Immunoultrastructural expression of ICAM-1 and PECAM-1 occurs prior to structural maturity of the murine blood-brain barrier

Developmental Neuroscience

Volumn 20, Issue 6, 1998, Pages 518-524

  Lossinsky, Albert S ^a   Wisniewski, Henryk M ^b  

^a HUNTINGTON MEDICAL RESEARCH INSTITUTES   (United States)

^b NEW YORK STATE INSTITUTE FOR BASIC RESEARCH IN DEVELOPMENTAL DISABILITIES   (United States)

Author keywords

Adhesion molecules; Angiogenesis; Developmental blood brain barrier; ICAM 1 CD54; PECAM 1 CD31

Indexed keywords

CD31 ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CELL ULTRASTRUCTURE; CONTROLLED STUDY; ENDOTHELIUM CELL; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; ANTIGENS, CD31; BLOOD-BRAIN BARRIER; CELL ADHESION MOLECULES; ENDOTHELIUM, VASCULAR; IMMUNOHISTOCHEMISTRY; INTERCELLULAR ADHESION MOLECULE-1; MICE; MICE, INBRED C57BL; NEOVASCULARIZATION, PHYSIOLOGIC;

EID: 0032406324     PISSN: 03785866     EISSN: None     Source Type: Journal    
DOI: 10.1159/000017352     Document Type: Article

References (39)

