Whole-animal cellular and molecular imaging to accelerate drug development

Drug Discovery Today

Volumn 7, Issue 10, 2002, Pages 555-562

  Contag, Pamela R ^a  

^a Xenogen Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NEW DRUG;

BIOLUMINESCENCE; DRUG APPROVAL; GENOMICS; IMAGING SYSTEM; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; REVIEW; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TRANSGENIC ANIMAL; ANIMAL; ANIMAL MODEL; DRUG DESIGN; EXPERIMENTAL ANIMAL; FOOD AND DRUG ADMINISTRATION; UNITED STATES;

ANIMAL; ANIMALS, LABORATORY; DRUG DESIGN; GENOMICS; MODELS, ANIMAL; UNITED STATES; UNITED STATES FOOD AND DRUG ADMINISTRATION; ANIMALS;

EID: 0037092618     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(02)02268-7     Document Type: Review

References (42)

1. Effective decision-making: Progressing compounds through clinical development
2. Investigational drugs
3. Efficiency control in drug discovery
4. The potential of molecular biophotonics in drug discovery
5. Early history of animal nodels of infection
6. Rabbit models of bacterial endocarditis
7. The use of animal models in cancer drug discovery and development
8. Transgenic model applications to drug discovery
9. Altering mice by homologous recombination using embryonic stem cells
10. Transgenic mice
11. Transgenic mice: A new and powerful experimental tool in mammalian developmental genetics
12. Bioluminescent indicators in living mammals
13. Rapid in vivo functional analysis of transgenes in mice using whole body imaging of luciferase expression
14. Production of human clotting Factor IX without toxicity in mice after vascular delivery of a lentiviral vector
15. Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors
16. Genetically engineered mice in drug development
17. Transgenic mice and oncogenesis
18. Microinjecting DNA into mouse ova to study DNA replication and gene expression and to produce transgenic animals
19. Quantitative imaging of gene induction in living animals
20. In vivo visualization of gene expression using magnetic resonance imaging
21. The development of in vivo imaging systems to study gene expression
22. Monitoring gene therapy with reporter gene imaging
23. In vivo magnetic resonance imaging of transgene expression
24. Imaging gene expression: Principles and assays
25. Seeing is believing: Non-invasive, quantitative and repetitive imaging of reporter gene expression in living animals, using positron emission tomography
26. Role of radionuclide imaging in trials of antiangiogenic therapy
27. Strategies in in vivo molecular imaging
28. Concurrent MRI and diffuse optical tomography of breast following indocyanine green enhancement
29. Noninvasive functional optical spectroscopy of human breast tissue
30. Monitoring tumor response during photodynamic therapy using near-infrared photon-migration spectroscopy
31. Sources of absorption and scattering contrast for near-infrared optical mammography
32. Non-invasive technique for obtaining fluorescence excitation and emission spectra in-vivo
33. Bacterial bioluminescence
34. Bioluminescence
35. Photonic detection of bacterial pathogens in living hosts
36. Applications of in vivo molecular imaging in biology and medicine
37. Illuminating drug discovery
38. Noninvasive optical imaging of firefly luciferase reporter gene expression in skeletal muscles of living mice
39. Use of reporter genes for optical measurements of neoplastic disease in vivo
40. Selection of potential therapeutics based on in vivo spatiotemporal transcription patterns of heme oxygenase
41. Visualizing gene expression in living mammals using a bioluminescent reporter
42. Generations of transgenics advance drug discovery