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Bidirectional signaling mediated by ephrin-B2 and EphB2 controls urorectal development
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Dravis C., Yokoyama N., Chumley M.J., Cowan C.A., Silvany R.E., Shay J., Baker L.A., and Henkemeyer M. Bidirectional signaling mediated by ephrin-B2 and EphB2 controls urorectal development. Dev Biol 271 (2004) 272-290
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Silvany, R.E.5
Shay, J.6
Baker, L.A.7
Henkemeyer, M.8
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EphA receptor tyrosine kinases interact with co-expressed ephrin-A ligands in cis
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Yin Y., Yamashita Y., Noda H., Okafuji T., Go M.J., and Tanaka H. EphA receptor tyrosine kinases interact with co-expressed ephrin-A ligands in cis. Neurosci Res 48 (2004) 285-296
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Go, M.J.5
Tanaka, H.6
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Modulation of EphA receptor function by coexpressed ephrinA ligands on retinal ganglion cell axons
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Hornberger M.R., Dutting D., Ciossek T., Yamada T., Handwerker C., Lang S., Weth F., Huf J., Wessel R., Logan C., et al. Modulation of EphA receptor function by coexpressed ephrinA ligands on retinal ganglion cell axons. Neuron 22 (1999) 731-742
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Weth, F.7
Huf, J.8
Wessel, R.9
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Silencing of EphA3 through a cis interaction with ephrinA5
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This study reveals a mechanism by which cis-expressed ephrinA5 can block EphA3 phosphorylation through an interaction with the fibronectin III domain of EphA3. This silences EphA3 signaling and reduces the response of the cell to ephrinA presented in trans.
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Carvalho R.F., Beutler M., Marler K.J., Knoll B., Becker-Barroso E., Heintzmann R., Ng T., and Drescher U. Silencing of EphA3 through a cis interaction with ephrinA5. Nat Neurosci 9 (2006) 322-330. This study reveals a mechanism by which cis-expressed ephrinA5 can block EphA3 phosphorylation through an interaction with the fibronectin III domain of EphA3. This silences EphA3 signaling and reduces the response of the cell to ephrinA presented in trans.
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Nat Neurosci
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Carvalho, R.F.1
Beutler, M.2
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Heintzmann, R.6
Ng, T.7
Drescher, U.8
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50
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Retinal axon response to ephrin-as shows a graded, concentration-dependent transition from growth promotion to inhibition
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The authors demonstrate that retinal axons respond with either attraction or repulsion to ephrinA5, depending on their retinal region of origin and on the concentration of ephrinA5 they encounter. They propose a model to explain how retinal axons target to the correct location on the tectal ephrinA5 gradient by regulating the balance between ephrin-Eph-mediated adhesion versus repulsion.
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Hansen M.J., Dallal G.E., and Flanagan J.G. Retinal axon response to ephrin-as shows a graded, concentration-dependent transition from growth promotion to inhibition. Neuron 42 (2004) 717-730. The authors demonstrate that retinal axons respond with either attraction or repulsion to ephrinA5, depending on their retinal region of origin and on the concentration of ephrinA5 they encounter. They propose a model to explain how retinal axons target to the correct location on the tectal ephrinA5 gradient by regulating the balance between ephrin-Eph-mediated adhesion versus repulsion.
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Neuron
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Hansen, M.J.1
Dallal, G.E.2
Flanagan, J.G.3
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51
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Coexpressed EphA receptors and ephrin-A ligands mediate opposing actions on growth cone navigation from distinct membrane domains
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The authors show that in motor axons, cis EphA and ephrinA are separated into distinct membrane domains that restrict their cis interactions. This mechanism allows independent signaling from ephrins and Ephs expressed in the same cell membrane.
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Marquardt T., Shirasaki R., Ghosh S., Andrews S.E., Carter N., Hunter T., and Pfaff S.L. Coexpressed EphA receptors and ephrin-A ligands mediate opposing actions on growth cone navigation from distinct membrane domains. Cell 121 (2005) 127-139. The authors show that in motor axons, cis EphA and ephrinA are separated into distinct membrane domains that restrict their cis interactions. This mechanism allows independent signaling from ephrins and Ephs expressed in the same cell membrane.
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(2005)
Cell
, vol.121
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Marquardt, T.1
Shirasaki, R.2
Ghosh, S.3
Andrews, S.E.4
Carter, N.5
Hunter, T.6
Pfaff, S.L.7
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