Novel (Immune) Nutrients in Critical Illness

Nutrition Support for the Critically Ill Patient: A Guide to Practice

Volumn , Issue , 2016, Pages 173-189

  Lipp, Joanna ^a   Sax, Harry C ^b  

^a UNIVERSITY OF ROCHESTER   (United States)

^b UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 33749316362     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1201/9781420039191-17     Document Type: Chapter

References (84)

1. Smith, R.J., Glutamine metabolism and its physiologic importance, JPEN, 14, 40S, 1990.
2. Lacey, J.M., and Wilmore, D.W., Is glutamine a conditionally essential nutrient? Nutr. Rev., 48, 297, 1990.
3. Souba, W.W., Smith, R.J., and Wilmore, D.W., Glutamine metabolism by the intestinal tract, JPEN, 9, 608, 1995.
4. Roth, E., et al., Metabolic disorders in severe abdominal sepsis: glutamine deficiency in skeletal muscle, Clin. Nutr., 1, 25, 1982.
5. Askanazi, J., et al., Muscle and plasma amino acids following injury: influence of intercurrent infection, Ann. Surg., 192, 78, 1980.
6. Hammarqvist, F., et al., Addition of glutamine to total parenteral nutrition after elective abdominal surgery spares free glutamine in muscle, counteracts the fall in muscle protein synthesis, and improves nitrogen balance, Ann. Surg., 209, 455, 1989.
7. Souba, W.W., and Austgen, T.R., Interorgan glutamine flow following surgery and infection, JPEN, 14, 90S, 1990.
8. Newsholme, E.A., and Parry-Billings, M., Properties of glutamine release from muscle and its importance for the immune system, JPEN, 14, 63S, 1990.
9. Ardawi, M.S.M., and Newsholme, E.A., Glutamine metabolism in lymphocytes and its importance in the immune response, Essays Biochem., 21, 1, 1985.
10. Wallace, C., and Keast, D., Glutamine and macrophage function, Metabolism, 41, 1016, 1992.
11. Ogle, C.K., et al., Effect of glutamine on phagocytosis and bacterial killing by normal and pediatric burn patient neutrophils, JPEN, 18, 128, 1994.
12. Ardawi, M.S.M., and Newsholme, E.A., Glutamine metabolism in lymphoid tissues. In Glutamine Metabolism in Mammalian Tissues, Haussinger, D., and Sies, H. (eds.), Springer-Verlag, Berlin, 235-246, 1984.
13. Brand, K., et al., Metabolism of glutamine in lymphocytes. Metabolism, 38, Suppl. 1, 29, 1989.
14. Spolaris, Z., et al., Glutamine and fatty acid oxidation are the main sources of energy for Kupffer and endothelial cells, Am. J. Physiol., 261, G185, 1990.
15. Hong, R.W., et al., Glutamine preserves liver glutathione after lethal hepatic injury, Ann. Surg., 215, 114, 1992.
16. Harward, T.R., et al., Glutamine preserves gut glutathione levels during intestinal ischemia/reperfusion, J. Surg. Res., 56, 351, 1994.
17. Roos, D., Weening, R.S., and Voetman, A.A., Protection of human neutrophils against oxidative damage, Agents and Actions, 10, 528, 1980.
18. Ziegler, T.R., et al., Safety and metabolic effects of L-glutamine administration in humans, JPEN, 14, 137S, 1990.
19. Ziegler, T.R., et al., Clinical and metabolic efficacy of glutamine-supplemented parenteral nutrition after bone marrow transplantation, Ann. Intern. Med., 116, 821, 1992.
20. Jensen, G.L., et al., A double-blind, prospective, randomized study of glutamine-enriched compared with standard peptide-based feeding in critically ill patients, Am. J. Clin. Nutr., 64, 615, 1996.
21. Long, C.L., et al., Impact of enteral feeding of a glutamine-supplemented formula on the hypoaminoacidemic response in trauma patients, J. Trauma, 40, 97, 1996.
22. Buchman, A.L., et al., Parenteral nutrition is associated with intestinal morphologic and functional changes in humans, JPEN, 19, 453, 1995.
23. Swails, W.S., et al., Glutamine content of whole proteins: implications for enteral formulas, Nutr. Clin. Pract., 7, 77, 1992.
24. Boza, J.J., et al., Free and protein-bound glutamine have identical splanchnic extraction in healthy human volunteers, Am. J. Gastrointest. Liver Physiol., 281, G267, 2001.
25. Hardy, G., et al., Stability of glutamine in parenteral feeding solutions, Lancet, 342, 186, 1993.
26. Hornsby-Lewis, L., et al., L-glutamine supplementation in home total parenteral nutrition patients:stability, safety, and effects on intestinal absorption, JPEN, 18, 268, 1994.
27. Furst, P., and Stehle, P., The potential use of parenteral dipeptides in clinical nutrition, Nutr. Clin. Prac., 8, 106, 1994.
28. Lochs, H., et al., Splanchnic, renal, and muscle clearance of alanylglutamine in man and organ fluxes of alanine and glutamine when infused in free and peptide forms, Metab., 39, 833, 1990.
