Molecular imaging: A primer for interventionalists and imagers

Journal of Vascular and Interventional Radiology

Volumn 17, Issue 9, 2006, Pages 1405-1423

  Wang, David S ^a,b   Dake, Michael D ^a   Park, Jinha M ^c   Kuo, Michael D ^a,d  

^a UCSD MEDICAL CENTER   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; CARBON 11; DOXORUBICIN; FLUORODEOXYGLUCOSE F 18; INDIUM 111; IODINE 123; IODINE 124; IODINE 131; NANOPARTICLE; NITROGEN 13; OXYGEN 15; PACLITAXEL; PENTETREOTIDE IN 111; TECHNETIUM 99M; THYMIDINE KINASE; TRACER; VASCULOTROPIN;

ANGIOGENESIS; ANGIOPLASTY; ATHEROSCLEROSIS; BIOLUMINESCENCE; CANCER DIAGNOSIS; CANCER STAGING; CARDIOVASCULAR DISEASE; CARDIOVASCULAR SYSTEM TUMOR; CLINICAL MEDICINE; CYTOLOGY; DIAGNOSTIC IMAGING; DISCIPLINES RELATING TO BIOMEDICINE; DISEASE CLASSIFICATION; HERPES SIMPLEX VIRUS 1; HUMAN; IMAGING SYSTEM; INTERVENTIONAL RADIOLOGY; ISOTOPE LABELING; MOLECULAR BIOLOGY; MOLECULAR IMAGING; MOLECULAR PROBE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MEDICINE; OPTICAL INSTRUMENTATION; PATHOLOGY; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIODIAGNOSIS; REPORTER GENE; RESTENOSIS; REVIEW; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; STEM CELL TRANSPLANTATION; THROMBOSIS; TIME MANAGEMENT; TREATMENT PLANNING; TREATMENT RESPONSE; TUMOR CLASSIFICATION; ULTRASOUND;

EID: 33748795370     PISSN: 10510443     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.RVI.0000235746.86332.DF     Document Type: Article

References (164)

1. Weissleder R, Mahmood U. Molecular imaging. Radiology 2001; 219:316-333.
2. Massoud TF, Gambhir SS. Molecular imaging in living subjects: seeing fundamental biological processes in a new light. Genes Dev 2003; 17:545-580.
3. Piwnica-Worms D. Introduction to molecular imaging. J Am Coll Radiol 2004; 1(suppl):S2-S3.
4. Jaffer FA, Weissleder R. Molecular imaging in the clinical arena. JAMA 2005; 293:855-862.
5. Tempany CM, McNeil BJ. Advances in biomedical imaging. JAMA 2001; 285:562-567.
6. Hengerer A, Wunder A, Wagenaar DJ, et al. From genomics to clinical molecular imaging. IEEE Eng Med Biol Mag 2005; 93:819-828.
7. Wickline SA, Lanza GM. Nanotechnology for molecular imaging and targeted therapy. Circulation 2003; 107:1092-1095.
8. Phelps ME. Nuclear medicine, molecular imaging, and molecular medicine. J Nucl Med 2002; 43:13N-14N.
9. Thrall JH. How molecular medicine will impact radiology. Diagn Imaging (San Franc) 1997; 19:23,27.
10. Jain KK. Personalized medicine. Curr Opin Mol Ther 2002; 4:548-558.
11. Voges J, Reszka R, Gossmann A, et al. Imaging-guided convection-enhanced delivery and gene therapy of glioblastoma. Ann Neurol 2003; 54:479-487.
12. Harisinghani MG, Barentsz J, Hahn PF, et al. Noninvasive detection of clinically occult lymph-node metastases in prostate cancer. N Engl J Med 2003; 348:2491-2499.
13. Jacobs AH, Voges J, Kracht LW, et al. Imaging in gene therapy of patients with glioma. J Neurooncol 2003; 65:291-305.
14. Kitano H. Systems biology: a brief overview. Science 2002; 295:1662-1664.
15. Serganova I, Doubrovin M, Vider J, et al. Molecular imaging of temporal dynamics and spatial heterogeneity of hypoxia-inducible factor-1 signal transduction activity in tumors in living mice. Cancer Res 2004; 64:6101-6108.
16. Lindner JR. Assessment of inflammation with contrast ultrasound. Prog Cardiovasc Dis 2001; 44:111-120.
17. Zhao M, Beauregard DA, Loizou L, et al. Non-invasive detection of apoptosis using magnetic resonance imaging and a targeted contrast agent. Nat Med 2001; 7:1241-1244.
