Blood-brain barrier flux of aluminum, manganese, iron and other metals suspected to contribute to metal-induced neurodegeneration

Journal of Alzheimer's Disease

Volumn 10, Issue 2-3, 2006, Pages 223-253

  Yokel, Robert A ^a,b  

^a UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Aluminum; Blood brain barrier; Brain efflux; Brain influx; Choroid plexus; Iron; Lead; Manganese; Mercury; Zinc

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); ALUMINUM; ALUMINUM CITRATE; CALCIUM CHANNEL; CARRIER PROTEIN; COPPER; CYSTEINE; HISTIDINE; IRON; LEAD; MANGANESE; MENKES PROTEIN; METHIONINE; METHYLMERCURY; ORGANIC ANION TRANSPORTER; ORGANOTIN COMPOUND; TRANSFERRIN RECEPTOR; WILSON DISEASE PROTEIN; ZINC; ZINC TRANSPORTER;

ALUMINUM OVERLOAD; ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; BLOOD BRAIN BARRIER; CENTRAL NERVOUS SYSTEM; CHOROID PLEXUS; DEGENERATIVE DISEASE; DIFFUSION; ENDOCYTOSIS; HUMAN; IRON TRANSPORT; MEMBRANE TRANSPORT; NERVE DEGENERATION; NEUROTOXICITY; NONHUMAN; OLFACTORY NERVE; OXIDATION; OXIDATIVE STRESS; PARKINSON DISEASE; PARKINSONISM; PRIORITY JOURNAL; REVIEW; TOXICOKINETICS; TRANSPORT KINETICS; TRIGEMINAL NERVE;

EID: 33748749719     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2006-102-309     Document Type: Review

References (285)

1. H.R. Massie, V.R. Aiello and A.A. Iodice, Changes with age in copper and superoxide dismutase levels in brains of C57BL/6J mice, Mech. Ageing Dev. 10 (1979), 93-99.
2. G. Bartzokis, M. Beckson, D.B. Hance, P. Marx, J.A. Foster and S.R. Marder, MR evaluation of age-related increase of brain iron in young adult and older normal males, Magn. Reson. Imaging 15 (1997), 29-35.
3. L. Zecca, M. Gallorini, V. Schunemann, A.X. Trautwein, M. Gerlach, P. Riederer, P. Vezzoni and D. Tampellini, Iron, neuromelanin and ferritin content in the substantia nigra of normal subjects at different ages: consequences for iron storage and neurodegenerative processes, J. Neurochem. 76 (2001), 1766-1773.
4. W.R. Markesbery, W.D. Ehmann, M. Alauddin and T.I.M. Hossain, Brain trace element concentrations in aging, Neurobiol. Aging 5 (1984), 19-28.
5. A. Morita, M. Kimura and Y. Itokawa, The effect of aging on the mineral status of female mice, Biol. Trace Elem. Res. 42 (1994), 165-177.
6. J.A. Yesavage, R. O'Hara, H. Kraemer, A. Noda, J.L. Taylor, S. Ferris, M.C. Gely-Nargeot, A. Rosen, L. Friedman, J. Sheikh and C. Derouesne, Modeling the prevalence and incidence of Alzheimer's disease and mild cognitive impairment, J. Psychiatr. Res. 36 (2002), 281-286.
7. K.R. Jones and D.E. Oorschot, Do aluminium and/or glutamate induce Alz-50 reactivity? A light microscopic immunohistochemical study, J. Neurocytol. 27 (1998), 45-57.
8. F. Trippi, N. Botto, R. Scarpato, L. Petrozzi, U. Bonuccelli, S. Latorraca, S. Sorbi and L. Migliore, Spontaneous and induced chromosome damage in somatic cells of sporadic and familial Alzheimer's disease patients, Mutagenesis 16 (2001), 323-327.
9. A. Eckert, C.A. Marques, U. Keil, K. Schussel and W.E. Muller, Increased apoptotic cell death in sporadic and genetic Alzheimer's disease, Ann. N. Y. Acad. Sci. 1010 (2003), 604-609.
10. R.E. Mrak and W.S. Griffin, Glia and their cytokines in progression of neurodegeneration, Neurobiol. Aging 26 (2005), 349-354.
11. A. Campbell, The potential role of aluminium in Alzheimer's disease, Nephrol. Dial. Transplant. 17(Suppl. 2) (2002), 17-20.
12. D.L. Sparks and B.G. Schreurs, Trace amounts of copper in water induce beta-amyloid plaques and learning deficits in a rabbit model of Alzheimer's disease, Proc. Natl. Acad. Sci. USA 100 (2003), 11065-11069.
13. W.Y. Ong and A.A. Farooqui, Iron, neuroinflammation, and Alzheimer's disease, J. Alzheimers Dis. 8 (2005), 183-200.
14. B. Mohandas and R.A. Colvin, The role of zinc in Alzheimer's disease, Recent Res. Devel. Physiol. 2 (2004), 225-245.
15. C. Koppenal, A.E. Finefrock, A.I. Bush and P.M. Doraiswamy, Copper, iron and zinc as therapeutic targets in Alzheimer's disease, Res. Prac. Alzheimer's Dis. 9 (2004), 250-255.
16. National Institute of Neurological Disorders and Stroke, http://www.ninds.nih.gov/disorders/parkinsons_disease/parkinsons_disease_ backgrounder.htm.
17. P. Poorkaj, J.G. Nutt, D. James, S. Gancher, T.D. Bird, E. Steinbart, G.D. Schellenberg and H. Payami, parkin mutation analysis in clinic patients with early-onset Parkinson's disease, Am. J. Med. Genet. A 129 (2004), 44-50.
18. M.C. Bennett, The role of alpha-synuclein in neurodegenerative diseases, Pharmacol. Ther. 105 (2005), 311-331.
19. H. Snyder and B. Wolozin, Pathological proteins in Parkinson's disease: focus on the proteasome, J. Mol. Neurosci. 24 (2004), 425-442.
20. N. Hattori, H. Kobayashi, Y. Sasaki-Hatano, K. Sato and Y. Mizuno, Familial Parkinson's disease: a hint to elucidate the mechanisms of nigral degeneration, J. Neurol. 250(Suppl 3) (2003), III2-III10.
21. A. McInerney-Leo, D.W. Hadley, K. Gwinn-Hardy and J. Hardy, Genetic testing in Parkinson's disease, Mov. Disord. 20 (2005), 1-10.
22. V.N. Uversky, J. Li and A.L. Fink, Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. A possible molecular link between Parkinson's disease and heavy metal exposure, J. Biol. Chem. 276 (2001), 44284-44296.
23. D.T. Dexter, A. Carayon, F. Javoy-Agid, Y. Agid, F.R. Wells, S.E. Daniel, A.J. Lees, P. Jenner and C.D. Marsden, Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia, Brain 114 (1991), 1953-1975.
24. Y. Qian, E. Tiffany-Castiglioni, J. Welsh and E.D. Harris, Copper efflux from murine microvascular cells requires expression of the menkes disease Cu-ATPase, J. Nutr. 128 (1998), 1276-1282.
25. L.S. Wechsler, H. Checkoway, G.M. Franklin and L.G. Costa, A pilot study of occupational and environmental risk factors for Parkinson's disease, NeuroToxicology 12 (1991), 387-392.
26. J.M. Gorell, B.A. Rybicki, C. Cole Johnson and E.L. Peterson, Occupational metal exposures and the risk of Parkinson's disease, Neuroepidemiology 18 (1999), 303-308.
27. A.S. Tavill, http://www.clevelandclinicmeded.com/diseasemanagement/ gastro/wilsons/wilsons.htm.
28. M. Reilly, L. Daly and M. Hutchinson, An epidemiological study of Wilson's disease in the Republic of Ireland, J. Neurol. Neurosurg. Psychiatry 56 (1993), 298-300.
29. G.V. Dedoussis, J. Genschel, T.E. Sialvera, B. Bochow, N. Manolaki, Y. Manios, E. Tsafantakis and H. Schmidt, Wilson disease: high prevalence in a mountainous area of Crete, Ann. Hum. Genet. 69 (2005), 268-274.
