Manganese distribution across the blood-brain barrier. I. Evidence for carrier-mediated influx of manganese citrate as well as manganese and manganese transferrin

NeuroToxicology

Volumn 24, Issue 1, 2003, Pages 3-13

  Crossgrove, Janelle S ^a   Allen, David D ^b   Bukaveckas, Bonny L ^a,c   Rhineheimer, Susan S ^a   Yokel, Robert A ^a  

^a UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

^b TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^c University of Louisville School of Medicine   (United States)

Author keywords

Blood brain barrier; Brain influx; Citrate; Manganese; Speciation; Transport kinetics

Indexed keywords

MANGANESE; MANGANESE CITRATE; MANGANESE TRANSFERRIN; OCTANOL; UNCLASSIFIED DRUG;

ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; BLOOD BRAIN BARRIER; BLOOD LEVEL; BLOOD VOLUME; BRAIN PERFUSION; BRAIN REGION; CHOROID PLEXUS; CONTROLLED STUDY; DIFFUSION; FLOW KINETICS; ION TRANSPORT; LATERAL BRAIN VENTRICLE; LIGAND BINDING; MOLECULAR WEIGHT; NEUROTOXICITY; NONHUMAN; PARTITION COEFFICIENT; PRIORITY JOURNAL; PROTEIN BINDING; RAT;

ANIMALS; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; BRAIN; CITRIC ACID; MANGANESE; RATS; RATS, SPRAGUE-DAWLEY; TRANSFERRIN;

EID: 0037234204     PISSN: 0161813X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0161-813X(02)00089-X     Document Type: Article

References (45)

