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Volumn 58, Issue 22, 1998, Pages 5239-5247

The presence of a constitutively active phosphoinositide 3-kinase in small cell lung cancer cells mediates anchorage-independent proliferation via a protein kinase B and p70(s6k)-dependent pathway

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE;

EID: 0032534025     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (149)

References (49)
  • 1
    • 0030876445 scopus 로고    scopus 로고
    • Small cell lung cancer: State of the art therapy in 1996
    • Elias, A. D. Small cell lung cancer: state of the art therapy in 1996. Chest, 772: 251S-258S, 1997.
    • (1997) Chest , vol.772
    • Elias, A.D.1
  • 2
    • 0029789038 scopus 로고    scopus 로고
    • Inhibition of neuropeptide-stimulated tyrosine phosphorylation and tyrosine kinase activity stimulates apoptosis in small cell lung cancer cells
    • Tallett, A., Chilvers, E. R., Hannah, S., Dransfield, I., Lawson, M. F., Haslett, C., and Sethi, T. Inhibition of neuropeptide-stimulated tyrosine phosphorylation and tyrosine kinase activity stimulates apoptosis in small cell lung cancer cells. Cancer Res., 56; 4255-4263, 1996.
    • (1996) Cancer Res. , vol.56 , pp. 4255-4263
    • Tallett, A.1    Chilvers, E.R.2    Hannah, S.3    Dransfield, I.4    Lawson, M.F.5    Haslett, C.6    Sethi, T.7
  • 3
    • 0024601010 scopus 로고
    • PDGF-dependent tyrosine phosphorylation stimulates production of novel phosphoinositides in intact cells
    • Auger, K. R., Serunian, L. A., Soltoff, S. P., Libby, P., and Cantley, L. C. PDGF-dependent tyrosine phosphorylation stimulates production of novel phosphoinositides in intact cells. Cell, 57: 167-175, 1989.
    • (1989) Cell , vol.57 , pp. 167-175
    • Auger, K.R.1    Serunian, L.A.2    Soltoff, S.P.3    Libby, P.4    Cantley, L.C.5
  • 5
    • 0025731596 scopus 로고
    • Pathway of phosphatidylinositol (3,4,5)-trisphosphate synthesis in activated neutrophils
    • Stephens, L. R., Hughes, K. T., and Irvine, R. F. Pathway of phosphatidylinositol (3,4,5)-trisphosphate synthesis in activated neutrophils. Nature (Lond.), 351: 33-39, 1991.
    • (1991) Nature (Lond.) , vol.351 , pp. 33-39
    • Stephens, L.R.1    Hughes, K.T.2    Irvine, R.F.3
  • 6
    • 0027366440 scopus 로고
    • Agonist-stimulated synthesis of phosphatidylinositol (3,4,5)-trisphosphate: A new intracellular signalling system?
    • Stephens, L. R., Jackson, T. R., and Hawkins, P. T. Agonist-stimulated synthesis of phosphatidylinositol (3,4,5)-trisphosphate: a new intracellular signalling system? Biochim. Biophys. Acta, 7779: 27-75, 1993.
    • (1993) Biochim. Biophys. Acta , vol.7779 , pp. 27-75
    • Stephens, L.R.1    Jackson, T.R.2    Hawkins, P.T.3
  • 7
    • 0025611910 scopus 로고
    • Phosphoinositide kinases
    • Carpenter, C. L., and Cantley, L. C. Phosphoinositide kinases. Biochemistry, 29: 11147-11156, 1990.
    • (1990) Biochemistry , vol.29 , pp. 11147-11156
    • Carpenter, C.L.1    Cantley, L.C.2
  • 8
    • 0023897684 scopus 로고
    • Type 1 phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate
    • Whitman, M., Downes, C. P., Keeler, M., Keller, T., and Cantley, L. Type 1 phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate. Nature (Lond.), 332: 644-646, 1988.
    • (1988) Nature (Lond.) , vol.332 , pp. 644-646
    • Whitman, M.1    Downes, C.P.2    Keeler, M.3    Keller, T.4    Cantley, L.5
  • 9
    • 0030839766 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase is required for integrin stimulated and raf-1/mitogen-activated protein kinase pathway activation
    • King, W. G., Mattaliano, M. D., Chan, T. O., Tsichlis, P. N., and Brugge, J. S. Phosphatidylinositol 3-kinase is required for integrin stimulated and raf-1/mitogen-activated protein kinase pathway activation. Mol. Cell. Biol., 17: 4406-4418, 1997.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 4406-4418
    • King, W.G.1    Mattaliano, M.D.2    Chan, T.O.3    Tsichlis, P.N.4    Brugge, J.S.5
  • 10
    • 0027432424 scopus 로고
    • Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: The role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses
    • Arcaro, A., and Wymann, M. P. Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses. Biochem. J., 296: 297-301, 1993.
