3-(Hydroxymethyl)-bearing phosphatidylinositol ether lipid analogues and carbonate surrogates block PI3-K, akt, and cancer cell growth

Journal of Medicinal Chemistry

Volumn 43, Issue 16, 2000, Pages 3045-3051

  Hu, Y ^a   Qiao, L ^a   Wang, S ^a   Rong, S B ^a   Meuillet, E J ^b   Berggren, M ^b   Gallegos, A ^b   Powis, G ^b   Kozikowski, A P ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 DEXTRO 3 HYDROXYMETHYL MYO INOSITOL 1 [2 0 METHYL 3 0 OCTADECYLCARBONATE]; 1 DEXTRO 3 HYDROXYMETHYL MYO INOSITOL 1 [2 O METHYL 3 O OCTADECYL HYDROGEN PHOSPHATE]; 1 LEVO 6 HYDROXYMETHYL INOSITOL 2 [2 0 METHYL 3 O OCTADECYL HYDROGEN PHOSPHATE]; 1 LEVO 6 HYDROXYMETHYL INOSITOL 2 [2 O METHYL 3 O OCTADECYLCARBAMATE]; ANTINEOPLASTIC AGENT; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CANCER INHIBITION; CELL STRAIN HT29; CELL STRAIN MCF 7; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROGEN BOND; IC 50; REACTION ANALYSIS; SEQUENCE HOMOLOGY; STEREOCHEMISTRY; STRUCTURE ANALYSIS;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANTINEOPLASTIC AGENTS; CELL DIVISION; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; PHOSPHATIDYLINOSITOLS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0034632791     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000117y     Document Type: Article

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