Molecular and cellular imaging with targeted contrast ultrasound

Proceedings of the IEEE

Volumn 93, Issue 4, 2005, Pages 809-818

  Christiansen, Jonathan Philip ^a   Lindner, Jonathan R ^b  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b UNIVERSITY OF VIRGINIA MEDICAL CENTER   (United States)

Author keywords

Angiogenesis; Contrast echocardiography; Contrast ultrasound; Inflammation; Microbubbles

Indexed keywords

ANTIGENS; CARDIOLOGY; CELLS; DATA PROCESSING; DISEASES; GENES; MEDICINE; TISSUE; TUMORS; ULTRASONICS;

ANGIOGENESIS; CONTRAST ECHOCARDIOGRAPHY; CONTRAST ULTRASOUND; INFLAMMATION; MICROBUBBLES;

IMAGING TECHNIQUES;

EID: 20744434250     PISSN: 00189219     EISSN: None     Source Type: Journal    
DOI: 10.1109/JPROC.2005.844260     Document Type: Conference Paper

References (48)

1. J. Narula, E. R. Acio, N. Narula, L. E. Samuels, B. Fyfe, D. Jain, and W. H. Strauss, "Annexin-V imaging for noninvasive detection of cardiac allograft rejection.," Nature Med., vol. 7, pp. 1347-1352, 2001.
2. R. Haubner, H. Wester, U. Reuning, and R. Senekowitsch-Schmidtke et al., "Glycosylated RGD-containing peptides: tracer for tumor targeting and angiogenesis imaging with improved biokinetics," J Nucl. Med., vol. 42, pp. 326-336, 2001.
3. 99mTc-RP517, a new leukotriene B4 receptor antagonist, that preferentially labels neutrophils in vivo," Circulation, vol. 106, pp. 592-598, 2002.
4. D. A. Sipkins, D. A. Cheresh, M. R. Kazemi, L. M. Nevin, M. D. Bednarski, and K. C. Li, "Detection of tumor angiogenesis in vivo by alpha-V-beta-3-targeted magnetic resonance imaging," Nature Med., vol. 4, pp. 623-626, 1998.
5. 3 targeted nanoparticles," Magn. Reson. Med., vol. 44, pp. 433-439, 2000.
6. S. Flacke, S. Fischer, and M. J. Scott et al., "Novel MRI contrast agent for molecular imaging of fibrin: implications for detecting vulnerable plaque," Circulation, vol. 104, pp. 1280-1285, 2001.
7. J. Egan and W. J. Sandborn, Inflammatory Bowel Disease, From Bench to Bedside, 2nd ed, S. R. Targan, F. Shanahan, and L. C. Karp, Eds. Dordrecht, The Netherlands: Kluwer, 2003, pp. 495-521.
8. J. R. Lindner, J. Song, A. R. Jayaweera, J. Sklenar, and S. Kaul, "Microvascular rheology of definity microbubbles following intraarterial and intravenous administration," J. Amer. Soc. Echocardiog., vol. 15, pp. 396-403, 2002.
9. D. M. Skyba, G. Camarano, N. C. Goodman, R. J. Price, T. C. Skalak, and S. Kaul, "Hemodynamic characteristics, myocardial kinetics and microvascular rheology of FS-069, a second generation echocardio-graphic contrast agent capable of producing myocardial opacification from a venous injection," J. Amer. Coll. Cardiol., vol. 28, pp. 1292-1300, 1996.
10. S. M. Demos, H. Alkan-Onyuksel, and B. J. Kane et al., "In vivo targeting of acoustically reflective liposomes for intravascular and transvalvular ultrasonic enhancement," J. Amer. Coll. Cardiol., vol. 33, pp. 867-875, 1999.
11. S. L. Huang, A. J. Hamilton, and E. Pozharski et al., "Physical correlates of the ultrasonic reflectivity of lipid dispersions suitable as diagnostic contrast agents," Ultrasound Med. Biol., vol. 28, pp. 339-348, 2002.
12. G. M. Lanza, D. R. Abendschein, and C. S. Hall et al., "In vivo molecular imaging of stretch-induced tissue factor in carotid arteries with ligand-targeted nanoparticles," J. Amer. Soc. Echocardiog., vol. 13, pp. 608-614, 2000.
