p21 is a transcriptional target of HOXA10 in differentiating myelomonocytic cells

Genes and Development

Volumn 14, Issue 20, 2000, Pages 2581-2586

  Bromleigh, V C ^a   Freedman, L P ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Cell cycle arrest; Homeobox proteins; Myeloid differentiation; Transcription

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR; HOMEODOMAIN PROTEIN; PROTEIN P21;

ARTICLE; CELL CYCLE; CELL DIFFERENTIATION; CELL STRAIN U937; CONTROLLED STUDY; GENE EXPRESSION; GENETIC TRANSFECTION; HOMEOBOX; HUMAN; HUMAN CELL; MACROPHAGE; MONOCYTE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN TARGETING; TRANSACTIVATION; TRANSCRIPTION REGULATION;

CELL DIFFERENTIATION; CELL LINE; CYCLINS; DNA-BINDING PROTEINS; G1 PHASE; HOMEODOMAIN PROTEINS; HUMAN; MYELOID CELLS; NEOPLASM PROTEINS; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION, GENETIC;

EID: 0034667988     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.817100     Document Type: Article

References (34)

1. p21Cip1/WAF1 is important for differentiation and survival of U937 cells
2. Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiation
3. The expression pattern of the routine Hoxa-10 gene and the sequence recognition of its homeodomain reveal specific properties of abdominal B-like genes
4. PKNOX1, a gene encoding PREP1, a new regulator of Pbx activity, maps on human chromosome 21q22.3 and routine chromosome 17B/C
5. The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity
6. A positive effect of p21cip1/waf1 in the colony formation from routine myeloid progenitor cells as assessed by retroviral-mediated gene transfer
7. Analysis of TALE superclass homeobox genes [MEIS, PBC, KNOX, Iroquois, TGIF) reveals a novel domain conserved between plants and animals
8. Enforced expression of HOXB7 promotes hematopoietic stem cell proliferation and myeloid-restricted progenitor differentiation
9. Hematopoietic stem cell quiescence maintained by p21cip1/waf1
10. WAF1, a potential mediator of p53 tumor suppression
11. Light scatter of isolated cell nuclei as a parameter discriminating the cell-cycle subcompartments
12. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
13. Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity
14. Dorsotonals/homothorax, the Drosophila homologue of MEIS1, interacts with extradenticle in patterning of the embryonic PNS
15. New functional activities for the p21 family of CDK inhibitors
16. Stage- and lineage-specific expression of the HOXA10 homeobox gene in normal and leukemic hematopoietic cells
17. Mice bearing a targeted interruption of the homeobox gene HOXA9 have defects in myeloid, erythroid, and lymphoid hematopoiesis
18. Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937
19. Cell-cycle inhibition by in-dependent CDK and PCNA binding domains in p21Cip1
20. Involvement of p21cip-1 and p27kip-1 in the molecular mechanisms of steel factor-induced proliferative synergy in vitro and of p21cip-1 in the maintenance of stem/progenitor cells in vivo
21. PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1
22. Identification of a new family of Pbx-related homeobox genes
23. Structure of a HoxB1-PBX1 heterodimer bound to DNA: Role of the hexapeptide and a fourth homeodomain helix in complex formation
24. A differ ential screen for ligand-regulated genes: Identification of HOXA10 as a target of vitamin D3 induction in myeloid leukemic cells
25. Differential expression of homeobox genes in functionally distinct CD34 + subpopulations of human bone marrow cells
26. HoxA9-mediated immortalization of myeloid progenitors requires functional interactions with TALE cofactors Pbx and Meis
27. PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins
28. The Abd-B-like Hox homeodomain proteins can be subdivided by the ability to form complexes with PBX1a, on a novel DNA target
29. HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells
30. Homeobox genes in hematopoiesis and leukemogenesis
31. A modified tetracycline-regulated system provides autoregulatory, inducible gene expression in cultured cells and transgenic mice
32. Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia
33. Hox gene products modulate the DNA binding activity of PBX1 and Pbx2
34. The p21 inhibitor of cyclin-dependent kinases controls DNA replication by inter-action with PCNA