18. Schirner M, Menrad A, Stephens A, et al. Molecular imaging of tumor angiogenesis. Ann N Y Acad Sci 2004; 1014:67-75.
19. Weissleder R. Scaling down imaging: molecular mapping of cancer in mice. Nat Rev Cancer 2002; 2:11-18.
20. Blasberg R. Imaging gene expression and endogenous molecular processes: molecular imaging. J Cereb Blood Flow Metab 2002; 22:1157-1164.
21. Gambhir SS, Herschman HR, Cherry SR, et al. Imaging transgene expression with radionuclide imaging technologies. Neoplasia 2000; 2:118-138.
22. Cao F, Lin S, Xie X, et al. In vivo visualization of embryonic stem cell survival, proliferation, and migration after cardiac delivery. Circulation 2006; 113:1005-1014.
23. Rudin M, Weissleder R. Molecular imaging in drug discovery and development. Nat Rev Drug Discov 2003; 2:123-131.
24. Contag PR. Whole-animal cellular and molecular imaging to accelerate drug development. Drug Discov Today 2002; 7:555-562.
25. Wang J, Maurer L. Positron emission tomography: applications in drug discovery and drug development. Curr Top Med Chem 2005; 5:1053-1075.
26. Hillman BJ, Neiman HL. Translating molecular imaging research into radiologic practice: summary of the proceedings of the American College of Radiology Colloquium, April 22-24, 2001. Radiology 2002; 222:19-24.
27. Wagenaar DJ, Weissleder R, Hengerer A. Glossary of molecular imaging terminology. Acad Radiol 2001; 8:409-420.
28. Pandit SD, Li KC. A primer on molecular biology for imagers: IV. concepts and basic methods in molecular biology. Acad Radiol 2004; 11:686-697.
29. Pandit SD, Li KC. A primer on molecular biology for imagers: III. Proteins: structure and function. Acad Radiol 2004; 11:448-461.
30. Pandit SD, Bednarski M, Li KC. A primer on molecular biology for imagers: I. DNA, how does it work? Acad Radiol 2003; 10:1215-1223.
31. Pandit SD, Li KC. A primer on molecular biology for imagers: II. Transcription and gene expression. Acad Radiol 2004; 11:333-344.
32. Blasberg RG, Tjuvajev JG. Molecular-genetic imaging: current and future perspectives. J Clin Invest 2003; 111:1620-1629.
33. Herschman HR. Molecular imaging: Looking at problems, seeing solutions. Science 2003; 302:605-608.
34. Weissleder R. Molecular imaging: exploring the next frontier. Radiology 1999; 212:609-614.
35. Miller JC, Thrall JH. Clinical molecular imaging. J Am Coll Radiol 2004; 1(suppl):S4-S23.
36. Phelps ME. Inaugural article: positron emission tomography provides molecular imaging of biological processes. Proc Natl Acad Sci U S A 2000; 97:9226-9233.
37. Krenning EP, Kwekkeboom DJ, Bakker WH, et al. Somatostatin receptor scintigraphy with [111In-DTPA-DPhe1]-and [123I-Tyr3]-octreotide: the Rotterdam experience with more than 1000 patients. Eur J Nucl Med 1993; 20:716-731.
38. Gambhir SS. Molecular imaging of cancer with positron emission tomography. Nat Rev Cancer 2002; 2:683-693.
39. Park JM, Gambhir SS. Multimodality radionuclide, fluorescence, and bioluminescence small-animal imaging. IEEE Eng Med Biol Mag 2005; 93:771-783.
40. Townsend DW, Beyer T. A combined PET/CT scanner: the path to true image fusion. Br J Radiol 2002; 75:S24-S30.
41. Grazioso R, Ladebeck R, Schmand M, et al. APD-based PET for combined MR-PET imaging [abstract]. Proc Intl Soc Mag Reson Med 2005; 13:408-.
42. Allen MJ, Meade TJ. Magnetic resonance contrast agents for medical and molecular imaging. Met Ions Biol Syst 2004; 42:1-38.
43. Basilion JP, Yeon S, Botnar R. Magnetic resonance imaging: utility as a molecular imaging modality. Curr Top Dev Biol 2005; 70:1-33.
