Farnesyltransferase inhibitors are potent lung cancer chemopreventive agents in A/J mice with a dominant-negative p53 and/or heterozygous deletion of Ink4a\Arf

Oncogene

Volumn 22, Issue 40, 2003, Pages 6257-6265

  Zhang, Zhongqiu ^a   Wang, Yian ^a   Lantry, Laura E ^b   Kastens, Elizabeth ^a   Liu, Gongjie ^b   Hamilton, Andrew D ^c   Sebti, Said M ^d   Lubet, Ronald A ^e   You, Ming ^a  

^a USA   (United States)

^b MEDICAL COLLEGE OF OHIO   (United States)

^c YALE UNIVERSITY   (United States)

^d H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^e NATIONAL CANCER INSTITUTE   (United States)

Author keywords

A J mice; Chemoprevention; Farnesyltransferase inhibitor; Ink4a Arf; Lung cancer; P53; Transgenic mice

Indexed keywords

ANTINEOPLASTIC AGENT; ARF PROTEIN; CARCINOGEN; IMIDAZOLE DERIVATIVE; L 778123; N [[5 [(2 AMINO 3 MERCAPTOPROPYL)AMINO][1,1' BIPHENYL] 2 YL]CARBONYL]METHIONINE; N [[5 [(2 AMINO 3 MERCAPTOPROPYL)AMINO][1,1' BIPHENYL] 2 YL]CARBONYL]METHIONINE METHYL ESTER; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PROTEIN P21; PROTEIN P53;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CANCER SIZE; CARBOXY TERMINAL SEQUENCE; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DRUG EFFICACY; DRUG SCREENING; GENE MUTATION; HETEROZYGOSITY; HETEROZYGOSITY LOSS; LUNG CARCINOMA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEIN PROCESSING; STATISTICAL SIGNIFICANCE; TRANSGENIC MOUSE; TREATMENT OUTCOME; TUMOR SUPPRESSOR GENE; WILD TYPE;

ADENOCARCINOMA; ALKYL AND ARYL TRANSFERASES; ANIMALS; ANTICARCINOGENIC AGENTS; CYCLIN-DEPENDENT KINASE INHIBITOR P16; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; GENE DELETION; GENES, DOMINANT; GENES, P53; HETEROZYGOTE; IMIDAZOLES; LUNG NEOPLASMS; METHIONINE; MICE; MICE, INBRED A; MICE, KNOCKOUT; MICE, TRANSGENIC;

ANIMALIA; MUS MUSCULUS;

EID: 0142088857     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1206630     Document Type: Article

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