the HOXB4 homeoprotein. Nat Med 2003;9:1423-1427.
20. Krosl J, Austin P, Beslu N et al. In vitro expansion of hematopoietic stem cells by recombinant TAT-HOXB4 protein. Nat Med 2003;9:1428-1432.
21. Buske C, Feuring-Buske M, Abramavich C et al. Deregulated expression of HOXB4 enhances the primitive growth activity of human hematopoietic cells. Blood 2002;100:862-868.
22. Brun AC, Fan X, Bjornsson JM et al. Enforced adenoviral vector-mediated expression of HOXB4 in human umbilical cord blood CD34+ cells promotes myeloid differentiation but not proliferation. Mol Ther 2003;8:618-628.
23. Magli MC, Largman C, Lawrence HJ. Effects of HOX homeobox genes in blood cell differentiation. J Cell Physiol 1997;173:168-177.
24. Buske C, Humphries RK. Homeobox genes in leukemogenesis. Int J Hematol 2000;71:301-308.
25. Lawrence HJ, Helgason CD, Sauvageau G et al. Mice bearing a targeted interruption of the homeobox gene HOXA9 have defects in myeloid, erythroid, and lymphoid hematopoiesis. Blood 1997;89:1922-1930.
26. Dorsam ST, Ferrell CM, Dorsam GP et al. The transcriptome of the leukemogenic homeoprotein HOXA9 in human hematopoietic cells. Blood 2004;103:1676-1684.
27. Crooks GM, Fuller J, Petersen D et al. Constitutive HOXA5 expression inhibits erythropoiesis and increases myelopoiesis from human hematopoietic progenitors. Blood 1999;94:519-528.
28. Bromleigh VC, Freedman LP. p21 is a transcriptional target of HOXA10 in differentiating myelomonocytic cells. Genes Dev 2000;14:2581-2586.
29. Bjornsson JM, Andersson E, Lundstrom P et al. Proliferation of primitive myeloid progenitors can be reversibly induced by HOXA10. Blood 2001;98:3301-3308.
30. Zimmermann F, Rich IN. Mammalian homeobox B6 expression can be correlated with erythropoietin production sites and erythropoiesis during development, but not with hematopoietic or nonhematopoietic stem cell populations. Blood 1997;89:2723-2735.
31. Mann RS, Affolter M. Hox proteins meet more partners. Curr Opin Genet Dev 1998;8:423-429.
32. Pineault N, Helgason CD, Lawrence HJ et al. Differential expression of Hox, Meis1, and Pbx1 genes in primitive cells throughout murine hematopoietic ontogeny. Exp Hematol 2002;30:49-57.
33. Di Rocco G, Mavilio F, Zappavigna V. Functional dissection of a transcriptionally active, target-specific Hox-Pbx complex. EMBO J 1997;16:3644-3654.
34. Asahara H, Dutta S, Kao HY et al. Pbx-Hox heterodimers recruit coactivator-corepressor complexes in an isoform-specific manner. Mol Cell Biol 1999;19:8219-8225.
35. Saleh M, Rambaldi I, Yang XJ et al. Cell signaling switches HOX-PBX complexes from repressors to activators of transcription mediated by histone deacetylases and histone acetyltransferases. Mol Cell Biol 2000;20:8623-8633.
36. Lu Y, Goldenberg I, Bei L et al. HoxA10 represses gene transcription in undifferentiated myeloid cells by interaction with histone deacetylase 2. J Biol Chem 2003;278:47792-47802.
37. Phelan ML, Rambaldi I, Featherstone MS. Cooperative interactions between HOX and PBX proteins mediated by a conserved peptide motif. Mol Cell Biol 1995;15:3989-3997.
38. Piper DE, Batchelor AH, Chang CP et al. Structure of a HoxB1-Pbx1 heterodimer bound to DNA: Role of the hexapeptide and a fourth homeodomain helix in complex formation. Cell 1999;96:587-597.
39. Shanmugam K, Featherstone MS, Saragovi HU. Residues flanking the HOX YPWM motif contribute to cooperative interactions with PBX. J Biol Chem 1997;272(30):19081-19087.
40. Sprules T, Green N, Featherstone M et al. Conformational changes in the PBX homeodomain and C-terminal extension upon binding DNA and HOX-derived YPWM peptides. Biochemistry 2000;39:9943-9950.
41. LaRonde-LeBlanc NA, Wolberger C. Structure of HoxA9 and Pbx1 bound to DNA: Hox hexapeptide and DNA recognition anterior to posterior. Genes Dev 2003;17:2060-2072.
42. Krosl J, Beslu N, Mayotte N et al. The competitive nature of HOXB4-transduced HSC is limited by PBX1: the generation of ultra-competitive stem cells retaining full differentiation potential. Immunity 2003;18:561-571.
43. Beslu N, Krosl J, Laurin M et al. Molecular interactions involved in HOXB4-induced activation of HSC self-renewal. Blood 2004;104:2307-2314.
