Synphilin-1 degradation by the ubiquitin-proteasome pathway and effects on cell survival

Journal of Neurochemistry

Volumn 83, Issue 2, 2002, Pages 346-352

  Lee, Gwang ^a,c   Junn, Eunsung ^a   Tanaka, Mikiei ^a   Kim, Yong Man ^a   Lee, Sang Seop ^a,d   Mouradian, M Maral ^a,b  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^c Ajou University School of Medicine   (South Korea)

^d Inje University   (South Korea)

Author keywords

synuclein; Inclusion; Parkinson; Proteasome; Synphilin 1; Ubiquitin

Indexed keywords

ALPHA SYNUCLEIN; PROTEASOME; SYNPHILIN 1; UBIQUITIN; UNCLASSIFIED DRUG;

ARTICLE; CELL INCLUSION; CELL LYSATE; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DNA LIBRARY; DOPAMINERGIC NERVE CELL; EXPRESSED SEQUENCE TAG; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LEWY BODY; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROCESSING;

ACETYLCYSTEINE; ALPHA-SYNUCLEIN; ANIMALS; BLOTTING, WESTERN; CARRIER PROTEINS; CELL LINE; CELL SURVIVAL; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; DIMETHYL SULFOXIDE; HUMANS; INCLUSION BODIES; KIDNEY; LEUPEPTINS; MACROMOLECULAR SUBSTANCES; MICE; MULTIENZYME COMPLEXES; NERVE TISSUE PROTEINS; NEUROBLASTOMA; PRECIPITIN TESTS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN PROCESSING, POST-TRANSLATIONAL; SYNUCLEINS; TRANSFECTION; UBIQUITIN;

EID: 0036797038     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2002.01136.x     Document Type: Article

References (29)

