Olfactory transport: A direct route of delivery of inhaled manganese phosphate to the rat brain

Journal of Toxicology and Environmental Health - Part A

Volumn 65, Issue 20, 2002, Pages 1493-1511

  Dorman, David C ^a   Brenneman, Karrie A ^a   McElveen, Anna M ^a   Lynch, Sean E ^a   Roberts, Kay C ^a   Wong, Brian A ^a  

^a CIIT CENTERS FOR HEALTH RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MANGANESE DERIVATIVE; MANGANESE PHOSPHATE; UNCLASSIFIED DRUG;

AEROSOL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL BLOOD; ARTICLE; AUTORADIOGRAPHY; BRAIN CIRCULATION; BRAIN REGION; CEREBELLUM; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORPUS STRIATUM; ENVIRONMENTAL EXPOSURE; GAMMA SPECTROMETRY; LUNG DEPOSIT; NONHUMAN; OLFACTORY BULB; OLFACTORY NERVE; OLFACTORY SYSTEM; PRIORITY JOURNAL; RAT; TRANSPORT KINETICS;

ANIMALIA;

EID: 0037174936     PISSN: 15287394     EISSN: None     Source Type: Journal    
DOI: 10.1080/00984100290071630     Document Type: Article

References (38)

1. Andersen, M. E., Gearhart, J. M., and Clewell, H. J. III. 1999. Pharmacokinetic data needs to support risk assessments for inhaled and ingested manganese. Neurotoxicology 20:161-171.
2. Arvidson, B. 1994. A review of axonal transport of metals. Toxicology 88:1-14.
3. Brenneman, K. A., Cattley, R. C., Ali, S. F., and Dorman, D. C. 1999. Manganese-induced developmental neurotoxicity in the CD rat: Is oxidative damage a mechanism of action? Neurotoxicology 20:477-488.
4. 2) to the rat brain: Toxicokinetic investigations in a unilateral nasal occlusion model. Toxicol. Appl. Pharmacol. 169:238-248.
5. Cannon, W. C., Blanton, E. F., and McDonald, K. E. 1983. The flow-past chamber: An improved nose-only exposure system for rodents. Am. Ind. Hyg. Assoc. J. 44:923-928.
6. Colmenares, C., Deutsch, S., Evans, C., Nelson, A. J., Terminello, L. J., Reynolds, J. G., Roos, J. W., and Smith, I. L. 1999. Analysis of manganese particulates from automotive decomposition of methylcyclopentadienyl manganese tricarbonyl. Appl. Surf. Sci. 151:189-202.
7. Davis, J. M. 1999. Inhalation health risks of manganese: An EPA perspective. Neurotoxicology 20:511-518.
8. Dorman, D. C., Struve, M. F., Vitarella, D., Byerly, F. I., Goetz, J., and Miller, R. 2000. Neurotoxicity of manganese chloride in neonatal and adult CD rat following subchronic (21-day) high-dose oral exposure. J. Appl. Toxicol. 20:179-187.
9. Dorman, D. C., Struve, M. F., James, R. A., Marshall, M. W., Parkinson, C. U., and Wong, B. A. 2001. Influence of particle solubility on the delivery of inhaled manganese to the rat brain: Manganese sulfate and manganese tetroxide pharmacokinetics following repeated (14-day) exposure. Toxicol. Appl. Pharmacol, 170:79-87.
10. Gianutsos, G., Morrow, G. R., and Morris, J. B. 1997. Accumulation of manganese in rat brain following intranasal administration. Fundam. Appl. Toxicol. 37:102-105.
11. Gross, E. A., Swenberg, J. A., Fields, S., and Popp, J. A. 1982. Comparative morphometry of the nasal cavity in rats and mice. J. Anat. 135:83-88.
12. Henriksson, J., and Tjälve, H. 2000. Manganese taken up into the CNS via the olfactory pathway in rats affects astrocytes. Toxicol. Sci. 55:392-398.
13. Kimbell, J. S., Godo, M. N., Gross, E. A., Joyner, D. R., Richardson, R. B., and Morgan, K. T. 1997. Computer simulation of inspiratory airflow in all regions of the F344 rat nasal passages. Toxicol. Appl. Pharmacol. 145:388-398.
14. Kontur, P. J., and Fechter, L. D. 1988. Brain regional manganese levels and monoamine metabolism in manganese-treated neonatal rats. Neurotoxicol. Teratol. 10:295-303.
15. Kucharski, D., Johanson, I. B., and Hall, W. G. 1986. Unilateral olfactory conditioning in 6-day-old rat pups. Behav. Neural Biol. 46: 472-490.
16. Lynam, D. R., Roos, J. W., Pfeifer, G. D., Fort, B. F., and Pullin, T. G. 1999. Environmental effects and exposures to manganese from use of methylcyclopentadienyl manganese tricarbonyl (MMT) in gasoline. Neurotoxicology 20:145-150.
