Hyperforin prevents β-amyloid neurotoxicity and spatial memory impairments by disaggregation of Alzheimer's amyloid-β-deposits

Molecular Psychiatry

Volumn 11, Issue 11, 2006, Pages 1032-1048

  Dinamarca, M C ^a   Cerpa, W ^a   Garrido, J ^b   Hancke, J L ^c   Inestrosa, N C ^a,b  

^a UNIVERSIDAD ANDRÉS BELLO   (Chile)

^b PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^c UNIVERSIDAD AUSTRAL DE CHILE   (Chile)

Author keywords

Amyloid peptide; Disaggregation; Hyperforin; Neurotoxicity; Spatial learning

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; HYPERFORIN; HYPERICUM PERFORATUM EXTRACT; REACTIVE OXYGEN METABOLITE;

ALZHEIMER DISEASE; AMYLOIDOSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR DISORDER; BRAIN NERVE CELL; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; HIPPOCAMPUS; MALE; MEMORY DISORDER; NEUROPATHOLOGY; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; RAT;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOIDOSIS; ANALYSIS OF VARIANCE; ANIMALS; BICYCLO COMPOUNDS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; ESCAPE REACTION; HIPPOCAMPUS; HYPERICUM; MALE; MAZE LEARNING; MICROINJECTIONS; NEUROPROTECTIVE AGENTS; PHLOROGLUCINOL; PHYTOTHERAPY; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; TERPENES; TIME FACTORS;

EID: 33750284656     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/sj.mp.4001866     Document Type: Article

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