30. S. Lutsenko and M.J. Petris, Function and regulation of the mammalian copper-transporting ATPases: insights from biochemical and cell biological approaches, J. Membr. Biol. 191 (2003), 1-12.
31. E.D. Harris, Cellular copper transport and metabolism, Annu. Rev. Nutr. 20 (2000), 291-310.
32. M. Frydman, Genetic aspects of Wilson's disease, J. Gastroenterol. Hepatol. 5 (1990), 483-490.
33. T. Tønnesen, W.J. Kleijer and N. Horn, Incidence of Menkes disease, Hum. Genet. 86 (1991), 408-410.
34. Y.H. Gu, H. Kodama, K. Shiga, S. Nakata, Y. Yanagawa and H. Ozawa, A survey of Japanese patients with Menkes disease from 1990 to 2003: incidence and early signs before typical symptomatic onset, pointing the way to earlier diagnosis, J. Inherit. Metab. Dis. 28 (2005), 473-478.
35. I. Voskoboinik, H. Brooks, S. Smith, P. Shen and J. Camakaris, ATP-dependent copper transport by the Menkes protein in membrane vesicles isolated from cultured Chinese hamster ovary cells, FEBS Lett. 435 (1998), 178-182.
36. M.J. Niciu, X.M. Ma, R. El Meskini, G.V. Ronnett, R.E. Mains and B.A. Eipper, Developmental changes in the expression of ATP7A during a critical period in postnatal neurodevelopment, Neurosci. 139 (2006), 947-964.
37. P. Krajacic, Y. Qian, P. Hahn, T. Dentchev, N. Lukinova and J.L. Dunaief, Retinal localization and copper-dependent relocalization of the Wilson and menkes disease proteins, Invest. Ophthalmol. Vis. Sci. 47 (2006), 3129-3134.
38. P.C. Liu, Y.W. Chen, J.A. Centeno, M. Quezado, K. Lem and S.G. Kaler, Downregulation of myelination, energy, and translational genes in Menkes disease brain, Mol. Genet. Metab. 85 (2005), 291-300.
39. B.J. Traynor, M.B. Codd, B. Corr, C. Forde, E. Frost and O. Hardiman, Incidence and prevalence of ALS in Ireland, 1995-1997: a population-based study, Neurology 52 (1999), 504-509.
40. O.B. Tysnes, S.E. Vollset and J.A. Aarli, Epidemiology of amyotrophic lateral sclerosis in Hordaland county, western Norway, Acta Neurol. Scand. 83 (1991), 280-285.
41. T. Arisato, R. Okubo, H. Arata, K. Abe, K. Fukada, S. Sakoda, A. Shimizu, X.H. Qin, S. Izumo, M. Osame and M. Nakagawa, Clinical and pathological studies of familial amyotrophic lateral sclerosis (FALS) with SOD1 H46R mutation in large Japanese families, Acta. Neuropathol. (Berl) 106 (2003), 561-568.
42. M. Gaudette, M. Hirano and T. Siddique, Current status of SOD1 mutations in familial amyotrophic lateral sclerosis, Amyotroph. Lateral Scler. Other Motor Neuron Disord. 1 (2000), 83-89.
43. D.O. Carpenter, Effects of metals on the nervous system of humans and animals, Int. J. Occup. Med. Environ. Health 14 (2001), 209-218.
44. T. Kihira, S. Yoshida, T. Kondo, Y. Yase and S. Ono, ALS-like skin changes in mice on a chronic low-Ca/Mg high-Al diet, J. Neurol. Sci. 219 (2004), 7-14.
45. F. Kamel, D.M. Umbach, T.L. Munsat, J.M. Shefner, H. Hu and D.P. Sandler, Lead exposure and amyotrophic lateral sclerosis, Epidemiology 13 (2002), 311-319.
46. R.S. Shiwach, Prevalence of Huntington's disease in the Oxford region, Br. J. Psychiatry 165 (1994), 414-415.
47. J.A. Burguera, P. Solis and A. Salazar, [Estimate of the prevalence of Huntington disease in the Valencia region using the capture-recapture method], Rev. Neurol. 25 (1997), 1845-1847.
48. G. Warren and P. Yellowlees, The prevalence of Huntington's disease, Med. J. Aust. 153 (1990), 629.
49. K. Nakashima, Y. Watanabe, M. Kusumi, E. Nanba, Y. Maeoka, M. Nakagawa, M. Igo, H. Irie, H. Ishino, A. Fujimoto, J. Goto and K. Takahashi, Epidemiological and genetic studies of Huntington's disease in the San-in area of Japan, Neuroepidemiology 15 (1996), 126-131.
50. K. Omi, N.S. Hachiya, K. Tokunaga and K. Kaneko, siRNA-mediated inhibition of endogenous Huntington disease gene expression induces an aberrant configuration of the ER network in vitro, Biochem. Biophys. Res. Commun. 338 (2005), 1229-1235.
51. D.R. Richardson, Novel chelators for central nervous system disorders that involve alterations in the metabolism of iron and other metal ions, Ann. N. Y. Acad. Sci. 1012 (2004), 326-341.
52. J.M. Lopez-Arlandis, J.J. Vilchez, F. Palau and T. Sevilla, Friedreich's ataxia: an epidemiological study in Valencia, Spain, based on consanguinity analysis, Neuroepidemiology 14 (1995), 14-19.
53. M. Leone, F. Brignolio, M.G. Rosso, E.S. Curtoni, A. Moroni, A. Tribolo and D. Schiffer, Friedreich's ataxia: a descriptive epidemiological study in an Italian population, Clin. Genet. 38 (1990), 161-169.
54. A.L. Bulteau, H.A. O'Neill, M.C. Kennedy, M. Ikeda-Saito, G. Isaya and L.I. Szweda, Frataxin acts as an iron chaperone protein to modulate mitochondrial aconitase activity, Science 305 (2004), 242-245.
55. R.A. Goyer and T.W. Clarkson, Toxic Effects of Metals, in: Casarett and Doull's Toxicology - The Basic Science of Poisons, C.D. Klaassen, ed., McGraw-Hill, New York, 2001, pp. 811-867.
56. E.O. Uthus and C.D. Seaborn, Deliberations and evaluations of the approaches, endpoints and paradigms for dietary recommendations of the other trace elements, J. Nutr. 126 (1996), 2452S-2459S.
57. W. Pardridge, Blood-brain barrier drug targeting: The future of brain drug development, Mol. Interventions 3 (2003), 90-105.
58. J. Laterra, R. Keep, A.L. Betz and G.W. Goldstein, Blood-brain- cerebrospinal fluid barriers, in: Basic Neurochemistry: Molecular, Cellular and Medical Aspects, G.J. Siegel and B.W. Agranoff, eds, Lippincott-Raven Publishers, Philadelphia, 1999, pp. 671-689.
59. W.R. Harris, Thermodynamic binding constants of the zinchuman serum transferrin complex, Biochem. 22 (1983), 3920-3926.
60. H.A. Huebers, E. Csiba, E. Huebers and C.A. Finch, Competitive advantage of diferric transferrin in delivering iron to reticulocytes, Proc. Natl. Acad. Sci. USA. 80 (1983), 300-304.
61. G. Liu, M.R. Garrett, P. Men, X. Zhu, G. Perry and M.A. Smith, Nanoparticle and other metal chelation therapeutics in Alzheimer disease, Biochim. Biophys. Acta 1741 (2005), 246-252.
62. W. Zheng, D.F. Perry, D.L. Nelson and H.V. Aposhian, Choroid plexus protects cerebrospinal fluid against toxic metals, FASEB J. 5 (1991), 2188-2193.
63. S. Choudhuri, N.J. Cherrington, N. Li and C.D. Klaassen, Constitutive expression of various xenobiotic and endobiotic transporter mRNAs in the choroid plexus of rats, Drug Metab. Dispos. 31 (2003), 1337-1345.
64. Z.Y. Wang, M. Stoltenberg, S.M. Jo, L. Huang, A. Larsen, A. Dahlstrom and G. Danscher, Dynamic zinc pools in mouse choroid plexus, Neuroreport 15 (2004), 1801-1804.
