Does arginine become a "near" essential amino acid during sepsis?

Critical Care Medicine

Volumn 31, Issue 2, 2003, Pages 657-659

  Carcillo, Joseph A ^a  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

Author keywords

Arginine; Nitric oxide; Sepsis

Indexed keywords

ARGININE; NITRIC OXIDE; OMEGA 3 FATTY ACID; UREA;

AMINO ACID METABOLISM; CLINICAL TRIAL; CRITICAL ILLNESS; DIET SUPPLEMENTATION; EDITORIAL; HUMAN; IMMUNE RESPONSE; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; SEPSIS;

AMINO ACIDS, ESSENTIAL; ARGININE; HUMANS; SEPSIS;

EID: 0037327063     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000050292.34520.A5     Document Type: Editorial

References (17)

1. Beaumier L, Castillo L, Yu YM, et al: Arginine: New and exciting developments for an "old" amino acid. Biomed Environ Sci 1996; 9:296-315
2. Castillo L, DeRojas-Walker T, Yu YM, et al: Whole body arginine metabolism and nitric oxide synthesis in newborns with pulmonary hypertension. Pediatr Res 1995; 38:17-24
3. Argaman Z, Young VR, Noviski N, et al: Arginine and nitric oxide metabolism in critically ill septic pediatric patients. Crit Care Med 2003:31:591-597
4. Hibbs JB Jr, Tainor RR, Vavrin Z, et al: Macrophage cytotoxicity: Role for L-arginine deaminase and imino nitrogen oxidation to nitrite. Science 1987; 235:473-476
5. Marletta MA, Yoon PS, Iyengar R, et al: Macrophage oxidation of L-arginine to nitrite and nitrate: Nitric oxide is an intermediate. Biochemistry 1988; 27:8706-8711
6. Schneider H, Atkinson SW: Immunonutrition - Fact or fad. J Nutr Health Aging 2000; 4:120-123
7. Pichard C, Sudre P, Karsegard V, et al: A randomized double blind controlled study of 6 months of oral nutritional supplementation with arginine and omega 3 fatty acids in HIV-infected patients. Swiss HIV Cohort Study. AIDS 1998; 12:53-63
8. Gianotti L, Braga M, Fortis C, et al: A prospective randomized clinical trial on perioperative feeding with an arginine-, omega-3 fatty acid, and RNA enriched enteral diet: Effect on host response and nutritional status. JPEN J Parenter Enteral Nutr 1999; 23:314-320
9. Weimann A, Bastian L, Bischoff WE, et al: Influence of arginine, omega 3 fatty acids and nucleotide supplemented enteral support on systemic inflammatory response syndrome and multiple organ failure in patients after severe trauma. Nutrition 1988; 14:165-172
10. Galban C, Montejo JC, Mesejo A, et al: An immune enhancing enteral diet reduces mortality rate and episodes of bacteremia in septic intensive care unit patients. Crit Care Med 2000; 28:643-648
11. Gurbuz AT, Kunzelman J, Ratzer EE: Supplemental dietary arginine accelerates intestinal mucosal regeneration and enhances bacterial clearance following radiation enteritis in rats. J Surg Res 1998; 74:149-154
12. Bruins MJ, Soeters PB, Lamers WH, et al: L-arginine supplementation in pigs decreases liver protein turnover and increases hindquarter protein turnover both during and after endotoxemia. Am J Clin Nutr 2002; 75:1031-1044
13. Yeh CL, Yeh SL, Lin MT, et al: Effects of arginine-enriched total parenteral nutrition on inflammatory-related mediator and T-cell population in septic rats. Nutrition 2002; 18:631-635
14. Bruins MJ, Soeters PB, Lamers WH, et al: L-arginine supplementation in hyperdynamic endotoxemic pigs: Effect on nitric oxide synthesis by the different organs. Crit Care Med 2002; 30:508-517
15. Carcillo JA, Task Force Members, Fields AI: Clinical practice parameters for hemodynamic support of pediatric and neonatal patients in septic shock. Crit Care Med 2002; 30:1-13
16. G methyl L-arginine hydrochloride (546C88), in patients with septic shock. Crit Care Med 1999; 27:913-922
17. Fink MP: Modulating the L-arginine-nitric oxide pathway in septic shock: Choosing the proper point of attack. Crit Care Med 1999; 27:913-922