Cerebral amyloid angiopathy in Alzheimer disease is associated with apolipoprotein E4 and cortical neuron loss

Alzheimer Disease and Associated Disorders

Volumn 13, Issue 1, 1999, Pages 1-8

  Zarow, Chris ^a,b   Zaias, B ^a   Lyness, S A ^a   Chui, H ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b LAC USC MEDICAL CENTER   (United States)

Author keywords

Alzheimer; Amyloid angiopathy; Neuron loss; Neuropathology

Indexed keywords

AMYLOID BETA PROTEIN; APOLIPOPROTEIN E4; DNA;

AGED; ALLELE; ALZHEIMER DISEASE; ARTICLE; AUTOPSY; BRAIN CELL; BRAIN DEGENERATION; CELL LOSS; DISEASE SEVERITY; FEMALE; FRONTAL LOBE; GENOME; HOMOZYGOSITY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; NERVE DEGENERATION; NEUROPATHOLOGY; PRIORITY JOURNAL; STATISTICAL ANALYSIS; TEMPORAL LOBE; VASCULAR AMYLOIDOSIS;

EID: 0032891220     PISSN: 08930341     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002093-199903000-00001     Document Type: Article

References (55)

1. Bergeron C, Ranalli PJ, Miceli PN. Amyloid angiopathy in Alzheimer's disease. Can J Neurol Sci 1987;14:564-9.
2. Bondareff W, Montjoy CQ, Roth M, Hauser DL. Neurofibrillary degeneration and neuronal loss in Alzheimer's disease. Neurobiol Aging 1989;10:709-15.
3. Chui HC, Tierney M, Zarow C, Lewis A, Sobel E, Perlmutter LS. Neuropathologic diagnosis of Alzheimer's disease: Interrater reliability in the assessment of senile plaques and neurofibrillary tangles. Alzheimer Dis Assoc Disord 1993;75:48-54.
4. Cohen J. A coefficient of agreement for nominal scales. Educ Psychol Measurement 1960;20:37-46.
5. Copani A, Koh JY, Cotman CW. Beta amyloid increases neuronal susceptibility to injury by glucose deprivation. NeuroReport 1991;2:763-5.
6. Coria F, Castano EM, Frangione B. Brain amyloid in normal aging and cerebral amyloid angiopathy is antigenically related to Alzheimer's disease B-protein. Am J Pathol 1987;129:422-8.
7. Cras P, Kawai M, Siedlak S, Perry G. Microglia are associated with the extracellular neurofibrillary tangles of Alzheimer disease. Brain Res 1991;558:312-4.
8. Cras P, Smith MA, Richey PL, Siedlak SL, Mulvihill P, Perry G. Extra-cellular neurofibrillary tangles reflect neuronal loss and provide further evidence of extensive protein cross-linking in Alzheimer's disease. Acta Neuropathol 1995;89:291-5.
9. Davies P. Neuronal abnormalities, not amyloid, are the cause of dementia in Alzheimer disease. Alzheimer Dis 1994;19:327-33.
10. Esiri MM, Wilcock GK. Cerebral amyloid angiopathy in dementia and old age. J Neurol Neurosurg Psychiatry 1986;49:1221-6.
11. Glenner GG, Henry JH, Fujihara S. Congophilic angiopathy in the pathogenesis of Alzheimer's degeneration. Ann Pathol 1981;2:120-9.
12. Glenner GG, Wong CW, Quaranta V, Eanes ED. The amyloid deposits in Alzheimer's disease: their nature and pathogenesis. Appl Pathol 1984;2:357-69.
13. Greenberg SM, Rebeck GW, Vonsattel JPG, Gomez-Isla T, Hyman BT. Apolipoprotein E ∈4 and cerebral hemorrhage associated with amyloid angiopathy. Ann Neurol 1995;38:254-9.
14. Heinonen O, Lehtovirta M, Soininen H, Helisalmi S, Mannermaa A, Sorvari I, Kosunen O, Paljärvi L, Ryynänen M, Riekkinen PJ. Alzheimer pathology of patients carrying apolipoprotein E ∈4 allele. Neurobiol Aging 1995;16:505-13.
