Role of suppressor of cytokine signaling in ocular allergy

Current Opinion in Allergy and Clinical Immunology

Volumn 6, Issue 5, 2006, Pages 361-366

  Kubo, Masato ^a   Ozaki, Akemi ^b   Tanaka, Shinya ^a   Okamoto, Mariko ^a   Fukushima, Atsuki ^b  

^a RIKEN Center for Integrative Medical Sciences   (Japan)

^b KOCHI MEDICAL SCHOOL   (Japan)

Author keywords

Allergic conjunctivitis; Asthma; Helper T cell; IL 4; Ocular allergy; Suppressor of cytokine signaling

Indexed keywords

CYTOKINE; INTERLEUKIN 4; SUPPRESSOR OF CYTOKINE SIGNALING; SUPPRESSOR OF CYTOKINE SIGNALING 3; SUPPRESSOR OF CYTOKINE SIGNALING 5; UNCLASSIFIED DRUG;

ALLERGIC CONJUNCTIVITIS; CELL DIFFERENTIATION; CELL INFILTRATION; DISEASE SEVERITY; EOSINOPHIL; EYE ALLERGY; HELPER CELL; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TH1 CELL; TH2 CELL;

ANIMALS; CONJUNCTIVITIS, ALLERGIC; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TH1 CELLS; TH2 CELLS;

EID: 33748545930     PISSN: 15284050     EISSN: 14736322     Source Type: Journal    
DOI: 10.1097/01.all.0000244797.48981.6d     Document Type: Review

References (66)

