Tear levels of interferon-γ, interleukin (IL) -2, IL-4 and IL-5 in patients with vernal keratoconjunctivitis, atopic keratoconjunctivitis and allergic conjunctivitis

Clinical and Experimental Allergy

Volumn 30, Issue 1, 2000, Pages 103-109

  Uchio, E ^a   Ono, S Y ^a   Ikezawa, Z ^a   Ohno, S ^a  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

Author keywords

Allergic conjunctivitis; Atopic dermatitis; Atopic keratoconjunctivitis; Interferon ; Interleukin 5; Interleukin 2; Interleukin 4; Tears; Vernal keratoconjunctivitis

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5;

ADOLESCENT; ADULT; ALLERGIC CONJUNCTIVITIS; ARTICLE; ATOPY; CHRONIC DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HELPER CELL; HUMAN; KERATOCONJUNCTIVITIS; LACRIMAL FLUID; MALE; PRIORITY JOURNAL; SCHOOL CHILD; VERNAL CONJUNCTIVITIS;

ADOLESCENT; ADULT; CHILD; CONJUNCTIVITIS, ALLERGIC; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; INTERFERON TYPE II; INTERLEUKIN-2; INTERLEUKIN-4; INTERLEUKIN-5; INTERLEUKINS; MALE; MIDDLE AGED; SEVERITY OF ILLNESS INDEX; TEARS;

EID: 0033953402     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2222.2000.00699.x     Document Type: Article

References (22)

1. 1 Mosmann TR, Coffman RL. Th1 and Th2 cells: Different patterns of lymphokine secretion lead to different functional properties. Ann Rev Immunol 1983; 7:145-73.
2. 2 Bernauer W, Wright P, Dart JK, Leonard JN, Lightman S. Cytokines in the conjunctiva of acute and chronic mucous membrane pemphigoid: an immunohistochemical analysis. Graefes Arch Clin Exp Ophthalmol 1993; 231:563-70.
3. 3 Metz DP, Hingorani M, Calder VL, Buckley RJ, Lightman S. T-cell cytokines in chronic allergic eye disease. J Allergy Clin Immunol 1997; 100:817-24.
4. 4 Del Prete G, Maggi E, Parronchi P et al. IL-4 is an essential factor for the IgE synthesis induced in vitro by human T cell clones and their supernatants. J Immunol 1988; 140:4193-8.
5. 5 Punnonen J, Aversa G, Cocks BG et al. Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression. Proc Natl Acad Sci USA 1993; 90:3730-4.
6. 6 Sanderson CJ. Interleukin-5, eosinophilia, and disease. Blood 1992; 79:3101-9.
7. 7 Maggi E, Del Prete GF, Parronchi P et al. Role for T cells, II-2 and IL-6 in the IL-4 dependent in vitro and human IgE synthesis. Immunology 1989; 68:300-6.
8. 8 Rousset F, Robert J, Andary M et al. Shifts in interleukin-4 and interferon-γ production by T cells of patients with elevated serum IgE levels and the modulatory effects of these lymphokines on spontaneous IgE synthesis. J Allergy Clin Immunol 1991; 87:58-69.
9. 9 Fujishima H, Shimazaki J, Takeuchi T, Saito I, Tsubota K. Interleukin-4 and IgE in seasonal allergic conjunctivitis. Ophthalmologica 1996; 210:325-8.
10. 10 Fujishima H, Takeuchi T, Shinozaki J, Saito I, Tsubola K. Measurement of IL-4 in tears of patients with seasonal allergic conjunctivitis and vernal keratoconjunctivitis. Clin Exp Immunol 1995; 102:395-8.
11. 11 Fujishima H, Saito I, Takeuchi T, Shinozaki N, Tsubota K. Characterization of cytokine mRNA transcripts in conjunctival cells in patients with allergic conjunctivitis. Invest Ophthalmol Vis Sci 1997; 38:1350-7.
12. 12 BenEzra D. Guidelines on the diagnosis and treatment of conjunctivitis. Ocul Immunol Inflam 1994; 2 (Suppl.):17-26.
13. 13 Hanifin JM, Rajka G. Diagnostic features of atopic dermatitis. Acta Dermatol Venereol 1980; 92 (Suppl.):44-7.
14. 14 Rajka G, Langeland T. Grading of the severity of atopic dermatitis. Acta Derm Venereol (Stockh) 1989; 144 (Suppl.): 13-4.
15. 15 Tuft SJ, Dart JKG. The measurement of IgE in tear fluid: a comparison of collection by sponge or capillary. Acta Ophthalmol 1989; 67:301-5.
16. 16 Pene J, Rousset F, Briere F et al. IgE production by normal human B cells induced by alloreactive T cell clones is mediated by IL-4 and suppressed by IFN-γ. J Immunol 1988; 141:1218-24.
17. L/CD23 positive circulating lymphocytes in patients with severe atopic dermatitis. Acta Derm Venereal (Stockh) 1989; 144 (Suppl.):127-30.
18. 18 Anderson DF, Macleod JDA, Baddeley SM et al. Seasonal allergic conjunctivitis is accompanied by increased mast cell numbers in the absence of leukocyte infiltration. Clin Exp Allergy 1997; 27:1060-6.
19. 19 Foster CS, Rice BA, Dutt JE. Immunopathology of atopic keratoconjunctivitis. Ophthalmology 1991; 98:1190-6.
20. 20 Furue M, Ohtsuka M, Ogata F, Ishibashi Y. Responsiveness to interleukin 4 and interleukin 2 of peripheral blood mononuclear cells in atopic dermatitis. J Invest Dermatol 1991; 96:468-72.
21. 21 Yokota T, Arai N, de Vries JE et al. Molecular biology of interleukin 4 and interleukin 5 genes and biology of their products that stimulate B cells, T cells and hemopoietic cells. Immunol Rev 1988; 102:137-87.
22. 22 Sewell WA, Mu H-H. Dissociation of production of interleukin-4 and interleukin-5. Immunol Cell Biol 1996; 74:274-7.