65. K.R. Oliver and J.K. Fazakerley, Transneuronal spread of Semliki Forest virus in the developing mouse olfactory system is determined by neuronal maturity, Neurosci. 82 (1998), 867-877.
66. J. Henriksson, J. Tallkvist and H. Tjälve, Uptake of nickel into the brain via olfactory neurons in rats, Toxicol. Lett. 91 (1997), 153-162.
67. H. Tjälve, J. Henriksson, J. Tallkvist, B.S. Larsson and N.G. Lindquist, Uptake of manganese and cadmium from the nasal mucosa into the central nervous system via olfactory pathways in rats, Pharmacol. Toxicol. 79 (1996), 347-356.
68. H. Tjälve, C. Mejare and K. Borg-Neczak, Uptake and transport of manganese in primary and secondary olfactory neurones in pike, Pharmacol. Toxicol. 77 (1995), 23-31.
69. 2) to the rat brain: toxicokinetic investigations in a unilateral nasal occlusion model, Toxicol. Appl. Pharmacol. 169 (2000), 238-248.
70. D.C. Dorman, K.A. Brenneman, A.M. McElveen, S.E. Lynch, K.C. Roberts and B.A. Wong, Olfactory transport: a direct route of delivery of inhaled manganese phosphate to the rat brain, J. Toxicol. Environ. Health A 65 (2002), 1493-1511.
71. D.B. Rao, B.A. Wong, B.E. McManus, A.M. McElveen, A.R. James and D.C. Dorman, Inhaled iron, unlike manganese, is not transported to the rat brain via the olfactory pathway, Toxicol. Appl. Pharmacol. 193 (2003), 116-126.
72. 54Mn(II) in the brown trout (Salmo trutta), Environ. Toxicol. Chem. 14 (1995), 483-490.
73. Y. Kanayama, S. Enomoto, T. Irie and R. Amano, Axonal transport of rubidium and thallium in the olfactory nerve of mice, Nucl. Med. Biol. 32 (2005), 505-512.
74. Y. Kanayama, T. Tsuji, S. Enomoto and R. Amano, Multi-tracer screening: brain delivery of trace elements by eight different administration methods, Biometals 18 (2005), 553-565.
75. 2+ in the olfactory system in pike, Toxicol. Lett. 84 (1996), 107-112.
76. J. Henriksson and H. Tjälve, Uptake of inorganic mercury in the olfactory bulbs via olfactory pathways in rats, Environ. Res. 77 (1998), 130-140.
77. J. Gottofrey and H. Tjälve, Axonal transport of cadmium in the olfactory nerve of the pike, Pharmacol. Toxicol. 69 (1991), 242-252.
78. E. Persson, J. Henriksson and H. Tjälve, Uptake of cobalt from the nasal mucosa into the brain via olfactory pathways in rats, Toxicol. Lett. 145 (2003), 19-27.
79. E. Persson, J. Henriksson, J. Tallkvist, C. Rouleau and H. Tjälve, Transport and subcellular distribution of intranasally administered zinc in the olfactory system of rats and pikes, Toxicology 191 (2003), 97-108.
80. C. Rouleau, K. Borg-Neczak, J. Gottofrey and H. Tjälve, Accumulation of waterborne mercury(II) in specific areas of fish brain, Environ. Sci. Technol. 33 (1999), 3384-3389.
81. C. Rouleau, Z.-H. Xiong, G. Pacepavicius and G.-L. Huang, Uptake of waterborne tributyltin in the brain of fish: axonal transport as a proposed mechanism, Environ. Sci. Technol. 37 (2003), 3298-3302.
82. D.P. Perl and P.F. Good, Uptake of aluminium into central nervous system along nasal-olfactory pathways, Lancet 1 (1987), 1028.
83. J.L. Lewis, F.F. Hahn and A.R. Dahl, Transport of inhaled toxicants to the central nervous system. Characteristics of a nose-brain barrier, in: The Vulnerable Brain and Environmental Risks, Toxins in Air and Water, (Vol. 3), R.L. Isaacson and K.F. Jensen, eds, Plenum Press, New York, 1994, pp. 77-103.
84. R.N. Katz, P.F. Good, A.A. Kaputsin, A. Hsu and D.P. Perl, Widespread autofluorescent granulomas in the rabbit central nervous system (CNS) following intranasal exposure to a lipophilic aluminum-containing compound aluminum flavonol. Presented at the 22nd Annual Meeting of The Society for Neuroscience, 1992 p. 1610, Anaheim, California, USA (Meeting abstract).
85. K.K. Divine, J.L. Lewis, P.G. Grant and G. Bench, Quantitative particle-induced X-ray emission imaging of rat olfactory epithelium applied to the permeability of rat epithelium to inhaled aluminum, Chem. Res. Toxicol. 12 (1999), 575-581.
86. P. Zatta, C. Bordin and M. Favarato, The inhibition of trypsin and alpha-chymotrypsin proteolytic activity by aluminum(III), Arch. Biochem. Biophys. 303 (1993), 407-411.
87. D.D. Hunter and R.D. Dey, Identification and neuropeptide content of trigeminal neurons innervating the rat nasal epithelium, Neurosci. 83 (1998), 591-599.
88. J. Lewis, G. Bench, O. Myers, B. Tinner, W. Staines, E. Barr, K.K. Divine, W. Barrington and J. Karlsson, Trigeminal uptake and clearance of inhaled manganese chloride in rats and mice, NeuroToxicology 26 (2005), 113-123.
89. M.A. Lovell, J.D. Robertson, W.J. Teesdale, J.L. Campbell and W.R. Markesbery, Copper, iron and zinc in Alzheimer's disease senile plaques, J. Neurol. Sci. 158 (1998), 47-52.
90. Z.M. Qian and Q. Wang, Expression of iron transport proteins and excessive iron accumulation in the brain in neurodegenerative disorders, Brain Res. Brain Res. Rev. 27 (1998), 257-267.
91. Y. Christen, Oxidative stress and Alzheimer disease, Am. J. Clin. Nutr. 71 (2000), 621S-629S.
92. R.A. Yokel, The toxicology of aluminum in the brain: A review, NeuroToxicology 21 (2000), 813-828.
93. V. Rondeau, A review of epidemiologic studies on aluminum and silica in relation to Alzheimer's disease and associated disorders, Rev. Environ. Health 17 (2002), 107-121.
94. R.A. Yokel and P.J. McNamara, Aluminum toxicokinetics: An updated mini-review, Pharmacol. Toxicol. 88 (2001), 159-167.
95. R.A. Yokel and R.L. Florence, Aluminum bioavailability from the approved food additive leavening agent acidic sodium aluminum phosphate, incorporated into a baked good, is lower than from water, Toxicology accepted for publication, 2006, draft available on-line (http://dx.doi.org/10.1016/j.tox. 2006.07.014).
96. S.L. Rifat, M.R. Eastwood, D.R. McLachlan and P.N. Corey, Effect of exposure of miners to aluminium powder, Lancet 336 (1990), 1162-1165.
97. E. Hosovski, Z. Mastelica, D. Sunderic and D. Radulovic, Mental abilities of workers exposed to aluminium, Med. Lav. 81 (1990), 119-123.
98. D.M. White, W.T. Longstreth, Jr., L. Rosenstock, K.H. Claypoole, C.A. Brodkin and B.D. Townes, Neurologic syndrome in 25 workers from an aluminum smelting plant, Arch. Intern. Med. 152 (1992), 1443-1448.
99. H. Hänninen, E. Matikainen, T. Kovala, S. Valkonen and V. Riihimäki, Internal load of aluminium and the central nervous system function of aluminium welders, Scand. J. Work Environ. Health 20 (1994), 279-285.
100. R. Akila, B.T. Stollery and V. Riihimäki, Decrements in cognitive performance in metal inert gas welders exposed to aluminium, Occup. Environ. Med. 56 (1999), 632-639.
101. V. Riihimäki, H. Hänninen, R. Akila, T. Kovala, E. Kuosma, H. Paakkulainen, S. Valkonen and B. Engström, Body burden of aluminum in relation to central nervous system function among metal inert-gas welders, Scand. J. Work. Environ. Health 26 (2000), 118-130.