    • (1993) Biochem. J. , vol.296 , pp. 297-301
    • Arcaro, A.1    Wymann, M.P.2
  • 11
    • 0028170210 scopus 로고
    • A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1 -benzopyran-4-one (LY294002)
    • Vlahos, C. J., Matter, W. F., Hui, K. Y., and Brown, R. F. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1 -benzopyran-4-one (LY294002). J. Biol. Chem., 269: 5241-5248, 1994.
    • (1994) J. Biol. Chem. , vol.269 , pp. 5241-5248
    • Vlahos, C.J.1    Matter, W.F.2    Hui, K.Y.3    Brown, R.F.4
  • 13
    • 0031456065 scopus 로고    scopus 로고
    • Activation of phosphoinositide 3-OH kinase by the α6β4 integrin promotes carcinoma invasion
    • Shaw, L. M., Rabinovitz, I., Wang, H. H., Toker, A., and Mercurio, A. M. Activation of phosphoinositide 3-OH kinase by the α6β4 integrin promotes carcinoma invasion. Cell, 97: 949-960, 1997.
    • (1997) Cell , vol.97 , pp. 949-960
    • Shaw, L.M.1    Rabinovitz, I.2    Wang, H.H.3    Toker, A.4    Mercurio, A.M.5
  • 14
    • 0031459917 scopus 로고    scopus 로고
    • Cdc42 and Rac 1 induce integrin-mediated cell motility and invasiveness through PI(3)K
    • Keely, P. J., Westwick, J. K., Whitehead, I. P., Der, C. J., and Parise, L. V. Cdc42 and Rac 1 induce integrin-mediated cell motility and invasiveness through PI(3)K. Nature (Lond.), 390: 632-636, 1997.
    • (1997) Nature (Lond.) , vol.390 , pp. 632-636
    • Keely, P.J.1    Westwick, J.K.2    Whitehead, I.P.3    Der, C.J.4    Parise, L.V.5
  • 17
    • 0028788935 scopus 로고
    • The 70 kDa S6 kinase: Regulation of a kinase with multiple roles in mitogenic signalling
    • Chou, M. M., and Blenis, J. The 70 kDa S6 kinase: regulation of a kinase with multiple roles in mitogenic signalling. Curr. Opin. Cell. Biol., 7: 806-814, 1995.
    • (1995) Curr. Opin. Cell. Biol. , vol.7 , pp. 806-814
    • Chou, M.M.1    Blenis, J.2
  • 18
    • 0027983480 scopus 로고
    • Positive regulation of the cAMP-responsive activator CREM by the p70 S6 kinase: An alternative route to mitogen-induced gene expression
    • De Groot, R. P., Ballou, L. M., and Sassone-Corsi, P. Positive regulation of the cAMP-responsive activator CREM by the p70 S6 kinase: an alternative route to mitogen-induced gene expression. Cell, 79: 81-91, 1994.
    • (1994) Cell , vol.79 , pp. 81-91
    • De Groot, R.P.1    Ballou, L.M.2    Sassone-Corsi, P.3
  • 19
    • 0029794614 scopus 로고    scopus 로고
    • S6k phosphorylation, cell proliferation and colony formation in small cell lung cancer cells
    • S6k phosphorylation, cell proliferation and colony formation in small cell lung cancer cells. Cancer Res., 56: 3895-3897, 1996.
    • (1996) Cancer Res. , vol.56 , pp. 3895-3897
    • Seufferlein, T.1    Rozengurt, E.2
  • 20
    • 0026095665 scopus 로고
    • A retroviral oncogene, Akt, encoding a serine-threonine kinase containing an SH2-like region
    • Washington DC
    • Bellacosa, A., Testa, J. R., Staal, S. P., and Tsichlis, P. N. A retroviral oncogene, Akt, encoding a serine-threonine kinase containing an SH2-like region. Science (Washington DC), 254: 274-277, 1991.
    • (1991) Science , vol.254 , pp. 274-277
    • Bellacosa, A.1    Testa, J.R.2    Staal, S.P.3    Tsichlis, P.N.4
  • 21
    • 0031053360 scopus 로고    scopus 로고
    • Akt signaling: Linking membrane events to life and death decisions
    • Washington DC
    • Hemmings, B. A. Akt signaling: linking membrane events to life and death decisions. Science (Washington DC), 275: 628-630, 1997.
