메뉴 건너뛰기




Volumn 287, Issue 4 50-4, 2004, Pages

Na+-dependent neutral amino acid transporters A, ASC, and N of the blood-brain barrier: Mechanisms for neutral amino acid removal

Author keywords

Active transport; Brain extracellular fluid; Capillaries; Endothelial cells; Essential amino acids

Indexed keywords

ALANINE; AMINO ACID TRANSPORTER; ASPARAGINE; CYSTEINE; GLUTAMINE; GLYCINE; HISTIDINE; ISOLEUCINE; LEUCINE; METHIONINE; PHENYLALANINE; PROLINE; SERINE; SODIUM; THREONINE; TRYPTOPHAN; TYROSINE; VALINE;

EID: 4544322971     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.00187.2004     Document Type: Article
Times cited : (52)

References (39)
  • 1
    • 0015210246 scopus 로고
    • The uptake of various amino acids by the mouse brain in vivo
    • Battistin L, Grynbaum A, and Lajtha A. The uptake of various amino acids by the mouse brain in vivo. Brain Res 29: 85-99, 1971.
    • (1971) Brain Res , vol.29 , pp. 85-99
    • Battistin, L.1    Grynbaum, A.2    Lajtha, A.3
  • 2
    • 0018080931 scopus 로고
    • Polarity of the blood-brain barrier: Neutral amino acid transport into isolated brain capillaries
    • Betz AL and Goldstein GW. Polarity of the blood-brain barrier: neutral amino acid transport into isolated brain capillaries. Science 202: 225-226, 1978.
    • (1978) Science , vol.202 , pp. 225-226
    • Betz, A.L.1    Goldstein, G.W.2
  • 3
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of dye binding
    • Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of dye binding. Anal Biochem 72: 248-254, 1976.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 4
    • 0018417086 scopus 로고
    • Developments in amino acid transport, illustrated for the blood-brain barrier
    • Christensen HN. Developments in amino acid transport, illustrated for the blood-brain barrier. Biochem Pharmacol 28: 1989-1992, 1979.
    • (1979) Biochem Pharmacol , vol.28 , pp. 1989-1992
    • Christensen, H.N.1
  • 5
    • 0014217343 scopus 로고
    • +-requiring transport system for alanine, serine, cysteine, and similar amino acids
    • +- requiring transport system for alanine, serine, cysteine, and similar amino acids. J Biol Chem 242: 5237-5246, 1967.
    • (1967) J Biol Chem , vol.242 , pp. 5237-5246
    • Christensen, H.N.1    Liang, M.2    Archer, E.G.3
  • 6
    • 0023277382 scopus 로고
    • Biochemistry and physiology of brain ammonia
    • Cooper AJ and Plum F. Biochemistry and physiology of brain ammonia. Physiol Rev 67: 440-519, 1987.
    • (1987) Physiol Rev , vol.67 , pp. 440-519
    • Cooper, A.J.1    Plum, F.2
  • 8
    • 0015548985 scopus 로고
    • Uptake of individual amino acids by the human brain
    • Felig P, Wahren J, and Ahlborg G. Uptake of individual amino acids by the human brain. Proc Soc Exp Biol Med 142: 230-231, 1972.
    • (1972) Proc Soc Exp Biol Med , vol.142 , pp. 230-231
    • Felig, P.1    Wahren, J.2    Ahlborg, G.3
  • 9
    • 0020614686 scopus 로고
    • Role of precursor availability in control of monoamine biosynthesis in brain
    • Fernstrom JD. Role of precursor availability in control of monoamine biosynthesis in brain. Physiol Rev 63: 484-456, 1983.
    • (1983) Physiol Rev , vol.63 , pp. 484-456
    • Fernstrom, J.D.1
  • 10
    • 0015526241 scopus 로고
    • Brain serotonin content: Physiological regulation by plasma neutral amino acids
    • Fernstrom JD and Wurtman RJ. Brain serotonin content: physiological regulation by plasma neutral amino acids. Science 178: 414-416, 1972.
    • (1972) Science , vol.178 , pp. 414-416
    • Fernstrom, J.D.1    Wurtman, R.J.2
