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Volumn , Issue 70, 2006, Pages 111-117

The role of protein aggregates in neuronal pathology: Guilty, innocent, or just trying to help?

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE; OLIGOMER; PROTEIN; PROTEIN PARK 1; PROTEIN PARK 2; PROTEIN PARK 5; UNCLASSIFIED DRUG;

EID: 33750350994     PISSN: 03036995     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-211-45295-0_18     Document Type: Conference Paper
Times cited : (24)

References (64)
  • 3
    • 14644419638 scopus 로고    scopus 로고
    • Neuronal dysfunction in a polyglutamine disease model occurs in the absence of ubiquitin-proteasome system impairment and inversely correlates with the degree of nuclear inclusion formation
    • Bowman AB, Yoo SY, Dantuma NP, Zoghbi HY (2005) Neuronal dysfunction in a polyglutamine disease model occurs in the absence of ubiquitin-proteasome system impairment and inversely correlates with the degree of nuclear inclusion formation. Hum Mol Genet 14(5): 679-691
    • (2005) Hum Mol Genet , vol.14 , Issue.5 , pp. 679-691
    • Bowman, A.B.1    Yoo, S.Y.2    Dantuma, N.P.3    Zoghbi, H.Y.4
  • 4
    • 0036392590 scopus 로고    scopus 로고
    • Staging of the intracerebral inclusion body pathology associated with idiopathic Parkinson's disease (preclinical and clinical stages)
    • Braak H, Del Tredici K, Bratzke H, Hamm-Clement J, Sandmann-Keil D, Rub U (2002) Staging of the intracerebral inclusion body pathology associated with idiopathic Parkinson's disease (preclinical and clinical stages). J Neurol 249 [Suppl 3]: III/1-5
    • (2002) J Neurol , vol.249 , Issue.SUPPL. 3
    • Braak, H.1    Del Tredici, K.2    Bratzke, H.3    Hamm-Clement, J.4    Sandmann-Keil, D.5    Rub, U.6
  • 7
    • 0034776095 scopus 로고    scopus 로고
    • Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: Implications for Lewy-body formation in Parkinson disease
    • Chung KK, Zhang Y, Lim KL, Tanaka Y, Huang H, Gao J, Ross CA, Dawson VL, Dawson TM (2001) Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease. Nat Med 7(10): 1144-1150
    • (2001) Nat Med , vol.7 , Issue.10 , pp. 1144-1150
    • Chung, K.K.1    Zhang, Y.2    Lim, K.L.3    Tanaka, Y.4    Huang, H.5    Gao, J.6    Ross, C.A.7    Dawson, V.L.8    Dawson, T.M.9
  • 8
    • 0034681163 scopus 로고    scopus 로고
    • Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: Implications for pathogenesis and therapy
    • Conway KA, Lee SJ, Rochet JC, Ding TT, Williamson RE, Lansbury PT Jr (2000) Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy. Proc Natl Acad Sci USA 97(2): 571-576
    • (2000) Proc Natl Acad Sci USA , vol.97 , Issue.2 , pp. 571-576
    • Conway, K.A.1    Lee, S.J.2    Rochet, J.C.3    Ding, T.T.4    Williamson, R.E.5    Lansbury Jr., P.T.6
  • 12
    • 0032887585 scopus 로고    scopus 로고
    • Multiple system atrophy: A sporadic synucleinopathy
    • Dickson DW, Lin W, Liu WK, Yen SH (1999) Multiple system atrophy: a sporadic synucleinopathy. Brain Pathol 9(4): 721-732
    • (1999) Brain Pathol , vol.9 , Issue.4 , pp. 721-732
    • Dickson, D.W.1    Lin, W.2    Liu, W.K.3    Yen, S.H.4
  • 13
  • 14
    • 20444450523 scopus 로고    scopus 로고
    • Alpha-synuclein and parkin contribute to the assembly of ubiquitin lysine 63-linked multiubiquitin chains