    • (1997) Science , vol.275 , pp. 628-630
    • Hemmings, B.A.1
  • 22
    • 0001457668 scopus 로고    scopus 로고
    • Amplification of AKT2 in human pancreatic cancer cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA
    • Cheng, J. Q., Ruggeri, B., Klein, W. M., Sonoda, G., Altomare, D. A., Watson, D. K., and Testa, A. Amplification of AKT2 in human pancreatic cancer cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA. Proc. Natl. Acad. Sci. USA, 93: 3636-3641, 1996.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 3636-3641
    • Cheng, J.Q.1    Ruggeri, B.2    Klein, W.M.3    Sonoda, G.4    Altomare, D.A.5    Watson, D.K.6    Testa, A.7
  • 24
    • 0016318441 scopus 로고
    • Cellular tumorigenicity in nude mice: Correlation with cell growth in semi-solid medium
    • Freedman, V., and Shin, S. Cellular tumorigenicity in nude mice: correlation with cell growth in semi-solid medium. Cell, 3: 355-359, 1974.
    • (1974) Cell , vol.3 , pp. 355-359
    • Freedman, V.1    Shin, S.2
  • 25
    • 0030661566 scopus 로고    scopus 로고
    • Integrins, oncogenes and anchorage independence
    • Schwartz, M. A. Integrins, oncogenes and anchorage independence. J. Cell. Biol., 139: 575-578, 1997.
    • (1997) J. Cell. Biol. , vol.139 , pp. 575-578
    • Schwartz, M.A.1
  • 26
    • 0024444825 scopus 로고
    • Long-term exposure to retrovirally expressed granulocyte-colony-stimulating factor induces a nonneoplastic granulocytic and progenitor cell hyperplasia without tissue damage in mice
    • Chang, J. M., Metcalf, D., Gonda, T. J., and Johnson, G. R. Long-term exposure to retrovirally expressed granulocyte-colony-stimulating factor induces a nonneoplastic granulocytic and progenitor cell hyperplasia without tissue damage in mice. J. Clin. Invest., 84: 1488-1496, 1989.
    • (1989) J. Clin. Invest. , vol.84 , pp. 1488-1496
    • Chang, J.M.1    Metcalf, D.2    Gonda, T.J.3    Johnson, G.R.4
  • 27
    • 0026764938 scopus 로고
    • Morphologic effects of hGRH gene expression on the pituitary, liver and pancreas of MT-hGRH transgenic mice. An in situ hybridization analysis
    • Lloyd, R. V., Jin, L., Chang, A., Kulig, E., Camper, S. A., Ross, B. D., Downs, T. R., and Frohman, L. A. Morphologic effects of hGRH gene expression on the pituitary, liver and pancreas of MT-hGRH transgenic mice. An in situ hybridization analysis. Am. J. Pathol., 141: 895-906, 1992.
    • (1992) Am. J. Pathol. , vol.141 , pp. 895-906
    • Lloyd, R.V.1    Jin, L.2    Chang, A.3    Kulig, E.4    Camper, S.A.5    Ross, B.D.6    Downs, T.R.7    Frohman, L.A.8
  • 28
    • 0025297086 scopus 로고
    • Overexpression of TGFα in transgenic mice: Induction of epithelial hyperplasia, pancreatic metaplasia and carcinoma of the breast
    • Sandgren, E. P., Luetteke, N. C., Palmiter, R. D., Brinster, R. L., and Lee, D. C. Overexpression of TGFα in transgenic mice: induction of epithelial hyperplasia, pancreatic metaplasia and carcinoma of the breast. Cell, 61: 1121-1135, 1990.
    • (1990) Cell , vol.61 , pp. 1121-1135
    • Sandgren, E.P.1    Luetteke, N.C.2    Palmiter, R.D.3    Brinster, R.L.4    Lee, D.C.5
  • 30
    • 0026002652 scopus 로고
    • Multiple neuropeptides stimulate clonal growth of small cell lung cancer: Effects of bradykinin, vasopressin, cholecystokinin, galanin, and neurotensin
    • Sethi, T., and Rozengurt, E. Multiple neuropeptides stimulate clonal growth of small cell lung cancer: effects of bradykinin, vasopressin, cholecystokinin, galanin, and neurotensin. Cancer Res., 51: 3621-3623, 1991.
    • (1991) Cancer Res. , vol.51 , pp. 3621-3623
    • Sethi, T.1    Rozengurt, E.2
  • 31
    • 0028057613 scopus 로고
    • Disruption of epithelial cell-matrix interactions induces apoptosis
    • Frisch, S. M., and Hunter, F. Disruption of epithelial cell-matrix interactions induces apoptosis. J. Cell. Biol., 124: 619-626, 1994.