29. Abumrad, N.N., et al., Possible sources of glutamine for parenteral nutrition: impact on glutamate metabolism, Am. J. Physiol., 257, E228, 1989.
30. Romero-Gomez, M., et al., Altered response to oral glutamine challenge as prognostic factor for overt episodes in patients with minimal hepatic encephalopathy, J. Hepatol., 37, 781, 2002.
31. Houdijk, A.P.J., et al., Randomized trial of glutamine-enriched enteral nutrition on infectious morbidity in patients with multiple trauma, Lancet, 352, 772, 1998.
32. Conejero R., et al., Effect of a glutamine-enriched enteral diet on intestinal permeability and infectious morbidity at 28 days in critically ill patients with systemic inflammatory response syndrome: a randomized, single-blind, prospective, multicenter study, Nutrition, 18, 716, 2002.
33. Zhou, Y.P., et al., The effect of supplemental enteral glutamine on plasma levels, gut function, and outcome in severe burns: a randomized, double-blind, controlled clinical trial, JPEN, 27, 241, 2003.
34. Garrel, D., et al., Decreased mortality and infectious morbidity in adult burn patients given enteral glutamine supplements: a prospective, controlled, randomized clinical trial, Crit. Care Med., 31, 2444, 2003.
35. Wischmeyer, P.E., et al., Glutamine administration reduces Gram-negative bacteremia in severely burned patients: a prospective, randomized, double-blind trial versus isonitrogenous control, Crit. Care Med., 29, 2075, 2001.
36. Griffiths, R.D., Jones, C., and Palmer, T.E.A., Six-month outcome of critically ill patients given glutamine-supplemented parenteral nutrition, Nutrition, 13, 295, 1997.
37. Powell-Tuck, J., et al., A double-blind, randomised, controlled trial of glutamine supplementation in parenteral nutrition, Gut, 45, 83, 1999.
38. Barbul, A., Arginine: biochemistry, physiology, and therapeutic implications, JPEN, 10, 227, 1986.
39. Efron D., Barbul A., The role of arginine in immunonutrition, J. Gastroenter., 35S 12, 20-28, 2000.
40. Saito H., Tocki O., Wang S.L., Gonce S.J., Joffe S.N., Alexander J.W., Metabolic and immune effects of dietary arginine supplementation after burn, Arch. Surg., 122, 784-789, 1987.
41. Witte M.D., Thornton F.J., Tantry V., Barbul A., L-Arginine supplementation enhances diabetic wound healing: involvement of nitric oxide and arginase pathways, Metab. Clin. Exp., 51, 1269-1273, 2002.
42. Kirk S.J., Hurson M., Regan M.C., Holt O.R., Wasserkreg H.L., Barbul A., Arginine stimulates wound healing and immune function in elderly human beings, Surg., 114, 155-159, 1993.
43. Williams J.Z., Abumrad N., Barbul A., Effect of specialized amino acid mixture on human collagen deposition, Ann. Surg., 236, 369-374, 2002.
44. Caparros T., Lopez J., Grau T., Early enteral nutrition in critically-ill patients with a high protein diet enriched with arginine, fiber and antioxidants compared with standard high-protein diet: the effect on nosocomial infections and outcome, JPEN, 25, 299-309, 2001.
45. Carcillo, J.A., Does arginine become a “near” essential amino acid during sepsis? Crit. Care Med.31, 657-659, 2003.
46. Brenna, T.J., Efficiency of conversion of linolenic acid to long chain n-3 fatty acids in manx, Curr. Opin. Nutr. Metab. Care, 5, 127, 2002.
47. Redgrave T.G., Lipids in enteral nutrition, Curr. Opin. Clin. Metab. Care, 2, 147, 1999.
48. Alexander, J.W., Immunonutrition: the role of -3 fatty acids, Nutrition, 14, 627, 1998.
49. Sprecher H., Chen, Q., and Yin, F.Q., Regulation of the biosynthesis of 22:5n-6 and 22:6n-3: a complex intracellular process, Lipids, 34, S153, 1999.
50. Emken, E., Alpha-linoleic acid conversion to n-3 LC-PUFAs, PUFA Newsletter, www.pufanewsletter. com, 2003.
51. Chen W, and Yeh, S., Effects of fish oil in parenteral nutrition, Nutrition, 19, 275, 2003.
52. Krause, M.L., Arlin, M., Lipids. In Krause’s Food, Nutrition and Diet Therapy, 8th ed. W.B. Saunders, Philadelphia, 1992.
53. Bimbo, A.P., The emerging marine oil industry, JAOCS, 64, 706, 1987.
54. Holub, B.J., Clinical nutrition: omega-3 fatty acids in cardiovascular care, Can. Med. Assoc. J., 166, 608, 2002.
55. American Society of Parenteral and Enteral Nutrition, Consensus recommendations from the U.S. summit on immune-enhancing enteral therapy, JPEN, 25 Suppl., S63, 2001.
56. Tashiro, T. et al., n-3 versus n-6 polyunsaturated fatty acids in criticalillness, Nutrition, 14, 551, 1998.
57. Calder, P.C., Lipids and the critically ill patient. In Nutrition and Critical Care, vol. 8, Cynober C.L., and Moore, F.A. (eds.), Nestle Nutrition Workshop Series Clinical and Performance Program, Southampton, U.K., 2003.