17. Malecki, E. A., Devenyi, A. G., Beard, J. L., and Connor, J. R. 1999. Existing and emerging mechanisms for transport of iron and manganese to the brain. J. Neurosci. Res. 56:113-122.
18. National Research Council. 1996. Guide for the Care and Use of Laboratory Animals. Washington, DC: National Academic Press.
19. Nelson, K., Golnick, J., Korn, T., and Angle, C. 1993. Manganese encephalopathy: Utility of early magnetic resonance imaging. Br. J. Ind. Med. 50:510-513.
20. Pal, P. K., Samii, A., and Calne, D. B. 1999. Manganese neurotoxicity: a review of clinical features, imaging and pathology. Neurotoxicology 20:227-238.
21. Proctor, D. F., and Chang, J. C. F. 1983. Comparative anatomy and physiology of the nasal cavity. In Nasal Tumors in Animals and Man, Vol. I, Anatomy, Physiology, and Epidemiology, eds. G. Reznik and S. F. Stinson, pp. 1-33. Boca Raton, FL: CRC Press.
22. Ressler, T., Wong, J., and Roos, J. 1999. Manganese speciation in exhaust particulates of automobiles using MMT containing gasoline. J. Synchrotron Radiat. 6:656-658.
23. Ressler, T., Wong, J., Roos, J., and Smith, I. L. 2000. Quantitative speciation of Mn-bearing particulates emitted from autos burning (methylcyclopentadienyl)manganese tricarbonyl-added gasolines using XANES spectroscopy. Environ. Sci. Technol. 34:950-958.
24. Rhoads, K., and Sanders, C. L. 1985. Lung clearance, translocation, and acute toxicity of arsenic, beryllium, cadmium, cobalt, lead, selenium, vanadium and ytterbium oxides following deposition in rat lung. Environ. Res. 36:359-378.
25. 2) on the absorption and cerebral distribution of manganese in rats. Arch. Toxicol. 71:223-230.
26. Roos, J. W., Lenane, D. L., Dykes, K. L., Scull, H. M., and Openshaw, M. J. 2000. A Systems Approach to Improved Exhaust Catalyst Durability: The Role of the MMT Fuel Additive. Society of Automotive Engineers paper 2000-01-1880.
27. Schreider, J. P. 1983. Nasal airway anatomy and inhalation deposition in experimental animals and people. In Nasal Tumors in Animals and Man, Vol. III, Experimental Nasal Carcinogenesis, eds. G. Reznik and S. F. Stinson, pp. 1-25. Boca Raton, FL: CRC Press.
28. Schlesinger, R. B. 1995. Deposition and clearance of inhaled particles. In Concepts in Inhalation Toxicology, eds. R. O. McClellan and R. F. Henderson, pp. 191-224. Washington, DC: Taylor & Francis.
29. Shargel, L., and Yu, A. B. C. 1985. Multicompartment models. In Applied Biopharmaceutics and Pharmacokinetics, eds. L. Shargel and A. B. C. Yu, pp. 51-66. Norwalk, CT: Appleton-Century-Crofts.
30. Shipley, M. T., McLean, J. H., and Ennis, M. 1995. Olfactory system. In The Rat Nervous System, 2nd Ed., ed. G. Paxinos, pp. 899-926. San Diego, CA: Academic Press.
31. Tjälve, H., and Henriksson, J. 1999. Uptake of metals in the brain via olfactory pathways. Neurotoxicology 20:181-195.
32. Tjälve, H., Mejare, C., and Borg-Neczak, K. 1995. Uptake and transport of manganese in primary and secondary olfactory neurones in pike. Pharmacol. Toxicol. 77:23-31.
33. Tjälve, H., Henriksson, J., Talkvist, J., Larsson, B. S., and Lindquist, N. G. 1996. Uptake of manganese and cadmium from the nasal mucosa into the central nervous system via olfactory pathways in rats. Pharmacol. Toxicol. 79:347-356.
34. U.S. Environmental Protection Agency. 1996. Air Quality Criteria for Particulate Matter, EPA/600/P-95/001, vol. 2. Washington DC: Office of Research and Development.
35. Vitarella D., Moss, O. R., and Dorman, D. C. 2000a. Pulmonary clearance of manganese phosphate, manganese sulfate, and manganese tetroxide by CD rats following intratracheal instillation. Inhal. Toxicol. 12:941-957.
36. Vitarella, D., Wong, B. A., Moss, O. R., and Dorman, D. C. 2000b. Pharmacokinetics of inhaled manganese phosphate in male Sprague-Dawley rats following subacute (14-day) exposure. Toxicol. Appl. Pharmacol. 163:279-285.
37. 2 aerosols: Influence of inhaled concentration. Pol. J. Occup. Med. 2:248-260.
38. Zayed, J., Hong, B., and L'Espérance, G. 1999. Characterization of manganese-containing particles collected from the exhaust emissions of automobiles running with MMT additive. Environ. Sci. Technol. 33:3341-3346.