Signaling through integrin LFA-1 leads to filamentous actin polymerization and remodeling, resulting in enhanced T cell adhesion

Journal of Immunology

Volumn 168, Issue 12, 2002, Pages 6330-6335

  Porter, Joanna C ^a   Bracke, Madelon ^a   Smith, Andrew ^a   Davies, Derek ^a   Hogg, Nancy ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

F ACTIN; INTEGRIN; INTERCELLULAR ADHESION MOLECULE 1; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1;

ACTIN FILAMENT; ACTIN POLYMERIZATION; ARTICLE; CELL ADHESION; CELL STRUCTURE; CELLULAR DISTRIBUTION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOMETRY; CYTOSKELETON; HUMAN; HUMAN CELL; LASER SCANNING CYTOMETRY; LYMPHOCYTE FUNCTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; QUANTITATIVE ASSAY; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

EID: 0037097767     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.168.12.6330     Document Type: Article

References (30)

1. Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function
2. 1 integrins on fibroblasts
3. Integrin function: Molecular hierarchies of cytoskeletal and signaling molecules
4. Cell migration: Movin' on
5. Leukocyte polarization in cell migration and immune interactions
6. The immunological synapse: A molecular machine controlling T cell activation
7. 2+-dependent protease, calpain
8. Divalent cation regulation of the function of the leukocyte integrin LFA-1
9. T cell adhesion to intercellular adhesion molecule-1 (ICAM-1) is controlled by cell spreading and the activation of integrin LFA-1
10. Microscope-based multiparameter laser scanning cytometer yielding data comparable to flow cytometry data
11. Laser-scanning cytometry: A new instrumentation with many applications
12. Enhancement of LFA-1-mediated cell adhesion by triggering through CD2 or CD3 on T lymphocytes
13. T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1
14. Effects of cytochalasin and phalloidin on actin
15. Inhibition of actin polymerization by latrunculin A
16. Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin
17. Avidity regulation of integrins: The driving force in leukocyte adhesion
18. Protein kinase C modulates actin conformation in human T lymphocytes
19. Microquantification of cellular and in vitro F-actin by rhodamine phalloidin fluorescence enhancement
20. Focal adhesion motility revealed in stationary fibroblasts
21. 1 integrin-dependent cell adhesion is regulated by a low affinity receptor pool that is conformationally responsive to ligand
22. The native structure of intercellular adhesion molecule-1 (ICAM-1) is a dimer: Correlation with binding to LFA-1
23. Intercellular adhesion molecule-1 dimerization and its consequences for adhesion mediated by lymphocyte function associated-1
24. Monocyte adhesion and spreading on human endothelial cells is dependent on Rho-regulated receptor clustering
25. 2integrin LFA-1 signaling through phospholipase C-γ1 activation
26. The interaction of activated integrin lymphocyte functionassociated antigen 1 with ligand intercellular adhesion molecule 1 induces activation and redistribution of focal adhesion kinase and proline-rich tyrosine kinase 2 in T lymphocytes
27. Crucial importance of PKC-β(I) in LFA-1-mediated locomotion of activated T cells
28. 2 integrin affinity and mobility changes: Differential regulation and roles in lymphocyte arrest under flow
29. Spatial control of actin polymerization during neutrophil chemotaxis
30. Actin polymerization and pseudopod reorganization accompany anti-CD3-induced growth arrest in Jurkat T cells