Dual action of estrogen on glutamate-induced calcium signaling: Mechanisms requiring interaction between estrogen receptors and src/mitogen activated protein kinase pathway

Brain Research

Volumn 930, Issue 1-2, 2002, Pages 216-234

  Nilsen, Jon ^a   Chen, Shuhua ^a   Brinton, Roberta Diaz ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Calcium; Estrogen; Glutamate; Kinase; Neuroprotection

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 3 DIMETHYLAMINO 1 PHENYL 6 PYRIDAZONE; CALCIUM; CONJUGATED ESTROGEN; DIZOCILPINE; ESTROGEN RECEPTOR; GLUTAMIC ACID; MITOGEN ACTIVATED PROTEIN KINASE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NIFEDIPINE; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; COGNITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; EMBRYO; ESTROGEN ACTIVITY; ESTROGEN THERAPY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT; REGULATORY MECHANISM;

ANIMALS; CALCIUM CHANNELS, L-TYPE; CALCIUM SIGNALING; CELLS, CULTURED; ENZYME INHIBITORS; ESTROGENS, CONJUGATED (USP); EXCITATORY AMINO ACID AGONISTS; FEMALE; FLUOROMETRY; GLUTAMIC ACID; HORSES; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOHISTOCHEMISTRY; LONG-TERM POTENTIATION; MICROSCOPY, FLUORESCENCE; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ESTROGEN; RECEPTORS, N-METHYL-D-ASPARTATE; SRC-FAMILY KINASES;

EID: 0037087099     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(02)02254-0     Document Type: Article

References (54)

1. Modulation of transcriptional activation by ligand-dependent phosphorylation of the human oestrogen receptor A/B region
2. Conjugated estrogens
3. The female sex hormone oestrogen as a neuroprotectant
4. The tyrosine kinase and mitogen-activated protein kinase pathways mediate multiple effects of estrogen in hippocampus
5. Estrogen induction of rapid changes in the growth of cultured hippocampal nerve cells
6. Cellular and molecular mechanisms of estrogen regulation of memory function and neuroprotection against Alzheimer's disease: Recent insights and remaining challenges
7. The women's health initiative estrogen replacement therapy is neurotrophic and neuroprotective
8. Equilin, a principal component of the estrogen replacement therapy premarin, increases the growth of cortical neurons via an NMDA receptor-dependent mechanism
9. 17Beta-estradiol enhances the outgrowth and survival of neocortical neurons in culture
10. Glutamate neurotoxicity and diseases of the nervous system
11. Synaptic plasticity. The role of NMDA receptors in learning and memory
12. A synthetic inhibitor of the mitogen-activated protein kinase cascade
13. The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility
14. 17Beta-estradiol enhances NMDA receptor-mediated EPSPs and long-term potentiation
15. Estrogen-related variations in human spatial and articulatory-motor skills
16. Reciprocal effects of hormonal fluctuations on human motor and perceptual-spatial skills
17. Cation channel control of neurite morphology
18. Neuronal plasticity: How changes in dendritic architecture can affect the spread of postsynaptic potentials
19. Proteomic analysis of NMDA receptor-adhesion protein signaling complexes
20. Estrogen use and verbal memory in healthy postmenopausal women
21. Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase
22. A prospective study of estrogen replacement therapy and the risk of developing Alzheimer's disease: The Baltimore Longitudinal Study of Aging
23. Benefits and risks of hormone replacement therapy
24. Subtype-specific regulation of recombinant NMDA receptor-channels by protein tyrosine kinases of the src family
25. NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones
26. Influence of dendritic structure on firing pattern in model neocortical neurons
27. Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cells
28. Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5
29. Regulation of dendritic spine density in cultured rat hippocampal neurons by steroid hormones
30. Morphological plasticity of dendritic spines in central neurons is mediated by activation of cAMP response element binding protein
31. Impact of progestins on estrogen-induced neuroprotection: Synergy by progesterone and 19-norprogesterone and antagonism by medroxyprogesterone acetate
32. Effects of estrogen on memory function in surgically menopausal women
33. Variations in memory function and sex steroid hormones across the menstrual cycle
34. Molecular components of striatal plasticity: The various routes of cyclic AMP pathways
35. Effects of estrogen replacement therapy on PET cerebral blood flow and neuropsychological performance
36. Estrogen replacement therapy and longitudinal decline in visual memory. A possible protective effect?
37. Postmenopausal estrogen and estrogen-progestin use and 2-year rate of cognitive change in a cohort of older Japanese American women: The Kame Project
38. Dorsal hippocampal muscarinic acetylcholine and NMDA receptors disrupt water maze navigation
39. Glutamate and the pathophysiology of hypoxic-ischemic brain damage
40. Src, N-methyl-D-aspartate (NMDA) receptors, and synaptic plasticity
41. Estrogenic effects on memory in women
42. Estrogen effects on cognition in menopausal women
43. Oestrogen and cognitive function throughout the female lifespan
44. The mitogen-activated protein kinase pathway mediates estrogen neuroprotection after glutamate toxicity in primary cortical neurons
45. Estrogen protects primary cortical neurons from glutamate toxicity
46. Estrogen-induced activation of mitogen-activated protein kinase in cerebral cortical explants: Convergence of estrogen and neurotrophin signaling pathways
47. Gonadal steroids: Effects on excitability of hippocampal pyramidal cells
48. Gonadal hormones and brain development: Implications for the genesis of sexual differentiation
49. Estrogen and NMDA receptor antagonism: Effects upon reference and working memory
50. Long-term and short-term electrophysiological effects of estrogen on the synaptic properties of hippocampal CA1 neurons
51. Effects of estrogen in the CNS
52. Estradiol regulates hippocampal dendritic spine density via an N-methyl-D-aspartate receptor-dependent mechanism
53. Use of menopausal estrogens and medroxyprogesterone in the United States, 1982-1992
54. Estrogen therapy in postmenopausal women: Effects on cognitive function and dementia