  • 11
    • 0024230927 scopus 로고
    • Neutral amino acid transport at the human blood-brain barrier
    • Hargreaves KM and Pardridge WM. Neutral amino acid transport at the human blood-brain barrier. J Biol Chem 263: 19392-19397, 1988.
    • (1988) J Biol Chem , vol.263 , pp. 19392-19397
    • Hargreaves, K.M.1    Pardridge, W.M.2
  • 12
    • 0036760638 scopus 로고    scopus 로고
    • The complementary membranes forming the blood-brain barrier
    • Hawkins RA, Peterson DR, and Vina JR. The complementary membranes forming the blood-brain barrier. IUBMB Life 54: 101-107, 2002.
    • (2002) IUBMB Life , vol.54 , pp. 101-107
    • Hawkins, R.A.1    Peterson, D.R.2    Vina, J.R.3
  • 14
    • 0038682500 scopus 로고    scopus 로고
    • Amino acid transporters: Roles in amino acid sensing and signaling in animal cells
    • Hyde R, Taylor PM, Hundal HS, Peyrollier K, and Christie GR. Amino acid transporters: roles in amino acid sensing and signaling in animal cells. Biochem J 373: 1-18, 2003.
    • (2003) Biochem J , vol.373 , pp. 1-18
    • Hyde, R.1    Taylor, P.M.2    Hundal, H.S.3    Peyrollier, K.4    Christie, G.R.5
  • 15
    • 0019195152 scopus 로고
    • Characteristics of an amino acid transport system in rat liver for glutamine, asparagine, histidine, and closely related analogs
    • Kilberg MS, Handlogten ME, and Christensen HN. Characteristics of an amino acid transport system in rat liver for glutamine, asparagine, histidine, and closely related analogs. J Biol Chem 255: 4011-4019, 1980.
    • (1980) J Biol Chem , vol.255 , pp. 4011-4019
    • Kilberg, M.S.1    Handlogten, M.E.2    Christensen, H.N.3
  • 16
    • 0027239610 scopus 로고
    • Recent advances in mammalian amino acid transport
    • Kilberg MS, Stevens BS, and Novak DA. Recent advances in mammalian amino acid transport. Annu Rev Nutr 13: 137-165, 1993.
    • (1993) Annu Rev Nutr , vol.13 , pp. 137-165
    • Kilberg, M.S.1    Stevens, B.S.2    Novak, D.A.3
  • 17
    • 0021812768 scopus 로고
    • Amino acid transport across the human blood-CSF barrier
    • Kruse T, Reiber H, and Neuhoff V. Amino acid transport across the human blood-CSF barrier. J Neurolog Sci 70: 129-138, 1985.
    • (1985) J Neurolog Sci , vol.70 , pp. 129-138
    • Kruse, T.1    Reiber, H.2    Neuhoff, V.3
  • 18
    • 0031958583 scopus 로고    scopus 로고
    • Glutamine transport by the blood-brain barrier: A possible mechanism for nitrogen removal
    • Lee WJ, Hawkins RA, Vina JR, and Peterson DR. Glutamine transport by the blood-brain barrier: a possible mechanism for nitrogen removal. Am J Physiol Cell Physiol 274: C1101-C1107, 1998.
    • (1998) Am J Physiol Cell Physiol , vol.274
    • Lee, W.J.1    Hawkins, R.A.2    Vina, J.R.3    Peterson, D.R.4
  • 19
    • 0027495352 scopus 로고
    • Altered cerebrospinal fluid amino acid pattern in the anorexia of aging: Relationship with biogenic amine metabolism
    • Martinez M, Arnalich F, Vazquez JJ, and Hernanz A. Altered cerebrospinal fluid amino acid pattern in the anorexia of aging: relationship with biogenic amine metabolism. Life Sci 53: 1643-1650, 1993.
    • (1993) Life Sci , vol.53 , pp. 1643-1650
    • Martinez, M.1    Arnalich, F.2    Vazquez, J.J.3    Hernanz, A.4
  • 20
    • 0017648362 scopus 로고
    • Studies of the inter-relationship between cerebrospinal fluid and plasma amino acid concentrations in normal individuals
    • McGale EHF, Pye IF, Stonier C, Hutchinson EC, and Aber GM. Studies of the inter-relationship between cerebrospinal fluid and plasma amino acid concentrations in normal individuals. J Neurochem 29: 291-297, 1977.