1. Archelos JJ, Jung S, Mäurer M, Schmied M, Lassmann H, Tamatani T, Miyasaka M, Toyka KV, Hartung H-P (1993) Inhibition of experimental autoimmune encephalomyelitis by an antibody to the intercellular adhesion molecule ICAM-1. Ann Neurol 34:145-154.
2. Åström KE, Webster H Def, Arnason BG (1968) The initial lesion in experimental allergic neuritis. A phase and electron microscopic study. J Exp Med 128:469-495.
3. Bashir R, Coakham H, Hochberg F (1992) Expression of LFA-1/ICAM-1 in CNS lymphomas: Possible mechanism for lymphoma homing into the brain. J Neurooncol 12:103-110.
4. Bradbury M (1979) The blood-brain barrier during the development of the individual and the evolution of the phylum; in Bradbury M (ed): The Concept of a Blood-Brain Barrier. New York, Wiley, pp 289-322.
5. Brown KA, Perry ME, Mustapha Y, Rothlein R, Dumonde DC (1993) Immuno-electron microscopic analysis of the distribution of ICAM-1 in human inflammatory tissue. Agents Action 38:C35-C38.
6. Cannella B, Cross AH, Raine CS (1991) Adhesion-related molecules in the central nervous system. Upregulation correlates with inflammatory cell influx during relapsing experimental autoimmune encephalomyelitis. Lab Invest 65: 23-31.
7. Cordes U, Pedersen M, Bastholm L, Nielsen M, Werdelin O (1997) Murine thymic nurse cells express ICAM-1 on caveolar and vacuolar membranes. Scand J Immunol 46:344-348.
8. DeLisser HM, Christofidou-Solomidou M, Strieter RM, Burdick MD, Robinson CS, Wexler RS, Kerr JS, Garlanda C, Merwin JR, Madri JA, Albelda SM (1997) Involvement of endothelial PECAM-1/CD31 in angiogenesis. Am J Pathol 151:671-677.
9. DeLisser HM, Newman PJ, Albelda SM (1994): Molecular and functional aspects of PECAM-1/CD31. Immunol Today 15:490-495.
10. Folkman J (1995) Angiogenesis in cancer, vascular, rheumatoid and other diseases. Nature Med 1: 27-31.
11. Fortenberry JD, Marolda JR, Anderson DC, Smith W, Mariscalco MM (1994) CD18 dependent and L-selectin-dependent neutrophil emigration is diminished in neonatal rabbits. Blood 84:889-897.
12. Greenwood J, Wang Y, Calder VL (1995) Lymphocyte adhesion and transendothelial migration in the central nervous system: the role of LFA-1, CAM-1, VLA-4 and VCAM-1. Immunology 86:408-415.
13. Johanson CE (1989) Ontogeny and phylogeny of the blood-brain barrier; in Neuwelt EA (ed): Implications of the Blood-Brain Barrier and Its Manipulation. New York, Plenum, vol 1, pp 157-198.
14. Kishimoto TK (1991) A dynamic model for neutrophil localization to inflammatory sites. J NIH Res 3:75-77.
15. Lassmann H (1997) Basic mechanisms of brain inflammation. J Neural Transm Suppl 50:183-190.
16. Lawton AR, Cooper MD (1996) Development and function of the immune system; in Stiehm ER (ed): Immunologic Disorders in Infants and Children. Philadelphia, Saunders, pp 1-13.
17. Lobb RR (1992) Integrin-immunoglobulin superfamily interactions in endothelial-leukocyte adhesion; in Harlin JM, Liu DY (eds): Adhesion. Its Role in Inflammatory Disease. New York, Freeman, pp 1-18.
18. Lossinsky AS, Badmajew V, Robson J, Moretz RC, Wisniewski HM (1989) Sites of egress of inflammatory cells and horseradish peroxidase transport across the blood-brain barrier in a murine model of chronic relapsing experimental allergic encephalomyelitis. Acta Neuropathol 78:359-371.
19. Lossinsky AS, Buttle K, Marko M, Pluta R, Mossakowski MJ, Wisniewski HM (1996) Immunoultrastructural and high-voltage electron microscopic studies of endothelial cell tubules and vesicular-vacuolar organelles in human brain tumors. Soc Neurosci Abstr 22:774.
20. Lossinsky AS, Mossakowski MJ, Pluta R, Wisniewski HM (1995) Intracellular adhesion molecule-1 (ICAM-1) upregulation in human brain tumors as an expression of increased blood-brain permeability. Brain Pathol 5:339-344.
21. Lossinsky AS, Pluta R, Song MJ, Badmajew V, Moretz RC, Wisniewski HM (1991) Mechanisms of inflammatory cell attachment in chronic relapsing experimental allergic encephalomyelitis. A scanning and high-voltage electron microscopic study of the injured mouse blood-brain barrier. Microvasc Res 41: 299-310.
22. Lossinsky AS, Vorbrodt AW, Wisniewski HM (1986) Characterization of endothelial cell transport in the developing mouse blood-brain barrier. Dev Neurosci 8:61-75.
23. Lossinsky AS, Wisniewski HM, Dambska M, Mossakowski MJ (1997) Ultrastructural studies of PECAM-1/CD-31 expression in the developing mouse blood-brain barrier with the application of a pre-embedding technique. Folia Pathol 35: 163-169.
24. Marchesi VT, Gowans JL (1964) The migration of lymphocytes through the endothelium of venules in lymph nodes: an electron microscope study. Proc R Soc Lond B Biol Sci 159:283-290.
25. Marlin SD, Springer TA (1987) Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1). Cell 51:813-819.
26. Muller WA, Weigl SA, Deng X, Phillips DM (1993) PECAM-1 is required for transendothelial migration of leukocytes. J Exp Med 178:449-460.
27. Neumann H, Wekerle H (1998) Neuronal control of the immune response in the central nervous system: Linking brain immunity to neurodegeneration. J Neuropathol ExpNeurol 57:1-9.
28. Risau W, Hallman R, Albrecht U (1986) Differentiation-dependent expression of proteins in brain endothelium during development of the blood-brain barrier. Dev Biol 117:537-545.
29. Rosenblum WI, Murata S, Nelson GH, Werner PK, Ranken R, Harmon RC (1994) Anti-CD31 delays platelet adhesion/aggregation at sites of endothelial injury in mouse cerebral arterioles. Am J Pathol 145:33-36.
30. Schoefl GI (1972) The migration of lymphocytes across the vascular endothelium in lymphoid tissue. A reexamination. J Exp Med 136:568-588.
31. Sessa G, Perez MM (1975) Biochemical changes in rat brain associated with development of the blood-brain barrier. J Neurochem 25:779-782.
32. Sobel RA, Mitchell MA, Fondren G (1990) Intercellular adhesion molecule-1 (ICAM-1) in cellular immune reactions in the human central nervous system. Am J Pathol 136:1309-1316.
33. Spurr AR (1969) A low-viscosity epoxy resin embedding medium for electron microscopy. J Ultrasound Res 26:31-43.
34. Vorbrodt AW, Lossinsky AS, Dobrogowska DH, Wisniewski HM (1990) Sequential appearance of anionic domains in the developing blood-brain barrier. Dev Brain Res 52:31-37.
35. Vorbrodt AW, Lossinsky AS, Wisniewski HM (1986) Localization of alkaline phosphatase activity in endothelia of developing and mature mouse blood-brain barrier. Dev Neurosci 8:1-13.
36. Williams KC, Zhao RW, Ueno K, Hickey WF (1996) PECAM-1 (CD31) expression in the central nervous system and its role in experimental allergic encephalomyelitis in the rat. J Neurosci Res 45:747-757.
37. Wilson CB (1986) Immunologic basis for enhanced susceptibility of the neonate to infection. J Pediatr 108:1-12.
38. Wisniewski HM, Lossinsky AS (1991) Structural and functional aspects of the interaction of inflammatory cells with the blood-brain barrier in experimental brain inflammation. (Mini Review). Brain Pathol 1:89-96.
39. Zagzag D (1995) Angiogenic growth factors in neural embryogenesis and neoplasia. Am J Pathol 146:293-309.