Synthesis and biological activity of Akt/PI3K inhibitors

Mini-Reviews in Medicinal Chemistry

Volumn 6, Issue 10, 2006, Pages 1127-1136

  Redaelli, Cristina ^a   Granucci, F ^a   De Gioia, L ^a   Cipolla, Laura ^a  

^a UNIVERSITY OF MILANO BICOCCA   (Italy)

Author keywords

Akt; Allosteric inhibitors; Cancer; Kinase inhibitors; Kinases; Phosphatidylinositol; Phosphatidylinositol analogues; PI3K

Indexed keywords

11 O DESACETYLWORTMANNIN; 2 MORPHOLINO 8 PHENYLCHROMONE; 2,3 DIPHENYLQUINOXALINE; ANTINEOPLASTIC AGENT; CARBONIC ACID DERIVATIVE; DEXTRO 3 DEOXYCARBONATEMYOINOSITOL ETHER LIPID; DEXTRO 3 DEOXYMYOINOSITOL DERIVATIVE; DEXTRO 3 DEOXYPHOSPHATIDYLMYOINOSITOL ETHER LIPID; INOSITOL 1,3,4,5,6 PENTAKISPHOSPHATE; INOSITOL 1,4,5,6 TETRAKISPHOSPHATE; INOSITOL 3,4,5, TRISPHOSPHATE; INOSITOL POLYPHOSPHATE; N (2 HYDROXYPROPYL)METHACRYLAMIDE; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHOTRANSFERASE INHIBITOR; PHYTIC ACID; PROTEIN KINASE B INHIBITOR; PROTEIN SERINE THREONINE KINASE; SULFOXIDE; UNCLASSIFIED DRUG; WORTMANNIN;

ANTINEOPLASTIC ACTIVITY; BIOLOGICAL ACTIVITY; CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CONCENTRATION RESPONSE; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; IC 50; NONHUMAN; REVIEW; STRUCTURE ACTIVITY RELATION; SYSTEMATIC REVIEW;

1-PHOSPHATIDYLINOSITOL 3-KINASE; CELL PROLIFERATION; HUMANS; INOSITOL; MOLECULAR STRUCTURE; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN CONFORMATION; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33749512191     PISSN: 13895575     EISSN: None     Source Type: Journal    
DOI: 10.2174/138955706778560139     Document Type: Review

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