1. Alves-Rodrigues A., Gregori L. and Figueiredo-Pereira M. E. (1998) Ubiquitin, cellular inclusions and their role in neurodegeneration. Trends Neurosci. 21, 516-520.
2. Bennett M. C., Bishop J. F., Leng Y., Chock P. B., Chase T. N. and Mouradian M. M. (1999) Degradation of alpha-synuclein by proteasome. J. Biol. Chem 274, 33855-33858.
3. Choi P., Ostrerova-Golts N., Sparkman D., Cochran E., Lee J. M. and Wolozin B. (2000) Parkin is metabolized by the ubiquitin/proteosome system. Neuroreport 11, 2635-2638.
4. Chung K. K., Zhang Y., Lim K. L., Tanaka Y., Huang H., Gao J., Ross C. A., Dawson V. L. and Dawson T. M. (2001) Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease. Nat. Med. 7, 1144- 1150.
5. Ciechanover A., Orian A. and Schwartz A. L. (2000) The ubiquitin-mediated proteolytic pathway: mode of action and clinical implications. J. Cell Biochem. 77, 40-51.
6. Engelender S., Kaminsky Z., Guo X., Sharp A. H., Amaravi R. K., Kleiderlein J. J., Margolis R. L., Troncoso J. C., Lanahan A. A., Worley P. F., Dawson V. L., Dawson T. M. and Ross C. A. (1999) Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions. Nat. Genet. 22, 110-114.
7. Fomo L. S. (1996) Neuropathology of Parkinson's disease. J. Neuropathol. Exp. Neurol. 55, 259-272.
8. Han H., Weinreb P. H. and Lansbury P. T. Jr (1995) The core Alzheimer's peptide NAC forms amyloid fibrils which seed and are seeded by beta-amyloid: is NAC a common trigger or target in neurodegenerative disease? Chem. Biol. 2, 163-169.
9. Ii K., Ito H., Tanaka K. and Hirano A. (1997) Immunocytochemical co-localization of the proteasome in ubiquitinated structures in neurodegenerative diseases and the elderly. J. Neuropathol. Exp. Neurol. 56, 125-131.
10. Imai Y., Soda M. and Takahashi R. (2000) Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity. J. Biol. Chem. 275, 35661-35664.
11. Imai Y., Soda M., Inoue H., Hattori N., Mizuno Y. and Takahashi R. (2001) An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin. Cell 105, 891-902.
12. Irizarry M. C., Growdon W., Gomez-Isla T., Newell K., George J. M., Clayton D. F. and Hyman B. T. (1998) Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain alpha-synuclein immunoreactivity. J. Neuropathol. Exp. Neurol. 57, 334-337.
13. Iwatsubo T., Yamaguchi H., Fujimuro M., Yokosawa H., Ihara Y., Trojanowski J. Q. and Lee V. M. (1996) Purification and characterization of Lewy bodies from the brains of patients with diffuse Lewy body disease. Am. J. Pathol. 148, 1517-1529.
14. Kawamata H., McLean P. J., Sharma N. and Hyman B. T. (2001) Interaction of alpha-synuclein and synphilin-1: effect of Parkinson's disease-associated mutations. J. Neurochem. 77, 929-934.
15. Kitada T., Asakawa S., Hattori N., Matsumine H., Yamamura Y., Minoshima S., Yokochi M., Mizuno Y. and Shimizu N. (1998) Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature 392, 605-608.
16. Leroy E., Boyer R., Auburger G., Leube B., Ulm G., Mezey E., Harta G., Brownstein M. J., Jonnalagada S., Chemova T., Dehejia A., Lavedan C., Gasser T., Steinbach P. J., Wilkinson K. D. and Polymeropoulos M. H. (1998) The ubiquitin pathway in Parkinson's disease. Nature 395, 451-452.
17. Lowe J., McDermott H., Landon M., Mayer R. J. and Wilkinson K. D. (1990) Ubiquitin carboxyl-terminal hydrolase (PGP 9.5) is selectively present in ubiquitinated inclusion bodies characteristic of human neurodegenerative diseases. J. Pathol. 161, 153-160.
18. McNaught K. S. and Jenner P. (2001) Proteasomal function is impaired in substantia nigra in Parkinson's disease. Neurosci. Lett. 297, 191-194.
19. McNaught K. S., Olanow C. W., Halliwell B., Isacson O. and Jenner P. (2001) Failure of the ubiquitin-proteasome system in Parkinson's disease. Nat. Rev. Neurosci. 2, 589-594.
20. Mouradian M. M. (2002) Recent advances in the genetics and pathogenesis of Parkinson disease. Neurology 58, 179-185.
21. O'Farrell C., Murphy D. D., Petrucelli L., Singleton A. B., Hussey J., Farrer M., Hardy J., Dickson D. W. and Cookson M. R. (2001) Transfected synphilin-1 forms cytoplasmic inclusions in HEK293 cells. Brain Res. Mol Brain Res. 97, 94-102.
22. Polymeropoulos M. H., Lavedan C., Leroy E., Ide S. E., Dehejia A., Dutra A., Pike B., Root H., Rubenstein J., Boyer R., Stenroos E. S., Chandrasekharappa S., Athanassiadou A., Papapetropoulos T., Johnson W. G., Lazzarini A. M., Duvoisin R. C., Di Iorio G., Golbe L. I. and Nussbaum R. L. (1997) Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 276, 2045-2047.
23. Rideout H. J., Larsen K. E., Sulzer D. and Stefanis L. (2001) Proteasomal inhibition leads to formation of ubiquitin/alpha-synuclein-immunoreactive inclusions in PC12 cells. J. Neurochem. 78, 899-908.
24. Shimura H., Hattori N., Kubo S., Yoshikawa M., Kitada T., Matsumine H., Asakawa S., Minoshima S., Yamamura Y., Shimizu N. and Mizuno Y. (1999) Immunohistochemical and subcellular localization of Parkin protein: absence of protein in autosomal recessive juvenile parkinsonism patients. Ann. Neurol. 45, 668-672.
25. Shimura H., Hattori N., Kubo S., Mizuno Y., Asakawa S., Minoshima S., Shimizu N., Iwai K., Chiba T., Tanaka K. and Suzuki T. (2000) Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase. Nat. Genet. 25, 302-305.
26. Spillantini M. G., Crowther R. A., Jakes R., Hasegawa M. and Goedert M. (1998) Alpha-synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies. Proc. Natl Acad. Sci. USA 95, 6469-6473.
27. Wakabayashi K., Hayashi S., Kakita A., Yamada M., Toyoshima Y., Yoshimoto M. and Takahashi H. (1998) Accumulation of alpha- synuclein/NACP is a cytopathological feature common to Lewy body disease and multiple system atrophy. Acta Neuropathol. (Berl) 96, 445-452.
28. Wakabayashi K., Engelender S., Yoshimoto M., Tsuji S., Ross C. A. and Takahashi H. (2000) Synphilin-1 is present in Lewy bodies in Parkinson's disease. Ann. Neurol. 47, 521-523.
29. Zhang Y., Gao J., Chung K. K., Huang H., Dawson V. L. and Dawson T. M. (2000) Parkin functions as an E2-dependent ubiquitin-protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1. Proc. Natl Acad. Sci. USA 97, 13354-13359.