102. K.H. Kilburn, Neurobehavioral impairment and symptoms associated with aluminum remelting, Arch. Environ. Health 53 (1998), 329-335.
103. H. Yang, Y. Zheng and Y. Liang, [Effects of aluminum on neurobehavioral function and metabolism of monoamine neurotransmitter], Chinese J. Prevent. Med. 32 (1998), 82-84.
104. E. Salib and V. Hillier, A case-control study of Alzheimer's disease and aluminium occupation, Br. J. Psychiatry 168 (1996), 244-249.
105. M. Sim, R. Dick, J. Russo, B. Bernard, P. Grubb, E. Krieg, Jr., C. Mueller and C. McCammon, Are aluminium potroom workers at increased risk of neurological disorders? Occup. Environ. Med. 54 (1997), 229-235.
106. S. Letzel, C.J. Lang, K.H. Schaller, J. Angerer, S. Fuchs, B. Neundorfer and G. Lehnert, Longitudinal study of neurotoxicity with occupational exposure to aluminum dust, Neurology 54 (2000), 997-1000.
107. A. Iregren, B. Sjögren, K. Gustafsson, M. Hagman, L. Nylén, W. Frech, M. Andersson, K.G. Ljunggren and A. Wennberg, Effects on the nervous system in different groups of workers exposed to aluminium, Occup. Environ. Med. 58 (2001), 453-460.
108. A.B. Graves, D. Rosner, D. Echeverria, J.A. Mortimer and E.B. Larson, Occupational exposures to solvents and aluminium and estimated risk of Alzheimer's disease, Occup. Environ. Med. 55 (1998), 627-633.
109. D.R. Crapper, S.S. Krishnan and A.J. Dalton, Brain aluminum distribution in Alzheimer's disease and experimental neurofibrillary degeneration, Science 180 (1973), 511-513.
110. D.P. Perl, The association of aluminum and neurofibrillary degeneration in Alzheimer's disease, a personal perspective, in: Aluminum and Alzheimer's disease, C. Exley, ed., Elsevier, 2001, pp. 133-146.
111. C.X. Xie, M.P. Mattson, M.A. Lovell and R.A. Yokel, Intraneuronal aluminum potentiates iron-induced oxidative stress in cultured rat hippocampal neurons, Brain Res. 743 (1996), 271-277.
112. S.C. Bondy, S.F. Ali and S. Guo-Ross, Aluminum but not iron treatment induces pro-oxidant events in the rat brain, Mol. Chem. Neuropathol. 34 (1998), 219-232.
113. D. Pratico, K. Uryu, S. Sung, S. Tang, J.Q. Trojanowski and V.M. Lee, Aluminum modulates brain amyloidosis through oxidative stress in APP transgenic mice, FASEB J. 16 (2002), 1138-1140.
114. J. Savory, J.K. Rao, Y. Huang, P.R. Letada and M.M. Herman, Age-related hippocampal changes in Bcl-2:Bax ratio, oxidative stress, redox-active iron and apoptosis associated with aluminum-induced neurodegeneration: increased susceptibility with aging, NeuroToxicology 20 (1999), 805-817.
115. H.-J. Fu, Q.-S. Hu, Z.-N. Lin, T.-L. Ren, H. Song, C.-K. Cai and S.-Z. Dong, Aluminum-induced apoptosis in cultured cortical neurons and its effect on SAPK/JNK signal transduction pathway, Brain Res. 980 (2003), 11-23.
116. V.J. Johnson, S.H. Kim and R.P. Sharma, Aluminum-maltolate induces apoptosis and necrosis in neuro-2a cells: potential role for p53 signaling, Toxicol. Sci. 83 (2005), 329-339.
117. J.F. Leterrier, D. Langui, A. Probst and J. Ulrich, A molecular mechanism for the induction of neurofilament bundling by aluminum ions, J. Neurochem. 58 (1992), 2060-2070.
118. R.W. Shin, V.M. Lee and J.Q. Trojanowski, Aluminum modifies the properties of Alzheimer's disease PHF tau proteins in vivo and in vitro, J. Neurosci. 14 (1994), 7221-7233.
119. N.A. Muma and S.M. Singer, Aluminum-induced neuropathology: transient changes in microtubule- associated proteins, Neurotoxicol. Teratol. 18 (1996), 679-690.
120. K. Abreo, F. Abreo, M.L. Sella and S. Jain, Aluminum enhances iron uptake and expression of neurofibrillary tangle protein in neuroblastoma cells, J. Neurochem. 72 (1999), 2059-2064.
121. I. Klatzo, H. Wisniewski and E. Streicher, Experimental production of neurofibrillary degeneration: 1. Light microscopic observation, J. Pathol. 24 (1965), 187-199.
122. M. Clauberg and J.G. Joshi, Regulation of serine protease activity by aluminum: implications for Alzheimer disease, Proc. Natl. Acad. Sci. USA. 90 (1993), 1009-1012.
123. P.W. Mantyh, J.R. Ghilardi, S. Rogers, E. DeMaster, C.J. Allen, E.R. Stimson and J.E. Maggio, Aluminum, iron, and zinc ions promote aggregation of physiological concentrations of beta-amyloid peptide, J. Neurochem. 61 (1993), 1171-1174.
124. M. Kawahara, K. Muramoto, K. Kobayashi, H. Mori and Y. Kuroda, Aluminum promotes the aggregation of Alzheimer's amyloid beta-protein in vitro, Biochim. Biophys. Res. Commun. 198 (1994), 531-535.
125. S.B. Vyas and L.K. Duffy, Stabilization of secondary structure of Alzheimer beta-protein by aluminum(III) ions and D-Asp substitutions, Biochem. Biophys. Res. Commun. 206 (1995), 718-723.
126. G.D. Fasman, A. Perczel and C.D. Moore, Solubilization of beta-amyloid-(1-42)-peptide: reversing the beta-sheet conformation induced by aluminum with silicates, Proc. Natl. Acad. Sci. USA. 92 (1995), 369-371.
127. 2, Arch. Biochem. Biophys. 335 (1996), 381-387.
128. Y.H. Chong and Y.H. Suh, Aggregation of amyloid precursor proteins by aluminum in vitro, Brain Res. 670 (1995), 137-141.
129. M. Kawahara, M. Kato and Y. Kuroda, Effects of aluminum on the neurotoxicity of primary cultured neurons and on the aggregation of beta-amyloid protein, Brain Res. Bull. 55 (2001), 211-217.
130. S.R. Paik, J.H. Lee, D.H. Kim, C.S. Chang and J. Kim, Aluminum-induced structural alterations of the precursor of the non-A beta component of Alzheimer's disease amyloid, Arch. Biochem. Biophys. 344 (1997), 325-334.
131. S. Matsuzaki, T. Manabe, T. Katayama, A. Nishikawa, T. Yanagita, H. Okuda, Y. Yasuda, S. Miyata, S. Meshitsuka and M. Tohyama, Metals accelerate production of the aberrant splicing isoform of the presenilin-2, J. Neurochem. 88 (2004), 1345-1351.
132. W.A. Banks, L.M. Maness, M.F. Banks and A.J. Kastin, Aluminum-sensitive degradation of amyloid beta-protein 1-40 by murine and human intracellular enzymes, Neurotoxicol. Teratol. 18 (1996), 671-677.
133. M. Kawahara, Effects of aluminum on the nervous system and its possible link with neurodegenerative diseases, J. Alzheimers Dis. 8 (2005), 171-182.
134. D.D. Allen and R.A. Yokel, Dissimilar aluminum and gallium permeation of the blood-brain barrier demonstrated by in vivo microdialysis, J. Neurochem. 58 (1992), 903-908.
135. H. Davson, K. Welch and M.B. Segal, The Secretion of the Cerebrospinal Fluid, in The physiology and pathophysiology of the cerebrospinal fluid, Churchill Livingstone, New York, 1987, 218-221.
136. J.H. Peng, Z.C. Xu, Z.X. Xu, J.C. Parker, Jr., E.R. Friedlander, J.P. Tang and S. Melethil, Aluminum-induced acute cholinergic neurotoxicity in rat, Mol. Chem. Neuropathol. 17 (1992), 79-89.