58. Calder P.C., and Deckelbaum, R.J., Dietary lipids: more than just a source of calories, Curr. Opin. Nutr. Metab. Care 2, 105, 1999.
59. Endres, S., et al., n-3 polyunsaturated fatty acids: update 1995, Eur. J. Clin. Invest., 25, 629, 1995.
60. Gadek, J.E., et al., Effect of enteral feeding with eicosapentaoic acid, -linolenic acid, and antioxidants in patients with acute respiratory distress syndrome, Crit. Care Med., 27, 1409, 1999.
61. Garrel D.R., et al., Improved clinical status and length of care with low-fat nutrition support in burn patients, JPEN, 19, 482, 1995.
62. Dupont, I.E., and Carpentier, Y.A., Clinical use of lipid emulsions, Curr. Opin. Clin. Nutr. Metab. Care, 2, 139, 1999.
63. Stark, K.D., et al., Fatty acid compositions of serum phospholipids of postmenopausal women: a comparison between Greenland Inuit and Canadians before and after supplementation with fish oil, Nutrition, 18, 627, 2002.
64. PUFA Newsletter, www.pufanewsletter.com, September 2003.
65. Van Buren, C.T., et al., Dietary nucleotides, a requirement for helper/inducer T lymphocytes, Transplantation, 40, 694, 1985.
66. Kulkarni, S.S., et al., Prolongation of cardiac allograft survival by pretreatment of recipient mice with donor blood or spleen cells plus cyclophosphamide, Cellular Immunol., 47, 192, 1979.
67. Fanslow, W.C., et al., Effect of nucleotide restriction and supplementation on resistance to experimental murine candidiasis, JPEN, 12, 49, 1988.
68. Yamauchi, K., et al., Glutamine and arginine affect Caco-2 cell proliferation by promotion of nucleotide synthesis, Nutrition, 18, 329, 2002.
69. Kulkarni, A.D., Yamauchi, K., Hales, N.W., Ramesh, V., Ramesh, G.T., Sundaresan, A., Andrassy R.J., Pellis, N.R., Nutrition beyond nutrition: plausibility of immunotrophic nutrition for space travel, Clin. Nutr., 21, 231, 2002.
70. Bower, R.H., et al., Early enteral administration of a formula (Impact) supplemented with arginine, nucleotides, and fish oil in intensive care unit patients: results of a multicenter, prospective, randomized, clinical trial, Crit. Care Med., 23, 436, 1995.
71. Kudsk, K.A., et al., A randomized trial of isonitrogenous enteral diets after severe trauma: an immuneenhancing diet reduces septic complications, Ann. Surg., 224, 531, 1996.
72. Atkinson, S., Sieffert, E., and Bihari, D.: A prospective, randomized, double-blind, controlled clinical trial of enteral immunonutrition in the critically ill, Crit. Care Med., 26, 1164, 1998.
73. Gottschlich, M.M., et al., Differential effects of three enteral dietary regimens on selected outcome variables in burn patients, JPEN, 14, 225, 1990.
74. Saffle, J.R., et al., Randomized trial of immune-enhancing enteral nutrition burn patients, J. Trauma, 42, 793, 1997.
75. Mendez, C., et al., Effects of immune-enhancing diet in critically injured patients, J. Trauma, 42, 933, 1997.
76. Weimann, A., et al., Influence of arginine, omega-3 fatty acids and nucleotide-supplemented enteral support on systemic inflammatory response syndrome and multiple organ failure in patients after severe trauma, Nutrition, 14, 165, 1998.
77. Galban, C, et al., An immune-enhancing enteral diet reduces mortality rate and episodes of bacteremia in septic intensive care unit patients, Crit. Care Med., 28, 643, 2000.
78. Heyland, D.K., et al., Should immunonutrition become routine in critically ill patients? A systematic review, JAMA, 268, 944, 2001.
79. Veterans Affairs Total Parenteral Nutrition Cooperative Study Group, Perioperative total parenteral nutrition in surgical patients, NEJM, 325, 525, 1991.
80. Heys, S.D, et al., Enteral nutritional supplementation with key nutrient in patients with criticalillness and cancer: a metaanalysis of randomized controlled clinical trials, Ann. Surg., 229, 467, 1999.
81. Tepaske, R., et al., Effect of preoperative oral immune-enhancing nutritional supplement on patients at high risk of infection after cardiac surgery: a randomised placebo-controlled trial, Lancet, 358, 696, 2001.
82. Braga, M., et al., Nutritional approach in malnourished surgical patients. Arch. Surg., 137, 174-180, 2002.
83. Braga, M., et al., Perioperative oral arginine and omega-3 fatty acid supplementation improves the immunometabolic host response and outcome after colorectal resection for cancer, Surgery, 132, 805, 2002.
84. Krauss, R.M., et al., AHA Dietary Guidelines Revision 2000: a statement for healthcare professionals from the Nutrition Committee of the American Heart Association, Circulation, 102, 2284, 2000.