1. Chambless SL, Trocme S. Developments in ocular allergy. Curr Opin Allergy Clin Immunol 2004; 4:431-434.
2. Durham SR. The inflammatory nature of allergic disease. Clin Exp Allergy 1998; 28 (Suppl 6):20-24.
3. Ozaki A, Seki Y, Fukushima A, Kubo M. The control of allergic conjunctivitis by suppressor of cytokine signaling (SOCS) 3 and SOCS5. J Immunol 2005; 175:5489-5497. This work directly shows the possibility that SOCS3 and SOCS5 function and expression regulate the development and maintenance of allergic conjunctivitis.
4. Anderson DF, MacLeod JD, Baddeley SM, et al. Seasonal allergic conjunctivitis is accompanied by increased mast cell numbers in the absence of leucocyte infiltration. Clin Exp Allergy 1997; 27:1060-1066.
5. Bacon AS, Ahluwalia P, Irani AM, et al. Tear and conjunctival changes during the allergen-induced early- and late-phase responses. J Allergy Clin Immunol 2000; 106:948-954.
6. Fukushima A, Ozaki A, Fukata K, et al. Ag-specific recognition, activation, and effector function of T cells in the conjunctiva with experimental immune-mediated blepharoconjunctivitis. Invest Ophthalmol Vis Sci 2003; 44:4366-4374.
7. Ozaki A, Fukushima A, Fukata K, Ueno H. Mast-cell activation augments the late phase reaction in experimental immune-mediated blepharoconjunctivitis. Graefes Arch Clin Exp Ophthalmol 2003; 241:394-402.
8. Oettgen HC, Geha RS. IgE in asthma and atopy: cellular and molecular connections. J Clin Invest 1999; 104:829-835.
9. Burrows B, Martinez FD, Halonen M, et al. Association of asthma with serum IgE levels and skin-test reactivity to allergens. N Engl J Med 1989; 320:271-277.
10. Oettgen HC. Regulation of the IgE isotype switch: new insights on cytokine signals and the functions of epsilon germline transcripts. Curr Opin Immunol 2000; 12:618-623.
11. Fallon PG, Jolin HE, Smith P, et al. IL-4 induces characteristic Th2 responses even in the combined absence of IL-5, IL-9, and IL-13. Immunity 2002; 17:7-17.
12. Kumar RK, Herbert C, Yang M, et al. Role of interleukin-13 in eosinophil accumulation and airway remodelling in a mouse model of chronic asthma. Clin Exp Allergy 2002; 32:1104-1111.
13. Alexander WS. Suppressors of cytokine signalling (SOCS) in the immune system. Nat Rev Immunol 2002; 2:410-416.
14. Greenhalgh CJ, Miller ME, Hilton DJ, Lund PK. Suppressors of cytokine signaling: relevance to gastrointestinal function and disease. Gastroenterology 2002; 123:2064-2081.
15. Kubo M, Hanada T, Yoshimura A. Suppressors of cytokine signaling and immunity. Nat Immunol 2003; 4:1169-1176.
16. Seki Y, Hayashi K, Matsumoto A, et al. Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation. Proc Natl Acad Sci USA 2002; 99:13003-13008.
17. Seki Y, Inoue H, Nagata N, et al. SOCS-3 regulates onset and maintenance of T(H)2-mediated allergic responses. Nat Med 2003; 9:1047-1054.
18. Yasukawa H, Sasaki A, Yoshimura A. Negative regulation of cytokine signaling pathways. Annu Rev Immunol 2000; 18:143-164.
19. Zhang JG, Farley A, Nicholson SE, et al. The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation. Proc Natl Acad Sci USA 1999; 96:2071-2076.
20. Kamura T, Sato S, Haque D, et al. The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families. Genes Dev 1998; 12:3872-3881.
21. Yoshimura A, Ohkubo T, Kiguchi T, et al. A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors. EMBO J 1995; 14:2816-2826.
22. Matsumoto A, Seki Y, Kubo M, et al. Suppression of STAT5 functions in liver, mammary glands, and T cells in cytokine-inducible SH2-containing protein 1 transgenic mice. Mol Cell Biol 1999; 19:6396-6407.
23. Naka T, Narazaki M, Hirata M, et al. Structure and function of a new STAT-induced STAT inhibitor. Nature 1997; 387:924-929.
24. Starr R, Willson TA, Viney EM, et al. A family of cytokine-inducible inhibitors of signalling. Nature 1997; 387:917-921.
25. Endo TA, Masuhara M, Yokouchi M, et al. A new protein containing an SH2 domain that inhibits JAK kinases. Nature 1997; 387:921-924.
26. Yasukawa H, Misawa H, Sakamoto H, et al. The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop. EMBO J 1999; 18:1309-1320.
27. Giordanetto F, Kroemer RT. A three-dimensional model of suppressor of cytokine signalling 1 (SOCS-1). Protein Eng 2003; 16:115-124.
28. Nicholson SE, De Souza D, Fabri LJ, et al. Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130. Proc Natl Acad Sci USA 2000; 97:6493-6498.
29. Lehmann U, Schmitz J, Weissenbach M, et al. SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130. J Biol Chem 2003; 278:661-671.
30. Sasaki A, Yasukawa H, Shouda T, et al. Yoshimura A: CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2. J Biol Chem 2000; 275:29338-29347.
31. Hortner M, Nielsch U, Mayr LM, et al. A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor. Eur J Biochem 2002; 269:2516-2526.
32. Bjorbak C, Lavery HJ, Bates SH, et al. SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985. J Biol Chem 2000; 275:40649-40657.
33. Frantsve J, Schwaller J, Sternberg DW, et al. Socs-1 inhibits TEL-JAK2-mediated transformation of hematopoietic cells through inhibition of JAK2 kinase activity and induction of proteasome-mediated degradation. Mol Cell Biol 2001; 21:3547-3557.
34. Kamizono S, Hanada T, Yasukawa H, et al. The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2. J Biol Chem 2001; 276:12530-12538.
35. Zhang JG, Metcalf D, Rakar S, et al. The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo. Proc Natl Acad Sci USA 2001; 98:13261-13265.