44. Artemov D. Molecular magnetic resonance imaging with targeted contrast agents. J Cell Biochem 2003; 90:518-524.
45. Christiansen JP, Lindner JR. Molecular and cellular imaging with targeted contrast ultrasound. IEEE Eng Med Biol Mag 2005; 93:809-818.
46. Lindner JR. Molecular imaging with contrast ultrasound and targeted microbubbles. J Nucl Cardiol 2004; 11:215-221.
47. Liang HD, Blomley MJ. The role of ultrasound in molecular imaging. Br J Radiol 2003; 76(suppl):S140-S150.
48. Ellegala DB, Leong-Poi H, Carpenter JE, et al. Imaging tumor angiogenesis with contrast ultrasound and microbubbles targeted to alpha(v)beta3. Circulation 2003; 108:336-341.
49. Leong-Poi H, Christiansen J, Klibanov AL, et al. Noninvasive assessment of angiogenesis by ultrasound and microbubbles targeted to alpha (v)-integrins. Circulation 2003; 107:455-460.
50. Lanza GM, Wallace KD, Fischer SE, et al. High-frequency ultrasonic detection of thrombi with a targeted contrast system. Ultrasound Med Biol 1997; 23:863-870.
51. Unger EC, Hersh E, Vannan M, et al. Local drug and gene delivery through microbubbles. Prog Cardiovasc Dis 2001; 44:45-54.
52. Spibey CA, Jackson P, Herick K. A unique charge-coupled device/xenon arc lamp based imaging system for the accurate detection and quantitation of multicolour fluorescence. Electrophoresis 2001; 22:829-836.
53. Weissleder R, Ntziachristos V. Shedding light onto live molecular targets. Nat Med 2003; 9:123-128.
54. Contag PR, Olomu IN, Stevenson DK, et al. Bioluminescent indicators in living mammals. Nat Med 1998; 4:245-247.
55. Tsien RY. Building and breeding molecules to spy on cells and tumors. FEBS Lett 2005; 579:927-932.
56. Chance B. Near-infrared images using continuous, phase-modulated, and pulsed light with quantitation of blood and blood oxygenation. Ann N Y Acad Sci 1998; 838:29-45.
57. Lin Y, Weissleder R, Tung CH. Novel near-infrared cyanine fluorochromes: synthesis, properties, and bioconjugation. Bioconjug Chem 2002; 13:605-610.
58. Slakter JS, Yannuzzi LA, Guyer DR, et al. Indocyanine-green angiography. Curr Opin Ophthalmol 1995; 6:25-32.
59. Hastings JW. Chemistries and colors of bioluminescent reactions: a review. Gene 1996; 173:5-11.
60. Voss SD, Kruskal JB. Gene therapy: a primer for radiologists. Radiographics 1998; 18:1343-1372.
61. Contag CH, Jenkins D, Contag PR, et al. Use of reporter genes for optical measurements of neoplastic disease in vivo. Neoplasia 2000; 2:41-52.
62. 121 fusion reporter gene. Abstract. Mol Imaging Biol 2005; 7:149.
63. Fischer F, Dickson EF, Pottier RH, et al. An affordable, portable fluorescence imaging device for skin lesion detection using a dual wavelength approach for image contrast enhancement and aminolaevulinic acid-induced protoporphyrin IX. Part I: design, spectral and spatial characteristics. Lasers Med Sci 2001; 16:199-206.
64. Raabe A, Beck J, Seifert V. Technique and image quality of intraoperative indocyanine green angiography during aneurysm surgery using surgical microscope integrated near-infrared video technology. Zentralbl Neurochir 2005; 66:1-6.
65. Funovics MA, Weissleder R, Mahmood U. Catheter-based in vivo imaging of enzyme activity and gene expression: feasibility study in mice. Radiology 2004; 231:659-666.
66. Ntziachristos V, Ripoll J, Weissleder R. Would near-infrared fluorescence signals propagate through large human organs for clinical studies? Opt Lett 2002; 27:333-335.
67. Herschman HR. Noninvasive imaging of reporter gene expression in living subjects. Adv Cancer Res 2004; 92:29-80.
68. Pomper MG. Molecular imaging: an overview. Acad Radiol 2001; 8:1141-1153.
69. Wu AM, Yazaki PJ, Tsai S, et al. High-resolution microPET imaging of carcinoembryonic antigen-positive xenografts by using a copper-64-labeled engineered antibody fragment. Proc Natl Acad Sci U S A 2000; 97:8495-8500.