    • Doss-Pepe EW, Chen L, Madura K (2005) Alpha-synuclein and parkin contribute to the assembly of ubiquitin lysine 63-linked multiubiquitin chains. J Biol Chem 280(17): 16619-16624
    • (2005) J Biol Chem , vol.280 , Issue.17 , pp. 16619-16624
    • Doss-Pepe, E.W.1    Chen, L.2    Madura, K.3
  • 15
  • 16
    • 0030579560 scopus 로고    scopus 로고
    • Prionics or the kinetic basis of prion diseases
    • Eigen M (1996) Prionics or the kinetic basis of prion diseases. Biophys Chem 63(1): A1-A18
    • (1996) Biophys Chem , vol.63 , Issue.1
    • Eigen, M.1
  • 19
    • 0034896748 scopus 로고    scopus 로고
    • Alzheimer's disease: Molecular concepts and therapeutic targets
    • Fassbender K, Masters C, Beyreuther K (2001) Alzheimer's disease: molecular concepts and therapeutic targets. Naturwissenschaften 88(6): 261-267
    • (2001) Naturwissenschaften , vol.88 , Issue.6 , pp. 261-267
    • Fassbender, K.1    Masters, C.2    Beyreuther, K.3
  • 20
    • 0036547110 scopus 로고    scopus 로고
    • Peptide inhibitors of beta amyloid aggregation
    • Findeis MA (2002) Peptide inhibitors of beta amyloid aggregation. Curr Top Med Chem 2(4): 417-423
    • (2002) Curr Top Med Chem , vol.2 , Issue.4 , pp. 417-423
    • Findeis, M.A.1
  • 23
    • 0343527226 scopus 로고    scopus 로고
    • Alpha-Synuclein immunoreactivity in dementia with Lewy bodies: Morphological staging and comparison with ubiquitin immunostaining
    • Gomez-Tortosa E, Newell K, Irizarry MC, Sanders JL, Hyman BT (2000) Alpha-Synuclein immunoreactivity in dementia with Lewy bodies: morphological staging and comparison with ubiquitin immunostaining. Acta Neuropathol (Berl) 99(4): 352-357
    • (2000) Acta Neuropathol (Berl) , vol.99 , Issue.4 , pp. 352-357
    • Gomez-Tortosa, E.1    Newell, K.2    Irizarry, M.C.3    Sanders, J.L.4    Hyman, B.T.5
  • 24
    • 0034612220 scopus 로고    scopus 로고
    • Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: Implications for Huntington's disease therapy
    • Heiser V, Scherzinger E, Boeddrich A, Nordhoff E, Lurz R, Schugardt N, Lehrach H, Wanker EE (2000) Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: implications for Huntington's disease therapy. Proc Natl Acad Sci USA 97(12): 6739-6744
    • (2000) Proc Natl Acad Sci USA , vol.97 , Issue.12 , pp. 6739-6744
    • Heiser, V.1    Scherzinger, E.2    Boeddrich, A.3    Nordhoff, E.4    Lurz, R.5    Schugardt, N.6    Lehrach, H.7    Wanker, E.E.8
  • 25
    • 0033811788 scopus 로고    scopus 로고
    • Nuclear localization or inclusion body formation of ataxin-2 are not necessary for SCA2 pathogenesis in mouse or human
    • Huynh DP, Figueroa K, Hoang N, Pulst SM (2000) Nuclear localization or inclusion body formation of ataxin-2 are not necessary for SCA2 pathogenesis in mouse or human. Nat Genet 26(1): 44-50
    • (2000) Nat Genet , vol.26 , Issue.1 , pp. 44-50
    • Huynh, D.P.1    Figueroa, K.2    Hoang, N.3    Pulst, S.M.4
  • 28
    • 0032840052 scopus 로고    scopus 로고
    • Neuronal intranuclear inclusions in spinocerebellar ataxia type 2: Triple-labeling immunofluorescent study
    • Koyano S, Uchihara T, Fujigasaki H, Nakamura A, Yagishita S, Iwabuchi K (1999) Neuronal intranuclear inclusions in spinocerebellar ataxia type 2: triple-labeling immunofluorescent study. Neurosci Lett 273(2): 117-120