36. Hilton DJ. Negative regulators of cytokine signal transduction. Cell Mol Life Sci 1999; 55:1568-1577.
37. Fujimoto M, Naka T. Regulation of cytokine signaling by SOCS family molecules. Trends Immunol 2003; 24:659-666.
38. Cohney SJ, Sanden D, Cacalano NA, et al. SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation. Mol Cell Biol 1999; 19:4980-4988.
39. Bjorbaek C, Elmquist JK, Frantz JD, et al. Identification of SOCS-3 as a potential mediator of central leptin resistance. Mol Cell 1998; 1:619-625.
40. Ito S, Ansari P, Sakatsume M, et al. Interleukin-10 inhibits expression of both interferon alpha- and interferon gamma-induced genes by suppressing tyrosine phosphorylation of STAT1. Blood 1999; 93:1456-1463.
41. Auernhammer CJ, Melmed S. Interleukin-11 stimulates proopiomelanocortin gene expression and adrenocorticotropin secretion in corticotroph cells: evidence for a redundant cytokine network in the hypothalamo-pituitary-adrenal axis. Endocrinology 1999; 140:1559-1566.
42. Suzuki A, Hanada T, Mitsuyama K, et al. CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation. J Exp Med 2001; 193:471-481.
43. Jo D, Liu D, Yao S, et al. Intracellular protein therapy with SOCS3 inhibits inflammation and apoptosis. Nat Med 2005; 11:892-898.
44. Yasukawa H, Yajima T, Duplain H, et al. The suppressor of cytokine signaling-1 (SOCS1) is a novel therapeutic target for enterovirus-induced cardiac injury. J Clin Invest 2003; 111:469-478.
45. Marine JC, Topham DJ, McKay C, et al. SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality. Cell 1999; 98:609-616.
46. Hanada T, Yoshida H, Kato S, et al. Suppressor of cytokine signaling-1 is essential for suppressing dendritic cell activation and systemic autoimmunity. Immunity 2003; 19:437-450.
47. Naka T, Tsutsui H, Fujimoto M, et al. SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN-gamma and IL-4 signaling in vivo. Immunity 2001; 14:535-545.
48. Hanada T, Tanaka K, Matsumura Y, et al. Induction of hyper Th1 cell-type immune responses by dendritic cells lacking the suppressor of cytokine signaling-1 gene. J Immunol 2005; 174:4325-4332.
49. + dendritic cell subset. Int Immunol 2005; 17:1167-1178.
50. Wills-Karp M. Immunologic basis of antigen-induced airway hyperresponsiveness. Annu Rev Immunol 1999; 17:255-281.
51. Uchio E, Ono SY, Ikezawa Z, Ohno S. Tear levels of interferon-gamma, interleukin (IL)-2, IL-4 and IL-5 in patients with vernal keratoconjunctivitis, atopic keratoconjunctivitis and allergic conjunctivitis. Clin Exp Allergy 2000; 30:103-109.
52. Magone MT, Whitcup SM, Fukushima A, et al. The role of IL-12 in the induction of late-phase cellular infiltration in a murine model of allergic conjunctivitis. J Allergy Clin Immunol 2000; 105:299-308.
53. van der Pouw Kraan TC, Boeije LC, de Groot ER, et al. Reduced production of IL-12 and IL-12-dependent IFN-gamma release in patients with allergic asthma. J Immunol 1997; 158:5560-5565.
54. Ozaki A, Fukushima A, Fukata K, Ueno H. Effects of IL-4 and IL-12 on experimental immune-mediated blepharoconjunctivitis in Brown Norway rats. Clin Exp Immunol 2000; 122:28-34.
55. Egwuagu CE, Yu CR, Zhang M, et al. Suppressors of cytokine signaling proteins are differentially expressed in Th1 and Th2 cells: implications for Th cell lineage commitment and maintenance. J Immunol 2002; 168:3181-3187.
56. Canfield S, Lee Y, Schroder A, Rothman P. Cutting edge: IL-4 induces suppressor of cytokine signaling-3 expression in B cells by a mechanism dependent on activation of p38 MAPK. J Immunol 2005; 174:2494-2498.
57. Yamamoto K, Yamaguchi M, Miyasaka N, Miura O. SOCS-3 inhibits IL-12-induced STAT4 activation by binding through its SH2 domain to the STAT4 docking site in the IL-12 receptor beta2 subunit. Biochem Biophys Res Commun 2003; 310:1188-1193.
58. Owaki T, Asakawa M, Kamiya S, et al. IL-27 suppresses CD28-mediated [correction of medicated] IL-2 production through suppressor of cytokine signaling 3. J Immunol 2006; 176:2773-2780.
59. Takatori H, Nakajima H, Kagami S, et al. Stat5a inhibits IL-12-induced Th1 cell differentiation through the induction of suppressor of cytokine signaling 3 expression. J Immunol 2005; 174:4105-4112.
60. Matsumoto A, Seki Y, Watanabe R, et al. A role of suppressor of cytokine signaling 3 (SOCS3/CIS3/SSI3) in CD28-mediated interleukin 2 production. J Exp Med 2003; 197:425-436.
61. Kubo M, Yamashita M, Abe R, et al. CD28 costimulation accelerates IL-4 receptor sensitivity and IL-4-mediated Th2 differentiation. J Immunol 1999; 163:2432-2442.
62. Kinjyo I, Inoue H, Hamano S, et al. Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor-{beta}1. J Exp Med 2006; 203:1021-1031.
63. Huang H, Paul WE. Impaired interleukin 4 signaling in T helper type 1 cells. J Exp Med 1998; 187:1305-1313.
64. Kubo M, Ransom J, Webb D, et al. T-cell subset-specific expression of the IL-4 gene is regulated by a silencer element and STAT6. EMBO J 1997; 16:4007-4020.
65. Arakawa S, Hatano Y, Katagiri K. Differential expression of mRNA for Th1 and Th2 cytokine-associated transcription factors and suppressors of cytokine signalling in peripheral blood mononuclear cells of patients with atopic dermatitis. Clin Exp Immunol 2004; 135:505-510.
66. Inoue H, Kubo M. SOCS proteins in T helper cell differentiation: implications for allergic disorders? Expert Rev Mol Med 2004; 6:1-11.