70. Artemov D, Mori N, Ravi R, et al. Magnetic resonance molecular imaging of the HER-2/neu receptor. Cancer Res 2003; 63:2723-2727.
71. Ke S, Wen X, Gurfinkel M, et al. Near-infrared optical imaging of epidermal growth factor receptor in breast cancer xenografts. Cancer Res 2003; 63:7870-7875.
72. Kelloff GJ, Hoffman JM, Johnson B, et al. Progress and promise of FDGPET imaging for cancer patient management and oncologic drug development. Clin Cancer Res 2005; 11:2785-2808.
73. Tavitian B, Terrazzino S, Kuhnast B, et al. In vivo imaging of oligonucleotides with positron emission tomography. Nat Med 1998; 4:467-471.
74. Mahmood U, Weissleder R. Near-infrared optical imaging of proteases in cancer. Mol Cancer Ther 2003; 2:489-496.
75. Weissleder R, Tung CH, Mahmood U, et al. In vivo imaging of tumors with protease-activated near-infrared fluorescent probes. Nat Biotechnol 1999; 17:375-378.
76. Bremer C, Tung CH, Weissleder R. Molecular imaging of MMP expression and therapeutic MMP inhibition. Acad Radiol 2002; 9:S314-S315.
77. Law B, Weissleder R, Tung CH. Mechanism-based fluorescent reporter for protein kinase A detection. Chembiochem 2005; 6:1361-1367.
78. Bullok K, Piwnica-Worms D. Synthesis and characterization of a small, membrane-permeant, caspase-activatable far-red fluorescent peptide for imaging apoptosis. J Med Chem 2005; 48:5404-5407.
79. Tung CH, Gerszten RE, Jaffer FA, et al. A novel near-infrared fluorescence sensor for detection of thrombin activation in blood. Chembiochem 2002; 3:207-211.
80. Louie AY, Huber MM, Ahrens ET, et al. In vivo visualization of gene expression using magnetic resonance imaging. Nat Biotechnol 2000; 18:321-325.
81. Gambhir SS, Barrio JR, Phelps ME, et al. Imaging adenoviral-directed reporter gene expression in living animals with positron emission tomography. Proc Natl Acad Sci U S A 1999; 96:2333-2338.
82. Tjuvajev JG, Stockhammer G, Desai R, et al. Imaging the expression of transfected genes in vivo. Cancer Res 1995; 55:6126-6132.
83. Yang M, Baranov E, Jiang P, et al. Whole-body optical imaging of green fluorescent protein-expressing tumors and metastases. Proc Natl Acad Sci U S A 2000; 97:1206-1211.
84. Weissleder R, Moore A, Mahmood U, et al. In vivo magnetic resonance imaging of transgene expression. Nat Med 2000; 6:351-355.
85. MacLaren DC, Gambhir SS, Satyamurthy N, et al. Repetitive, noninvasive imaging of the dopamine D2 receptor as a reporter gene in living animals. Gene Ther 1999; 6:785-791.
86. Rogers BE, McLean SF, Kirkman RL, et al. In vivo localization of [(111)In]-DTPA-D-Phe1-octreotide to human ovarian tumor xenografts induced to express the somatostatin receptor subtype 2 using an adenoviral vector. Clin Cancer Res 1999; 5:383-393.
87. Haberkorn U. Gene therapy with sodium/iodide symporter in hepatocarcinoma. Exp Clin Endocrinol Diabetes 2001; 109:60-62.
88. Doubrovin M, Ponomarev V, Beresten T, et al. Imaging transcriptional regulation of p53-dependent genes with positron emission tomography in vivo. Proc Natl Acad Sci U S A 2001; 98:9300-9305.
89. Gambhir SS, Bauer E, Black ME, et al. A mutant herpes simplex virus type 1 thymidine kinase reporter gene shows improved sensitivity for imaging reporter gene expression with positron emission tomography. Proc Natl Acad Sci U S A 2000; 97:2785-2790.
90. Perry MJ, Todryk SM, Dalgleish AG. The role of herpes simplex virus thymidine kinase in the treatment of solid tumours. Expert Opin Investig Drugs 1999; 8:777-785.
91. Min JJ, Gambhir SS. Gene therapy progress and prospects: noninvasive imaging of gene therapy in living subjects. Gene Ther 2004; 11:115-125.