    • (1999) Neurosci Lett , vol.273 , Issue.2 , pp. 117-120
    • Koyano, S.1    Uchihara, T.2    Fujigasaki, H.3    Nakamura, A.4    Yagishita, S.5    Iwabuchi, K.6
  • 29
    • 0036786139 scopus 로고    scopus 로고
    • Paradoxical absence of nuclear inclusion in cerebellar Purkinje cells of hereditary ataxias linked to CAG expansion
    • Koyano S, Iwabuchi K, Yagishita S, Kuroiwa Y, Uchihara T (2002) Paradoxical absence of nuclear inclusion in cerebellar Purkinje cells of hereditary ataxias linked to CAG expansion. J Neurol Neurosurg Psychiatry 73(4): 450-452
    • (2002) J Neurol Neurosurg Psychiatry , vol.73 , Issue.4 , pp. 450-452
    • Koyano, S.1    Iwabuchi, K.2    Yagishita, S.3    Kuroiwa, Y.4    Uchihara, T.5
  • 33
    • 0036797038 scopus 로고    scopus 로고
    • Synphilin-1 degradation by the ubiquitinproteasome pathway and effects on cell survival
    • Lee G, Junn E, Tanaka M, Kim YM, Mouradian MM (2002) Synphilin-1 degradation by the ubiquitinproteasome pathway and effects on cell survival. J Neurochem 83(2): 346-352
    • (2002) J Neurochem , vol.83 , Issue.2 , pp. 346-352
    • Lee, G.1    Junn, E.2    Tanaka, M.3    Kim, Y.M.4    Mouradian, M.M.5
  • 35
    • 0037131567 scopus 로고    scopus 로고
    • The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility
    • Liu Y, Fallon L, Lashuel HA, Liu Z, Lansbury PT Jr (2002) The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility. Cell 111(2): 209-218
    • (2002) Cell , vol.111 , Issue.2 , pp. 209-218
    • Liu, Y.1    Fallon, L.2    Lashuel, H.A.3    Liu, Z.4    Lansbury Jr., P.T.5
  • 36
    • 0034701278 scopus 로고    scopus 로고
    • Repeat instability and motor incoordination in mice with a targeted expanded CAG repeat in the Seal locus
    • Lorenzetti D, Watase K, Xu B, Matzuk MM, Orr HT, Zoghbi HY (2000) Repeat instability and motor incoordination in mice with a targeted expanded CAG repeat in the Seal locus. Hum Mol Genet 9(5): 779-785
    • (2000) Hum Mol Genet , vol.9 , Issue.5 , pp. 779-785
    • Lorenzetti, D.1    Watase, K.2    Xu, B.3    Matzuk, M.M.4    Orr, H.T.5    Zoghbi, H.Y.6
  • 37
    • 0028172886 scopus 로고
    • Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red
    • Lorenzo A, Yankner BA (1994) Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red. Proc Natl Acad Sci USA 91(25): 12243-12247
    • (1994) Proc Natl Acad Sci USA , vol.91 , Issue.25 , pp. 12243-12247
    • Lorenzo, A.1    Yankner, B.A.2
  • 41
    • 3042794162 scopus 로고    scopus 로고
    • Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease
    • McNaught KS, Perl DP, Brownell AL, Olanow CW (2004) Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease. Ann Neurol 56(1): 149-162
    • (2004) Ann Neurol , vol.56 , Issue.1 , pp. 149-162
    • McNaught, K.S.1    Perl, D.P.2    Brownell, A.L.3    Olanow, C.W.4
  • 42
    • 0041691176 scopus 로고    scopus 로고
    • Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington's disease with 140 CAG repeats
    • Menalled LB, Sison JD, Dragatsis I, Zeitlin S, Chesselet MF (2003) Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington's disease with 140 CAG repeats. J Comp Neurol 465(1): 11-26
    • (2003) J Comp Neurol , vol.465 , Issue.1 , pp. 11-26
    • Menalled, L.B.1    Sison, J.D.2    Dragatsis, I.3    Zeitlin, S.4    Chesselet, M.F.5
  • 43
    • 0036848793 scopus 로고    scopus 로고