137. Z.C. Xu, J.P. Tang, Z.X. Xu and S. Melethil, Kinetics of aluminum in rats. IV: Blood and cerebrospinal fluid kinetics, Toxicol. Lett. 63 (1992), 7-12.
138. W.R. Harris, Z. Wang and Y.Z. Hamada, Competition between transferrin and the serum ligands citrate and phosphate for the binding of aluminum, Inorg. Chem. 42 (2003), 3262-3273.
139. C.M. Morris, J.M. Candy, A.E. Oakley, G.A. Taylor, S. Mountfort, H. Bishop, M.K. Ward, C.A. Bloxham and J.A. Edwardson, Comparison of the regional distribution of transferrin receptors and aluminium in the forebrain of chronic renal dialysis patients, J. Neurol. Sci. 94 (1989), 295-306.
140. A.J. Roskams and J.R. Connor, Aluminum access to the brain: a role for transferrin and its receptor, Proc. Natl. Acad. Sci. USA. 87 (1990), 9024-9027.
141. 26Al exposure, Toxicol. Sci. 64 (2001), 77-82.
142. D.D. Allen, C. Orvig and R.A. Yokel, Evidence for energy-dependent transport of aluminum out of brain extracellular fluid, Toxicology 98 (1995), 31-39.
143. R.A. Yokel, V. Lidums, P.J. McNamara and U. Ungerstedt, Aluminum distribution into brain and liver of rats and rabbits following intravenous aluminum lactate or citrate: a microdialysis study, Toxicol. Appl. Pharmacol. 107 (1991), 153-163.
144. A. Jagarlamudi and S. Melethil, Aluminum transport across the rat blood-brain barrier: Role of transferrin, Pharm. Res. 12 (1995), S-350 (Meeting abstract).
145. A. Radunovic, F. Ueda, K.B. Raja, R.J. Simpson, J. Templar, S.J. King, J.S. Lilley, J.P. Day and M.W. Bradbury, Uptake of 26-Al and 67-Ga into brain and other tissues of normal and hypotransferrinaemic mice, Biometals 10 (1997), 185-191.
146. M.A. Akeson and D.N. Munns, Lipid bilayer permeation by neutral aluminum citrate and by three alpha-hydroxy carboxylic acids, Biochim. Biophys. Acta 984 (1989), 200-206.
147. K. Ohno, K.D. Pettigrew and S.I. Rapoport, Lower limits of cerebrovascular permeability to nonelectrolytes in the conscious rat, Am. J. Physiol. 235 (1978), H299-H307.
148. 55Fe and effect of calcium deficiency, J. Neurochem. 58 (1992), 898-902.
149. A. Radunovic and M.W.B. Bradbury, Transport of aluminium into brain - Its relation to that of gallium and iron, in: Aluminum in Chemistry Biology and Medicine, M. Nicolini, P.F. Zatta and B. Corain, eds, Harwood Academic Publishers, Switzerland, 1994, pp. 159-163.
150. R. Deloncle, O. Guillard, F. Clanet, P. Courtois and A. Piriou, Aluminum transfer as glutamate complex through blood-brain barrier. Possible implication in dialysis encephalopathy, Biol. Trace Elem. Res. 25 (1990), 39-45.
151. R.B. Martin, Aluminium speciation in biology, in: Aluminium in Biology and Medicine, D. Chadwick and J. Whelan, eds, John Wiley, New York, 1992, pp. 5-25 and pp. 104-108.
152. R. Deloncle, B. Fauconneau, A. Piriou, F. Huguet and O. Guillard, Aluminum L-glutamate complex in rat brain cortex: in vivo prevention of aluminum deposit by magnesium D-aspartate, Brain Res. 946 (2002), 247-252.
153. - in immortalized rat brain endothelial cells, Toxicol. Lett. 155 (2005), 289-296.
154. lII-citrate system: potentiometric and NMR studies, Eur. J. Inorg. Chem. 2001 (2001), 461-469.
155. D.C. Ackley and R.A. Yokel, Aluminum citrate is transported from brain into blood via the monocarboxylic acid transporter located at the blood-brain barrier, Toxicology 120 (1997), 89-97.
156. D.C. Ackley and R.A. Yokel, Aluminum transport out of brain extracellular fluid is proton dependent and inhibited by mersalyl acid, suggesting mediation by the monocarboxylate transporter (MCT1), Toxicology 127 (1998), 59-67.
157. R.A. Yokel, M. Wilson, W.R. Harris and A.P. Halestrap, Aluminum citrate uptake by immortalized brain endothelial cells: Implications for its blood-brain barrier transport, Brain Res. 930 (2002), 101-110.
158. B. Sjögren, P. Gustavsson and C. Hogstedt, Neuropsychiatric symptoms among welders exposed to neurotoxic metals, Br. J. Ind. Med. 47 (1990), 704-707.
159. D.R. Lynam, J.W. Roos, G.D. Pfeifer, B.F. Fort and T.G. Pullin, Environmental effects and exposures to manganese from use of methylcyclopentadienyl manganese tricarbonyl (MMT) in gasoline, NeuroToxicology 20 (1999), 145-150.
160. M. Yamada, S. Ohno, I. Okayasu, R. Okeda, S. Hatakeyama, H. Watanabe, K. Ushio and H. Tsukagoshi, Chronic manganese poisoning: a neuropathological study with determination of manganese distribution in the brain, Acta Neuropathol. (Berl). 70 (1986), 273-278.
161. A.M. McKinney, R.W. Filice, M. Teksam, S. Casey, C. Truwit, H.B. Clark, C. Woon and H.Y. Liu, Diffusion abnormalities of the globi pallidi in manganese neurotoxicity, Neuroradiology 46 (2004), 291-295.
162. C.W. Olanow, Manganese-induced parkinsonism and Parkinson's disease, Ann. N. Y. Acad. Sci. 1012 (2004), 209-223.
163. J. Couper, On the effects of black oxide of manganese when inhaled into the lungs, Br. Ann. Med. Pharmacy, Vital Stat. Gen. Sci. 1 (1837), 41-42.
164. C.L. Keen and B. Lönnerdal, Toxicity of essential and beneficial metal ions. Manganese, in: Handbook of Metal-Ligand Interactions in Biological Fluids, G. Berthon, ed., Marcel Dekker, Inc., New York, NY., 1995, pp. 683-688.
165. J.M. Fell, A.P. Reynolds, N. Meadows, K. Khan, S.G. Long, G. Quaghebeur, W.J. Taylor and P.J. Milla, Manganese toxicity in children receiving long-term parenteral nutrition, Lancet 347 (1996), 1218-1221.
166. H.K. Hudnell, Effects from environmental Mn exposures: a review of the evidence from non-occupational exposure studies, NeuroToxicology 20 (1999), 379-397.
167. B. Sjögren, A. Iregren, W. Frech, M. Hagman, L. Johansson, M. Tesarz and A. Wennberg, Effects on the nervous system among welders exposed to aluminium and manganese, Occup. Environ. Med. 53 (1996), 32-40.
168. D. Mergler, G. Huel, R. Bowler, A. Iregren, S. Belanger, M. Baldwin, R. Tardif, A. Smargiassi and L. Martin, Nervous system dysfunction among workers with long-term exposure to manganese, Environ. Res. 64 (1994), 151-180.
169. J.M. Gorell, C.C. Johnson, B.A. Rybicki, E.L. Peterson, G.X. Kortsha, G.G. Brown and R.J. Richardson, Occupational exposures to metals as risk factors for Parkinson's disease, Neurology 48 (1997), 650-658.
170. J. Zayed, S. Ducic, G. Campanella, J.C. Panisset, P. Andre, H. Masson and M. Roy, [Environmental factors in the etiology of Parkinson's disease], Can. J. Neurol. Sci. 17 (1990), 286-291.
171. B.A. Racette, L. McGee-Minnich, S.M. Moerlein, J.W. Mink, T.O. Videen and J.S. Perlmutter, Welding-related parkinsonism: clinical features, treatment, and pathophysiology, Neurology 56 (2001), 8-13.
172. J.M. Gorell, E.L. Peterson, B.A. Rybicki and C.C. Johnson, Multiple risk factors for Parkinson's disease, J. Neurol. Sci. 217 (2004), 169-174.