13. B. E. Noltingk and E. A. Neppiras, "Cavitation produced by ultrasonics," Proc. Phys. Soc., vol. B63, pp. 674-685, 1950.
14. P. S. Epstein and M. S. Plesset, "On the stability of gas bubbles in liquid-gas solutions," J. Chem Phys., vol. 18, pp. 1505-1509, 1950.
15. N. de Jong, L. Hoff, T. Skotland, and N. Bom, "Absorption and scatter of encapsulated gas-filled microspheres: theroetical considerations and some measurements," Ultrasonics, vol. 30, pp. 95-103, 1992.
16. N. de Jong, R. Cornet, and C. T. Lancee, "Higher harmonics of vibrating gas-filled microspheres," Ultrasonics, vol. 32, pp. 455-459, 1994.
17. L. Hoff, P. C. Sontum, and B. Hoff, "Acoustic properties of shell-encapsulated, gas-filled ultrasound contrast agents," in Proc. IEEE Ultrasonics Symp., 1996, pp. 1441-1444.
18. P. N. Burns, J. E. Powers, D. H. Simpson, V. Uhlendorf, and T. Fritzsche, "Harmonic imaging: priciples and preliminary results," Clin. Radiol., vol. 51, pp. 50-55, 1996.
19. G. Lanza, R. Trousil, and K. Wallace et al., "In vitro characterization of a novel, tissue-targeted ultrasonic contrast system with acoustic microscopy," J. Acoust. Soc. Amer., vol. 104, pp. 3665-3672, 1998.
20. C. C. Coussios, C. K. Holland, and L. Jakubowska, "In vitro characterization of liposomes and optison by acoustic scattering at 3.5 MHz," Ultrasound Med. Biol., vol. 30, pp. 181-190, 2004.
21. K. Wei, A. R. Jayaweera, S. Firoozan, A. Linka, D. M. Skyba, and S. Kaul, "Quantification of myocardial blood flow with ultrasound induced destruction of microbubbles administered as a constant venous infusion," Circulation, vol. 97, pp. 473-483, 1998.
22. J. R. Lindner, J. Song, F. Xu, A. L. Klibanov, K. Singbartl, K. Ley, and S. Kaul, "Noninvasive ultrasound imaging of inflammation using microbubbles targeted to activated leukocytes," Circulation, vol. 102, pp. 2745-2750, 2000.
23. J. R. Lindner, P. A. Dayton, and M. P. Coggins et al., "Noninvasive imaging of inflammation by ultrasound detection of phagocytosed microbubbles," Circulation, vol. 102, pp. 531-538, 2000.
24. J. P. Christiansen, H. Leong-Poi, A. L. Klibanov, S. Kaul, and J. R. Lindner, "Noninvasive imaging of myocardial reperfusion injury using leukocyte-targeted contrast echocardiography," Circulation, vol. 105, pp. 1764-1767, 2002.
25. J. R. Lindner, J. Song, J. P. Christiansen, A. L. Klibanov, F. Xu, and K. Ley, "Ultrasound assessment of inflammation and renal tissue injury with microbubbles targeted to P-selectin," Circulation, vol. 104, pp. 2107-2112, 2001.
26. G. M. Lanza, D. Abendschein, and C. Hall et al., "Molecular imaging of stretch-induced tissue factor expression in carotid arteries with intravascular ultrasound," Invest Radiol, vol. 35, pp. 227-234, 2000.
27. G. M. Lanza, K. D. Wallace, and K. D. Scott et al., "A novel site-targeted ultrasonic contrast agent with broad biomedical application," Circulation, vol. 94, pp. 3334-3340, 1996.
28. A. J. Hamilton, S. L. Huang, and D. Warnick et al., "Intravascular ultrasound molecular imaging of atheroma components in vivo," J. Amer. Coll. Cardiol., vol. 43, pp. 453-460, 2004.
29. A. Hamilton, S. L. Huang, and D. Warnick et al., "Left ventricular thrombus enhancement after intravenous injection of echogenic immunoliposomes," Circulation, vol. 105, pp. 2772-2778, 2002.
30. K. Ley, "Molecular mechanisms of leukocyte recruitment in the inflammatory process," Cardiovasc. Res., vol. 32, pp. 733-742, 1996.