    • Purification of polyglutamine aggregates and identification of elongation factor-1alpha and heat shock protein 84 as aggregate-interacting proteins
    • Mitsui K, Nakayama H, Akagi T, Nekooki M, Ohtawa K, Takio K, Hashikawa T, Nukina N (2002) Purification of polyglutamine aggregates and identification of elongation factor-1alpha and heat shock protein 84 as aggregate-interacting proteins. J Neurosci 22(21): 9267-9277
    • (2002) J Neurosci , vol.22 , Issue.21 , pp. 9267-9277
    • Mitsui, K.1    Nakayama, H.2    Akagi, T.3    Nekooki, M.4    Ohtawa, K.5    Takio, K.6    Hashikawa, T.7    Nukina, N.8
  • 45
    • 0025950987 scopus 로고
    • A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease
    • Murrell J, Farlow M, Ghetti B, Benson MD (1991) A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease. Science 254(5028): 97-99
    • (1991) Science , vol.254 , Issue.5028 , pp. 97-99
    • Murrell, J.1    Farlow, M.2    Ghetti, B.3    Benson, M.D.4
  • 48
    • 0031859927 scopus 로고    scopus 로고
    • The prion diseases
    • Prusiner SB (1998) The prion diseases. Brain Pathol 8(3): 499-513
    • (1998) Brain Pathol , vol.8 , Issue.3 , pp. 499-513
    • Prusiner, S.B.1
  • 52
    • 0037461730 scopus 로고    scopus 로고
    • Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders
    • Sanchez I, Mahlke C, Yuan J (2003) Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders. Nature 421(6921): 373-379
    • (2003) Nature , vol.421 , Issue.6921 , pp. 373-379
    • Sanchez, I.1    Mahlke, C.2    Yuan, J.3
  • 58
    • 0035411641 scopus 로고    scopus 로고
    • Beta-amyloid aggregation inhibitors for the treatment of Alzheimer's disease: Dream or reality?
    • Talaga P (2001) Beta-amyloid aggregation inhibitors for the treatment of Alzheimer's disease: dream or reality? Mini Rev Med Chem 1(2): 175-186
    • (2001) Mini Rev Med Chem , vol.1 , Issue.2 , pp. 175-186
    • Talaga, P.1
  • 59
    • 0036432244 scopus 로고    scopus 로고
    • The presenilins
    • reviews 3014
    • Tandon A, Fraser P (2002) The presenilins. Genome Biol 3(11): reviews 3014
    • (2002) Genome Biol , vol.3 , Issue.11
    • Tandon, A.1    Fraser, P.2
  • 60
    • 0028878943 scopus 로고
    • Inherited prion diseases and transmission to rodents
    • Tateishi J, Kitamoto T (1995) Inherited prion diseases and transmission to rodents. Brain Pathol 5(1): 53-59
    • (1995) Brain Pathol , vol.5 , Issue.1 , pp. 53-59
    • Tateishi, J.1    Kitamoto, T.2
  • 62
    • 12944335007 scopus 로고    scopus 로고
    • Reversal of a full-length mutant huntingtin neuronal cell phenotype by chemical inhibitors of polyglutamine-mediated aggregation
    • Wang J, Gines S, MacDonald ME, Gusella JF (2005) Reversal of a full-length mutant huntingtin neuronal cell phenotype by chemical inhibitors of polyglutamine-mediated aggregation. BMC Neurosci 6(1): 1
    • (2005) BMC Neurosci , vol.6 , Issue.1 , pp. 1
    • Wang, J.1    Gines, S.2    MacDonald, M.E.3    Gusella, J.F.4
  • 64
    • 0034094873 scopus 로고    scopus 로고
    • Glutamine repeats and neurodegeneration
    • Zoghbi HY, Orr HT (2000) Glutamine repeats and neurodegeneration. Annu Rev Neurosci 23: 217-247
    • (2000) Annu Rev Neurosci , vol.23 , pp. 217-247
    • Zoghbi, H.Y.1    Orr, H.T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.