92. Blasberg RG, Gelovani J. Moleculargenetic imaging: a nuclear medicinebased perspective. Mol Imaging 2002; 1:280-300.
93. Ray P, Bauer E, Iyer M, et al. Monitoring gene therapy with reporter gene imaging. Semin Nucl Med 2001; 31:312-320.
94. Libby P. Inflammation in atherosclerosis. Nature 2002; 420:868-874.
95. Ross R. Atherosclerosis: an inflammatory disease. N Engl J Med 1999; 340:115-126.
96. Li AC, Glass CK. The macrophage foam cell as a target for therapeutic intervention. Nat Med 2002; 8:1235-1242.
97. Moreno PR, Falk E, Palacios IF, et al. Macrophage infiltration in acute coronary syndromes: implications for plaque rupture. Circulation 1994; 90:775-778.
98. Lendon CL, Davies MJ, Born GV, et al. Atherosclerotic plaque caps are locally weakened when macrophages density is increased. Atherosclerosis 1991; 87:87-90.
99. Kooi ME, Cappendijk VC, Cleutjens KB, et al. Accumulation of ultrasmall superparamagnetic particles of iron oxide in human atherosclerotic plaques can be detected by in vivo magnetic resonance imaging. Circulation 2003; 107:2453-2458.
100. Trivedi RA, JM UK-I, Graves MJ, et al. In vivo detection of macrophages in human carotid atheroma: temporal dependence of ultrasmall superparamagnetic particles of iron oxide-enhanced MRI. Stroke 2004; 35:1631-1635.
101. Sukhova GK, Shi GP, Simon DI, et al. Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells. J Clin Invest 1998; 102:576-583.
102. Galis ZS, Khatri JJ. Matrix metalloproteinases in vascular remodeling and atherogenesis: the good, the bad, and the ugly. Circulation Res 2002; 90:251-262.
103. Chen J, Tung CH, Mahmood U, et al. In vivo imaging of proteolytic activity in atherosclerosis. Circulation 2002; 105:2766-2771.
104. Liu J, Sukhova GK, Yang JT, et al. Cathepsin L expression and regulation in human abdominal aortic aneurysm, atherosclerosis, and vascular cells. Atherosclerosis 2006; 184:302-311.
105. Cheng XW, Kuzuya M, Sasaki T, et al. Increased expression of elastolytic cysteine proteases, cathepsins S and K, in the neointima of balloon-injured rat carotid arteries. Am J Pathol 2004; 164:243-251.
106. Wilson WR, Schwalbe EC, Jones JL, et al. Matrix metalloproteinase 8 (neutrophil collagenase) in the pathogenesis of abdominal aortic aneurysm. Br J Surg 2005; 92:828-833.
107. Libby P, Tanaka H. The molecular bases of restenosis. Prog Cardiovasc Dis 1997; 40:97-106.
108. Johnson LL, Schofield LM, Weber DK, et al. Uptake of 111In-Z2D3 on SPECT imaging in a swine model of coronary stent restenosis correlated with cell proliferation. J Nucl Med 2004; 45:294-299.
109. Lanza GM, Yu X, Winter PM, et al. Targeted antiproliferative drug delivery to vascular smooth muscle cells with a magnetic resonance imaging nanoparticle contrast agent: implications for rational therapy of restenosis. Circulation 2002; 106:2842-2847.
110. Marmur JD, Rossikhina M, Guha A, et al. Tissue factor is rapidly induced in arterial smooth muscle after balloon injury. J Clin Invest 1993; 91:2253-2259.
111. Jaffer FA, Weissleder R. Seeing within: molecular imaging of the cardiovascular system. Circulation Res 2004; 94:433-445.
112. Jaffer FA, Tung CH, Gerszten RE, et al. In vivo imaging of thrombin activity in experimental thrombi with thrombin-sensitive near-infrared molecular probe. Arterioscler Thromb Vasc Biol 2002; 22:1929-1935.
113. Jaffer FA, Tung CH, Wykrzykowska JJ, et al. Molecular imaging of factor XIIIa activity in thrombosis using a novel, near-infrared fluorescent contrast agent that covalently links to thrombi. Circulation 2004; 110:170-176.
114. Botnar RM, Perez AS, Witte S, et al. In vivo molecular imaging of acute and subacute thrombosis using a fibrin-binding magnetic resonance imaging contrast agent. Circulation 2004; 109:2023-2029.
