The p110δ isoform of PI3K differentially regulates β1 and β2 integrin-mediated monocyte adhesion and spreading and modulates diapedesis

Microcirculation

Volumn 13, Issue 6, 2006, Pages 439-456

  Ferreira, Alexander M ^a   Isaacs, Harold ^a   Hayflick, Joel S ^b   Rogers, Kem A ^a   Sandig, Martin ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

Atherosclerosis; Integrin activation; Monocyte; PI3K p110 ; Transendothelial migration

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; BETA1 INTEGRIN; BETA2 INTEGRIN; INTERCELLULAR ADHESION MOLECULE 1; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN CDC42; PROTEIN P110; PROTEIN P110 DELTA; RAC1 PROTEIN; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; WORTMANNIN; 1 PHOSPHATIDYLINOSITOL 3 KINASE P110 SUBUNIT, HUMAN; 1-PHOSPHATIDYLINOSITOL 3-KINASE P110 SUBUNIT, HUMAN; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; ADENINE; ANDROSTANE DERIVATIVE; CD18 ANTIGEN; CHROMONE DERIVATIVE; DRUG DERIVATIVE; IC 87114; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MORPHOLINE DERIVATIVE; PROTEIN KINASE INHIBITOR; QUINAZOLINE DERIVATIVE; RAC1 PROTEIN, HUMAN; VERY LATE ACTIVATION ANTIGEN 4;

ARTICLE; CELL ADHESION; CELL SPREADING; CELL SURFACE; CHEMOTAXIS; CONTROLLED STUDY; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; LYMPHOCYTE MIGRATION; MONOCYTE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; BIOSYNTHESIS; CELL LINE; CELL MOTION; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION REGULATION; METABOLISM; PHYSIOLOGY;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADENINE; ANDROSTADIENES; ANTIGENS, CD18; ANTIGENS, CD29; CDC42 GTP-BINDING PROTEIN; CELL LINE; CELL MOVEMENT; CHROMONES; GENE EXPRESSION REGULATION; HUMANS; INTEGRIN ALPHA4BETA1; INTERCELLULAR ADHESION MOLECULE-1; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MONOCYTES; MORPHOLINES; PROTEIN KINASE INHIBITORS; QUINAZOLINES; RAC1 GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; VASCULAR CELL ADHESION MOLECULE-1;

EID: 33748320811     PISSN: 10739688     EISSN: 15498719     Source Type: Journal    
DOI: 10.1080/10739680600776062     Document Type: Article

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