15. Hixson JA, Vernier DT. Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. J Lipid Res 1990;31:545-8.
16. Ikeda K, Akiyama H, Haga C, Haga S. Evidence that neurofibrillary tangles undergo glial modification. Acta Neuropathol 1992;85:101-4.
17. Iruela-Arispe ML, Sage EH. Endothelial cells exhibiting angiogenesis in vitro proliferate in response to TGFbeta 1. J Cell Biochem 1993;52:414-30.
18. Itoh Y, Yamada M, Suematsu N, Matsushita M, Otemo E. Influence of apolipoprotein E genotype on cerebral amyloid angiopathy in the elderly. Stroke 1996;27:216-8.
19. Iwamoto N, Ishihara T, Ito H, Uchino F. Morphological evaluation of amyloid-laden arteries in leptomeninges, cortices and subcortices in cerebral amyloid angiopathy with subcortical hemorrhage. Acta Neuropathol 1993;86:418-21.
20. Jellinger K. Cerebrovascular amyloidosis with cerebral hemorrhage. J Neurol 1977;214:195-206.
21. Kalyan-Raman UP, Kalyan-Raman K. Cerebral amyloid angiopathy causing intracranial hemorrhage. Ann Neurol 1984;16:321-9.
22. Khachaturian ZS. Diagnosis of Alzheimer's disease. Arch Neurol 1985;42:1097-105.
23. Koh JY, Yang LL, Cotman CW. Beta-amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage. Brain Res 1990;533:315-20.
24. Leblanc R, Haddad G, Robitaille Y. Cerebral hemorrhage from amyloid angiopathy and coronary thrombolysis. Neurosurgery 1992;31:586-90.
25. Ma J, Yee A, Brewer HB, Das S, Potter H. Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments. Nature 1994;372:92-4.
26. Mandybur TI. The incidence of cerebral amyloid angiopathy in Alzheimer's disease. Neurology 1975;25:120-6.
27. Mandybur TI. Cerebral amyloid angiopathy: the vascular pathology and complications. J Neuropathol Exp Neurol 1986;45:79-90.
28. Mann DMA, Yates PO, Marcyniuk B. Correlation between senile plaque and neurofibrillary tangle counts in cerebral cortex and neuronal counts in cortex and subcortical structures in Alzheimer's disease. Neurosci Lett 1985;56:51-5.
29. Mirra SS, Heyman A, McKeel D, et al. The consortium to establish a registry for Alzheimer's disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 1991; 41:479-86.
30. Mountjoy CQ, Tomlinson BE, Gibson PH. Amyloid and senile plaques and cerebral blood vessels. A semiquantitative investigation of a possible relationship. J Neurol Sci 1982;57:89-103.
31. Okazaki H, Reagan TJ, Campbell RJ. Clinicopathologic studies of primary cerebral amyloid angiopathy. Mayo Clin Proc 1979;54:22-31.
32. Pantelakis S. Un type particulier d'angiopathie śenile du systeme nerveux central: l'angiopathie Congophile. Topographie et frequence. Monatschr Psychiatr Neurol 1954;128:219-56.
33. Perlmutter LS. Microvascular pathology and vascular basement membrane components in Alzheimer's disease. Mol Neurobiol 1993;1:1-17.
34. Perlmutter LS, Athanikar J, Zarow C, Chui HC. Basement membrane pathology in dementia. Soc Neurosci Abstr 1988;14:639.
35. Perlmutter LS, Myers MA, Barron E. Vascular basement membrane components and the lesions of Alzheimer's disease: light and electron microscopic analyses. Microsc Res Tech 1994;15:204-15.
36. Perlmutter LS, Scott SA, Barron E, Chui HC. MHC class II-positive microglia in human brain: association with Alzheimer lesions. J Neurosci Res 1992;33:549-58.