173. K.M. Semchuk, E.J. Love and R.G. Lee, Parkinson's disease: a test of the multifactorial etiologic hypothesis, Neurology 43 (1993), 1173-1180.
174. P. Vieregge, B. Heinzow, G. Korf, H.M. Teichert, P. Schleifenbaum and H.U. Mosinger, Long term exposure to manganese in rural well water has no neurological effects, Can. J. Neurol. Sci. 22 (1995), 286-289.
175. A. Seidler, W. Hellenbrand, B.P. Robra, P. Vieregge, P. Nischan, J. Joerg, W.H. Oertel, G. Ulm and E. Schneider, Possible environmental, occupational, and other etiologic factors for Parkinson's disease: a case-control study in Germany, Neurology 46 (1996), 1275-1284.
176. J. Park, C.I. Yoo, C.S. Sim, H.K. Kim, J.W. Kim, B.S. Jeon, K.R. Kim, O.Y. Bang, W.Y. Lee, Y. Yi, K.Y. Jung, S.E. Chung and Y. Kim, Occupations and Parkinson's disease: a multicenter case-control study in South Korea, NeuroToxicology 26 (2005), 99-105.
177. V.A. Murphy, K.C. Wadhwani, Q.R. Smith and S.I. Rapoport, Saturable transport of manganese(II) across the rat blood-brain barrier, J. Neurochem. 57 (1991), 948-954.
178. A. Takeda, T. Akiyama, J. Sawashita and S. Okada, Brain uptake of trace metals, zinc and manganese, in rats, Brain Res. 640 (1994), 341-344.
179. A. Takeda, S. Ishiwatari and S. Okada, Influence of transferrin on manganese uptake in rat brain, J. Neurosci. Res. 59 (2000), 542-552.
180. O. Rabin, L. Hegedus, J.M. Bourre and Q.R. Smith, Rapid brain uptake of manganese (II) across the blood-brain barrier, J. Neurochem. 61 (1993), 509-517.
181. J.S. Crossgrove, D.D. Allen, B.L. Bukaveckas, S.S. Rhineheimer and R.A. Yokel, Manganese distribution across the blood-brain barrier. I. Evidence for carrier-mediated influx of managanese citrate as well as manganese and manganese transferrin, NeuroToxicology 24 (2003), 3-13.
182. H.V. Aposhian, R.T. Ingersoll and E.B. Montgomery, Jr., Transport and control of manganese ions in the central nervous system, Environ. Res. 80 (1999), 96-98.
183. E.S. Cole and J. Glass, Transferrin binding and iron uptake in mouse hepatocytes, Biochim. Biophys. Acta 762 (1983), 102-110.
184. 54Mn in the anaesthetized rat, J. Physiol. (Lond). 446 (1992), 507P (Meeting abstract).
185. T.K. Dickinson, A.G. Devenyi and J.R. Connor, Distribution of injected iron 59 and manganese 54 in hypotransferrinemic mice, J. Lab. Clin. Med. 128 (1996), 270-278.
186. 54Mn in mouse brain, J. Neurol. Sci. 170 (1999), 112-118.
187. 2+ binding to serum transferrin, J. Inorg. Biochem. 54 (1994), 1-19.
188. R.A. Yokel and J.S. Crossgrove, Manganese toxicokinetics at the blood-brain barrier, Res. Rep. Health Eff. Inst. (2004), 7-58; discussion 59-73.
189. J.R. Burdo, S.L. Menzies, I.A. Simpson, L.M. Garrick, M.D. Garrick, K.G. Dolan, D.J. Haile, J.L. Beard and J.R. Connor, Distribution of divalent metal transporter 1 and metal transport protein 1 in the normal and Belgrade rat, J. Neurosci. Res. 66 (2001), 1198-1207.
190. X.S. Wang, W.Y. Ong and J.R. Connor, A light and electron microscopic study of the iron transporter protein DMT-1 in the monkey cerebral neocortex and hippocampus, J. Neurocytol. 30 (2001), 353-360.
191. T. Moos and E.H. Morgan, The significance of the mutated divalent metal transporter (DMT1) on iron transport into the Belgrade rat brain, J. Neurochem. 88 (2004), 233-245.
192. J.S. Crossgrove and R.A. Yokel, Manganese distribution across the blood-brain barrier III. The divalent metal transporter-1 is not the major mechanism mediating brain manganese uptake, NeuroToxicology 25 (2004), 451-460.
193. J.S. Crossgrove and R.A. Yokel, Manganese distribution across the blood-brain barrier. IV. Evidence for brain influx through store-operated calcium channels, NeuroToxicology 26 (2005), 297-307.
194. V.A. Fitsanakis, G. Piccola, J.L. Aschner and M. Aschner, Characteristics of manganese (Mn) transport in rat brain endothelial (RBE4) cells, an in vitro model of the blood-brain barrier, NeuroToxicology27 (2006), 60-70.
195. V.A. Fitsanakis, G. Piccola, J.L. Aschner and M. Aschner, Manganese transport by rat brain endothelial (RBE4) cell-based transwell model in the presence of astrocyte conditioned media, J. Neurosci. Res. 81 (2005), 235-243.
196. A. Kakee, T. Terasaki and Y. Sugiyama, Brain efflux index as a novel method of analyzing efflux transport at the blood-brain barrier, J. Pharmacol. Exp. Ther. 277 (1996), 1550-1559.
197. R.A. Yokel, J.S. Crossgrove and B.L. Bukaveckas, Manganese distribution across the blood-brain barrier II. Manganese efflux from the brain does not appear to be carrier mediated, NeuroToxicology 24 (2003), 15-22.
198. G. Gianutsos, M.D. Seltzer, R. Saymeh, M.L. Wu and R.G. Michel, Brain manganese accumulation following systemic administration of different forms, Arch. Toxicol. 57 (1985), 272-275.
199. W.R. Markesbery, W.D. Ehmann, T.I. Hossain and M. Alauddin, Brain manganese concentrations in human aging and Alzheimer's disease, NeuroToxicology 5 (1984), 49-57.
200. I.A. Romero, N.J. Abbott and M.W.B. Bradbury, The blood-brain barrier in normal CNS and in metal-induced neurotoxicity, in: Toxicology of Metals, L.W. Chang, L. Magos and T. Suzuki, eds, CRC Lewis Publishers, Boca Raton, 1996, pp. 561-585.
201. J.B. Fishman, J.B. Rubin, J.V. Handrahan, J.R. Connor and R.E. Fine, Receptor-mediated transcytosis of transferrin across the blood-brain barrier, J. Neurosci. Res. 18 (1987), 299-304.
202. T. Moos and E.H. Morgan, Transferrin and transferrin receptor function in brain barrier systems, Cell. Mol. Neurobiol. 20 (2000), 77-95.
203. W.A. Banks, A.J. Kastin, M.B. Fasold, C.M. Barrera and G. Augereau, Studies of the slow bidirectional transport of iron and transferrin across the blood-brain barrier, Brain Res. Bull. 21 (1988), 881-885.
204. T.J. Raub and C.R. Newton, Recycling kinetics and transcytosis of transferrin in primary cultures of bovine brain microvessel endothelial cells, J. Cell. Physiol. 149 (1991), 141-151.
205. L. Descamps, M.P. Dehouck, G. Torpier and R. Cecchelli, Receptor-mediated transcytosis of transferrin through blood-brain barrier endothelial cells, Am. J. Physiol. 270 (1996), H1149-H1158.
206. R. Roberts, A. Sandra, G.C. Siek, J.J. Lucas and R.E. Fine, Studies of the mechanism of iron transport across the blood-brain barrier, Ann. Neurol. 32 (1992), S43-S50.
207. 59Fe uptake into brain and cerebrospinal fluid and the influence thereon of antibodies against the transferrin receptor, J. Neurochem. 60 (1993), 106-113.
208. A. Crowe and E.H. Morgan, Iron and transferrin uptake by brain and cerebrospinal fluid in the rat, Brain Res. 592 (1992), 8-16.
209. C.M. Morris, A.B. Keith, J.A. Edwardson and R.G. Pullen, Uptake and distribution of iron and transferrin in the adult rat brain, J. Neurochem. 59 (1992), 300-306.