    • (1994) J. Cell. Biol. , vol.124 , pp. 619-626
    • Frisch, S.M.1    Hunter, F.2
  • 32
    • 0030913673 scopus 로고    scopus 로고
    • Matrix adhesion and ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway
    • Khwaja, A., Rodriguez-Viciana, P., Wennstrom, S., Warne, P. H., and Downward, J. Matrix adhesion and ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway. EMBO J., 16: 2783-2793, 1997.
    • (1997) EMBO J. , vol.16 , pp. 2783-2793
    • Khwaja, A.1    Rodriguez-Viciana, P.2    Wennstrom, S.3    Warne, P.H.4    Downward, J.5
  • 33
    • 0025785811 scopus 로고
    • Mutations of ras genes distinguish a subset of non-small-cell lung cancer cell lines from small-cell lung cancer cell lines
    • Mitsudomi, T., Viallet, J., Mulshine, J. L., Linnoila, R. I., Minna, J. D., and Gazdar, A. F. Mutations of ras genes distinguish a subset of non-small-cell lung cancer cell lines from small-cell lung cancer cell lines. Oncogene, 6: 1353-1362, 1991.
    • (1991) Oncogene , vol.6 , pp. 1353-1362
    • Mitsudomi, T.1    Viallet, J.2    Mulshine, J.L.3    Linnoila, R.I.4    Minna, J.D.5    Gazdar, A.F.6
  • 34
    • 0025293818 scopus 로고
    • Detection of ras gene mutations in human lung cancers by single strand conformation polymorphism analysis of polymerase chain reaction products
    • Suzuki, Y., Orita, M., Shiraishi, M., Hayashi, K., and Sekiya, T. Detection of ras gene mutations in human lung cancers by single strand conformation polymorphism analysis of polymerase chain reaction products. Oncogene, 5: 1037-1043, 1990.
    • (1990) Oncogene , vol.5 , pp. 1037-1043
    • Suzuki, Y.1    Orita, M.2    Shiraishi, M.3    Hayashi, K.4    Sekiya, T.5
  • 35
    • 0028520779 scopus 로고
    • Activity of pp60c-src in 60 different cell lines derived from human tumors
    • Budde, R. J., Ke, S., and Levin, V. A. Activity of pp60c-src in 60 different cell lines derived from human tumors. Cancer Biochem. Biophys., 14: 171-175, 1994.
    • (1994) Cancer Biochem. Biophys. , vol.14 , pp. 171-175
    • Budde, R.J.1    Ke, S.2    Levin, V.A.3
  • 36
    • 0029785079 scopus 로고    scopus 로고
    • A regulatory role for cAMP in phosphatidylinositol 3-kinase/ p70 ribosomal S6 kinase-mediated DNA synthesis in platelet-derived-growth-factor stimulated bovine airway smooth-muscle cells
    • Scott, P. H., Belham, C. M., Al-Hafidh, J., Chilvers, E. R., Peacock, A. J., Gould, G. W., and Plevin, R. A regulatory role for cAMP in phosphatidylinositol 3-kinase/ p70 ribosomal S6 kinase-mediated DNA synthesis in platelet-derived-growth-factor stimulated bovine airway smooth-muscle cells. Biochem. J., 315: 965-971, 1996.
    • (1996) Biochem. J. , vol.315 , pp. 965-971
    • Scott, P.H.1    Belham, C.M.2    Al-Hafidh, J.3    Chilvers, E.R.4    Peacock, A.J.5    Gould, G.W.6    Plevin, R.7
  • 37
    • 0002230857 scopus 로고
    • Morphological and
    • J. E. Coligan, A. M. Kruisbeek, D. H. Marguiles, E. M. Shevach, and W. Strober (eds.), New York: John Wiley & Sons
    • Duke, R. C., and Cohen, J. J. Morphological and biochemical assays of apoptosis. In: J. E. Coligan, A. M. Kruisbeek, D. H. Marguiles, E. M. Shevach, and W. Strober (eds.), Current Protocols in Immunology, pp. 3.17.1-3.17.16. New York: John Wiley & Sons, 1992.
    • (1992) Current Protocols in Immunology , pp. 3171-31716
    • Duke, R.C.1    Cohen, J.J.2    Apoptosis, B.A.O.3
  • 39
    • 0018876637 scopus 로고
    • Positive correlation between histological tumor involvement and generation of tumor cell colonies in agarose in specimens taken directly from patients with small-cell carcinoma of the lung
    • Carney, D. N., Gazdar, A. F., and Minna, J. D. Positive correlation between histological tumor involvement and generation of tumor cell colonies in agarose in specimens taken directly from patients with small-cell carcinoma of the lung. Cancer Res., 40: 1820-1823, 1980.
