Metabolism and cellular functions of IP6: A review

Anticancer Research

Volumn 19, Issue 5 A, 1999, Pages 3733-3736

  Shamsuddin, Abulkalam M ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Differentiation; Inositol hexaphosphate; Phytate; Signal transduction

Indexed keywords

ANTINEOPLASTIC AGENT; INOSITOL; INOSITOL PHOSPHATE; PHYTATE; PROTEIN P21; PROTEIN P53; TRITIUM;

CANCER CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONFERENCE PAPER; DRUG ABSORPTION; DRUG EXCRETION; DRUG METABOLISM; DRUG TRANSPORT; DRUG URINE LEVEL; ION EXCHANGE CHROMATOGRAPHY; MITOSIS INHIBITION; ONCOGENE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STOMACH EPITHELIUM; TUMOR SUPPRESSOR GENE;

ANIMALS; CELL DIFFERENTIATION; CELL DIVISION; HUMANS; PHYTIC ACID; RATS; SIGNAL TRANSDUCTION;

EID: 0032763994     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (33)

1. 31P NMR. Biochem Biophys Res Commun 264: 874-881, 1987.
2. Homann MJ, Poole MA, Gaynor PM, Ho C-T and Carman GM: Effect of growth phase on phospholipid biosynthesis in Saccharomyces cerevisiae. J Bacteriol 169: 533-539, 1987.
3. Shamsuddin AM: Reduction of cell proliferation and enhancement of NK-cell activity, U.S. Patent #5 082 833, 1992.
4. Shamsuddin AM, Ullah A and Chakravarthy A: Inositol and inositol hexaphosphate suppresses cell proliferation and tumor formation in CD-1 mice. Carcinogenesis 10: 1461-1463, 1989.
5. Stephens LR and Irvine RF: Stepwise phosphorylation of myoinositol leading to myo-inositol hexakisphosphate in Dictyostelium. Nature 346: 580-583, 1990.
6. Shamsuddin AM, Baten A and Lalwani ND: Effect of inositol hexaphosphate on growth and differentiation in K-562 erythroleukemia cell line. Cancer Lett 64: 195-202, 1992.
7. Ji H, Sandberg K, Baukal AJ and Catt KJ: Metabolism of inositol pentakisphosphate to inositol hexakisphosphate in Xenopus laevis oocytes. J Biol Chem 264: 20185-20188, 1989.
8. 2+ channel activity by inositol hexakisphosphate. Science 278: 471-474, 1997.
9. 3H]Phytic acid (inositol hexaphosphate) is absorbed and distributed to various tissues in rats. J Nutr 123: 713-720, 1993.
10. 3H]-Inositol hexaphosphate (phytic acid) is rapidly absorbed and metabolized by murine and human malignant cells in vitro. J Nutr 124: 861-868, 1994.
11. Iqbal TH, Lewis KO and Cooper BT: Phytase activity in human and rat small intestine. Gut 35: 1233-1236, 1994.
12. Grases F, García-Ferragut L and Costa-Bauza A: A new procedure to evaluate the inhibitory capacity of calcium oxalate crystallization in whole urine. Intl Urol Nephrol 27: 653-661, 1995.
13. Grases F and L'lobera A: Determination of phytic acid in urine by ICP atomic emission spectrometry. Analyt Lett 29: 1193-1199, 1996.
14. 6) as a powerful agent on preventing calcifications in biological fluids. Usefulness in renal lithiasis treatment. Anticancer Res 19: 3717-3726, 1999.
15. Nicoletti F, Bruno V, Cavallaro S, Copani A, Sortino MA and Canonico PL: Specific binding sites for inositol hexakisphosphate in brain and anterior pituitary. Mol Pharmacol 37: 689-693, 1990.
16. Theibert AB, Estevez VA, Ferris CD, Danoff SK, Barrow RK Prestwich GD and Snyder SH: Inositol 1,3,4,5-tetrakisphosphate and inositol hexakisphosphate receptor proteins: isolation and characterization from rat brain. Proc Natl Acad Sci USA 88: 3165-3169, 1991.
17. Voglmaier SM, Keen JH, Murphy JE, Ferris CD, Prestwich GD, Snyder SH and Theibert AB: Inositol hexaphosphate receptor identified as the clathrin assembly protein AP-2. Biochem Biophys Res Commun 187: 158-163, 1992.
18. Camilli PD, Emr SC, McPherson PS and Novick P: Phosphoinositides as regulators in membrane traffic. Science 271: 1533-1539, 1996.
19. 6) and high- bran diet in the prevention of DMBA-induced rat mammary carcinogenesis. Nutr Cancer 28: 7-13, 1997.
20. 6 regresses pre-existing human liver cancer xenotransplanted in nude mice. Anticancer Res 18: 4091-4096, 1998.
21. Vucenik I, Kalebic, Tantivejkul K and Shamsuddin AM: Novel anticancer function of inositol hexaphosphate: inhibition of human rhabdomyosarcoma in vitro and in vivo. Anticancer Res 18: 1377-1384, 1998.
22. 6, in HT-29 human colon carcinoma cell line. Anticancer Res 18: 1479-1484, 1998.
23. 6-induced growth inhibition and differentiation of HT-29 human colon cancer cells: Involvement of intracellular inositol phosphates. Anticancer Res 15: 2479-2488, 1995.
24. Sakamoto K, Venkatraman G and Shamsuddin AM: Growth inhibition and differentiation of HT-29 cells in vitro by inositol hexaphosphate (phytic acid). Carcinogenesis 14: 1815-1819, 1993.
25. Shamsuddin AM, and Yang G-Y: Inositol hexaphosphate inhibits growth and induces differentiation of PC-3 human prostate cancer cell. Carcinogenesis 16: 1975-1979, 1995.
26. 6: Growth inhibition and differentiation of human mammary cancer cell lines in vitro. Anticancer Res 16: 3287-3292, 1996.
27. 6) and insulin like growth factor II receptor binding sites in the rat brain. Neuroreport 5: 625-628, 1994.
28. Gicquel C, Bertagna X, Schneid H, Francillard-Lablond M Luton JP, Girard F and Le Bouc Y. J Clin Endocrinol Metab 78: 1444-1453, 1994.
29. Lamonerie T, Lavialle C, deGalle B, Binoux M and Brison O: Constitutive or inducible overexpression of the IGF-2 gene in cells of a human colon carcinoma cell line. Exp Cell Res 216: 342-351, 1995.
30. Lamonerie T, Lavialle C, Haddada H and Brison O: IGF-2 autocrine stimulation in tumorigenic clones of a human colon carcinoma cell line. Int J Cancer 61: 587-592, 1995.
31. Pittet D, Schlegel W, Lew DP, Monod A and Mayr GW: Mass changes in inositol tetrakis- and pentakisphosphate isomers induced by chemotactic peptide stimulation in HL-60 cells. J Biol Chem 264: 18489-18493, 1989.
32. Sasakawa N, Sharif M and Hanley MR: Metabolism and biological activities of inositol pentakisphosphate and inostiol hexakisphosphate. Biochem Pharm 50: 137-146, 1995.
33. 6-Nature's Revolutionary Cancer Fighter. Kensington Publishing Corporation, New York, 1998.