Molecular imaging of factor XIIIa activity in thrombosis using a novel, near-infrared fluorescent contrast agent that covalently links to thrombi

Circulation

Volumn 110, Issue 2, 2004, Pages 170-176

  Jaffer, Farouc A ^a   Tung, Ching Hsuan ^a   Wykrzykowska, Joanna J ^a   Ho, Nan Hui ^a   Houng, Aiilyan K ^b   Reed, Guy L ^a,b   Weissleder, Ralph ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Blood factors; Contrast media; Fluorescence; Imaging; Thrombosis

Indexed keywords

ACYLGLYCYLASPARAGINYLALANYLGLUTAMYLGLUTAMINYLVALYLSERYLPROLYLLEUCYLTHREONYL LEUCYLLEUCYLLYSYLTRYPTOPHYLCYSTEINE; ACYLGLYCYLASPARAGINYLGLUTAMYLGLUTAMINYLGLUTAMYLVALYLSERYLPROLYLLEUCYLTHREON YLLEUCYLLEUCYLLYSYLTRYPTOPHYLCYSTEINE; AF 680; ALPHA 2 ANTIPLASMIN; BLOOD CLOTTING FACTOR 13A; C 15; CONTRAST MEDIUM; FIBRIN; FLUORESCENT DYE; FLUOROCHROME; GLUTAMINE; PEPTIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTRAST ENHANCEMENT; CONTROLLED STUDY; COVALENT BOND; FIBRINOLYSIS; FLUORESCENCE; FLUORESCENCE MICROSCOPY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMAGING; INFRARED RADIATION; MOUSE; NEAR INFRARED FLUORESCENT IMAGING; NONHUMAN; PRIORITY JOURNAL; THROMBOSIS;

ANIMALS; ANTIPLASMIN; CONTRAST MEDIA; CROSS-LINKING REAGENTS; FACTOR XIIIA; FEASIBILITY STUDIES; FERRIC COMPOUNDS; FIBRIN; FLUORESCENT DYES; HUMANS; MICE; MICE, INBRED BALB C; MICROSCOPY, FLUORESCENCE; PEPTIDE FRAGMENTS; PROTEIN BINDING; SPECTROSCOPY, NEAR-INFRARED; THROMBOSIS; TIME FACTORS;

EID: 3142770490     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000134484.11052.44     Document Type: Article

References (20)

1. Fibrinolytic Therapy Trialists' (FTT) Collaborative Group. Indications for fibrinolytic therapy in suspected acute myocardial infarction: collaborative overview of early mortality and major morbidity results from all randomised trials of more than 1000 patients. Lancet. 1994;343:311-322.
2. Muszbek L, Yee VC, Hevessy Z. Blood coagulation factor XIII: structure and function. Thromb Res. 1999;94:271-305.
3. Reed GL, Houng AK. The contribution of activated factor XIII to fibrinolytic resistance in experimental pulmonary embolism. Circulation. 1999;99:299-304.
4. Leidy EM, Stern AM, Friedman PA, et al. Enhanced thrombolysis by a factor XIIIa inhibitor in a rabbit model of femoral artery thrombosis. Thromb Res. 1990;59:15-26.
5. Shebuski RJ, Sitko GR, Claremon DA, et al. Inhibition of factor XIIIa in a canine model of coronary thrombosis: effect on reperfusion and acute reocclusion after recombinant tissue-type plasminogen activator. Blood. 1990;75:1455-1459.
6. Robinson BR, Houng AK, Reed GL. Catalytic life of activated factor XIII in thrombi: implications for fibrinolytic resistance and thrombus aging. Circulation. 2000;102:1151-1157.
7. Badimon JJ, Fuster V. Can we image the "active" thrombus? Arterioscler Thromb Vasc Biol. 2002;22:1753-1754.
8. Jaffer FA, Tung CH, Gerszten RE, et al. In vivo imaging of thrombin activity in experimental thrombi with thrombin-sensitive near-infrared molecular probe. Arterioscler Thromb Vasc Biol. 2002;22:1929-1935.
9. Lorand L, Losowsky MS, Miloszewski KJ. Human factor XIII: fibrin-stabilizing factor. Prog Hemost Thromb. 1980;5:245-290.
10. Weller M, Bresgen M, Heimann K, et al. Blood coagulation factor XIII contributes to the development of traction retinal detachment. Acta Ophthalmol (Copenh). 1990;68:246-252.
11. Schubring C, Grulich-Henn J, Burkhard P, et al. Fibrinolysis and factor XIII in women with spontaneous abortion. Eur J Obstet Gynecol Reprod Biol. 1990;35:215-221.
12. Serrano K, Devine DV. Intracellular factor XIII crosslinks platelet cytoskeletal elements upon platelet activation. Thromb Haemost. 2002;88:315-320.
13. Ariens RA, Lai TS, Weisel JW, et al. Role of factor XIII in fibrin clot formation and effects of genetic polymorphisms. Blood. 2002;100:743-754.
14. Tung C, Ho N-H, Zeng Q, et al. Novel factor XIII probes for blood coagulation imaging. Chembiochem. 2003;4:897-899.
15. Mahmood U, Tung C, Bogdanov A, et al. Near infrared optical imaging system to detect tumor protease activity. Radiology. 1999;213:866-870.
16. Farrehi PM, Ozaki CK, Carmeliet P, et al. Regulation of arterial thrombolysis by plasminogen activator inhibitor-1 in mice. Circulation. 1998;97:1002-1008.
17. Jaffer FA, Weissleder R. Seeing within: molecular imaging of the cardiovascular system. Circ Res. 2004;94:433-445.
18. Hope-Ross M, Yannuzzi LA, Gragoudas ES, et al. Adverse reactions due to indocyanine green. Ophthalmology. 1994;101:529-533.
19. Taggart DP, Choudhary B, Anastasiadis K, et al. Preliminary experience with a novel intraoperative fluorescence imaging technique to evaluate the patency of bypass grafts in total arterial revascularization. Ann Thorac Surg. 2003;75:870-873.
20. Ntziachristos V, Tung CH, Bremer C, et al. Fluorescence molecular tomography resolves protease activity in vivo. Nat Med. 2002;8:757-760.