Signaling through the Leukocyte Integrin LFA-1 in T Cells Induces a Transient Activation of Rac-1 That Is Regulated by Vav and PI3K/Akt-1

Journal of Biological Chemistry

Volumn 279, Issue 16, 2004, Pages 16194-16205

  Sánchez Martín, Lorena ^a   Sánchez Sánchez, Noelia ^a   Gutiérrez López, M Dolores ^a   Rojo, Ana I ^b   Vicente Manzanares, Miguel ^d   Pérez Alvarez, María José ^a   Sánchez Mateos, Paloma ^c   Bustelo, Xosé R ^e   Cuadrado, Antonio ^b   Sánchez Madrid, Francisco ^d   Rodríguez Fernández, José Luis ^a   Cabañas, Carlos ^a,d  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^c HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^d HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

^e UNIVERSITY OF SALAMANCA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; CELLS; ENZYME KINETICS; MORPHOLOGY; MUTAGENESIS;

GENE EXPRESSION; MULTIPLE INTRACELLULAR SIGNALS;

BIOCHEMICAL ENGINEERING;

GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE TRIPHOSPHATASE; INTEGRIN; INTEGRIN LFA 1; INTERCELLULAR ADHESION MOLECULE 1; MUTANT PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RAC1 PROTEIN; UNCLASSIFIED DRUG; VAV PROTEIN;

ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME KINETICS; ENZYME REGULATION; HUMAN; HUMAN CELL; LYMPHOCYTE ACTIVATION; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; CELL ADHESION; CELLS, CULTURED; DOWN-REGULATION; ENZYME ACTIVATION; HUMANS; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-VAV; RAC1 GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 11144355979     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M400905200     Document Type: Article

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