    • (1977) J Neurochem , vol.29 , pp. 291-297
    • McGale, E.H.F.1    Pye, I.F.2    Stonier, C.3    Hutchinson, E.C.4    Aber, G.M.5
  • 21
    • 0344896637 scopus 로고    scopus 로고
    • Na+-dependent transport of large neutral amino acids occurs at the abluminal membrane of the blood-brain barrier
    • O'Kane RL and Hawkins RA. Na+-dependent transport of large neutral amino acids occurs at the abluminal membrane of the blood-brain barrier. Am J Physiol Endocrinol Metab 285: E1167-E1173, 2003.
    • (2003) Am J Physiol Endocrinol Metab , vol.285
    • O'Kane, R.L.1    Hawkins, R.A.2
  • 22
    • 0039967156 scopus 로고    scopus 로고
    • Na(+)-dependent glutamate transporters (EAAT1, EAAT2, and EAAT3) of the blood-brain barrier. A mechanism for glutamate removal
    • O'Kane RL, Martinez-Lopez I, DeJoseph MR, Viña JR, and Hawkins RA. Na(+)-dependent glutamate transporters (EAAT1, EAAT2, and EAAT3) of the blood-brain barrier. A mechanism for glutamate removal. J Biol Chem 274: 31891-31895, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 31891-31895
    • O'Kane, R.L.1    Martinez-Lopez, I.2    DeJoseph, M.R.3    Viña, J.R.4    Hawkins, R.A.5
  • 23
    • 0015015914 scopus 로고
    • Uptake of radiolabeled essential amino acids by brain following arterial injection
    • Oldendorf WH. Uptake of radiolabeled essential amino acids by brain following arterial injection. Proc Soc Exp Biol Med 136: 385-386, 1971.
    • (1971) Proc Soc Exp Biol Med , vol.136 , pp. 385-386
    • Oldendorf, W.H.1
  • 24
    • 0017238493 scopus 로고
    • Amino acid assignment to one of three blood-brain barrier amino acid carriers
    • Oldendorf WH and Szabo J. Amino acid assignment to one of three blood-brain barrier amino acid carriers. Am J Physiol 230: 94-98, 1976.
    • (1976) Am J Physiol , vol.230 , pp. 94-98
    • Oldendorf, W.H.1    Szabo, J.2
  • 25
    • 78651131107 scopus 로고
    • Distinct mediating systems for the transport of neutral amino acids by the Ehrlich cell
    • Oxender DL and Christensen HN. Distinct mediating systems for the transport of neutral amino acids by the Ehrlich cell. J Biol Chem 238: 3686-3699, 1963.
    • (1963) J Biol Chem , vol.238 , pp. 3686-3699
    • Oxender, D.L.1    Christensen, H.N.2
  • 26
    • 0000212114 scopus 로고
    • Regulation of amino acid availability to the brain
    • Pardridge WM. Regulation of amino acid availability to the brain. Nutr Br 1: 141-205, 1977.
    • (1977) Nutr Br , vol.1 , pp. 141-205
    • Pardridge, W.M.1
  • 27
    • 0021020420 scopus 로고
    • Brain metabolism: A perspective from the blood-brain barrier
    • Pardridge WM. Brain metabolism: a perspective from the blood-brain barrier. Physiol Rev 63: 1481-1535, 1983.
    • (1983) Physiol Rev , vol.63 , pp. 1481-1535
    • Pardridge, W.M.1
  • 28
    • 0021965663 scopus 로고
    • Rapid sequestration and degradation of somatostatin analogues by isolated brain microvessels
    • Pardridge WM, Eisenberg J, and Yamada T. Rapid sequestration and degradation of somatostatin analogues by isolated brain microvessels. J Neurochem 44: 1178-1184, 1985.
    • (1985) J Neurochem , vol.44 , pp. 1178-1184
    • Pardridge, W.M.1    Eisenberg, J.2    Yamada, T.3
  • 29
    • 0019981426 scopus 로고
    • Cerebral uptake of amino acids in human subjects and rhesus monkeys in vivo
    • Sacks W, Sacks S, Brebbia DR, and Fleischer A. Cerebral uptake of amino acids in human subjects and rhesus monkeys in vivo. J Neurosci Res 7: 431-436, 1982.