210. R.L. Roberts, R.E. Fine and A. Sandra, Receptor-mediated endocytosis of transferrin at the blood-brain barrier, J. Cell Sci. 104 (1993), 521-532.
211. M.E. Strahan, A. Crowe and E.H. Morgan, Iron uptake in relation to transferrin degradation in brain and other tissues of rats, Am. J. Physiol. 263 (1992), R924-R929.
212. E.A. Farcich and E.H. Morgan, Diminished iron acquisition by cells and tissues of Belgrade laboratory rats, Am. J. Physiol. 262 (1992), R220-R224.
213. J.R. Burdo, J. Martin, S.L. Menzies, K.G. Dolan, M.A. Romano, R.J. Fletcher, M.D. Garrick, L.M. Garrick and J.R. Connor, Cellular distribution of iron in the brain of the Belgrade rat, Neurosci. 93 (1999), 1189-1196.
214. M.W. Bradbury, Transport of iron in the blood-brain-cerebrospinal fluid system, J. Neurochem. 69 (1997), 443-454.
215. J.R. Burdo, D.A. Antonetti, E.B. Wolpert and J.R. Connor, Mechanisms and regulation of transferrin and iron transport in a model blood-brain barrier system, Neurosci. 121 (2003), 883-890.
216. I. Moroo, M. Ujiie, B.L. Walker, J.W. Tiong, T.Z. Vitalis, D. Karkan, R. Gabathuler, A.R. Moise and W.A. Jefferies, Identification of a novel route of iron transcytosis across the mammalian blood-brain barrier, Microcirculation 10 (2003), 457-462.
217. D.R. Richardson and E.H. Morgan, The transferrin homologue, melanotransferrin (p97), is rapidly catabolized by the liver of the rat and does not effectively donate iron to the brain, Biochim. Biophys. Acta 1690 (2004), 124-133.
218. 2+ into brain during cerebrovascular perfusion in the anaesthetized rat, J. Physiol. (Lond). 479 (1994), 37, (Meeting abstract).
219. A. Takeda, K. Takatsuka, J.R. Connor and N. Oku, Abnormal iron accumulation in the brain of neonatal hypotransferrinemic mice, Brain Res. 912 (2001), 154-161.
220. J.L. Beard, J.A. Wiesinger, N. Li and J.R. Connor, Brain iron uptake in hypotransferrinemic mice: influence of systemic iron status, J. Neurosci. Res. 79 (2005), 254-261.
221. R. Deane, W. Zheng and B.V. Zlokovic, Brain capillary endothelium and choroid plexus epithelium regulate transport of transferrin-bound and free iron into the rat brain, J. Neurochem. 88 (2004), 813-820.
222. 67copper by two ligand-dependent saturable processes. A high affinity, low capacity and a low affinity, high capacity process, J. Biol. Chem. 263 (1988), 799-805.
223. B.M. Katz and A. Barnea, The ligand specificity for uptake of complexed copper-67 by brain hypothalamic tissue is a function of copper concentration and copper:ligand molar ratio, J. Biol. Chem. 265 (1990), 2017-2021.
224. Y.M. Kuo, A.A. Gybina, J.W. Pyatskowit, J. Gitschier and J.R. Prohaska, Copper transport protein (Ctr1) levels in mice are tissue specific and dependent on copper status, J. Nutr. 136 (2006), 21-26.
225. S.A. Samsonov, N.A. Platonova, A.N. Skvortsov, N.V. Tsymbalenko, A.V. Vasin and L.V. Puchkova, Relationships between CTR1 activity and copper status in different rat organs, Mol. Biol. 40 (2006), 207-217.
226. 65Zn transport into brain and other soft tissues of the rat, J. Physiol. (Lond). 423 (1990), 40, (Meeting abstract).
227. 65Zinc uptake from blood into brain and other tissues in the rat, Neurochem. Res. 15 (1990), 1003-1008.
228. 65Zn in rat brain, Neurochem. Res. 17 (1992), 767-771.
229. S. Buxani-Rice, F. Ueda and M.W. Bradbury, Transport of zinc-65 at the blood-brain barrier during short cerebrovascular perfusion in the rat: its enhancement by histidine, J. Neurochem. 62 (1994), 665-672.
230. S.P. Aiken, N.M. Horn and N.R. Saunders, Effects of histidine on tissue zinc distribution in rats, Biometals 5 (1992), 235-243.
231. 65Zn- histidine, Brain Res. 863 (2000), 241-244.
232. J. Yamakami, E. Sakurai and Y. Tanaka, [Effect of zinc ion on the uptake of histidine and its analogue into blood-brain barrier], J. Tohoku Pharm. U. 46 (1999), 165-170.
233. E. Sakurai, J. Yamakami, T. Sakurada, Y. Ochiai and Y. Tanaka, Blood-brain barrier carrier-mediated transport and metabolism of L-histidine, Biogenic Amines 17 (2003), 335-348.
234. D.J. Bobilya, J.L. Guerin and D.J. Rowe, Zinc transport across an in vitro blood-brain barrier model, J. Trace Elem. Exp. Med. 10 (1997), 9-18.
235. H.M. Lehmann, B.B. Brothwell, L.P. Volak and D.J. Bobilya, Zinc status influences zinc transport by porcine brain capillary endothelial cells, J. Nutr. 132 (2002), 2763-2768.
236. R.D. Palmiter and L. Huang, Efflux and compartmentalization of zinc by members of the SLC30 family of solute carriers, Pflugers Arch. 447 (2004), 744-751.
237. J.P. Liuzzi and R.J. Cousins, Mammalian zinc transporters, Annu. Rev. Nutr. 24 (2004), 151-172.
238. W. Chowanadisai, S.L. Kelleher and B. Lonnerdal, Zinc deficiency is associated with increased brain zinc import and LIV-1 expression and decreased ZnT-1 expression in neonatal rats, J. Nutr. 135 (2005), 1002-1007.
239. Z.Y. Wang, M. Stoltenberg, S.M. Jo, L. Huang, A. Larsen, A. Dahlstrom and G. Danscher, Dynamic zinc pools in mouse choroid plexus, Neuroreport 15 (2004), 1801-1804.
240. 203Pb into brain and other soft tissues of rats, J. Pharmacol. Exp. Ther. 239 (1986), 548-553.
241. M.W. Bradbury and R. Deane, Permeability of the blood-brain barrier to lead, NeuroToxicology 14 (1993), 131-136.
242. L.E. Kerper and P.M. Hinkle, Lead uptake in brain capillary endothelial cells: activation by calcium store depletion, Toxicol. Appl. Pharmacol. 146 (1997), 127-133.
243. R. Deane and M.W. Bradbury, Transport of lead-203 at the blood-brain barrier during short cerebrovascular perfusion with saline in the rat, J. Neurochem. 54 (1990), 905-914.
244. L.A. O'Tuama, C.S. Kim, J.T. Gatzy, M.R. Krigman and P. Mushak, The distribution of inorganic lead in guinea pig brain and neural barrier tissues in control and lead-poisoned animals, Toxicol. Appl. Pharmacol. 36 (1976), 1-9.
245. L. Magos, Uptake of mercury by the brain, Br. J. Ind. Med. 25 (1968), 315-318.
246. K. Hirayama, Transport mechanism of methyl mercury. Intestinal absorption, biliary excretion and distribution of methyl mercury, Kumamoto Med. J. 28 (1975), 151-163.
247. K. Hirayama, Effect of amino acids on brain uptake of methyl mercury, Toxicol. Appl. Pharmacol. 55 (1980), 318-323.
248. M. Aschner and T.W. Clarkson, Uptake of methylmercury in the rat brain: effects of amino acids, Brain Res. 462 (1988), 31-39.
249. M. Aschner and T.W. Clarkson, Methyl mercury uptake across bovine brain capillary endothelial cells in vitro: the role of amino acids, Pharmacol. Toxicol. 64 (1989), 293-297.
250. L.E. Kerper, N. Ballatori and T.W. Clarkson, Methylmercury transport across the blood-brain barrier by an amino acid carrier, Am. J. Physiol. 262 (1992), R761-R765.