44. Tanaka H, Matsumura I, Ezoe S et al. E2F1 and c-Myc potentiate apoptosis through inhibition of NF-kappaB activity that facilitates Mn-SOD-mediated ROS elimination Mol Cell 2002;9:1017-1029.
45. Cannon MJ, Papalia GA, Navratilova I et al. Comparative analyses of a small molecule/enzyme interaction by multiple users of Biacore technology. Anal Biochem 2004;330:98-113.
46. Tajima S, Tsuji K, Ebihara Y et al. Analysis of interleukin 6 receptor and gp130 expressions and proliferative capability of human CD34+ cells. J Exp Med 1996;184:1357-1364.
47. Bhatia M, Bonnet D, Kapp U et al. Quantitative analysis reveals expansion of human hematopoietic repopulating cells after short-term ex vivo culture. J Ex Med 1997;186:619-624.
48. Wang JC, Doedens M, Dick JE. Primitive human hematopoietic cells are enriched in cord blood compared with adult bone marrow or mobilized peripheral blood as measured by the quantitative in vivo SCID-repopulating cell assay. Blood 1997;89:3919-3924.
49. Satoh Y, Matsumura I, Tanaka H et al. Roles for c-Myc in self-renewal of hematopoietic stem cells. J Biol Chem 2004;279:24986-24993.
50. Matsumura I, Kitamura T, Wakao H et al. Transcriptional regulation of the cyclin D1 promoter by STAT5: its involvement in cytokine-dependent growth of hematopoietic cells. EMBO J 1999;18:1367-1377.
51. Matsumura I, Ishikawa J, Nakajima K et al. Thrombopoietin-induced differentiation of a human megakaryoblastic leukemia cell line, CMK, involves transcriptional activation of p21(WAF1/Cip1) by STAT5. Mol Cell Biol 1997;17:2933-2943.
52. Hodel MR, Corbett AH, Hodel AE. Dissection of a nuclear localization signal. J Biol Chem 2001;276:1317-1325.
53. Gao J, Mazella J, Tseng L. Hox proteins activate the IGFBP-1 promoter and suppress the function of hPR in human endometrial cells. DNA Cell Biol 2002;21:819-825.
54. Dorrell C, Gan OI, Pereira DS et al. Expansion of human cord blood CD34(+)CD38(-) cells in ex vivo culture during retroviral transduction without a corresponding increase in SCID repopulating cell (SRC) frequency: Dissociation of SRC phenotype and function. Blood 2000;95:102-110.
55. Brun AC, Bjornsson JM, Magnusson M et al. Hoxb4-deficient mice undergo normal hematopoietic development but exhibit a mild proliferation defect in hematopoietic stem cells. Blood 2004;103:4126-4133.
56. Björnsson JM, Larsson N, Brun AC et al. Reduced proliferative capacity of hematopoietic stem cells deficient in Hoxb3 and Hoxb4. Mol Cell Biol 2003;23:3872-3883.
57. Knoepfler PS, Sykes DB, Pasillas M et al. HoxB8 requires its Pbx-interaction motif to bl7ck differentiation of primary myeloid progenitors and of most cell line models of myeloid differentiation. Oncogene 2001;20:5440-5448.
58. Kroon E, Thorsteinsdottir U, Mayotte N et al. NUP98-HOXA9 expression in hemopoietic stem cells induces chronic and acute myeloid leukemias in mice. EMBO J 2001;20:350-361.
59. Noguchi H, Matsushita M, Okitsu et al. A new cell-permeable peptide allows successful allogeneic islet transplantation in mice. Nat Med 2004;10:305-309.
60. Kaneto H, Nakatani Y, Miyatsuka T et al. Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide. Nat Med 2004;10:1128-1132.
61. DiMartino JF, Selleri L, Traver D et al. The Hox cofactor and proto-oncogene Pbx1 is required for maintenance of definitive hematopoiesis in the fetal liver. Blood 2001;98:618-626.
62. Furukawa U, Kikuchi J, Nakamura M et al. Lineage-specific regulation of cell cycle control gene expression during haematopoietic cell differentiation. Br J Haematol 2000;110:663-673.
63. Cheng T, Rodrigues N, Shen H et al. Hematopoietic stem cell quiescence maintained by p21cip1/waf1. Science 2000;287:1804-1808.
64. Yuan Y, Shen H, Franklin DS et al. In vivo self-renewing divisions of haematopoietic stem cells are increased in the absence of the early G1-phase inhibitor, p18INK4C. Nat Cell Biol 2004;6:436-442.
65. Ito K, Hirao A, Arai F et al. Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells. Nature 2004;431:997-1002.
66. Cheng T, Rodrigues N, Dombkowski D et al. Stem cell repopulation efficiency but not pool size is governed by p27(kip1). Nat Med 2000;6:1235-1240.