Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins

Science

Volumn 307, Issue 5707, 2005, Pages 265-268

  Gu, Chenghua ^a   Yoshida, Yutaka ^b   Livet, Jean ^c   Reimert, Dorothy V ^a   Mann, Fanny ^c   Merte, Janna ^a   Henderson, Christopher E ^c   Jessell, Thomas M ^b   Kolodkin, Alex L ^a   Ginty, David D ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Howard Hughes Medical Institute   (United States)

^c AIX MARSEILLE UNIVERSITÉ   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; GENETIC ENGINEERING;

NEUROPILINS; PLEXIN-D1; SEMAPHORIN 3E; SOMITES;

NEUROLOGY;

NEUROPILIN; PLEXIN; PLEXIN D1; SEMAPHORIN; SEMAPHORIN 3E; UNCLASSIFIED DRUG;

SCIENCE AND TECHNOLOGY;

ANGIOGENESIS; ARTICLE; ENDOTHELIUM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SOMITE;

ANIMALS; BINDING SITES; BLOOD VESSELS; BODY PATTERNING; CERCOPITHECUS AETHIOPS; CHICK EMBRYO; COS CELLS; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; GLYCOPROTEINS; IN SITU HYBRIDIZATION; LIGANDS; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MICE; MORPHOGENESIS; MUTATION; NERVE TISSUE PROTEINS; NEUROPILIN-1; NEUROPILIN-2; PHENOTYPE; PROTEIN BINDING; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; SOMITES; TRANSFECTION;

MAMMALIA;

EID: 19944430075     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1105416     Document Type: Article

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22. We thank X. Chen, C. Deppmann, C.-M. Fan, J. Pasterkamp, and T. Pietri for helpful comments on the manuscript; B. Tice, T. Hippe, F. Lauro, and N. Senant for excellent technical assistance; A. Chen for help with chick electroporation; B. Han for cell culture; M. Mendelsohn for generation of plexin-D1 mice; T. Pietri, E. R. Rodriguez and X. Chen for help with figures; and H. Cremer and J. Sager for helpful discussions. This work was supported by INSERM, CNRS, Association Française contre les Myopathies (AFM), European Commission contract QLG3-CT-1999-00602, ARC and IRME (J.L.), Christopher Reeve Paralysis Foundation (CRPF GB2-0301-1) (C.G.), a Human Frontier Science Program Fellowship (Y.Y.), the Packard Center for Amyotrophic Lateral Sclerosis Research at Johns Hopkins (D.D.G. and A.L.K.). NIH grants CA23767-24 (T.M.J.) and MHS9199-06 (D.D.G. and A.L.K.), and the Howard Hughes Medical Institute (T.M.J. and D.D.G.). T.M.J. and D.D.G. are investigators of the Howard Hughes Medical Institute. Molecular interaction data have been deposited in the Biomolecular Interaction Network Database with accession codes 183369, 183370, 183371, 183372, and 183373.