251. M. Aschner, N.B. Eberle, S. Goderie and H.K. Kimelberg, Methylmercury uptake in rat primary astrocyte cultures: the role of the neutral amino acid transport system, Brain Res. 521 (1990), 221-228.
252. M. Aschner, N.B. Eberle and H.K. Kimelberg, Interactions of methylmercury with rat primary astrocyte cultures: methylmercury efflux, Brain Res. 554 (1991), 10-14.
253. K.L. Audus and R.T. Borchardt, Characteristics of the large neutral amino acid transport system of bovine brain microvessel endothelial cell monolayers, J. Neurochem. 47 (1986), 484-488.
254. K. Suzuki, Some new observations in triethyl-tin intoxication of rats, Exp. Neurol. 31 (1971), 207-213.
255. F.P. Aleu, R. Katzman and R.D. Terry, Fine structure and electrolyte analyses of cerebral edema induced by alkyl tin intoxication, J. Neuropathol. Exp. Neurol. 22 (1963), 403-413.
256. P. Gunasekar, L. Li, K. Prabhakaran, V. Eybl, J.L. Borowitz and G.E. Isom, Mechanisms of the apoptotic and necrotic actions of trimethyltin in cerebellar granule cells, Toxicol. Sci. 64 (2001), 83-89.
257. P.G. Gunasekar, V. Mickova, D. Kotyzova, L. Li, J.L. Borowitz, V. Eybl and G.E. Isom, Role of astrocytes in trimethyltin neurotoxicity, J. Biochem. Mol. Toxicol. 15 (2001), 256-262.
258. T. Inoue, H. Nagara, A. Kondo, M. Fukui and J. Tateishi, Effects of intracarotid hyperosmolar mannitol in triethyl tin (TET)-induced rat brain edema - preservation of blood-brain barrier (BBB) in TET edema, Brain Res. 414 (1987), 309-313.
259. D. Hultstrom, M. Forssen, A. Pettersson, C. Tengvar, M. Jarild and Y. Olsson, Vascular permeability in acute triethyltin-induced brain edema studied with FITC-dextrans, sodium fluorescein and horseradish peroxidase as tracers, Acta Neurol. Scand. 69 (1984), 255-263.
260. G. Lee, S. Dallas, M. Hong and R. Bendayan, Drug transporters in the central nervous system: brain barriers and brain parenchyma considerations, Pharmacol. Rev. 53 (2001), 569-596.
261. C.L. Graff and G.M. Pollack, Drug transport at the blood-brain barrier and the choroid plexus, Curr. Drug Metab. 5 (2004), 95-108.
262. F. Bourasset, S. Cisternino, J. Temsamani and J.M. Scherrmann, Evidence for an active transport of morphine-6-beta-d-glucuronide but not P-glycoprotein-mediated at the blood-brain barrier, J. Neurochem. 86 (2003), 1564-1567.
263. A.G. de Boer, I.C. van der Sandt and P.J. Gaillard, The role of drug transporters at the blood-brain barrier, Annu. Rev. Pharmacol. Toxicol. 43 (2003), 629-656.
264. R.L. O'Kane, J.R. Vina, I. Simpson and R.A. Hawkins, Na+-dependent neutral amino acid transporters A, ASC, and N of the blood-brain barrier: mechanisms for neutral amino acid removal, Am. J. Physiol. Endocrinol. Metab. 287 (2004), E622-E629.
265. R.A. Hawkins, R.L. O'Kane, I.A. Simpson and J.R. Vina, Structure of the blood-brain barrier and its role in the transport of amino acids, J. Nutr. 136 (2006), 218S-226S.
266. K. Tetsuka, H. Takanaga, S. Ohtsuki, K. Hosoya and T. Terasaki, The l-isomer-selective transport of aspartic acid is mediated by ASCT2 at the blood-brain barrier, J. Neurochem. 87 (2003), 891-901.
267. A. Sacher, A. Cohen and N. Nelson, Properties of the mammalian and yeast metal-ion transporters DCT1 and Smf1p expressed in Xenopus laevis oocytes, J. Exp. Biol. 204 (2001), 1053-1061.
268. L.J. Wu, A.G. Leenders, S. Cooperman, E. Meyron-Holtz, S. Smith, W. Land, R.Y. Tsai, U.V. Berger, Z.H. Sheng and T.A. Rouault, Expression of the iron transporter ferroportin in synaptic vesicles and the blood-brain barrier, Brain Res. 1001 (2004), 108-117.
269. H. Kusuhara and Y. Sugiyama, Efflux transport systems for drugs at the blood-brain barrier and blood-cerebrospinal fluid barrier (Part 1), Drug Discov. Today 6 (2001), 150-156.
270. H. Kusuhara and Y. Sugiyama, Efflux transport systems for drugs at the blood-brain barrier and blood-cerebrospinal fluid barrier (Part 2), Drug Discov. Today 6 (2001), 206-212.
271. K. Hoffmann, A.M. Gastens, H.A. Volk and W. Loscher, Expression of the multidrug transporter MRP2 in the blood-brain barrier after pilocarpine-induced seizures in rats, Epilepsy Res 69 (2006), 1-14.
272. T. Eisenblatter, S. Huwel and H.J. Galla, Characterisation of the brain multidrug resistance protein (BMDP/ABCG2/BCRP) expressed at the blood-brain barrier, Brain Res 971 (2003), 221-231.
273. D. Sugiyama, H. Kusuhara, H. Taniguchi, S. Ishikawa, Y. Nozaki, H. Aburatani and Y. Sugiyama, Functional characterization of rat brain-specific organic anion transporter (Oatp14) at the blood-brain barrier: high affinity transporter for thyroxine, J. Biol. Chem. 278 (2003), 43489-43495.
274. M. Maccarrone, A. Fiori, M. Bari, F. Granata, V. Gasperi, M.E. De Stefano, A. Finazzi-Agro and R. Strom, Regulation by cannabinoid receptors of anandamide transport across the blood-brain barrier and through other endothelial cells, Thromb. Haemost. 95 (2006), 117-127.
275. W.M. Pardridge, CNS drug design based on principles of blood-brain barrier transport, J. Neurochem. 70 (1998), 1781-1792.
276. Y. Takasato, S.I. Rapoport and Q.R. Smith, An in situ brain perfusion technique to study cerebrovascular transport in the rat, Am. J. Physiol. 247 (1984), H484-H493.
277. C.S. Patlak, R.G. Blasberg and J.D. Fenstermacher, Graphical evaluation of blood-to-brain transfer constants from multiple- time uptake data, J. Cereb. Blood Flow Metab. 3 (1983), 1-7.
278. A. Radunovic, H.T. Delves, J.P. Day and M.W. Bradbury, Transport of iron, aluminium and gallium at the blood-brain barrier, in: Metal Ions in Biology and Medicine, P. Collery, J. Corbella, J.L. Domingo, J.C. Etienne, J.M. Llobet and J. Libbey, eds, Eurotext, Paris, 1996, pp. 244-246.
279. Q.R. Smith, Regulation of metal uptake and distribution within the brain, in: Nutrition and the Brain, R.J. Wurtman and J.J. Wurtman, eds, Raven Press, New York, 1990, pp. 25-74.
280. D.D. Allen and Q.R. Smith, Characterization of the blood-brain barrier choline transporter using the in situ rat brain perfusion technique, J. Neurochem. 76 (2001), 1032-1041.
281. R.G.L. Pullen and P.A. Franklin, Brain uptake of mercury in the anaesthetized rat, J. Physiol. (Lond). 482.P (1995), 33P, (Meeting abstract).
282. Society for Neuroscience, Brain Briefings: Blood-Brain Barrier, http://apu.sfn.org/content/Publications/BrainBriefings/blood-brain.html, 1999.
283. G.W. Goldstein and A.L. Betz, The blood-brain barrier, Sci. Am. 255 (1986), 74-83.
284. T. Speake, C. Whitwell, H. Kajita, A. Majid and P.D. Brown, Mechanisms of CSF secretion by the choroid plexus, Microsc. Res. Tech. 52 (2001), 49-59.
285. Society for Neuroscience, Brain Briefings: Smell and the olfactory system, http://apu.sfn.org/content/Publications/BrainBriefings/smell.html, 1995.