37. Premkumar DRD, Cohen DL, Hedera P, Friedland RP, Kalana RN. Apolipoprotein E-∈4 alleles in cerebral amyloid angiopathy and cerebrovascular pathology associated with Alzheimer's disease. Am J Pathol 1996;148:2089-95.
38. Saunders AM, Strittmatter WJ, Schmechel D, et al. Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease. Neurology 1993;43:1467-72.
39. Scholz W. Studien zur Pathologie der Hirngefasse: II. Die drüsige Entartung der Hirnarterien und Kapillaren. Z Gestamte Neurol Psychiatr 1938;162:694-715. Trends Neurosci 1993;16:403-9.
40. Scholz W. Studien zur Pathologie der Hirngefasse: II. Die drüsige Entartung der Hirnarterien und Kapillaren. Z Gestamte Neurol Psychiatr 1938;162:694-715. Trends Neurosci 1993;16:403-9.
41. Su JH, Anderson AJ, Cummings BJ, Cotman CW. Immunohistochemical evidence for apoptosis in Alzheimer's disease. NeuroReport 1994;5: 2529-33.
42. Takadera T, Sakura N, Mohri T, Hashimoto T. Toxic effect of a beta-amyloid peptide (beta 22-35) on the hippocampal neuron and its prevention. Neurosci Lett 1993;161:41-4.
43. Timmers WF, Tagliavini F, Haan J, Frangione B. Parenchymal preamyloid and amyloid deposits in the brains of patients with hereditary cerebral hemorrhage with amyloidosis-Dutch type. Neurosci Lett 1990; 118:223-6.
44. Ueda K, Fukui Y, Kageyama H. Amyloid β protein-induced neuronal cell death: neurotoxic properties of aggregated amyloid β protein. Brain Res 1994;639:240-4.
45. Vinters HV, Gilbert JJ. Cerebral amyloid angiopathy: incidence and complications in the aging brain. II. The distribution of amyloid vascular changes. Stroke 1983;14:924-8.
46. Vonsattel JPG, Myers RH, Hedley-White ET, Ropper AH, Bird ED, Richardson EP. Cerebral amyloid angiopathy without and with cerebral hemorrhages: a comparative histological study. Ann Neurol 1991;30:637-49.
47. Whitson JS, Glabe CG, Shinani E, Abcar A, Cotman CW. Beta-amyloid protein promotes neuritic branching in hippocampal culture. Neurosci Lett 1990;110:319-24.
48. Whitson JS, Selkoe DJ, Cotman CW. Amyloid β protein enhances the survival of hippocampal neurons in vitro. Science 1989;243:1488-90.
49. Wisniewski HM, Wegiel J, Wang C, Lach B. Ultrastructural studies of the cells forming amyloid in the cortical vessel wall in Alzheimer's disease. Acta Neuropathol 1992;84:117-27.
50. Wisniewski T, Frangione B. Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid. Neurosci Lett 1992;135:235-8.
51. Wong CW, Quaranta V, Glenner GG. Neuritic plaques and cerebrovascular amyloid in Alzheimer disease are antigenically related. Proc Natl Acad Sci USA 1985;82:8729-32.
52. Yamada M, Tsukagoshi H, Otomo E, Hayakawa M. Cerebral amyloid angiopathy in the aged. J Neurol 1987;234:371-6.
53. Yamaguchi H, Yamazaki T, Lemere CA, Frosch MP, Selkoe DJ. Beta amyloid is focally deposited within the outer basement membrane in the amyloid angiopathy of Alzheimer's disease: an immunoelectron microscopic study. Am J Pathol 1992;141:249-59.
54. Yankner BA, Dawes LR, Fisher S, Villa-Komaroff L, Oster-Granite ML, Neve RL. Neurotoxicity of a fragment of the Alzheimer's disease amyloid precursor. Science 1989;245:417-20.
55. Yankner BA, Duffy LK, Kirschner DA. Neurotrophic and neurotoxic effects of amyloid β protein: reversal by tachykinin neuropeptides. Science 1990;250:279-82.