31. K. Ley and T. F. Tedder, "Leukocyte interactions with vascular endothelium," J. Immunol, vol. 155, pp. 525-528, 1995.
32. J.R.Lindner, M.P.Coggins, S.Kaul, A.L.Klibanov, G.H.Branden-burger, and K. Ley, "Microbubble persistence in the microcirculation during ischemia/reperfusion and inflammation is caused by integrin-and complement-mediated adherence to activated leukocytes," Circulation, vol. 101, pp. 668-675, 2000.
33. P. A. Dayton, J. E. Chomas, and A. Lum et al., "Optical and acoustical dynamics of microbubble contrast agents inside neutrophils," Biophys. J., vol. 80, pp. 1547-1556, 2001.
34. F. S. Villanueva, R. J. Jankowski, A. L. Klibanov, G. H. Branden-burger, and W. R. Wagner, "Microbubble targeted to intercellular adhesion molecule-1 bind to activated coronary endothelial cells," Circulation, vol. 98, pp. 1-5, 1998.
35. G. E. Weller, E. Lu, and M. M.Csikari et al., "Ultrasound imaging of acute cardiac transplant rejection with microbubbles targeted to intercellular adhesion molecule-1," Circulation, vol. 108, pp. 218-224, 2003.
36. C. Davis, J. P. Christiansen, I. Sarembock, A. L. Klibanov, and J. R. Lindner, "VCAM-targeted microbubbles adhere to atherosclerotic plaque in the aorta of Apo-E knockout mice," Circulation, vol. 108, p. 624, 2003.
37. C. Bachmann, A. L. Klibanov, and T. Oison et al., "A novel diagnostic tool for the noninvasive evaluation of intestinal inflammation," Nature Biotechnol., submitted for publication.
38. A. M. Takalkar, A. L. Klibanov, J. J. Rychak, J. R. Lindner, and K. Ley, "Binding and detachment of microbubbles targeted to p-selectin under controlled shear flow," J. Contr. Rel., vol. 96, pp. 473-482, 2004.
39. G. E. Weller, R S. Villanueva, A. L. Klibanov, and W. R. Wagner, "Modulating targeted adhesion of an ultrasound contrast agent to dysfunctional endothelium," Ann. Biomed. Eng., vol. 30, pp. 1012-1019, 2002.
40. S. Benedict Freedman and J. M. Isner, "Therapeutic angiogenesis for coronary artery disease," Ann. Int. Med., vol. 136, pp. 54-71, 2002.
41. M. Arras, W. D. Ito, D. Scholz, B. Winkler, and W. Schaper, "Monocyte activation in angiogenesis and collateral growth in the rabbit hindlimb," J. Clin. Invest., vol. 101, pp. 40-50, 1998.
42. P. C. Brooks, R. A. F. Clark, and D. A. Cheresh, "Requirement of vascular integrin αvβ3 for angiogenesis," Science, vol. 264, pp. 569-571, 1994.
43. M. Friedlander, P.C. Brooks, R. Shaffer, and D. A. Cheresh, "Definition of two angiogenic pathways by distinct αv integrins," Science, vol. 270, pp. 1500-1503, 1995.
44. v integrins," Circulation, vol. 107, pp. 455-460, 2003.
45. H. Leong-Poi, J. P. Christiansen, and P. Heppner et al., "Assessment of endogenous and therapeutic arteriogenesis by integrin imaging with targeted contrast ultrasound," Circulation, to be published.
46. D. Ellegala, H. Leong-Poi, J. Carpenter, M. Shaffrey, S. Kaul, J. Sklenar, A. L. Klibanov, and J. R. Lindner, "Imaging tumor angiogenesis with contrast ultrasound and microbubbles targeted to αvβ3," Circulation, vol. 108, pp. 336-341, 2003.
47. E. Unger, T. P. McCrecry, R. H. Sweitzer, D. Shen, and G. Wu, "In vitro studies of a new thrombus-specific ultrasound contrast agent," Amer. J. Cardiol., vol. 81, pp. 58G-61G, 1998.
48. P. A. Schumann, J. P. Christiansen, and R. M. Quigley et al., "Targeted microbubble binding selectively to GPIIbIIIa receptors on platelet thrombi," Invest. Radiol., vol. 37, pp. 587-593.