115. Spuentrup E, Buecker A, Katoh M, et al. Molecular magnetic resonance imaging of coronary thrombosis and pulmonary emboli with a novel fibrin-targeted contrast agent. Circulation 2005; 111:1377-1382.
116. Sirol M, Fuster V, Badimon JJ, et al. Chronic thrombus detection with in vivo magnetic resonance imaging and a fibrin-targeted contrast agent. Circulation 2005; 112:1594-1600.
117. Knight LC. Radiolabeled peptide ligands for imaging thrombi and emboli. Nucl Med Biol 2001; 28:515-526.
118. Lanza GM, Wallace KD, Scott MJ, et al. A novel site-targeted ultrasonic contrast agent with broad biomedical application. Circulation 1996; 94:3334-3340.
119. Flacke S, Fischer S, Scott MJ, et al. Novel MRI contrast agent for molecular imaging of fibrin: implications for detecting vulnerable plaques. Circulation 2001; 104:1280-1285.
120. Bates SM, Lister-James J, Julian JA, et al. Imaging characteristics of a novel technetium Tc 99m-labeled platelet glycoprotein IIb/IIIa receptor antagonist in patients With acute deep vein thrombosis or a history of deep vein thrombosis. Arch Intern Med 2003; 163:452-456.
121. Takeuchi M, Ogunyankin K, Pandian NG, et al. Enhanced visualization of intravascular and left atrial appendage thrombus with the use of a thrombus-targeting ultrasonographic contrast agent (MRX-408A1): In vivo experimental echocardiographic studies. J Am Soc Echocardiogr 1999; 12:1015-1021.
122. Johansson LO, Bjornerud A, Ahlstrom HK, et al. A targeted contrast agent for magnetic resonance imaging of thrombus: implications of spatial resolution. J Magn Reson Imaging 2001; 13:615-618.
123. Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. Nature 2000; 407:249-257.
124. Meoli DF, Sadeghi MM, Krassilnikova S, et al. Noninvasive imaging of myocardial angiogenesis following experimental myocardial infarction. J Clin Invest 2004; 113:1684-1691.
125. Hua J, Dobrucki LW, Sadeghi MM, et al. Noninvasive imaging of angiogenesis with a 99mTc-labeled peptide targeted at alphavbeta3 integrin after murine hindlimb ischemia. Circulation 2005; 111:3255-3260.
126. Sipkins DA, Cheresh DA, Kazemi MR, et al. Detection of tumor angiogenesis in vivo by alphaVbeta3-targeted magnetic resonance imaging. Nat Med 1998; 4:623-626.
127. Winter PM, Morawski AM, Caruthers SD, et al. Molecular imaging of angiogenesis in early-stage atherosclerosis with alpha (v) beta3-integrin- targeted nanoparticles. Circulation 2003; 108:2270-2274.
128. Lin PC. Optical imaging and tumor angiogenesis. J Cell Biochem 2003; 90:484-491.
129. Shweiki D, Itin A, Soffer D, et al. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 1992; 359:843-845.
130. Lu E, Wagner WR, Schellenberger U, et al. Targeted in vivo labeling of receptors for vascular endothelial growth factor: approach to identification of ischemic tissue. Circulation 2003; 108:97-103.
131. Liddell RP, Weiss CR, Hofmann LV. Therapeutic angiogenesis: the next frontier for interventional radiology. Tech Vasc Interv Radiol 2004; 7:40-48.
132. Wu JC, Chen IY, Wang Y, et al. Molecular imaging of the kinetics of vascular endothelial growth factor gene expression in ischemic myocardium. Circulation 2004; 110:685-691.
133. Orlic D, Hill JM, Arai AE. Stem cells for myocardial regeneration. Circulation Res 2002; 91:1092-1102.
134. Sheikh AY, Wu JC. Molecular imaging of cardiac stem cell transplantation. Curr Cardiol Rep 2006; 8:147-154.
135. Schellingerhout D, Josephson L. Molecular imaging of cell-based therapies. Neuroimaging Clin North Am 2004; 14:331-342.
136. Shapiro EM, Sharer K, Skrtic S, et al. In vivo detection of single cells by MRI. Magn Reson Med 2006; 55:242-249.
137. Hill JM, Dick AJ, Raman VK, et al. Serial cardiac magnetic resonance imaging of injected mesenchymal stem cells. Circulation 2003; 108:1009-1014.
138. Kim DE, Schellingerhout D, Ishii K, et al. Imaging of stem cell recruitment to ischemic infarcts in a murine model. Stroke 2004; 35:952-957.