1. Aisen P, Aasa R, Redfield AG. The chromium, manganese, and cobalt complexes of transferrin. J Biol Chem 1969;244:4628-33.
2. Allen DD, Smith QR. Characterization of the blood-brain barrier choline transporter using the in situ rat brain perfusion technique. J Neurochem 2001;76:1032-41.
3. Amico P, Daniele PG. Equilibrium study of iron(II) and manganese(I) complexes with citrate ion in aqueous solution: relevance to coordination of citrate to the active site of aconitase and to gastrointestinal absorption of some essential metal ions. Inorg Chim Acta 1979;36:1-7.
4. Aschner M, Aschner JL. Manganese transport across the bloodbrain barrier: relationship to iron homeostasis. Brain Res Bull 1990;24:857-60.
5. Aschner M, Gannon M. Manganese (Mn) transport across the rat blood-brain barrier: saturable and transferrin-dependent transport mechanisms. Brain Res Bull 1994;33:345-9.
6. Aschner M, Vrana KE, Zheng W. Manganese uptake and distribution in the central nervous system (CNS). Neurotoxicology 1999;20:173-80.
7. Bradbury MW. Transport of iron in the blood-brain-cerebrospinal fluid system. J Neurochem 1997;69:443-54.
8. Cole ES, Glass J. Transferrin binding and iron uptake in mouse hepatocytes. Biochim Biophys Acta 1983;762:102-10.
9. Couper I. On the effects of black oxide of manganese when inhaled into the lungs. Brit Ann Med Pharm Vital Stat Gen Sci 1837;1:41-2.
10. Crone C. The permeability of capillaries in various organs as determined by use of the indicator diffusion method. Acta Physiol Scand 1963;58:292-305.
11. Garrick LM, Dolan KG, Romano MA, Garrick MD. Non-transferrin-bound iron uptake in Belgrade and normal rat erythroid cells. J Cell Physiol 1999;178:349-58.
12. Glusker PJ, Carrell HD. X-ray crystal analysis of the substrates of aconitase. XI. Manganous citrate decahydrate. J Mol Struct 1973;15:151-9.
13. Harris WR, Chen Y. Electron paramagnetic resonance and difference ultraviolet studies of Mn2+ binding to serum transferrin. J Inorg Biochem 1994;54:1-19.
14. Hill JM, Ruff MR, Weber RJ, Pert CB. Transferrin receptors in rat brain: neuropeptide-like pattern and relationship to iron distribution. Proc Natl Acad Sci USA 1985;82:4553-7.
15. Huang JD. Comparative drug exsorption in the perfused rat intestine. J Pharm Pharmacol 1990;42:167-70.
16. Hudnell HK. Effects from environmental Mn exposures: a review of the evidence from non-occupational exposure studies. Neurotoxicology 1999;20:379-97.
17. Iregren A. Manganese neurotoxicity in industrial exposures: proof of effects, critical exposure level, and sensitive tests. Neurotoxicology 1999;20:315-23.
18. Keen CL, Lönnerdal B. Toxicity of essential and beneficial metal ions: manganese. In: Berthon G, editor. Handbook of metalligand interactions in biological fluids. New York: Marcel-Dekker; 1995. p. 683-8.
19. Keen CL, Ensunsa JL, Clegg MS. Manganese metabolism in animals and humans including the toxicity of manganese. In: Sigel A, Sigel H, editors. Manganese and its role in biolgical processes. New York: Marcel-Dekker; 2000. p. 89-121.
20. Knopfel M, Schulthess G, Funk F, Hauser H. Characterization of an integral protein of the brush border membrane mediating the transport of divalent metal ions. Biophys J 2000;79:874-84.
21. Levin VA. Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability. J Med Chem 1980;23:682-4.
22. Malecki EA. Limited role of transferrin in manganese transport to the brain. J. Nutr 2001;131:1584-5.
23. Malecki EA, Devenyi AG, Beard JL, Connor JR. Existing and emerging mechanisms for transport of iron and manganese to the brain. J Neurosci Res 1999;56:113-22.
24. Mena I, Marin O, Fuenzalida S, Cotzias GC. Chronic manganese poisoning. Clinical picture and manganese turnover. Neurology 1967;17:128-36.
25. Murphy VA, Wadhwani KC, Smith QR, Rapoport SI. Saturable transport of manganese(II) across the rat blood-brain barrier. J Neurochem 1991;57:948-54.
26. NIST. Critically selected stability constants of metal complexes database. Gaithersburg MD, editor. USA: US Department of Commerce; 1995.
27. Pavlinova AV, Shnarevich AI. The composition and the stability of the citrate compound of manganese. Z Neorg Khim 1960;5: 2759-63.
28. Picard V, Govoni G, Jabado N, Gros P. Nramp 2 (DCT1/DMT1) expressed at the plasma membrane transports iron and other divalent cations into a calcein-accessible cytoplasmic pool. J Biol Chem 2000;275:35738-45.
29. Rabin O, Hegedus L, Bourre JM, Smith QR. Rapid brain uptake of manganese(II) across the blood-brain barrier. J Neurochem 1993;61:509-17.
30. Schuler P, Oyanguren H, Maturana V, Valenzuela A, Cruz E, Plaza V, et al. Manganese poisoning: environmental and medical study at a Chilean mine. Ind Med Surg 1957;26:167-73.
31. Shnarevich AI. Structure of manganese(II) citrate. Z Neorg Khim 1963;8:2074-9.
32. Sigel A, Sigel H. Metal ions in biological systems. In: Manganese and its role in biological processes. New York: Marcel-Dekker; 2000.
33. Smith QR. Quantitation of blood-brain barrier permeation. In: Neuwelt EA, editor. Implications of the blood-brain barrier and its manipulation. New York: Plenum Press; 1989. p. 85-118.
34. Smith QR. Regulation of brain metal uptake and distribution within the brain. In: Wurtman RJ, Wurtman JJ, editors. Nutrition and the brain. New York: Raven Press; 1990.
35. Smith QR. Brain perfusion systems for studies of drug uptake and metabolism in the central nervous system. Pharm Biotechnol 1996;8:285-307.
36. Takasato Y, Rapoport SI, Smith QR. An in situ brain perfusion technique to study cerebrovascular transport in the rat. Am J Physiol 1984;247:H484-93.
37. Takeda A, Ishiwatari S, Okada S. Influence of transferrin on manganese uptake in rat brain. J Neurosci Res 2000;59:542-52.
38. Triguero D, Buciak J, Pardridge WM. Capillary depletion method for quantification of blood-brain barrier transport of circulating peptides and plasma proteins. J Neurochem 1990;54:1882-8.
39. Verity MA. Manganese neurotoxicity: a mechanistic hypothesis. Neurotoxicology 1999;20:489-97.
40. Wadhwani KC, Murphy VA, Smith QR, Rapoport SI. Saturable transport of manganese(II) across blood-nerve barrier of rat peripheral nerve. Am J Physiol 1992;262:R284-8.
41. Wedler FC, Denman RB. Glutamine synthetase: the major Mn(II) enzyme in mammalian brain. Curr Top Cell Regulat 1984;24: 153-69.
42. Yokel RA, Kostenbauder HB. Assessment of potential aluminum chelators in an octanol/aqueous system and in the aluminum-loaded rabbit. Toxicol Appl Pharmacol 1987;91:281-94.
43. Yokel RA, Crossgrove JS, Bukaveckas BL. Manganese distribution across the blood-brain barrier. II. Manganese efflux from the brain does not appear to be carrier-mediated. Neurotoxicology 2003;24:15-22.
44. Zheng W. Toxicology of choroid plexus: special reference to metal-induced neurotoxicities. Microsc Res Tech 2001;52:89-103.
45. Zheng W, Perry DF, Nelson DL, Aposhian HV. Choroid plexus protects cerebrospinal fluid against toxic metals. FASEB J 1991;5:2188-93.