    • (1982) J Neurosci Res , vol.7 , pp. 431-436
    • Sacks, W.1    Sacks, S.2    Brebbia, D.R.3    Fleischer, A.4
  • 30
    • 0027049962 scopus 로고
    • Neutral amino acid transport by the blood-brain barrier: Membrane vesicle studies
    • Sánchez del Pino MM, Hawkins RA, and Peterson DR. Neutral amino acid transport by the blood-brain barrier: membrane vesicle studies. J Biol Chem 267: 25951-25957, 1992.
    • (1992) J Biol Chem , vol.267 , pp. 25951-25957
    • Sánchez Del Pino, M.M.1    Hawkins, R.A.2    Peterson, D.R.3
  • 31
    • 0029074070 scopus 로고
    • Biochemical discrimination between luminal and abluminal enzyme and transport activities of the blood-brain barrier
    • Sánchez del Pino MM, Hawkins RA, and Peterson DR. Biochemical discrimination between luminal and abluminal enzyme and transport activities of the blood-brain barrier. J Biol Chem 270: 14907-14912, 1995.
    • (1995) J Biol Chem , vol.270 , pp. 14907-14912
    • Sánchez Del Pino, M.M.1    Hawkins, R.A.2    Peterson, D.R.3
  • 32
    • 0029034862 scopus 로고
    • Neutral amino acid transport characterization of isolated luminal and abluminal membranes of the blood-brain barrier
    • Sánchez del Pino MM, Peterson DR, and Hawkins RA. Neutral amino acid transport characterization of isolated luminal and abluminal membranes of the blood-brain barrier. J Biol Chem 270: 14913-14918, 1995.
    • (1995) J Biol Chem , vol.270 , pp. 14913-14918
    • Sánchez Del Pino, M.M.1    Peterson, D.R.2    Hawkins, R.A.3
  • 33
    • 0015410772 scopus 로고
    • Distinct patterns of entry of two non-metabolizable amino acids into brain and other organs of infant guinea pigs
    • Schain RJ and Watanabe KS. Distinct patterns of entry of two non-metabolizable amino acids into brain and other organs of infant guinea pigs. J Neurochem 19: 2279-2288, 1972.
    • (1972) J Neurochem , vol.19 , pp. 2279-2288
    • Schain, R.J.1    Watanabe, K.S.2
  • 34
    • 0017181113 scopus 로고
    • Capillary transport of amino acids in the developing brain
    • Sershen H and Lajtha A. Capillary transport of amino acids in the developing brain. Exp Neurol 53: 465-474, 1976.
    • (1976) Exp Neurol , vol.53 , pp. 465-474
    • Sershen, H.1    Lajtha, A.2
  • 37
    • 0022930655 scopus 로고
    • Kinetics of amino acid transport at the blood-brain barrier studied using an in situ brain perfusion technique
    • Smith QR and Takasato Y. Kinetics of amino acid transport at the blood-brain barrier studied using an in situ brain perfusion technique. Ann NY Acad Sci 481: 186-201, 1986.
    • (1986) Ann NY Acad Sci , vol.481 , pp. 186-201
    • Smith, Q.R.1    Takasato, Y.2
  • 38
    • 0023434082 scopus 로고
    • Evidence for alanine, serine, and cystine system of transport in isolated brain capillaries
    • Tayarani I, Lefauconnier JM, Roux F, and Bourrer JM. Evidence for alanine, serine, and cystine system of transport in isolated brain capillaries. J Cerebr Blood Flow Metab 7: 585-591, 1987.
    • (1987) J Cerebr Blood Flow Metab , vol.7 , pp. 585-591
    • Tayarani, I.1    Lefauconnier, J.M.2    Roux, F.3    Bourrer, J.M.4
  • 39
    • 0023805136 scopus 로고
    • Some characteristics of the threonine transport across the blood-brain barrier of the rat
    • Tovar A, Tews JK, Torres N, and Harper AE. Some characteristics of the threonine transport across the blood-brain barrier of the rat. J Neurochem 51: 1285-1293, 1988.
    • (1988) J Neurochem , vol.51 , pp. 1285-1293
    • Tovar, A.1    Tews, J.K.2    Torres, N.3    Harper, A.E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.