    • (1980) Cancer Res. , vol.40 , pp. 1820-1823
    • Carney, D.N.1    Gazdar, A.F.2    Minna, J.D.3
  • 40
    • 0027970468 scopus 로고
    • Stimulation of phosphatidylinositol 3′-kinase association with focal adhesion kinase by platelet-derived growth factor
    • Chen, H-C., and Guan, J-L. Stimulation of phosphatidylinositol 3′-kinase association with focal adhesion kinase by platelet-derived growth factor. J. Biol. Chem., 269: 31229-31233, 1994.
    • (1994) J. Biol. Chem. , vol.269 , pp. 31229-31233
    • Chen, H.-C.1    Guan, J.-L.2
  • 42
    • 0026556566 scopus 로고
    • Constitutive presence of a catalytic fragment of protein kinase C epsilon in a small cell lung carcinoma line
    • Baxter, G., Oto, E., Daniel-Issakani, S., and Strulovici, B. Constitutive presence of a catalytic fragment of protein kinase C epsilon in a small cell lung carcinoma line. J. Biol. Chem., 267: 1910-1917, 1992.
    • (1992) J. Biol. Chem. , vol.267 , pp. 1910-1917
    • Baxter, G.1    Oto, E.2    Daniel-Issakani, S.3    Strulovici, B.4
  • 43
    • 0030766846 scopus 로고    scopus 로고
    • Growth factor activation of MAP kinase requires cell adhesion
    • Renshaw, M. W., Ren, X-D., and Schwartz, M. A. Growth factor activation of MAP kinase requires cell adhesion. EMBO J., 16: 5593-5599, 1997.
    • (1997) EMBO J. , vol.16 , pp. 5593-5599
    • Renshaw, M.W.1    Ren, X.-D.2    Schwartz, M.A.3
  • 44
  • 45
    • 0019459788 scopus 로고
    • Hormone production by cultures of small-cell carcinoma of the lung
    • Phila.
    • Sorenson, G. D., Pettengill, O. S., Brinck-Johnsen, T., Cate, C. C., and Maurer, L. H. Hormone production by cultures of small-cell carcinoma of the lung. Cancer (Phila.), 47: 1289-1296, 1981.
    • (1981) Cancer , vol.47 , pp. 1289-1296
    • Sorenson, G.D.1    Pettengill, O.S.2    Brinck-Johnsen, T.3    Cate, C.C.4    Maurer, L.H.5
  • 46
    • 0029730774 scopus 로고    scopus 로고
    • Galanin, neurotensin, and phorbol esters rapidly stimulate activation of mitogen-activated protein kinase in small cell lung cancer cells
    • Seufferlein T., and Rozengurt, E. Galanin, neurotensin, and phorbol esters rapidly stimulate activation of mitogen-activated protein kinase in small cell lung cancer cells. Cancer Res., 56: 5758-5764, 1996.
    • (1996) Cancer Res. , vol.56 , pp. 5758-5764
    • Seufferlein, T.1    Rozengurt, E.2
  • 47
    • 0029160069 scopus 로고
    • Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
    • Burgering, B. M., and Coffer, P. J. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature (Lond.), 376: 599-602, 1995.
    • (1995) Nature (Lond.) , vol.376 , pp. 599-602
    • Burgering, B.M.1    Coffer, P.J.2
  • 48
    • 0032518467 scopus 로고    scopus 로고
    • 3-Phosphoinositide-dependent protein kinase 1 (PDK 1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro
    • Alessi, D. R., Kozlowski, M. T., Weng, Q-P., Morrice, N., and Avruch, J. 3-Phosphoinositide-dependent protein kinase 1 (PDK 1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro. Curr. Biol., 8: 69-81, 1997.
    • (1997) Curr. Biol. , vol.8 , pp. 69-81
    • Alessi, D.R.1    Kozlowski, M.T.2    Weng, Q.-P.3    Morrice, N.4    Avruch, J.5
  • 49
    • 0032548942 scopus 로고    scopus 로고
    • Differential regulation by calcium reveals distinct signaling requirements for the activation of Akt and p70s6k
    • Conus, N. M., Hemmings, B. A., and Pearson, R. B. Differential regulation by calcium reveals distinct signaling requirements for the activation of Akt and p70s6k. J. Biol. Chem., 273: 4776-4782, 1998.
    • (1998) J. Biol. Chem. , vol.273 , pp. 4776-4782
    • Conus, N.M.1    Hemmings, B.A.2    Pearson, R.B.3


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