Attenuation of staurosporine-induced apoptosis, oxidative stress, and mitochondrial dysfunction by synthetic superoxide dismutase and catalase mimetics, in cultured cortical neurons

Experimental Neurology

Volumn 171, Issue 1, 2001, Pages 84-97

  Pong, Kevin ^a   Doctrow, Susan R ^b   Huffman, Karl ^b   Adinolfi, Christy A ^b   Baudry, Michel ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b Eukarion Inc   (United States)

Author keywords

Apoptosis; Catalase; Nuerodegenerative disease; Oxidative stree; Reactive oxygen species; Staurosporine; Superoxide dismutase

Indexed keywords

ACETYLASPARTYLGLUTAMYLVALYLASPARTALDEHYDE; ACETYLTYROSYLVALYLALANYLASPARTALDEHYDE; CASPASE INHIBITOR; CATALASE; CYTOCHROME C; ENZYME ACTIVATOR; EUK 189; FLUORESCEIN DERIVATIVE; LACTATE DEHYDROGENASE; MANGANESE N,N' ETHYLENEBIS(3 METHOXYSALICYLIDENEAMINE); REACTIVE OXYGEN METABOLITE; STAUROSPORINE; SUPEROXIDE DISMUTASE; TRYPAN BLUE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN MITOCHONDRION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG EFFECT; DRUG EFFICACY; DRUG EXPOSURE; ENZYME RELEASE; LIPID PEROXIDATION; NERVE CELL CULTURE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; TIME;

EID: 0034853453     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.2001.7747     Document Type: Article

References (65)

1. Synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: A key role for reactive oxygen species in ischemic brain injury
2. Salen-manganese complexes are superoxide dismutase mimics
3. Induction of a common pathway of apoptosis by staurosporine
4. Neuronal apoptosis: Genetic and biochemical modulation
5. Neural apoptosis
6. Beta-amyloid toxicity in organotypic hippocampal cultures: Protection by EUK-8, a synthetic catalytic free radical scavenger
7. Caspases: The executioners of apoptosis
8. Regulation of lymphocyte survival by the Bcl-2 gene family
9. A mimic of superoxide dismutase activity based upon desferrioxamine B and manganese IV
10. A metalloporphyrin superoxide dismutase mimetic protects against paraquat-induced lung injury in vivo
11. A metalloporphyrin superoxide dismutase mimetic protects against paraquat-induced endothelial injury in vitro
12. Manganic porphyrins possess catalase activity and protect endothelial cells against hydrogen peroxide-mediated injury
13. Salen-manganese complexes: Combined superoxide dismutase/catalase mimics with broad pharmacological efficacy
14. Activation of a caspase-3 related cysteine protease is required for glutamate-mediated apoptosis of cultured cerebellar granule neurons
15. The role of CED-3-related cysteine proteases in apoptosis of cerebellar granule cells
16. Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis
17. Stable Mn (III) porphyrins mimic superoxide dismutase in vitro and substitutes for it in vivo
18. 2+ -mediated endogenous endonuclease activation in apoptotic thymocytes
19. EUK-8, a synthetic superoxide dismutase and catalase mimetic ameliorates acute lung injury in endotoxemic swine
20. Oxidative stress and apoptosis in HIV infection: A role for plant-derived metabolites with synergistic antioxidant activity
21. Drug antioxidant effects. A basis for drug selection
22. Reactive oxygen species and the central nervous system
23. Programmed cell death in the developing nervous system
24. 3H]-staurosporine on various protein kinases
25. Bcl-2 is an inner mitochondrial membrahe protein that blocks programmed cell death
26. Bcl-2 functions in an antioxidant pathway to prevent apoptosis
27. Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA
28. Programmed cell death and Bcl-2 protection in the absence of a nucleus
29. Programmed cell death and Bcl-2 protection in very low oxygen
30. Role of Ced-3/ICE-family proteases in stanrosporme induced programmed cell death
31. Programmed cell death in animal development
32. Synthetic superoxide dismutase/catalase mimetics reduce oxidative stress and prolong survival in a mouse amyotrophic lateral sclerosis model
33. Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay
34. Staurosporine-induced neuronal apoptosis
35. Mitochondrial control of apoptosis
36. Staurosporine-induced apoptosis of cultured rat hippocampal neurons involves caspase-1-like proteases as upstream initiators and increased production of superoxide as a main downstream effector
37. Mitochondrial depolarization is not required for neuronal apoptosis
38. Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice
39. Preparation and characterization of Mn-salophen complex with superoxide scavenging activity
40. Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
41. Inactivation of catacholamines by superoxide gives new insights on the pathogenesis of septic shock
42. Extension of life-span with superoxide dismutase/catalase mimetics
43. Effects of EUK-8, a synthetic catalytic superoxide scavenger, on hypoxia-and acidosis-induced damage in hippocampal slices
44. Apoptosis by death factor
45. Mitochondrial phospholipid hydroperoxide glutathione peroxidase suppresses apoptosis mediated by a mitochondrial death pathway
46. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
47. Cell death during development of the nervous system
48. Requirement for superoxide in excitotoxic cell death
49. Inhibition of neuronal apoptosis by a metalloporphyrin superoxide dismutase mimic
50. β-amyloid neurotoxicity in vitro: Evidence of oxidative stress by not protection by antioxidants
51. Inhibition of glial cell line-derived neurotrophic factor induced intracellular activity by K-252b on dopaminergic neurons
52. Prevention of 1-methyl-4-phenylpyridinium-and 6-hydroxydopamine-induced nitration of tyrosine hydroxylase and neurotoxicity by EUK-134, a superoxide dismutase and catalase mimetic, in cultured dopaminergic neurons
53. 2+: Their relationship to apoptosis and oncogenesis
54. Manganese macrocyclic ligand complexes as mimics of SOD
55. EUK-134, a synthetic superoxide dismutase and catalase mimetic, prevents oxidative stress and attenuates kainate-induced neuropathology
56. Staurosporine, K-252, and UCN-01: Potent but nonspecific inhibitors of protein kinases
57. A nonpeptidyl mimic of superoxide dismutase with therapeutic activity in rats
58. Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xl
59. Mechanisms and genes of cellular suicide
60. Bcl-2 inhibits the mitochondrial release of an apoptogenic protease
61. Evaluation of the relative contribution of nitric oxide and peroxynitrite in the suppression of mitochondrial respiration in immunostimulated macrophages using a manganese mesophrphyrin superoxide dismutase mimetic and peroxynitrite scavenger
62. 2+-dependent protein kinase
63. Apoptosis in the pathogenesis and treatment of disease
64. Manganese-based superoxide dismutase mimetics inhibit neutrophil in vivo