139. Hakumaki JM, Savitt JM, Gearhart JD, et al. MRI detection of labeled neural progenitor cells in a mouse model of Parkinson's disease. Dev Brain Res 2001; 132:A43-A44.
140. Evgenov NV, Medarova Z, Dai G, et al. In vivo imaging of islet transplantation. Nat Med 2006; 12:144-148.
141. Walter G, Cordier L, Bloy D, et al. Noninvasive monitoring of gene correction in dystrophic muscle. Magn Reson Med 2005; 54:1369-1376.
142. Barbash IM, Leor J, Feinberg MS, et al. Interventional magnetic resonance imaging for guiding gene and cell transfer in the heart. Heart 2004; 90:87-91.
143. Mahmood U. Can MR imaging be used to track delivery of intravascularly administered stem cells? Radiology 2004; 233:625-626.
144. Welch HG, Schwartz LM, Woloshin S. Are increasing 5-year survival rates evidence of success against cancer? JAMA 2000; 283:2975-2978.
145. Achilefu S. Lighting up tumors with receptor-specific optical molecular probes. Technol Cancer Res Treat 2004; 3:393-409.
146. Lucignani G, Losa M, Moresco RM, et al. Differentiation of clinically nonfunctioning pituitary adenomas from meningiomas and craniopharyngiomas by positron emission tomography with [18F]fluoro-ethyl-spiperone. Eur J Nucl Med 1997; 24:1149-1155.
147. Moon WK, Lin Y, O'Loughlin T, et al. Enhanced tumor detection using a folate receptor-targeted near-infrared fluorochrome conjugate. Bioconjug Chem 2003; 14:539-545.
148. Sidransky D. Emerging molecular markers of cancer. Nat Rev Cancer 2002; 2:210-9.
149. Bar-Shalom R, Valdivia AY, Blaufox MD. PET imaging in oncology. Semin Nucl Med 2000; 30:150-185.
150. Lardinois D, Weder W, Hany TF, et al. Staging of non-small-cell lung cancer with integrated positron-emission tomography and computed tomography. N Engl J Med 2003; 348:2500-2507.
151. Maguire TM, Shering SG, Duggan CM, et al. High levels of cathepsin B predict poor outcome in patients with breast cancer. Int J Biol Markers 1998; 13:139-144.
152. Ang KK, Berkey BA, Tu X, et al. Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma. Cancer Res 2002; 62:7350-7356.
153. Sato H, Takino T, Miyamori H. Roles of membrane-type matrix metalloproteinase-1 in tumor invasion and metastasis. Cancer Sci 2005; 96:212-217.
154. Bremer C, Tung CH, Bogdanov Aet al. Imaging of differential protease expression in breast cancers for detection of aggressive tumor phenotypes. Radiology 2002; 222:814-818.
155. Jonson SD, Welch MJ. PET imaging of breast cancer with fluorine-18 radiolabeled estrogens and progestins. Q J Nucl Med 1998; 42:8-17.
156. Prasad SR, Jhaveri KS, Saini S, et al. CT tumor measurement for therapeutic response assessment: comparison of unidimensional, bidimensional, and volumetric techniques initial observations. Radiology 2002; 225:416-419.
157. Rehman S, Jayson GC. Molecular imaging of antiangiogenic agents. Oncologist 2005; 10:92-103.
158. Bremer C, Tung CH, Weissleder R. In vivo molecular target assessment of matrix metalloproteinase inhibition. Nat Med 2001; 7:743-748.
159. Avril NE, Weber WA. Monitoring response to treatment in patients utilizing PET. Radiol Clin North Am 2005; 43:189-204.
160. Demetri GD, von Mehren M, Blanke CD, et al. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med 2002; 347:472-480.
161. Hakumaki JM, Liimatainen T. Molecular imaging of apoptosis in cancer. Eur J Radiol 2005; 56:143-153.
162. Partain CL, Chan HP, Gelovani JG, et al. Biomedical Imaging Research Opportunities Workshop II: report and recommendations. Radiology 2005; 236:389-403.
163. Elgort DR, Duerk JL. A review of technical advances in interventional magnetic resonance imaging. Acad Radiol 2005; 12:1089-1099.
164. Lee JT, White RA. Basics of intravascular ultrasound: an essential tool for the endovascular surgeon. Semin Vasc Surg 2004; 17:110-118.